• Tuberculosis and Respiratory Diseases
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• 제54권3호
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• pp.338-345
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• 2003

과민성 폐장염은 원인 물질들이 호흡기로 반복적으로 흡입되어 이들 감작된 항원에 의한 면역학적 반응이 일어나 폐실질에 염증성 또는 육아종성 병변이 초래되는 면역학적 염증 질환이다. 저자들은 호흡 곤란을 주소로 내원한 남자 환자에서, 주거지의 실내 벽지에 기생한 진균인 Alternaria가 원인으로 추정된 과민성 폐장염 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• Clinical and Experimental Pediatrics
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• 제53권10호
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• pp.886-891
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• 2010

Purpose: This study aims to investigate the clinical characteristics of children diagnosed with the novel influenza A (H1N1) in the winter of 2009 at a single medical institution. Methods: Out of 545 confirmed cases of influenza A (H1N1) in children, using the real time RT-PCR method at Kosin University Gospel Hospital from September to December of 2009, 149 patients and their medical records were reviewed in terms of symptoms, laboratory findings, complications and transmission within a family. Results: Median age of subjects was 7 years (range: 2 months-18 years). New cases increased rapidly from September to reach a peak in November, then declined rapidly. Most frequently observed symptoms were fever (96.7%), cough (73.2%), rhinorrhea (36.9%) and sore throat (31.5%). Average body temperatures on the 1st, 2nd and 3rd hospital day were $38.75{\pm}0.65^{\circ}C$, $38.08{\pm}0.87^{\circ}C$ and $37.51{\pm}0.76^{\circ}C$, respectively. Complete blood counts and biochemical tests performed on the first admission day showed within the reference values in most cases. Of the 82 patients with simple chest radiography, 18 (22%) had pneumonic lesions; multi-focal bronchopneumonia in eleven, single or multi-segmental lobar pneumonia in five, and diffuse interstitial pneumonia in two patients. All of the 149 patients improved from their symptoms and discharged within 9 days of admission without any late complication. Conclusion: Children with 2009 pandemic influenza A (H1N1) at our single institution displayed nonspecific symptoms and laboratory findings, resembling those of common viral respiratory illnesses, and did not appear to develop more severe disease.

• Journal of Chest Surgery
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• 제39권9호
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• pp.718-721
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• 2006

환자는 37세 여자로 잦은 심한 기침을 주소로 내원하였다. 수술 전 시행한 흥부 전산화 단층 촬영상좌상엽 기관지 입구부의 폐종양으로 의심되는 종괴가 발견되었다. 좌상엽 기관지를 거의 완전히 막고 있는 종괴의 기관지 내시경을 통한 조직 생검 결과는 육아조직을 포함한 만성염증 소견을 보였다. 수술적 절제를 시행하였으며 좌상엽 절제술 후 기관지 절단면의 종양 조직 침범 소견이 보여 소매절제술을 시행하였다. 절제된 종양의 수술 후 조직학적 소견은 원발성 폐부신경절종의 특징을 보였다. 부신경절종은 교감신경절에서 발생하는 종양으로 폐의 실질에서 발생하는 원발성 폐부신경절은 매우 희귀한 질병이다. 이에 저자들은 소매절제술을 시행하여 좋은 결과를 얻었기에 치험 결과를 보고 하는 바이다.

• Tuberculosis and Respiratory Diseases
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• 제49권3호
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• pp.372-375
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• 2000

척추 경막외 기종은 드문 질환으로 흉부 CT상 우연히 발견되는 경우가 많고, 고식적 치료로 완치되는 양성 질환이다. 저자들은 기종격동 및 경막외 기종까지 동반된 기관지 천식 1례를 치료하였기에 문헌고찰과 함께 보고하는 바이다.

• Clinical and Experimental Pediatrics
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• 제60권7호
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• pp.232-236
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• 2017

Pulmonary alveolar proteinosis (PAP) is a rare disease in children characterized by intra-alveolar accumulation of surfactant proteins, which severely reduces gaseous exchange. Whole lung lavage (WLL) is the preferred technique for the treatment of severe PAP. Herein, we present a pediatric case of PAP treated with WLL. An 11-year-old boy was admitted with the chief complaint of a dry cough lasting 6 months. He developed symptoms of dyspnea on exertion and had difficulty in climbing stairs. He was ultimately diagnosed with PAP through video-assisted thoracoscopic lung biopsy. As first-line of treatment for PAP, he underwent therapeutic WLL for each of his lungs on separate days. After a brief recovery, his symptoms gradually worsened; therefore, he underwent a second WLL. This is the first pediatric case of PAP relapse despite successful WLL in Korea.

• 한국임상수의학회지
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• 제23권2호
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• pp.169-174
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• 2006

This work described 3 infection cases caused by Rhodococcus equi in foals between 3 and 5 months of age. The disease histories were not fully taken from local veterinarians. At least 1 sick foal has been treated with cephalothins followed by penicillins during approximately 1 week, but died without effectiveness and other foals rearing with the animal have been suffering from severe pneumonia which show high fever, laboring respiration, cough and/or nasal discharge. There were many abscessations into lungs of 2 foals in postmortem examination and another 1 sample was pus collected from abscess around the shoulder, indicating the osteomyelitis. Those bacteria were grampositive coryneform and were identified as a R. equi by a polymerase chain reaction (PCR) using primers for R. equi-specific vapA gene. The pathogens were usually resistant to penicillin, ampicillin, amoxycillin/clavulanic acid, cefazolin, clindamycin, sulfamethoxazol/trimethoprim, kanamycin, and tetracycline, while were sensitive to ciprofloxacin, norfloxacin, orfloxacin, gentamicin, erythromycin, neomycin, and vancomycin. Some more foals with respiratory symptoms in 1 horse farm were treated by orally administration with erythromycin during 2 weeks. Because the combination of erythromycin and rifampin has recommended as the treatment for R. equi infections in foals, the local equine veterinarian can choose those antibiotics for the treatment of this disease in future. However, another antimicrobial agent may be necessary if R. equi resistant to both agents is isolated.

