• Journal of Music and Human Behavior
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• v.10 no.1
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• pp.25-45
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• 2013

The purpose of this study is to explain experiences of non-music majors to changing their majors into music therapy and to provide the preliminary study for deriving a grounded theory. For that, in-depth interviews were performed targeting 5 students who did not major in music in their undergraduate courses selected from the graduate students who are majoring in music therapy at the colleges located in Seoul. Data was analyzed for the study by applying the modified grounded theory. The result of study showed that they selected the course of music therapy career as they were motivated by the realistic demand for future employment, career potentials and other realistic causes. These factors caused them to study the surrounding situations and conduct the detailed research on the possibility of music therapy. These factors were also dependent on the individual characteristics, external elements and music background. These experiences were connected to the self-integration and pursuit of growth by newly setting their relation to the 'Music Child'. In addition, the demand of being the meaningful existence in relationship also affected them to more specify their aspirations in the progress of career selection on a continual basis. This study is meaningful as it provides the actual information on them.

• Journal of Pharmaceutical Investigation
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• v.30 no.3
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• pp.191-199
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• 2000

Genomics is providing targets faster than we can validate them and combinatorial chemistry is providing new chemical entities faster than we can screen them. Historically, the drug discovery cascade has been established as a sequential process initiated with a potency screening against a selected biological target. In this sequential process, pharmacokinetics was often regarded as a low-throughput activity. Typically, limited pharmacokinetics studies would be conducted prior to acceptance of a compound for safety evaluation and, as a result, compounds often failed to reach a clinical testing due to unfavorable pharmacokinetic characteristics. A new paradigm in drug discovery has emerged in which the entire sample collection is rapidly screened using robotized high-throughput assays at the outset of the program. Higher-throughput pharmacokinetics (HTPK) is being achieved through introduction of new techniques, including automation for sample preparation and new experimental approaches. A number of in vitro and in vivo methods are being developed for the HTPK. In vitro studies, in which many cell lines are used to screen absorption and metabolism, are generally faster than in vivo screening, and, in this sense, in vitro screening is often considered as a real HTPK. Despite the elegance of the in vitro models, however, in vivo screenings are always essential for the final confirmation. Among these in vivo methods, cassette dosing technique, is believed the methods that is applicable in the screening of pharmacokinetics of many compounds at a time. The widespread use of liquid chromatography (LC) interfaced to mass spectrometry (MS) or tandem mass spectrometry (MS/MS) allowed the feasibility of the cassette dosing technique. Another approach to increase the throughput of in vivo screening of pharmacokinetics is to reduce the number of sample analysis. Two common approaches are used for this purpose. First, samples from identical study designs but that contain different drug candidate can be pooled to produce single set of samples, thus, reducing sample to be analyzed. Second, for a single test compound, serial plasma samples can be pooled to produce a single composite sample for analysis. In this review, we validated the issue whether the second method can be applied to practical screening of in vivo pharmacokinetics using data from seven of our previous bioequivalence studies. For a given drug, equally spaced serial plasma samples were pooled to achieve a 'Pooled Concentration' for the drug. An area under the plasma drug concentration-time curve (AUC) was then calculated theoretically using the pooled concentration and the predicted AUC value was statistically compared with the traditionally calculated AUC value. The comparison revealed that the sample pooling method generated reasonably accurate AUC values when compared with those obtained by the traditional approach. It is especially noteworthy that the accuracy was obtained by the analysis of only one sample instead of analyses of a number of samples that necessitates a significant man-power and time. Thus, we propose the sample pooling method as an alternative to in vivo pharmacokinetic approach in the selection potential lead(s) from combinatorial libraries.

• Journal of Environmental Policy
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• v.13 no.3
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• pp.43-73
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• 2014

Cities in Korea have rapidly urbanized and they are not well prepared for natural disasters which have been increased by climate change. In particular, they often struggle with urban flooding. Recently, green infrastructure has been emphasized as a critical strategy for flood mitigation in developed countries due to its capability to infiltrate water into the ground, provide the ability to absorb and store rainfall, and contribute to mitigating floods. However, in Korea, green infrastructure planning only focuses on esthetic functions or accessibility, and does not think how other functions such as flood mitigation, can be effectively realized. Based on this, we address this critical gap by suggesting the new green infrastructure planning framework for improving urban water cycle and maximizing flood mitigation capacity. This framework includes flood vulnerability assessment for identifying flood risk area and deciding suitable locations for green infrastructure. We propose the use of the combination of frequency ratio model and GIS for flood vulnerability assessment. The framework also includes the selection process of green infrastructure practices under local conditions such as geography, flood experience and finance. Finally, we applied this planning framework to the case study area, namely YeonJe-gu an Nam-gu in Busan. We expect this framework will be incorporated into green infrastructure spatial planning to provide effective decision making process regarding location and design of green infrastructure.

