Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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Clinical characteristics of children with 2009 pandemic influenza A (H1N1) admitted in a single institution

  • Park, San-In (Department of Pediatrics, Kosin University Gospel Hospital) ;
  • Kim, Min-Ji (Department of Pediatrics, Kosin University Gospel Hospital) ;
  • Hwang, Ho-Yeon (Department of Pediatrics, Kosin University Gospel Hospital) ;
  • Oh, Chi-Eun (Department of Pediatrics, Kosin University Gospel Hospital) ;
  • Lee, Jung-Hyun (Department of Pediatrics, Kosin University Gospel Hospital) ;
  • Park, Jae-Sun (Department of Pediatrics, Kosin University Gospel Hospital)
  • Received : 2010.05.31
  • Accepted : 2010.08.05
  • Published : 2010.10.15
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Abstract

Purpose: This study aims to investigate the clinical characteristics of children diagnosed with the novel influenza A (H1N1) in the winter of 2009 at a single medical institution. Methods: Out of 545 confirmed cases of influenza A (H1N1) in children, using the real time RT-PCR method at Kosin University Gospel Hospital from September to December of 2009, 149 patients and their medical records were reviewed in terms of symptoms, laboratory findings, complications and transmission within a family. Results: Median age of subjects was 7 years (range: 2 months-18 years). New cases increased rapidly from September to reach a peak in November, then declined rapidly. Most frequently observed symptoms were fever (96.7%), cough (73.2%), rhinorrhea (36.9%) and sore throat (31.5%). Average body temperatures on the 1st, 2nd and 3rd hospital day were $38.75{\pm}0.65^{\circ}C$, $38.08{\pm}0.87^{\circ}C$ and $37.51{\pm}0.76^{\circ}C$, respectively. Complete blood counts and biochemical tests performed on the first admission day showed within the reference values in most cases. Of the 82 patients with simple chest radiography, 18 (22%) had pneumonic lesions; multi-focal bronchopneumonia in eleven, single or multi-segmental lobar pneumonia in five, and diffuse interstitial pneumonia in two patients. All of the 149 patients improved from their symptoms and discharged within 9 days of admission without any late complication. Conclusion: Children with 2009 pandemic influenza A (H1N1) at our single institution displayed nonspecific symptoms and laboratory findings, resembling those of common viral respiratory illnesses, and did not appear to develop more severe disease.

Keywords

References

  1. WHO. World now at the start of 2009 influenza pandemic. Available from: http://www.who.int/mediacentre/statements/2009/h1n1_ pandemic_phase6-20090611/en/index.html. Accessed 23 April 2010.
  2. Korean Centers for Disease Control and Prevention. http://flu.cdc.go.kr. Accessed 4 Feb 2010.
  3. Centers for Disease Control and Prevention (CDC). 2009 Pandemic influenza A (H1N1) virus infections--Chicago, Illinois, April-July 2009. MMWR Morb Mortal Wkly Rep 2009;58:913-8.
  4. Korean Centers for Disease Control and Prevention. Analysis of reported pandemic influenza (A/H1N1 2009) virus infections in Korea. Public Health Weekly Report. Vol. 3 No. 38. Available from: http://www.cdc. go.kr/phwr Accessed 24 September 2010.
  5. Heikkinen T, Silvennoinen H, Peltola V, Ziegler T, Vainionpaa R, Vuorinen T, et al. Burden of Influenza in Children in the Community. J Infect Dis 2004;190:1369. https://doi.org/10.1086/424527
  6. Oh CH, Son BH, Kim KD, Lee JA, Kim SW, Cho KS, et al. Retrospective Study for the Isolation of Influenza Virus and Prevalence Period in Busan from 2000 to 2002. Korean J Pediatr 2005;48:260-5.
  7. Hancock K, Veguilla V, Lu X, Zhong W, Butler EN, Sun H, et al. Cross- Reactive Antibody Responses to the 2009 Pandemic H1N1 Influenza Virus. NEJM. NEJM org. N Engl J Med 2009;361:1945-52. https://doi.org/10.1056/NEJMoa0906453
  8. National Center for Immunization and Respiratory Diseases, CDC; Centers for Disease Control and Prevention (CDC). Use of influenza A (H1N1) 2009 monovalent vaccine: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2009. MMWR Recomm Rep 2009;58(RR-10):1-8.
  9. Human infection with pandemic A (H1N1) 2009 influenza virus: clinical observations in hospitalized patients, Americas, July 2009--update. Wkly Epidemiol Rec 2009;84:305-8.
  10. Novel Swine-Origin Influenza A (H1N1) Virus Investigation Team, Dawood FS, Jain S, Finelli L, Shaw MW, Lindstrom S, et al. Emergence of a novel swine-origin influenza A (H1N1) virus in Humans. N Engl J Med 2009;361:102.
  11. Korean Centers for Disease Control and Prevention. Characteristics of survival versus death related Influenza A (H1N1) 2009 in Korea. Available from: http://www.cdc.go.kr/kcdchome/jsp/home/information/had/ INFOHAD0001 Accessed 29 September 2010.
  12. Perez-Padilla R, de la Rosa-Zamboni D, Ponce de Leon S, Hernandez M, Quiñones-Falconi F, Bautista E, et al. Pneumonia and respiratory failure from swine-origin influenza A (H1N1) in Mexico. N Engl J Med 2009; 361:680-9. https://doi.org/10.1056/NEJMoa0904252
  13. Senanayake SN. Swine Flu Update: Bringing Home the Bacon. Med J Aust 2009;191:138-40.
  14. European Centre for Disease Prevention and Control. Interim Risk Assesment Pandemic (H1N1) 2009 Influenza. 2 October 2009.
  15. Centers for Disease Control and Prevention (CDC). Intensive-care patients with severe novel influenza A (H1N1) virus infection - Michigan, June 2009. MMWR Morb Mortal Wkly Rep 2009;58:749-52.
  16. Centers for Disease Control and Prevention. Updated Interim Recommendations for the Use of Antiviral Medications in the Treatment and Prevention of Influenza for the 2009-2010 Season. Available from: http:// www.cdc.gov/h1n1flu/recommendations.htm. Accessed 8 February 2010.
  17. Halasa NB. Update on the 2009 pandemic influenza A H1N1 in children. Curr Opin Pediatr 2010;22:83-87 https://doi.org/10.1097/MOP.0b013e3283350317
  18. World Health Organization. Mathematical modelling of the pandemic H1N1 2009. Wkly Epidemiol Rec 2009;84:341-8.
  19. Kim WJ. Epidemiology, clinical manifestations, and management of pandemic novel influenza A (H1N1). Korean J Med 2009;77:157-64.

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