• BMB Reports
• /
• v.56 no.11
• /
• pp.612-617
• /
• 2023

Pleiotropic regulator 1 (PLRG1), a highly conserved element in the spliceosome, can form a NineTeen Complex (NTC) with Prp19, SPF27, and CDC5L. This complex plays crucial roles in both pre-mRNA splicing and DNA repair processes. Here, we provide evidence that PLRG1 has a multifaceted impact on cancer cell proliferation. Comparing its expression levels in cancer and normal cells, we observed that PLRG1 was upregulated in various tumor tissues and cell lines. Knockdown of PLRG1 resulted in tumor-specific cell death. Depletion of PLRG1 had notable effects, including mitotic arrest, microtubule instability, endoplasmic reticulum (ER) stress, and accumulation of autophagy, ultimately culminating in apoptosis. Our results also demonstrated that PLRG1 downregulation contributed to DNA damage in cancer cells, which we confirmed through experimental validation as DNA repair impairment. Interestingly, when PLRG1 was decreased in normal cells, it induced G1 arrest as a self-protective mechanism, distinguishing it from effects observed in cancer cells. These results highlight multifaceted impacts of PLRG1 in cancer and underscore its potential as a novel anti-cancer strategy by selectively targeting cancer cells.

• Fashion & Textile Research Journal
• /
• v.21 no.6
• /
• pp.754-765
• /
• 2019

The purpose of this study is to find out about the impact on self-identity and creativity of college students through the fashion collage program. The methods of research were content analysis and statistical analysis. The research subjects consisted of six fashion major college students experiment group and six control group students attending P university in Busan. The period of investigation was conducted once a week in the 9th session (2019. 04. 25. - 06. 18). The analysis criteria of fashion collage were divided into formality and contents, and the analysis criteria consisted of number of collage pieces, margin, overlapping, cut method, text position, color, space layout, and location of fashion design drawing. Collage maps were analyzed based on formal analysis, and fashion design drawings were analyzed based on formal and contents analysis. In order to verify the effectiveness of the fashion collage program, a pre-post test of self-identity and creativity was conducted. Statistical analysis was conducted by using the SPSS WIN 25.0 program, U-test of Mann-Whitney, Wilcoxon signed-rank test. In pre-post test of self-identity and creativity, there were significant differences. In conclusion, it has been shown that fashion collage programs are effective in improving self-identity and creativity for college students majoring in fashion. This study has a limitation of collage programs focused on self-discovery, so it should be carefully analyzed.

• Analytical Science and Technology
• /
• v.30 no.3
• /
• pp.122-129
• /
• 2017

Methamphetamine addiction is a critical issue due to the lack of effective pharmacotherapy and high potential for relapse. Nevertheless, there are no distinct biomarkers for diagnosis or prognosis for methamphetamine addiction. In the present study, a rat model for methamphetamine self-administration was established and alteration of urinary metabolites by methamphetamine addiction was investigated by the targeted metabolite analysis using mass spectrometry. Rat urine samples were collected at three time points (before and after addiction and after extinction) from the methamphetamine-addicted group as well as the age-matched control group. The collected samples were prepared using AbsoluteIDQ p180 kit and analyzed using flow injection analysis (FIA) - or high performance liquid chromatography (HPLC) - tandem mass spectrometry (MS/MS). The levels of lysine, acetylornithine and methioninesulfoxide were distinctively altered depending on the status of metheamphetamine addiction or extinction. In particular, the level of acetylornithine was reversely changed from addiction to extinction, for which further studies could be useful for biomarker discovery or mechanistic studies for methamphetamine addiction.

• Journal of Korean Academy of Nursing
• /
• v.19 no.1
• /
• pp.92-98
• /
• 1989

Concept analysis is a formal linguistic exercise to determine certain defining attributes. The basic purpose of concept analysis is to clarify ambiguous concepts in a theory, and to propose a precise operational definition which reflects its theoretical base (Walker, 1983, 27~28). In later life, elderly people are faced with various psychological problems such as depression, and lowered self-esteem for these psychological problems of the elderly. Reminiscence has been studied as an effective therapeutic measure by gerontologists and psychologists. It is considered to have potential as an effective nursing intervention with geriatric clients. The purpose of this paper was to explore the feasibility of adopting reminiscence as a nursing intervention through analysis of the concept. The concept can be defined as follows : Reminiscence is thinking and talking about one's past with or without a specific purpose. It is a composite mental process which involves psychological, emotional, and social interactional aspects. The defining attributes of reminiscence are : 1. Thinking about past experiences which are meaningful to oneself. 2. It includes the emotional aspect of past experiences. 3. It occurs with or without specific purposes. 4. It is communicated to others by means of language and the subject has the feeling of being heard. In regard to the consequences of reminiscence, it is expected to contribute to psychological adaptation by providing a sense of self-fulfillment and self-achievement, promoting the discovery of the meaning of life, decreasing depression, and overcoming guilt feelings and conflict about one's past. However, if the past is regarded as a total failure, it may be harmful to the psychological well-being of the subject.

• Journal of the Korea Convergence Society
• /
• v.12 no.11
• /
• pp.391-401
• /
• 2021

The purpose of this study was to verify the moderating effects of the stress coping styles on the effects of internet addiction on the self-esteem of the 2030 generation during the Covid19 period. The 762 samples were selected through an online survey, and the collected data were conducted using the SPSS WIN26.0 program for frequency analysis, correlation analysis, and hierarchical regression analysis. As a result of the analysis, Internet addiction had a negative effect on self-esteem, and only seeking social support among the four sub-factors of stress response served as a moderator variable in the relationship between Internet addiction and self-esteem. Based on the results, the followings were suggested: expansion of research subjects regarding Internet addiction and interdisciplinary convergence study, providing universal provision of stress coping management programs, building a community at the local level, and discovery and reinforcing variables that offset the negative role of self-esteem of 2030 generations.

