• Transactions of the Korean Society of Automotive Engineers
• /
• v.7 no.8
• /
• pp.190-198
• /
• 1999

Continuously controlled semi-active suspension system may improve ride and handling properties. Here, as a mechanism to control the fluid flow solenoid valve mechanism is introduced and added to the basic passive damper to create damping forces of the shock absorbers. The system may produce continuously controlled damping forces in both solenoid valve only and combination with passive shock absorber including fluid flow is studied, and then the combined model is added to the full vehicle model to evaluate its ride and handling performance. Finally, the simulation results are compared to the vehicle models having similar suspension system.

• Journal of Power System Engineering
• /
• v.22 no.6
• /
• pp.80-86
• /
• 2018

A damper is a hydraulic device designed to absorb or eliminate shock impulses which is acting on the sprung mass of car body. It converts the kinetic energy of the shock into another form of energy, typically heat. The main mechanism for providing damping is by shearing the hydraulic fluid as it flows through restrictions. Since the damping mechanism depends on the flow restrictions, these restrictions are very important in damper design. Damper engineers often try several combinations of valve shims, piston orifices and bleed orifices before finding the best combination for a particular setup on a car. Therefore, the ability to tune a damper properly without testing is of great interest in damper design. For this reason, many previous researches have been done on modeling and simulation of the damper. This paper explains a genetic algorithm method to find the optimal parameters for the design objective and the simulation results agree well with the targeted damping characteristics.

• Journal of the Korean Society for Precision Engineering
• /
• v.14 no.6
• /
• pp.28-36
• /
• 1997

Even if the shock absorber is developed to Variable S/V or Active S/A, it is necrssary to construct database or bulid the dynamic performance characteristic program of Oil S/A. Since both Variable S/A and Active S/A are based on the principle of Oil S/A. To obtain the design technique of Oil S/A, we model the daping mechanism and characteristics of an Oil S/A whose performance was testified. And then it is analyzed the dynamic behaviour characteristics of damping mechanism.

• Journal of Microbiology and Biotechnology
• /
• v.13 no.1
• /
• pp.85-89
• /
• 2003

The difference in the thermotolerance between Saccharomyces cerevisiae KNU5377 and ATCC24858 was compared by assaying the amounts of trehalose accumulated under growth and heat shock conditions. Both strains exhibited similar trehalose accumulation during the growth period, but an intrinsic thermotolerance was much higher in KNU5377 than in the control strain. This result implied that some strain-specific characteristics of KNU5377, other than trehalose accumulation, primarily were responsible fur its higher intrinsic thermotolerance. Heat shock at $43^{\circ}C$ for 90 min to the exponentially growing cells resulted in the maximum level of trehalose In both strains. Trehalose accumulated at least twice more in KNU5377 by the heat shock than in the control, due to the maintenance of its neutral trehalase activity even after the heat shock. Consequently, the Increase of acquired thermotolerance in both strains correlated with an increase in the trehalose content in each strain. In conclusion, KNU5377 exhibited a well-modulated trehalose-related mechanism to accumulate more trehalose by means of maintaining neutral trehalase activity after heat shock than the control strain, thereby contributing to its acquired thermotolerance.

• Proceedings of the IEEK Conference
• /
• 2008.06a
• /
• pp.1075-1076
• /
• 2008

Hemorrhagic shock is a common cause of death in emergency rooms. The objective evaluation of hemorrhagic shock is very important for early diagnosis and treatment. The purpose of this study is to understand its mechanism by analyzing the changes of bio-signals in hemorrhagic shock using controlled hemorrhage of SD rats. In this study, we constructed a hemorrhagic integrated system to control bleeding and to simultaneously measure bio-signals such as ECG, blood pressure, temperature, and respiration. In order to verify the system, we measured the bio-signals mentioned above while hemorrhagic shock was induced by withdrawing blood (2.5ml/100g/15min) from a femoral vein for 10 rats.

• Biomedical Science Letters
• /
• v.12 no.4
• /
• pp.435-438
• /
• 2006

In eukaryotes, ER stress induces UPR (unfolded protein response) via IRE1 activation which sends a molecular signal for XBP1 mRNA splicing in the cytosol. During this mRNA splicing, 23 nt removed in which contains PstI site and then resulting XBP1 product is not digested with PstI restriction enzyme. In this study, using this XBP1 mRNA splicing mechanism, the effect of heat shock on thyrocytes is studied, because heat shock response in the thyrocytes needs more study to understand thyroid physiology under alternative environments. ER inducible drugs (tunicamycin, DTT, $Ca^{2+}$ ionopore A23187, BFA) induce ER stress in the thyrocytes. From 3 hours after heat shock, ER stress is induced and which is reversible when heat shock is without. While $Ca^{2+}$ ionopore A23187 is reversible from ER stress by washing out the drug, thapsigagin is irreversible. Other ER inducible drugs are not so sensitive to ER stress repairing. XBP1 mRNA splicing in a cell is very available method to detect ER stress. It needs only a small quantity of total RNA and processing also very easy.