• Culinary science and hospitality research
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• v.15 no.1
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• pp.254-270
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• 2009

As consumers are becoming more conscious about food safety and high quality standards, they are getting more interested in influencing the food policy-making process. Triggered by FTA (Free Trade Agreement) ratification between the Republic of Korea and the U.S. in 2008, a sharp conflict was created in importing U.S. beef between the government of Republic of Korea and its people. Food selection is known as a complex mental process of consumers, which incorporates social and cultural values, personal tastes, and other psychological factors. This study utilized the concept of antinomy which was signified by Immanuel Kant in his thesis. The concept of antinomy indicates a contradiction between conclusions which seem equally logical, reasonable or necessary. This study is designed to investigate the changes in the amount of beef consumption among Korean consumers after the Republic of Korea resumed U.S. beef imports and the impact of a consumer's trust in the U.S. on his/her antinomic acceptance. Also, it examined the effects of antinomic acceptance and whether a consumer is a potential restaurateur or a general consumer on the changes in the amount of beef consumption.

• Phonetics and Speech Sciences
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• v.6 no.2
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• pp.73-79
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• 2014

Alveolar fricative sounds /s/ and /s'/ are learned last for normal children in the speech development process for Koreans. These are especially difficult to articulate for hearing-impaired children often causing articulation errors. The acoustic phonetic evaluation uses testing tools to provide indirect and object information. These objective resources can be compared with standardized resources on speech when interpreting the results of a test. However, most previous studies in Korea did not consider acoustic studies that used the spectrum moment values of hearing-impaired children. Therefore, this study was conducted to compare the characteristics of hearing-impaired children's pronunciation of fricative sounds using spectrum moment values. For this purpose, the study selected a total of 10 hearing-impaired children (5 boys and 5 girls) currently in 3rd or 5th grade and attending one of the elementary schools in Seoul or Gyeonggi-do. For the selection process, their age, type of hearing aid, implantation of hearing aid (CI) before two years of age, hearing capacity (dB) before and after wearing the hearing aid, duration of speech rehabilitation, and time of learning alveolar fricative sounds were all considered. Also, 10 normal children (5 boys and 5 girls) were selected among 3rd or 5th grade students attending one of the elementary schools in Seoul or Gyeonggi-do. The subjects were asked to read the carrier sentence, "I say _______," including a list of 12 meaningless syllables composed of CV and VCV syllables, including alveolar fricative sounds /s/ and /s'/ and vowels /a/, /i/, and /u/. The recorded resources were processed through the Time-frequency Analysis Software Program to measure M1 (mean), M2 (variance), M3 (skewness), and M4 (kurtosis) of the fricative noise. No significant differences were found when comparing spectrum threshold values in the acoustic phonetic characteristics of hearing-impaired children and normal children in alveolar fricative sound pronunciation according to vowels /a/, /i/, and /u/, alveolar fricative sounds /s/ and /s'/, and syllable structure (CV, VCV) other than, for M3 in the comparison of groups according to disability. In the comparison of syllable structures, there were statistically significant differences in M1, M2, M3, and M4 with clinical significance. However, there was no significant difference in results when comparing the alveolar fricative sounds according to the vowels.

• Journal of Navigation and Port Research
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• v.34 no.3
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• pp.229-234
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• 2010

The aim of this study is to select the import and export goods which contribute to activate the operation of port hinterland. The spatial ranges of this study are A-am 1 logistics complex and 4dock hinterland. The Factor Analysis(FA) and Analytic Hierarchy Process(AHP) are used as the methodologies. Eleven low evaluation factors including 'creation of traffic cargo volume' are selected by precedent studies and four high evaluation factors including 'effective management' are grouped through factor analysis. As the result of priority among low evaluation factors through AHP, 'creation of traffic cargo volume' is the most important factor. Moreover using the AHP, 'electronic component' is the most important item which activate the Port of Incheon and its hinterland. So cargos which have the potential to create traffic cargo volume such as 'electronic component' must be managed strategically and this study can be used as important index when people concerned attract items.

