• Title/Summary/Keyword: Self regulation

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Transcription Factor EB-Mediated Lysosomal Function Regulation for Determining Stem Cell Fate under Metabolic Stress

  • Chang Woo Chae;Young Hyun Jung;Ho Jae Han
    • Molecules and Cells
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    • v.46 no.12
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    • pp.727-735
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    • 2023
  • Stem cells require high amounts of energy to replicate their genome and organelles and differentiate into numerous cell types. Therefore, metabolic stress has a major impact on stem cell fate determination, including self-renewal, quiescence, and differentiation. Lysosomes are catabolic organelles that influence stem cell function and fate by regulating the degradation of intracellular components and maintaining cellular homeostasis in response to metabolic stress. Lysosomal functions altered by metabolic stress are tightly regulated by the transcription factor EB (TFEB) and TFE3, critical regulators of lysosomal gene expression. Therefore, understanding the regulatory mechanism of TFEB-mediated lysosomal function may provide some insight into stem cell fate determination under metabolic stress. In this review, we summarize the molecular mechanism of TFEB/TFE3 in modulating stem cell lysosomal function and then elucidate the role of TFEB/TFE3-mediated transcriptional activity in the determination of stem cell fate under metabolic stress.

Thermal-hydraulic and load following performance analysis of a heat pipe cooled reactor

  • Guanghui Jiao;Genglei Xia;Jianjun Wang;Minjun Peng
    • Nuclear Engineering and Technology
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    • v.56 no.5
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    • pp.1698-1711
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    • 2024
  • Heat pipe cooled reactors have gained attention as a potential solution for nuclear power generation in space and deep sea applications because of their simple design, scalability, safety and reliability. However, under complex operating conditions, a control strategy for variable load operation is necessary. This paper presents a two-dimensional transient characteristics analysis program for a heat pipe cooled reactor and proposes a variable load control strategy using the recuperator bypass (CSURB). The program was verified against previous studies, and steady-state and step-load operating conditions were calculated. For normal operating condition, the predicted temperature distribution with constant heat pipe temperature boundary conditions agrees well with the literature, with a maximum temperature difference of 0.4 K. With the implementation of the control strategy using the recuperator bypass (CSURB) proposed in this paper, it becomes feasible to achieve variable load operation and return the system to a steady state solely through the self-regulation of the reactor, without the need to operate the control drum. The average temperature difference of the fuel does not exceed 1 % at the four power levels of 70 %,80 %, 90 % and 100 % Full power. The output power of the turbine can match the load change process, and the temperature difference between the inlet and outlet of the turbine increases as the power decreases.

Development of Self-Managed Food Sanitation Check-List and On-Site Monitoring of Food Sanitation Management Practices in Restaurants for Control of Foodborne Illness Risk Factors (식중독 발생 위험요인 관리를 위한 외식업체 자가위생관리점검표 개발 및 현장모니터링)

  • Chung, Min-Jae;Choi, Jung-Hwa;Ryu, Kyung;Kwak, Tong-Kyung
    • Korean journal of food and cookery science
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    • v.26 no.5
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    • pp.603-616
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    • 2010
  • Based on recent dramatic increases in foodborne outbreaks in restaurants, self-managed sanitation systems are now recommended to control contributing risk factors. This study aimed to improve sanitation management practices in restaurants and had two objectives. First, we tried to develop a self-managed sanitation check-list, including risk factors contributing to foodborne illness and Korean food hygiene regulation articles. We also tried to evaluate current sanitation management practices in restaurants according to operation and restaurant type. Thirty restaurants were evaluated by on-the-spot inspectors using an auditing tool consisting of four dimensions, seventeen categories, and forty-one items. Total compliance rate categorized by operation type significantly differed between chain restaurants and self-managed restaurants, with values of 85.5% and 51.6%, respectively. Therefore, self-managed restaurants, which showed the lowest compliance rate of below 30.0%, need more strict control to improve current unsanitary management practices, specifically relating to 'sterilization of knives, chopping boards, and wiping cloths', 'sanitation training', 'not allowing access into the kitchen to outsiders', 'handling of food or utensils on shelves at a 15 cm distance away from floor', 'prevention of cross-contamination of cooked foods or vegetables', and 'records of kitchen access or inspection'. Thus, an effective food sanitation system is essential and should be implemented to improve the existing sanitary conditions in restaurants. However, the most important factor to achieving food sanitation management objectives is food handlers' self-motivation.

