• 한국미생물학회:학술대회논문집
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• 한국미생물학회 2006년도 International Meeting of the Microbiological Society of Korea
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• pp.129-131
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• 2006

Through molecular phylogenetic analysis using the nef gene sequences of HIV-l isolated from Korean registered in the NCBI GenBank together with 41 reference strains and 94 foreign isolates, we verified that most (${\sim}80%$) of Korean isolates belonged to subtype B and 78% of subtype B were clustered together exclusively of foreign isolates, and this cluster was named Korean clade subtype B ($K_cB$). Similarity study suggested that the $K_cB$ cluster was more homogeneous than and clearly distinctive from the non-Korean subtype B ($NK_cB$). Comparison of the consensus amino acid sequences of the $K_cB\;or\;NK_cB$ revealed characteristic $K_cB$ signature amino acid pattern comprised of 13 amino acid residues. The $K_cB$ signature amino acid residues were critical in separating the $K_cB$ ftom the $NK_cB$, since substitution of the $NK_cB$ sequences with $K_cB$ signature amino acids relocated them to the Koran clade, and vice versa. Synonymous and nonsynonymous substitution rate study suggested positive selection event for the $K_cB$.

• Journal of Information Processing Systems
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• 제10권4호
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• pp.555-567
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• 2014

Biometric performance improvement is a challenging task. In this paper, a hierarchical strategy fusion based on multimodal biometric system is presented. This strategy relies on a combination of several biometric traits using a multi-level biometric fusion hierarchy. The multi-level biometric fusion includes a pre-classification fusion with optimal feature selection and a post-classification fusion that is based on the similarity of the maximum of matching scores. The proposed solution enhances biometric recognition performances based on suitable feature selection and reduction, such as principal component analysis (PCA) and linear discriminant analysis (LDA), as much as not all of the feature vectors components support the performance improvement degree.

• Asian-Australasian Journal of Animal Sciences
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• 제26권5호
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• pp.603-608
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• 2013

Hanwoo have been subjected over the last seventy years to intensive artificial selection with the aim of improving meat production traits such as marbling and carcass weight. In this study, we performed a signature of selection analysis to identify recent positive selected regions driven by a long-term artificial selection process called a breeding program using whole genome SNP data. In order to investigate homozygous regions across the genome, we estimated iES (integrated Extended Haplotype Homozygosity SNP) for the each SNPs. As a result, we identified two highly homozygous regions that seem to be strong and/or recent positive selection. Five genes (DPH5, OLFM3, S1PR1, LRRN1 and CRBN) were included in this region. To go further in the interpretation of the observed signatures of selection, we subsequently concentrated on the annotation of differentiated genes defined according to the iES value of SNPs localized close or within them. We also described the detection of the adaptive evolution at the molecular level for the genes of interest. As a result, this analysis also led to the identification of OLFM3 as having a strong signal of selection in bovine lineage. The results of this study indicate that artificial selection which might have targeted most of these genes was mainly oriented towards improvement of meat production.

• Asian-Australasian Journal of Animal Sciences
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• 제33권9호
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• pp.1378-1386
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• 2020

Objective: Chinese indigenous sheep breeds can be classified into the following three categories by their tail morphology: fat-tailed, fat-rumped and thin-tailed sheep. The typical sheep breeds corresponding to fat-tailed, fat-rumped, and thin-tailed sheep are large-tailed Han, Altay, and Tibetan sheep, respectively. Detection of copy number variation (CNV) and selection signatures provides information on the genetic mechanisms underlying the phenotypic differences of the different sheep types. Methods: In this study, PennCNV software and F-statistics (F_ST) were implemented to detect CNV and selection signatures, respectively, on the X chromosome in three Chinese indigenous sheep breeds using ovine high-density 600K single nucleotide polymorphism arrays. Results: In large-tailed Han, Altay, and Tibetan sheep, respectively, a total of six, four and 22 CNV regions (CNVRs) with lengths of 1.23, 0.93, and 7.02 Mb were identified on the X chromosome. In addition, 49, 34, and 55 candidate selection regions with respective lengths of 27.49, 16.47, and 25.42 Mb were identified in large-tailed Han, Altay, and Tibetan sheep, respectively. The bioinformatics analysis results indicated several genes in these regions were associated with fat, including dehydrogenase/reductase X-linked, calcium voltage-gated channel subunit alpha1 F, and patatin like phospholipase domain containing 4. In addition, three other genes were identified from this analysis: the family with sequence similarity 58 member A gene was associated with energy metabolism, the serine/arginine-rich protein specific kinase 3 gene was associated with skeletal muscle development, and the interleukin 2 receptor subunit gamma gene was associated with the immune system. Conclusion: The results of this study indicated CNVRs and selection regions on the X chromosome of Chinese indigenous sheep contained several genes associated with various heritable traits.

