• Proceedings of the Korea Society of Costume Conference
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• 2003.10a
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• pp.59-59
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• 2003

Millions of people invest a lot of money and endeavours to improve their look, feel, and smell of their bodies. This quest for beauty has a long history, and cosmetics industries are expanding to fulfill these requests. Also, cosmetics industries are suffering severe competitions and try to segment cosmetics market to cope with the their customers' sensitive.

• Journal of the Korean Society of Clothing and Textiles
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• v.24 no.2
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• pp.199-204
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• 2000

This study was conducted to investigate the thermoregulatory responses and wearing behavior of the cold-sensitive men when exposed to the mild cold of 14$^{\circ}C$. Two sessions of experiment were carried out and five healthy young men for the cold-sensitive group(CSG) and four healthy young for the cold-insensitive group(CIG) participated in the study as subjects CSG maintained rectal temperature lower than CIG due to their thicker clothing resulted in larger decrease of rectal temperature. CSG maintained skin temperatures higher than CIG. CSG felt cooler than CIG but wore thicker clothing for thermal comfort and this made keep their sensation warmer. These results were discussed in terms of autonomic and behavioral temperature regulation.

• Archives of design research
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• v.19 no.4 s.66
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• pp.91-100
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• 2006

The contemporary consumer's fashion retail shops are becoming diverse in function and sensitivity while keeping in mind the effects of consumer's lifestyles according to changing fashions. Recently, external changes and expressive characteristics have become symbolic in retail fashion shops. This reinforces the importance of the skin, which is becoming image-sensitive and increasingly important. Therefore, this thesis will study the relationship between expressive tendency and skin in fashion retail shops by distinguishing the characteristics of a skin historically as well by categorizing the four brands from flagship stores which have introduced brand identity and an exceptional expressiveness of skin into types of form and space.

• Proceedings of the SCSK Conference
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• 1999.10a
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• pp.145-154
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• 1999

A novel retinol derivative, polyethoxylated retinamide (Medimin A) was synthesized, as an anti-aging agent. Collagen synthesis, skin permeation, stability, and toxicity of Medimin A were evaluated and compared with those of retinol and retinyl palmitate. In vitro collagen synthesis was evaluated by quantitative assay of [$^3H$]-proline incorporation into collagenase sensitive protein in fibroblast cultures. For in vitro skin permeation experiments, Franz diffusion cells (effective diffusion area: $1, 766{\;}\textrm{cm}^2$) and the excised skin of female hairless mouse aged 8 weeks were used The stabilities of retlnoids were evaluated at two different temperature ($25{\;}^{\circ}C$ and $40{\;}^{\circ}C$) and under UV in solubilized state and in OW emulsion. To estimate the safety, acute oral toxicity, acute dermal toxicity, primary skin irritation, acute eye irritation and human patch test were performed The effect of Medimin A on collagen synthesis was similar to that of retinol. The skin permeability of Medimin A was higher than those of retinol and retinyl palmitate. The Medimin A was more stable than retinol and retinyl palmitate. Medimin A was nontoxic in various toxicological tests. These results suggest that Medimin A would be a good anti-aging agent for enhancing bioavailability and stability.

• Nutritional Sciences
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• v.9 no.3
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• pp.212-226
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• 2006

The involvement of arachidonic acid (AA) metabolizing enzyme, lipoxygenase (LOX), in the development of particular tumors in humans has gradually been acknowledged and LOX has emerged as a novel target to prevent or treat human cancers. In the mouse skin carcinogenesis model, which provides an excellent model to study multistage nature of human cancer development, many studies have shown that some of the LOXs are constitutively upregulated in their expression. Moreover, application of LOX inhibitors effectively reduced tumor burdens, which implicates the involvement of LOX in mouse skin tumor development as well. 8S-LOX is a recently cloned LOX, which is specifically expressed in mouse skin after 12-O-tetradecanoyl-phorbol-13-acetate (TPA) treatment but not in normal skin. Unlike other members of the LOX 'family' expressed in mouse skin, this TPA-induced expression of 8S-LOX is prominent only in the skin of the TPA tumor promotion-sensitive strains of mice (SENCAR, CD-1, and NMRI) but not in the promotion-resistant C57BL/6J mice. This is a very unique phenomenon among strains of mice. Constitutive upregulation of 8S-LOX was also found in early stage papillomas and the expression was gradually reduced as the tumors became malignant. Based on these observations, it has been thought that 8S-LOX is involved in TPA-induced tumor promotion as well as in tumor conversion from papillomas to carcinomas. In accordance with this hypothesis, several studies have suggested possible roles of 8S-hydroxyeicosatetraenoic acid (HETE), an AA metabolite of 8S-LOX, in mouse skin tumor development. A clastogenic activity of 8S-HETE was demonstrated in primary keratinocytes and a close correlation between the levels of etheno-DNA adducts and 8S-HETE during skin carcinogenesis was also reported. On the other hand, it has been reported that 8S-LOX protein expression is restricted to a differentiated keratinocyte compartment Moreover, reported findings on the ability of 8S-HETE to cause keratinocyte differentiation appear to be contrary to the procarcinogenic features of the 8S-LOX expression, presenting a question as to the role of 8S-LOX during mouse skin carcinogenesis. In this review, molecular and biological features of 8S-LOX as well as current views on the functional role of 8S-LOX/8S-HETE during mouse skin carcinogenesis are presented.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.5
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• pp.3131-3138
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• 2015

At a dermatology during the skin care, photodynamic therapy(PDT) is carried after 5-aminolevulinic acid(ALA), light sensitive material, is applied. At a skin care shop, using drug is prohibited. Thus, the aim of this research was to see the effect of the acne skin by irradiating PDT to the skin without applying ALA. The research method was that 24 female undergraduates who had acne on their face at the level of mild or comedonal, and the participants were divided into four groups(group1: no treatment, group 2: 420 nm of blue visible light, group 3: 660 nm of red visible light and group 4: blue and red visible light). The participants of group 2, 3 and 4 were irradiated with visible light for 20 minutes per week for 6 weeks, and they were compared to group 1. As a result of the research, the number of erythema, sebum, papules and pustules of those who were irradiated with visible light decreased, and the pore size of those also decreased while the amount of moisture increased. If an skin care shop applies PDT to the existing acne skin care, that PDT will influence on the program of a skin care shop is expected.