A Study on the Change of Perception through the dating experiences in College Students (대학생의 이성교제를 통해 경험하는 인식 변화에 관한 연구)

  • Sim, In-Ok;Nam, Bo-Gyeong;Bak, Ma-Ru
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.18 no.11
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    • pp.197-207
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    • 2017
  • This study was conducted to evaluate changes in self-awareness in response to dating members of the opposite sex among college students. The point of view of college students who have experienced the dating, it has put the purpose of clarifying the nature of the change in the strength and self-awareness. To accomplish this, interviews of 18 people who met the study criteria were conducted. This study was a qualitative investigation. Respondents were placed in one of five categories: 'change in perception of role', 'understanding of communication skills', 'strengthened coping ability', 'behavioral change in emotion regulation', or 'awareness of self-maturity'. Changes in perceptions experienced by college students through dating were shown to improve the quality of college students' future life and applied in the strength to adapt to social life. Therefore, the significance of this study was discovered a positive outcome in the individuals' life, trying to present the grounds that to strengthen the various regions.

Effect of Arousal Control Training Conjugated Heart Rate Biofeedback for National Substitute Archery Players (심박수 바이오피드백기법을 활용한 국가대표 후보 양궁선수의 각성조절훈련 효과 분석)

  • Hong, Seong-Taek
    • The Journal of the Korea Contents Association
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    • v.11 no.9
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    • pp.469-484
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    • 2011
  • The purpose of this study was to examine the effect of arousal control training conjugated heart rate biofeedback for national substitute three archery players. The arousal control training programs was developed on previous researches and 3 archery experts and 1 sport psychologist had meetings. The training programs contained as orientation, breathing regulation, progressive relaxation technique, heart rate biofeedback, cognitive restructuring, routine and consisted of 24 weeks. XCOACH was utilized as heart rate biofeedback instrument. The effects was examined on competitive state anxiety inventory-2, archery score and ranking, observation, interviews and self assessment. As the results, the score of subfactor was improved on somatic state anxiety, cognitive state anxiety and self-confidence. As the results of observation, interviews and self assessment, the ability of arousal control was enhanced by using effective psychological skills conjugated heart rate biofeedback.

The study about occupational ability of dental hygiene department students required of the dental clinics (치과병의원에서 요구하는 치위생과 졸업생들의 직업능력에 관한 연구)

  • Kim, Jung;Um, June-Young
    • Journal of Korean society of Dental Hygiene
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    • v.9 no.4
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    • pp.633-643
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    • 2009
  • Objectives : This study is aimed to help the dental hygiene department students to improve their adaptive ability to the field work by letting them know the performing levels required of the job world, by renovating the knowledge-centered curriculum, and by finding out the core competencies needed for successfully performing their duties and tasks in the work field. Methods : The survey tool was recomposed through the examination of the preceeding studies on basic vocational competencies and skills, and the survey has been done to 200 dentists in Seoul and Gyunggi provice. Results : 1. As for the job-getting routs, 35.1% of them finds their jobs through the job portal sites, and 21.3% through the recommendation by professors. So we can see the meaningful difference in the employment ways. 2. Dental hygiene clinics think that the purpose of their cooperation with the colleges is mainly to secure human resources by requiring the colleges to give field-centered education the colleges through. 3. The clinics for dental hygienic students' field learning have a great power for hiring the students. So it is necessary to set up a good management system of the clinics for dental hygienic students' field learning in order to reinforce the students' competitive power in getting jobs. 4. The priorities in basic working abilities needed for the task performance are in the order of vocational responsibility, self-managing & developing ability, interpersonal skill, and problem solving ability. 5. The core competencies required of those who graduate from dental hygiene school show the following scores by Likert measurement; good personality and vocational consciousness 2.16(${\pm}.677$), understanding power of major-related knowledge 2.19(${\pm}.723$), field adapting ability 2.31(${\pm}.748$), get-along-with ability 2.32(${\pm}.799$), interpersonal skill 2.42(${\pm}.768$), and self-development ability such as getting certificates 2.43(${\pm}.729$). Among the core competencies, the only meaningful factor which influences on their satisfaction measurement has been identified as the professional ability related to the major. Conclusions : The results suggest that the knowledge and skill related to the major are core competencies of able human resources and closely related with the professionality of the job, and so they are very important. However, job basic abilities are also proved to be important, which reinforce the students' activeness, self-regulation, and creativeness, and help them to pursue their lasting growth in their abilities.