• 정보과학회 컴퓨팅의 실제 논문지
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• 제24권2호
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• pp.99-104
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• 2018

최근 랜섬웨어에 의한 피해가 전 세계적으로 급증하고 있으며, 국가 기관, 기업, 민간 등 사회전반에 막대한 피해를 입히고 있다. 랜섬웨어는 컴퓨터 시스템을 감염시켜 사용자의 접근을 제한하고 일종의 몸값을 요구하는 악성 소프트웨어이다. 컴퓨터 시스템 자체를 잠그거나 하드 디스크에 존재하는 파일들을 암호화하여 사용자가 컴퓨터를 정상적으로 이용할 수 없게 만들고, 컴퓨터의 정상 복구를 위해 사용자들은 공격자로부터 몸값(Ransom) 지불을 요구받는다. 기존의 기타 악성코드들에 비해 공격수법이 매우 악랄하고 피해규모가 막대하므로 확실한 해결책이 필요하다. 악성코드 분석 방식은 크게 정적 분석, 동적 분석 두 가지로 나뉜다. 최신 악성코드들은 정교한 패킹 기술이 도입된 경우가 많아 정적분석은 분석에 한계가 있다. 따라서 본 논문에서는 랜섬웨어의 활동 모니터링 및 보다 정밀한 분석을 위해 동적 분석 방법을 제안한다. 정상파일, 랜섬웨어, 기타 악성코드의 시그니처를 추출하는 방법과 랜섬웨어 탐지에 가장 적절한 시그니처를 선정하는 방법을 제안한다.

• Animal Bioscience
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• 제37권3호
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• pp.461-470
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• 2024

Objective: The objective of this study was to investigate the genetic diversity, population structure and whole-genome selection signatures of Luxi cattle to reveal its genomic characteristics in terms of meat and carcass traits, skeletal muscle development, body size, and other traits. Methods: To further analyze the genomic characteristics of Luxi cattle, this study sequenced the whole-genome of 16 individuals from the core conservation farm in Shandong region, and collected 174 published genomes of cattle for conjoint analysis. Furthermore, three different statistics (pi, F_st, and XP-EHH) were used to detect potential positive selection signatures related to selection in Luxi cattle. Moreover, gene ontology and Kyoto encyclopedia of genes and genomes pathway enrichment analyses were performed to reveal the potential biological function of candidate genes harbored in selected regions. Results: The results showed that Luxi cattle had high genomic diversity and low inbreeding levels. Using three complementary methods (pi, F_st, and XP-EHH) to detect the signatures of selection in the Luxi cattle genome, there were 2,941, 2,221 and 1,304 potentially selected genes identified, respectively. Furthermore, there were 45 genes annotated in common overlapping genomic regions covered 0.723 Mb, including PLAG1 zinc finger (PLAG1), dedicator of cytokinesis 3 (DOCK3), ephrin A2 (EFNA2), DAZ associated protein 1 (DAZAP1), Ral GTPase activating protein catalytic subunit alpha 1 (RALGAPA1), mediator complex subunit 13 (MED13), and decaprenyl diphosphate synthase subunit 2 (PDSS2), most of which were enriched in pathways related to muscle growth and differentiation and immunity. Conclusion: In this study, we provided a series of genes associated with important economic traits were found in positive selection regions, and a scientific basis for the scientific conservation and genetic improvement of Luxi cattle.