• Journal of Veterinary Clinics
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• v.34 no.5
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• pp.381-383
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• 2017

A two-year-old intact male Labrador retriever was presented with generalized erythema, pustule and pruritus. A skin screening test revealed that there were no fleas but bacteria and dermatophytes were present. Blood testing revealed no remarkable findings. The patient was prescribed systemic medication of enrofloxacin 30 mg/kg once a day and itraconazole 10 mg/kg once a day and topical medication of 2% chlorhexidine shampoo twice a week for 2 weeks. Two weeks after the prescription, aerobic culture confirmed that the bacteria were Leclercia Adecarboxylata and Pseudomonas putida was sensitive to enrofloxacin. Therefore, more medicine was prescribed for 4 weeks to alleviate clinical signs. After six weeks of medication, clinical signs were alleviated and skin screening test revealed no remarkable findings. Bacterial and fungal skin infections are common in dogs. However, there are no reports of Leclercia Adecarboxylata infection even in gastrointestinal tract in veterinary medicine. This is the first report of Leclercia Adecarboxylata infection in dogs. This report proved that Leclercia Adecarboxylata can cause skin problem in dogs.

• Biomolecules & Therapeutics
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• v.9 no.4
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• pp.298-306
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• 2001

To develop a novel transdermal delivery system of loxoprofen (LP), a potent antiinflammatory and analgesic agent, the effects of vehicle composition and drug loading dose on the skin permeation property were investigated. And in vivo skin absorption property studied by analysing the $C_{max}$ and AUC was investigated after applying the developed plaster systems on rabbit back skin. Addition of isopropyl myristate (IPM) and IPM-diethylene glycol monoethyl ether (DGME) cosolvent in the plaster showed higher permeation rates than those from propylene glycol laurate-DGME cosolvent systems. As the concentration of LP in the plaster increased from 0.56 mg/$\textrm{cm}^2$ to 1.19 mg/$\textrm{cm}^2$, the drug release and skin permeation rates increased linearly. At loading dose of 1.19 mg/$\textrm{cm}^2$, the flux reached 35.6 $\mu$g/$\textrm{cm}^2$/hr. New LP plasters showed a good adhesive property onto skin, and showed no crystal formation. The AU $C_{0-24hr}$ and $C_{max}$ after dermal application of LP plaster (60 mg/70 $\textrm{cm}^2$) were found to be 6951$\pm$230 ng.hr/ml and 400$\pm$44 ng/ml, respectively. And the plasma concentration maintained above 300 ng/ml up to 24 hr period. In the carrageenan-induced rat paw edema test, LP plaster showed similar inhibition rate with marketed ketoprofen (Ketoto $p^{R}$) plaster.aster.r.

• Proceedings of the KOSOMBE Conference
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• v.1992 no.05
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• pp.198-202
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• 1992

In this paper, we have performed an experiment to obtain an optimized electric stimulation condition on the tip or a ringer skin. The desired parameters for stimulation of the finger tip skin are waveforms, frequency, stimulation intensity, duty cycle. As a result, when the finger skin was stimulated with monophasic, biphasic, and differntial phasic, the most appropriate condition was 200 to 250[Hz] in frequency, 10 to 25[%] in duty cycle. Burst type pulse was more sensitive effect than that of continuous pulse methode.

• 유체기계공업학회:학술대회논문집
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• 2006.08a
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• pp.397-400
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• 2006

In this study, we experimentally investigate the possibility of skin-friction drag reduction by series of transverse cavities in a turbulent boundary layer flow. The effects of cavity depth (d), cavity length (l) and cavity spacing (s) on the skin friction drag are examined in the range of $Re_{\theta}\;=\;4030\;{\sim}\;7360$, $d/{\theta}_0\;=\;0.13\;{\sim}1.03$, l/d = 1 ~ 4 and s/d = 5 ~ 20. We perform experiments for twenty different cavity geometries and directly measure total drag force using in-house force measurement system. In most cases, the skin friction drag is increased. At several cases, however, small drag reduction is obtained. The variation of the skin ftiction drag is more sensitive to the cavity length than to the cavity depth or cavity spacing, and drag is reduced at $s/l\;{\geq}\;10$ and $l/{\theta}_0\;{\leq}\;0.26$ irrespective of the cavity depth. At $l/\bar{\theta}_0\;=\;0.13$ and s/l = 10, maximum 2% drag reduction is achieved. When the skin friction drag is reduced, there is little interaction between the flows inside and outside cavity, and the flow changed by the cavity is rapidly recovered at the following crest. A stable vortex is formed inside a cavity in the case of drag reduction. This vortex generates negative skin friction drag at the cavity bottom wall. Although there is form drag due to the cavity itself, total drag is reduced due to the negative skin friction drag.