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The Impact of Social Exclusion on Consumer Response : The Moderating Effect of Embodied Cognition (사회적 배제가 소비자 반응에 미치는 효과 : 체화된 인지의 조절효과를 중심으로)

  • Son, Jung-sik;Lee, Byung-kwan
    • Science of Emotion and Sensibility
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    • v.18 no.3
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    • pp.107-114
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    • 2015
  • In today's society, the experience of social exclusion caused by being rejected or ignored, leads to negative social consequences, such as aggressive behavior, self-defeating thoughts, and diminished intelligence. This study is performed to examine 1) how two types of social exclusion, rejection and ignorance, affect conspicuous consumption and prosocial behavior and 2) how embodied cognition formed with a firmed muscle moderates their causal relationships. For this purpose, half of the participants in ignorance and rejection conditions were asked to grip their hands to form a firmed muscle (firmed muscle group) while the other half (control group) were not. After the manipulation of embodied cognition, their conspicuous consumption and intention of prosocial behavior were measured. Results show that, in ignorance condition, the firmed muscle group exhibited lower conspicuous consumption and higher intention of prosocial behavior than the control group while, in rejection condition, there were no differences in conspicuous consumption and intention of social behavior between firmed muscle and control groups. Findings indicate that, in the case of social exclusion caused by ignorance, firmed muscle improves self-efficacy, which may increase prosocial behavior.

Professional Belief and Attitude of Dental Hygiene Students (치위생(학)과 학생들의 전문직업적 신념 및 태도)

  • Yang, Seung-Kyeong;Kim, Young-Nam
    • Journal of dental hygiene science
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    • v.10 no.4
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    • pp.287-293
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    • 2010
  • The purpose of this study was to examine the professionalism of dental hygiene students as dental hygienists, who received education to become dental hygienists. The findings of the study were as follows: 1. Concerning the relationship of degree programs to the factors of professionalism, there were statistically significant gaps in use of the professional organization as a major reference, beliefs in service to the public and autonomy according to degree programs(p<0.001), and statistically significant gaps were found belief in self-regulation and sense of calling to the field according to degree programs(p>0.05). 2. As for connections between geographic region and the factors of professionalism, there were statistically significant differences in use of the professional organization as a major reference and sense of calling to the field(p<0.001) according to geographic region. Statistically significant gaps were found in beliefs in service to the public and autonomy(p<0.01), and there were statistically significant differences in self-control(p>0.05). 3. Concerning links between the background of the establishment of the educational system and the factors of professionalism, there were statistically significant differences in use of the professional organization as a major reference, beliefs in service to the public, sense of calling to the field and autonomy(p<0.001), and a belief in self-regulation(p<0.05). 4. In regard to the background variables of the students, there were statistically significant differences in their background variables according to bachelor's degree programs(p>0.05), and statistically significant gaps were found according to geographic region and the background of the establishment of the educational system(p<0.001).

Problems Analysis Related to Nutrition and the Development of Nutrition Education Programs for High School Students(II) - A Study Centered on the Development of Nutrition Education Programs for High School Students - (고등학생의 영양 관련 문제점 분석 및 영양 교육 프로그램 개발 ( II ) - 고등학생 대상 영양 교육 프로그램 개발 -)