• Journal of KIISE:Computing Practices and Letters
• /
• v.14 no.8
• /
• pp.813-817
• /
• 2008

Intelligent Robots (IR) get data of the current situation from sensors and perform knowledgeable services. Self-reconfiguration of IR is an important factor to change itself without stopping while supporting environment and technology change. In this paper, we propose an agent based self-reconfiguration framework of IR using ESB (Enterprise Service Bus). This framework focuses on dynamic discovery and reconfiguration of service-oriented applications using multi-agent system in intelligent robots. When IR meets an irresolvable situation it downloads a necessary service agent from an external service repository, executes the agent, and resolves the situation. Agent technology provides an intelligent approach for collaborations of IR. The prototype has also been implemented to show the validity of our study.

• The Journal of the Korea Contents Association
• /
• v.20 no.1
• /
• pp.573-580
• /
• 2020

The purpose of this study was to explore and to suggest the effective teaching methods for university students to improve their speaking abilities through peer assessment-feedback and self assessment-feedback based presentation and debate class. The objects and content of the study were the students who took a class "Reading and Communication" of H university, and here examine closely the speaking activities and their effects during the integrated activities of 'reading, speaking and writing'. In speaking education peer and self assessment feedback is to form an emotional consensus among the students and encourage active participation, and enable self-discovery and communication learning to students. As a result of the study, it was found that the variety speaking practice had a very positive effect on the attitude of speaking and the psychological aspect, and it was confirmed that the evaluation and feedback activities had a meaningful learning effect on the students. Effective speech education and guidance measures should be continuously studied and developed.

• KIPS Transactions on Software and Data Engineering
• /
• v.11 no.1
• /
• pp.11-18
• /
• 2022

De novo drug design is the process of developing new drugs that can interact with biological targets such as protein receptors. Traditional process of de novo drug design consists of drug candidate discovery and drug development, but it requires a long time of more than 10 years to develop a new drug. Deep learning-based methods are being studied to shorten this period and efficiently find chemical compounds for new drug candidates. Many existing deep learning-based drug design models utilize recurrent neural networks to generate a chemical entity represented by SMILES strings, but due to the disadvantages of the recurrent networks, such as slow training speed and poor understanding of complex molecular formula rules, there is room for improvement. To overcome these shortcomings, we propose a deep learning model for SMILES string generation using variational autoencoders with self-attention mechanism. Our proposed model decreased the training time by 1/26 compared to the latest drug design model, as well as generated valid SMILES more effectively.

• Journal of the Korea Convergence Society
• /
• v.13 no.1
• /
• pp.425-436
• /
• 2022

The purpose of this study was to explore the trends of research on MBTI (Myers-Briggs Type Indicator) and nursing students, and to suggest directions for nursing education geared to the needs of the future. The literature was searched using the National Assembly Library, Korean Studies Information Service System, DBPIA, Korean Medical database and National Discovery for Science Library to identify studies including MBTI personalty among nursing students. This study selected a total of 22 precedent studies regarding the investigation of MBTI personalty and nursing students. All studies were quantitative study and 63.6% of them were nonexperimental cross-sectional study. The most frequently selected category of variables was cognitive-perceptual related variables includes self-efficacy, self-eseem, academic self efficacy and etc. The most frequent MBTI personality type of nursing students was ISTJ (12.3%) and ESTJ (11.5%) was the second. Based on the findings of this study, longitudinal reasearch is recommanded on MBTI personality type and nursing specialty choice. Implications for teaching and learning strategies, and for using the results of MBTI in nursing students' career guidence are discussed.

• Journal of Korean Public Health Nursing
• /
• v.17 no.1
• /
• pp.132-143
• /
• 2003

The purpose of this study was to verify the effects of psychodrama group counselling, and to determine its applicability as a nursing intervention for the promotion of mental health of clients in their developmental stages. Methodological triangulation was used for research design. For quantitative study, quasi experimental study design with nonequivalent control group was used to test the effects of psychodrama group counselling. For each experimental and control group convenient samples of 15 nursing students were selected, and observed from May to Nov. 2000. For experimental group, the treatment was given for 2 hours each week, totaling 20 hours. The questionnaire consisted of 24 items of physical symptoms from CMI. 40 items of Spielberger Anxiety Scale, and 21 items of Beck Depression Scale. Reflective journal was written by the experimental group. The data were analyzed using chi-square and Mann-Whitney U test. For the qualitative study, the contents of the reflective journal were analyzed into categories and classifications. The results of the study were as follows; 1. There was a significant difference on physical health status between the experimental and the control group 2. There was a significant difference between two groups on the mean scores of mental health before and after psychodrama group counselling. 3. The qualitative analysis of reflective journal resulted in 4 categories and 13 classifications, which was reflected by the experience of the psychodrama group counselling. The four categories were self introspection, psychological support, improvement of interpersonal relationship and self development. The thirteen classifications are self-discovery, discovering others, emotional catharsis, positive thinking, formation of consensus, comforting, being free, being comfortable, understanding, maturing personal relationship, acquiring self-confidence, new challenges, and planning for the future. Based on the study findings, the psychodrama group counselling had promoted not only physical but also mental health of nursing students. The characteristics identified by the study suggested the applicability of psychodrama group counselling as an effective measure of nursing intervention for clients.