• Korean Chemical Engineering Research
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• v.51 no.5
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• pp.561-567
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• 2013

Mixed hardwood chips were pre-pulping extracted with green liquor prior to kraft pulping in order to recover hemicelluloses for use as biofuels. This green liquor solution containing mainly sodium sulfide and sodium carbonate was applied at different alkali charges (expressed as $Na_2O$) of 0, 1, 3, and 5% on dry wood weight. The extractions were performed at $160^{\circ}C$ for residence times ranging from about 1-2 h to determine the effect of extraction severity on composition of the pre-pulping extract. The severity of hemicellulose extraction time and green liquor charge controls the concentration of acetic acid and monosaccharide sugars available for downstream processing, the accumulation of degradation products such as organic acids and furans in the extract. As the alkali charge was increased, the amount of acetate side chains on the hemicelluloses and the dissolved lignin in the extract increased but the carbohydrate and sugars in the extract decreased appreciably. Hot water extraction (0% alkali addition) released the greatest amount of carbohydrates, up to 29.80 g/L measured as component sugars, but resulted in the greatest decrease in pulp yield. Meanwhile, pre-pulping extraction with 3% green liquor increased the pulp yield while greatly reducing the component sugars to 7.08 g/L. Fundamental data obtained in this study will allow selection of optimum hemicellulose extraction conditions for integrating the extraction operation into the Kraft pulping process.

• Korean Chemical Engineering Research
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• v.46 no.4
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• pp.714-721
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• 2008

Chemical plants which consume lots of energy are not operating in the best conditions due to their own peculiar nonlinearity, instability, and diverse disturbances. In order to improve this, the plant wide optimization was performed. It is important to select the most appropriate number of decision variables which strongly affect the operating cost because there are too many decision variables which economically have an effect on plant wide. For instance, if all decision variables which can economically affect are applied in optimization and then the result of the optimization is applied to operation, a lot of operating conditions should be going to be changed. As a result of changing a plenty of operating conditions, the cost of the change will absolutely increase. Thus, in this study, the method of selecting the most appropriate decision variables which can influence on saving operation costs was presented in order to optimize plant wide. TPA (Terephthalic-acid) plant is considered as a case study. In other word, after modeling, the most proper decision variables was selected by examining the degree which decision variables influence on operating costs through sensitivity analysis. In TPA process, the three decision variables were selected by the presented method in this study. Then the plant was optimized by selected the decision variables. Consequently, it was seen that the plant are expected to save the 350 million won of energy annually without additional investment for facilities or remodeling of the plant.

• Management & Information Systems Review
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• v.39 no.3
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• pp.53-82
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• 2020

Daejeon Metropolitan City has the best innovation capability infrastructure (ICT) required for the 4th industry. Nevertheless, there are scattered factors that hinder the industrial ecosystem. In this study, the factor of job creation was approached from the viewpoint of organizational ecology in consideration of regional characteristics during the 4th Industrial Revolution.That is, the case of job creation through overseas ICT-based clusters (or cities) was examined. Then, the factors of organizational ecology, 'niche', 'variation', 'selection', and 'retention' were derived. Through this process, we explored the environment surrounding Daejeon Metropolitan City and benchmarked lessons from existing overseas cluster cases. As a result, we discover the 'niche' of ICT-based job creation and suggest strategies for the 'variation' process to survive in the ecosystem and how to be 'retention' in the ecosystem. n conclusion, the strategy of the organizational ecological approach to establish itself as a metropolitan city as the strength of Daejeon city and the 'innovation hub' that is evident, such as '4th Industrial Revolution City', 'Innovation City Designation', and 'Secure Excellent Capability of SW' Insist on need. Through this study, we hope that there will be a theoretical contribution to the prior research lacking from original research such as the scarcity of ICT-based job creation research in response to the era of the fourth industrial revolution, recognition of the importance of the region in job creation, and presentation of an organizational ecological approach of sustainable clusters.

• Trans-
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• v.3
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• pp.29-53
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• 2017

The film scholar Vincent Amiel divides into three types of montage through his book The Aesthetics of Montage ; Montage narratif, Montage discursif, and Montage decorrespondances. These three categories are the concept that encompasses the aesthetic class to which most movies belong. Early films pursued the essential and basic functions of editing, which tend to be modified in the direction of enhancing the director's goals over time. In this way, "Expressive Montage" is one of most important concepts of montage, not as a 'methodology' that combines narrative but as a 'purpose'. In the montage stage, the expressive montage work is done through three steps of decision. The process of 'combining' to combine the selected films in a certain order, after the process of 'selection' which selects only necessary parts of the rush film, and 'connection' to determine the scene connection considering the duration of the shot. The connection is the final stage of the montage. There are exceptions, of course. When fiction films of classical narratives use close-ups, or when using models or objects of neutered animals, the film induces the tendency of a "montage decorrespondances" rather than a "montage narratif" or "montage discursif". This study attempts to analyze the tendency of montage of works with 'uncertain connection' through 'collage' used by close-ups and montage decorrespondances as 'fragmentation tendency of modern films'. The fragmentation of the montage in contemporary film breaks the continuous and structural nature of the film, and confuses the narration structure that is visible on the surface of the film. The tendency of the fragmentation of the montage, which started from this close-up, seems to give an answer to the extensibility of the modern image.