• BMB Reports
• /
• v.48 no.8
• /
• pp.467-472
• /
• 2015

Heat shock increases skin temperature during sun exposure and some evidence indicates that it may be involved in skin aging. The antioxidant response mediated by the transcription factor NF-E2-related factor 2 (Nrf2) is a critically important cellular defense mechanism that serves to limit skin aging. We investigated the effects of heat shock on collagenase expression when the antioxidant defense system was downregulated by knockdown of Nrf2. GSH and collagenases were analyzed, and the expression of inducible Nrf2, HO-1, and NQO1 was measured. HS68 cells were transfected with small interfering RNA against Nrf2. Heat shock induced the downregulation of Nrf2 in both the cytosol and nucleus and reduced the expression of HO-1, GSH, and NQO1. In addition, heat-exposed Nrf2-knockdown cells showed significantly increased levels of collagenase protein and decreased levels of procollagen. Our data suggest that Nrf2 plays an important role in protection against heat shock-induced collagen breakdown in skin. [BMB Reports 2015; 48(8): 467-472]

• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.32 no.11
• /
• pp.832-840
• /
• 2008

Ablation occurs at irradiance beyond $10^9\;W/cm^2$ with nanosecond and short laser pulses focused onto any materials. Phenomenologically, the surface temperature is instantaneously heated past its vaporization temperature. Before the surface layer is able to vaporize, underlying material will reach its vaporization temperature. Temperature and pressure of the underlying material are raised beyond their critical values, causing the surface to explode. The pressure over the irradiated surface from the recoil of vaporized material can be as high as $10^5\;MPa$. The interaction of high power nanosecond laser with a thin metal in air has been investigated. The nanosecond pulse laser beam in atmosphere generates intensive explosions of the materials. The explosive ejection of materials make the surrounding gas compressed, which form a shock wave that travels at several thousand meters per second. To understand the laser ablation mechanism including the heating and ionization of the metal after lasing, the temporal evolution of shock waves is captured on an ICCD camera through laser flash shadowgraphy. The expansion of shock wave in atmosphere was found to agree with the Sedov's self-similar spherical blast wave solution.

• The Korean Journal of Pharmacology
• /
• v.2 no.1 s.2
• /
• pp.99-109
• /
• 1966

It has been known that the pronounced hypotension resulting from hemorrhage gives rise to compensatory stimulation of the adrenosympathetic system, which leads to an increase of liberation of catecholamines from sympathetic nervous system and adrenal medulla. It is obvious, therefore, that numerous physiological and biochemical changes during the hemorrhagic hypotention might be mediated through the increased liberation of catecholamines. Although an extensive studies have been reported on changes of protein and carbohydrate metabolism in hemorrhagic shock a few studies on the changes of lipid metabolism have been reported. Levenson(1961) observed a marked increase of serum lipids content during hemorrhagic shock and also noticed a marked elevation of serum free fatty acids. He suggested that these effects were due to mobilization and accelerated metabolic breakdown of lipids which might be resulted by sympathetic stimulation as a cause. To elucidate the mechanism of this, author studied the change of serum free fatty acids and blood sugar with relation to catecholamines during experimentally induced hemorrhagic shock in dog. Healthy male mongrel dogs weighing approximately 15kg were used. Under the general anesthesia with pentobarbital, rapid hemorrhage was produced from the femoral artery maintaining blood pressure level of 40 mmHg measured by the manometer connected with the opposite femoral artery throughout the experiment. Serum free fatty acids(FFA) and blood sugar were measured by the methods of Dole(1956) and Folin-wu,(1920) respectively. Tissue catecholamine was measured by Shore and Olin method(1958) using Aminco-Bowman spectrophotofluorometer.

• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.24 no.1
• /
• pp.132-142
• /
• 2000

The objective of this study is to experimentally investigate the noise propagating characteristics, the noise reduction mechanism and the performance of a slotted tube attached at the exit plane of a circular convergent nozzle. The experiment is performed through the systematic change of the jet pressure ratio and the slot length under the condition of two kinds of open area ratios, 25% and 51%. The open area ratio calculated by the tube length equivalent for the slot length is defined as the ratio of the total slot area to the surface area of a slotted tube. The experimental results for the near and far field sound, the visualization of jet structures and the static pressure distributions in the jet passing through a slotted tube are presented and explained in comparison with those for a simple tube. The propagating characteristics of supersonic jet noises from the slotted tube is closely connected with the slot length rather than the open area ratio, and its propagating pattern is similar to the simple tube. It is shown that the slotted tube has a good performance to suppress the shock-associated noise as well as the turbulent mixing noise in the range of a limited jet pressure and slot dimension. The considerable suppression of the shock‘associated noise is mainly due to the pressure relief caused by the high-speed jets passing through the slots on the tube. Both the strength of shock waves and the interval between them in a jet plume are decreased by the pressure relief. Moreover, the pressure relief is divided into the gradual and the sudden relief depending upon the open area ratio of the slotted tube. Consequently, the shock waves in a jet plume are also changed by the type of pressure relief. The gradual pressure relief caused by the slotted tube with the open area ratio 25% generates the weak oblique shock waves. On the contrary, the weak normal shock waves appear due to the sudden pressure relief caused by the slotted tube with the open area ratio 51%.