• Journal of Chest Surgery
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• 제30권4호
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• pp.462-466
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• 1997

원발성으로 종격동에서 발생한 융모막암종은 드문 질환으로 젊은 남자에서 주로 발견되었으며, 기침, 흉통, 여성형 유방 등의 증상을 보이는 것으로 알려졌다. 33세 여자로 약 3개월 전부터 가벼운 기침으로 시작하였으나 심한 호흡곤란과흉통증 등 증상이 급격히 악화되어 내원하였다. 방사선학적 검사상 후종격에서 직경 13cm크기의 종양이 발견되었고, 혈중 $\beta$-HCG가 20만 mIU 이상 증가하였으며, 적출된 종양은 $\beta$-HCG에 대한 면역조직화학적 검사상 양성반응을 보였다. 융모막암종 절제술을 받고 EMA-CO투여 받은후 약 7개월만에 뇌에 전이된 종양 때문에 뇌출혈을 일으켜 다시 뇌종양 적출술을 받았다. 환자는 그 후 약 7개월동안 두통외의 증상은 없었고 흉부단순촬영상 종격종양의 재발소견도 없었다.

• Journal of Chest Surgery
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• 제37권11호
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• pp.946-950
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• 2004

혈관주위세포종은 모세혈관을 둘러싼 주위세포(pericyte)에서 발생하는 종양이다. 비록 혈관이 많이 분포한 장기이나 폐에서 발생은 매우 희귀하다고 알려진 악성 종양이다. 63세 여자 환자는 약 8년간 기침, 객담과 간헐적인 가슴통증을 호소하였으며 최근 3개월 간 점진적으로 악화되는 호흡곤란 및 기좌호흡상태로 본원 흉부외과에 입원하였다. 침 폐조직 생검에서 폐혈관주위세포종으로 확인되었으며 흉부 X-선 소견, 흉부 전산화단층촬영에서 진행된 폐종괴로 확인되어 항암약물치료가 예정되었다. 그러나, 흉곽의 대부분을 차지한 종양이 파열되고 흉관삽관술로 혈흉이 제거되지 않아 응급 개흉수술을 하여 응고된 혈괴제거 및 종양을 포함한 좌전폐절제수술을 시행하였다. 수술 후 경과가 양호하여 술 후 7일째 퇴원하였다. 병리조직 검사상 악성 침습성 폐혈관주위세포종으로 확인되었고, 현재 방사선 치료 후 항암약물치료 중이다.

• Tuberculosis and Respiratory Diseases
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• 제71권3호
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• pp.221-224
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• 2011

Poncet's disease is an aseptic polyarthritis developing in the presence of active Tuberculosis occurring elsewhere, and is not due to direct involvement of joints but to an immunological reaction to tuberculoprotein. We experienced a case of Poncet's disease accompanying erythema nodosum in a 55-year-old female patient with pulmonary tuberculosis. She had multiple tender erythematous nodules on both lower limbs for 3 months and a cough and sputum from one month ago. She felt severe pain in both knees and ankles with swelling one week before admission. Her chest X-ray, computed tomography (CT) scan and positive sputum AFB stain results revealed that she had active pulmonary tuberculosis accompanying erythema nodosum and aseptic polyarthritis. Her arthritis and erythema nodosum were dramatically improved within four weeks after anti-tuberculosis therapy. We report a case of Poncet's disease in pulmonary tuberculosis accompanying erythema nodosum.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2018년도 춘계학술발표회
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• pp.8-8
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• 2018

Muscle atrophy, known as a sarcopenia, is defined as a loss of muscle mass resulting from a reduction in muscle fiber area or density due to a decrease in muscle protein synthesis and an increase in protein breakdown. Many conditions are associated with muscle atrophy, such as aging, denervation, disuse, starvation, severe injury and inflammation, prolonged bed rest, glucocorticoid treatment, sepsis, cancer, and other cachectic diseases. On the other hand, osteoarthritis (OA) is the most common form of joint disease and is wide spread in the elderly population and is characterized by erosion of articular cartilage, osteophyte formation, and subchondral bone sclerosis. The cytokine network plays an important role in the development and progression of OA with the inflammatory cytokine. Schisandrae Fructus (SF) derived from the ripe fruit of Schisandra chinensis (Turcz.) Baill. (Magnoliaceae) has been extensively used in traditional herbal medicines in Asia. It was originally used as a tonic and has been traditionally used for the treatment of many uncomfortable symptoms, such as cough, dyspnea, dysentery, insomnia, and amnesia for a long time. Previous reports have shown that SF and its related compounds possess various biological activities such as antioxidant, anti-inflammatory, anticancer, anti-microbial, antiseptic, anti-aging, hepatoprotective and immunostimulating effects. However, the therapeutic effects of SF on muscle atrophy and OA has not yet been evaluated. In the present study, we aimed to determine whether extracts of SF, the dried fruit of S. chinensis, mitigates the development of muscle atrophy and OA.