  • Lee, Eun-Ju;Soh, Hye-Kyung;Choi, Bong-Soon
    • Journal of the East Asian Society of Dietary Life
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    • v.17 no.3
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    • pp.351-363
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    • 2007
  • Previously, we analyzed for nutrition knowledge and the use of nutrition knowledge in the everyday lives of students in order to develop nutrition education programs that focus on desirable behavior change. From this, we found that female students desired to participate in nutrition education more than male students, and regarding their concerns for nutrition education, 73.2% of the females and 50.0% of the males displayed interest in 'obesity and the regulation of body weight'. Therefore, this study showed female students give more attention to the obesity and the regulation of body weight than male students(p=.000<.001). In addition, female students had higher interests($8.63{\pm}1.67$) than male students ($7.45{\pm}2.03$) in nutrition knowledge(p=.000<.001). By investigating the use of nutrition knowledge in everyday life, our research indicated that the actual use of nutrition knowledge was less. To encourage students to persue dietary lives addressing the concerns confirmed above, the following needed to occur. 1) Provide them nutrition information for the main processed foodstuffs encountered when dining out(breads, cakes, cookies, and carbonated beverage). 2) Teach them to read food nutrition labels. 3) Help them find a lifestyle connection through lasting self-management methods and the generation of social support. Accordingly, this required developing effective and practical nutrition education programs that considered regional characteristics and gender differences. The most important factors considered during nutrition education program development were the need for motivation and ongoing education by stage of change, rather than temporal education through specific problem analysis, in order that those being educated may bring about a change of behavior by themselves. Therefore, from this study, we have suggested the use of multilateral operating strategies for successful nutrition education. In addition the phase model of behavior change should be applied. Our programs were aimed at self owned nutritional management so that students could master their own methods for acquiring skills and enjoying dietary life. The research may be summed up as follows. First, the purpose of education at the recognition stage of change was to attempt motivation for nutrition improvement, by analyzing the problems such as food buying habit and the main purchasing viewpoints when dining out. Second, the purpose of education at the action stage of change was to help students acquire of concrete methods for behavior modification by linking the program to their home as well as to teachers with various activities that suited the situation at school. This was done by analyzing the processes and decisions pertaining to dining out the main processed foodstuffs and principal components, etc. through data and experimental practice. Third, the purpose of education for changing of habits and values, or the maintenance stage, was to investigate the various reasons that undesirable behaviors were induced, and then determine a lasting self-management method as well as how to generate social support. If the nutrition education program developed in this study is utilized on site, someone in the primary role as the nutrition educator and trained specifically in nutrition, can help induce the health promotion in the community as well as lasting dietary management, by executing a link with families in parallel with educating teaching staff and students' parents. In addition, this program can playa role in the government policies related to the health promotion for our youth who are the foundation of our nation and who can enhance our national competitive power.

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The Relationship between Cultural Self-construal of Korean and Alexithymia: A Serial Mediation Process Model of Ambivalence over Emotion Expression and Emotion Suppression Moderated by Generation (한국인의 문화적 자기관과 감정표현불능증의 관계: 세대에 의해 조절된 정서표현양가성 및 정서억제 연속매개과정 모형)

  • Haejin Kim;Soyoung Kwon;Sunho Jung;Donghoon Lee
    • Korean Journal of Culture and Social Issue
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    • v.29 no.2
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    • pp.171-197
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    • 2023
  • The traditional Korean society has been classified as an Eastern collectivist culture, but in the flow of globalization and digitalization along with the post-Cold War era of the 1970s, Western individualistic culture and values quickly permeated the Korean younger generation. Since rapid changes occurred within a short period of time, there may be differences in cultural self-construal between generations living in the same era. Due to this, psychological problems related to emotional expression and suppression may appear differently depending on generations. Therefore, in the current study, 1,000 Korean adult men and women from their 20s to 60s were investigated for their level of independent and interdependent self-construal, alexithymia, ambivalence over emotional expression(AEE) and emotional suppression(ES). Then the relationship between the variables(self-construal and alexithymia,) and the mediating process of AEE and ES were examined. The generation of participants were divided into the industrialization cohort (birth year < 1970) and the digitalization cohort (birth year starting from 1970). Using the PROCESS macro(Hayes, 2022), we tested a serial mediation model of AEE and ES between the relative independent self-construal(RIS) and alexithymia. The results indicate that the level of alexithymia increases by the serial increase of AEE and ES when RIS decreases. Next, we examined a moderation effect of generatione on the mediation process of AEE and ES, and found that generation moderates the relationship between ES and alexithymia. That is, the effect of ES on alexithymia is significant for the digitalization cohort, while it is not significant for the industrialization cohort. The current results imply that emotion regulation strategies of Koreans have been differently developed according to prevailing cultural values in each generation, and that the negative influence of emotion suppression could be different according to the cultural background of each generation.