Toxicological Research
- Volume 8 Issue 2
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- Pages.171-177
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- 1992
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- 1976-8257(pISSN)
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- 2234-2753(eISSN)
A Short Term Screening Method for Carcinogenic Quinone Compounds
Quinone계 화합물의 발암성 조기검색법에 관한 연구
-
Cho, Dae-Hyun
(National Institute of Safety Research) ;
-
Hong, Jin-Tae
(National Institute of Safety Research) ;
- Park, Jeong-Sik (National Institute of Safety Research) ;
- Hong, Youn-Tack (National Institute of Safety Research) ;
- Chin, Kang (National Institute of Safety Research) ;
-
Jung, Myung-Hee
(College of Medicine, Seoul National University) ;
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Lee, Byung-Mu
(College of Pharmacy, Sung Kyun Kawn University)
-
조대현
(국립보건안전연구원) ;
-
홍진태
(국립보건안전연구원) ;
- 박정식 (국립보건안전연구원) ;
- 홍연탁 (국립보건안전연구원) ;
- 진강 (국립보건안전연구원) ;
-
정명희
(서울대학교 의과대학) ;
-
이병무
(성균관대학교 약학대학)
- Published : 1992.12.01
Abstract
To investigate a short term screening method for carcinogenic quinone compounds, 8-hydroxydeoxyguanosine (8-OHdG), an oxidative DNA damage, was determined in the kidney and liver DNA isolated from Sprague-Dawley rats after i.p.injection of 7 mg/kg adriamycin (AM), 7mg/kg tetrahydropyranyladriamycin (THP), and 10mg/kg daunomycin (DM) by HPLC-electrochemical detector system. 8-OHdG was also determined from rat hepatocvtes and calf thymus DNA exposed to AM, DM and THP. When rats were treated with DM and THP, 8-OHdG was significantly increased in the kidney compared to control group, and remained at high level (7.9~9.0, 8-OHdG/dG
Keywords
- 8-Hydroxydeoxyguanosine;
- Oxidative DNA damage;
- Quinone chemicals;
- Carcinogen;
- Free radical;
- Adriamycin