• International Journal of Costume and Fashion
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• 제15권1호
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• pp.51-74
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• 2015

The purpose of this exploratory research is to study Cashin's fashion philosophy and to draw her design characteristics through analysis of her work. As a result of this research, 76 garment pieces were selected from the 180 Bonnie Cashin collections at the University of Cincinnati to document and evaluate. The final selection includes: sixteen jackets, fifteen skirts, five pants, five tops, seven dresses, twenty five coats, and three capes. Bonnie Cashin specialized in practical and functional; yet innovative designs such as leather trimmed tweed Jackets/coats, canvas raincoats, suede leather coats, and ponchos. Her trademark elements include toggle closures, oversized pockets, her Noh coats, tweed suits, canvas raincoats, fringed suede dresses, funnel neck pullovers, jersey dresses, and ponchos. She emphasized function and comfort and she believed that a good design must also be practical. The examination of these 76 pieces from the University of Cincinnati's private Bonnie Cashin Collection brings to light Bonnie Cashin's creative design and what she represented in the development of American fashion design in the $20^{th}$ century.

• 한국융합학회논문지
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• 제9권11호
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• pp.75-81
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• 2018

블록체인 내의 모든 트랜잭션이 공개되기 때문에 익명성과 프라이버시 문제는 중요해지고 있다. 공개 블록체인은 사용자 대신 공개키 주소를 사용하여 익명성을 보장하는 것처럼 보이지만 트랜잭션 그래프를 기반으로 다양한 기법을 통해 추적함으로써 익명성을 약화시킬 수 있다. 본 논문에서는 블록체인 환경에서 익명성과 프라이버스를 보호하기 위하여 다양한 보안 기법을 융합하여 사용자의 추적을 어렵게 하는 기법을 제안한다. 제안 기법은 k-anonymity 기술, 믹싱 기술, 은닉서명, 다단계 기법, 램덤 선택기법, 영지식 증명 기법 등을 융합하여 인센티브 및 기여자의 참여를 통해 익명성과 프라이버시를 보호한다. 성능 분석을 통해 제안기법은 기여자의 수가 공모자의 수보다 많은 환경에서는 공모를 통한 프라이버시 및 익명성 훼손이 어렵다는 것을 보였다.

• Animal Bioscience
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• 제37권10호
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• pp.1683-1691
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• 2024

Objective: Yellow Korean native chicken (KNC-Y) is one of the five pure Korean indigenous chicken breeds that were restored through a government project in 1992. KNC-Y is recognized for its superior egg production performance compared to other KNC lines. In this study, we performed runs of homozygosity (ROH) analysis to discover selection signatures associated with egg production traits in the KNC-Y population. Methods: A total of 675 DNA samples from KNC-Y were genotyped to generate single nucleotide polymorphism (SNP) data using custom 60K Affymetrix SNP chips. ROH analysis was performed using PLINK software, with predefined parameters set for the analysis. The threshold of ROH island was defined as the top 1% frequency of SNPs withing the ROH among the population. Results: In the KNC-Y population, a total of 29,958 runs of homozygosity (ROH) fragments were identified. The average total length of ROH was 120.84 Mb, with each ROH fragment having an average length of 2.71 Mb. The calculated ROH-based inbreeding coefficient (F_ROH) was 0.13. Furthermore, we revealed the presence of ROH islands on chromosomes 1, 2, 4, 5, 7, 8, and 11. Within the identified regions, a total of 111 genes were annotated, and among them were genes related to economic traits, including PRMT3, ANO5, HDAC4, LSS, PLA2G4A, and PTGS2. Most of the overlapping quantitative trait locus regions with ROH islands were found to be associated with production traits. Conclusion: This study conducted a comprehensive analysis of ROH in the KNC-Y population. Notably, among the findings, the PTGS2 gene is believed to play a crucial role in influencing the laying performance of KNC-Y.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2004년도 Proceedings of ISRS 2004
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• pp.425-427
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• 2004

Motivation of this study is based on these two aspects: geologic uses of ASTER and application scheme of Spectral Mixture Analysis. This study aims at geologic mapping for mineral exploration using ASTER and LANDSAT 7 ETM+ at Mongolian plateau region by SMA. After basic pre-processing such as the normalization, geometric corrections and calibration of reflectance, related to endmembers selection and spectral signature deviation, both methods using spectral library and using PPI(Pixel Purity Index) are performed and compared on a given task. Based on these schemes, SMA is performed using LANDSAT 7 ETM+ and ASTER image. As the results, fraction map showing geologic rock types are enough to meet purposes such as geologic mapping and mineral potential mapping in the case of both uses of these different types of remotely sensed images. It concluded that this approach based on SMA with LANDSAT and ASTER is regarded as one of effective schemes for geologic remote sensing.