Preliminary study on physiological changes of hemorrhagic shock in rats

백서에서의 출혈성 쇼크로 인한 생리 변화에 관한 예비 연구

  • Lee, Ju-Hyung (The Graduate Program in Biomedical Engineering, Yonsei University) ;
  • Kim, Soo-Chan (The Graduate School of Bio &information Technology, Hankyong National University) ;
  • Lee, Tak-Hyung (The Graduate Program in Biomedical Engineering, Yonsei University) ;
  • Chung, Sang-Won (The Dept. of Emergency Medicine, College of Medicine, Kwandong University) ;
  • Kim, Deok-Won (The Dept. of Medical Engineering, College of Medicine, Yonsei University)
  • 이주형 (연세대학교 일반대학원 생체공학협동과정) ;
  • 김수찬 (한경대학교 생물정보통신전문대학원) ;
  • 이탁형 (연세대학교 일반대학원 생체공학협동과정) ;
  • 정상원 (관동대학교 의과대학 응급의학과) ;
  • 김덕원 (연세대학교 의과대학 의학공학교실)
  • Published : 2008.06.18

Abstract

Hemorrhagic shock is a common cause of death in emergency rooms. The objective evaluation of hemorrhagic shock is very important for early diagnosis and treatment. The purpose of this study is to understand its mechanism by analyzing the changes of bio-signals in hemorrhagic shock using controlled hemorrhage of SD rats. In this study, we constructed a hemorrhagic integrated system to control bleeding and to simultaneously measure bio-signals such as ECG, blood pressure, temperature, and respiration. In order to verify the system, we measured the bio-signals mentioned above while hemorrhagic shock was induced by withdrawing blood (2.5ml/100g/15min) from a femoral vein for 10 rats.

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