• 제목/요약/키워드: Sedative-hypnotics

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2008년 국내 중독환자 실태조사; 예비연구 (2008 Database of Korean Toxic Exposures: A Preliminary Study)

  • 소병학;이미진;김현;문정미;박경혜;성애진;염석란;오성범;유지영;이경우;이경원
    • 대한임상독성학회지
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    • 제8권2호
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    • pp.51-60
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    • 2010
  • Purpose: The aim of this study was to investigate toxic exposures in emergency centers with using a toxic exposure surveillance system-based report form as a preliminary study. Methods: We retrospectively reviewed the medical records of toxic exposure patients who visited emergency centers from January to December 2008. Results: 3,157 patients from 11 emergency centers were enrolled. Males were involved in 47.9% of the total cases of exposure and in 60.1% of the cases of fatal exposure. Suicidal intent was the most common (61.0%) reason and most (87.4%) fatal exposures were suicidal. Pesticides were involved in 30.7% of the cases and sedative/hypnotics/antipsychotics were involved in 20.5%. The substances most frequently involved in fatalities were pesticides, and a 48.4% fatality rate was recorded for paraquat exposure. Conclusion: The toxic exposure data showed the preliminary poisoning events in emergency centers. It is recommended that toxicology professionals should develop a toxic surveillance system and serial reporting should be performed.

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한국 청소년의 약물남용과 비행행위

  • 김성이
    • 한국인구학
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    • 제11권2호
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    • pp.54-66
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    • 1988
  • I. Introduction Since the 1970's drug abuse among young people has increasingly become a social problem in Korea. In the 1980's, drug abuse, especially glue sniffing, has become the cause of many unfortunated incidents resulting in harm to others as well as the abusers themselves. Taking into consideration of the seriousness of this problem, the Republic of Korea National Red Cross initiated a nation-wide research programme, to understand the present situation and to raise the level of public awareness. The goal of this research was to begin a nation - wide campaign against drug abuse. The research team was composed of the Advisary Committee members and the staff of the Youth Department of the Republic of Korea National Red Cross. The data were collected in February 1988 with the collaboration of the staff and volunteers in the local Chapters. The respondents were allocated nation-wide by the quota sampling method. The questionnaires were distributed to the respondents in three groups :2, 700 to junior and senior high school students, 605 to working youths, and 916 to delinquent youths. A total of 4, 221 questionnaires were collected. II. Characteristics of the Respondents The respondents in each group were selected evenly from rural and urban areas. The general characteristics of the respondents can be described as follow: in case of students, the proportions between male and female respondents, and between senior high school and junior high school students were almost evenly distributed. In case of working youths, the proportion of females (80.5%) was higher than those of the students and the delinquents groups. Delinquent youths were defined as those currently being under custody of the centers for juvenile delinquents. Of this number, 38.8% and 68.2% were junior and senior high school drop-outs respectively. The majority of them (92.6%) were male. As for the family background of the respondents, the proportion of those residing in poverty - stricken areas, and the proportion of those from broken families were higher in case of working youths and delinquent youths than those in case of students. III. Present Patterns of Drug Abuse The following summarizes the presents of drug abuse, as tabulated from the results of the survey. 1. Smoking The percentage of youths who smoke was 36% in the student group, 32% m the working youths group, and 94.4% in the delinquent youths group. 2. Alcohol 50.3% of students, 71.6% of working youths, and 93.3% of delinquent youths has experienced drinking alcohol beverages. 3. Tonic: non - alcoholic, caffeinated beverages popular in Korea and Japan The percentage of those who have used tonic at least once was over 90% in all of the three groups. 4. Sedative About 70% of each group has used sedative with the proportion of working youths use higher than those in other groups. 5. Stimulants Those who have used stimulants comprised around 15% in each group. 6. Tranquilizers Somewhat less than 5% of students and working youths, and 28% of delinquent youths, have used tranquilizers. 7. Hypnotics The users of hypnotics amounted to 0.4% of students, 2.6% of working youths and 7.1% of delinquent youths. 8. Marihuana Those who have used marihuana indicated 0.7% of students, 0.8% of working youths, and 13% of delinquent youths. 9. Glue-sniffing The percentage of glue-sniffing was 3.7%, 5% in the students group and in the youths group respectively, but the proportion was unusually high, at 40.7% in the delinquent youths group. From the results of the survey the present situation of drug abuse in Korea can be summarized as follows: 1. A high percentage of Korean youths have experienced smoking cigarettes and drinking alcoholic beverages. 2. Tonics (non - alcoholic, caffeinated beverages), antipyretic analgesics and stimulants quite regularly used. 3. Tranquilizers, hypnotics, marihuana and glue-sniffing are more widely used among delinquent youths than the other youths. From this fact, there exists a correlation between drug abuse and juvenile delinquency. IV. Time-series Analysis of the First Experience of Drug Abuse and Deviant Behaviour The respoundents were asked when they were first exposed to drugs and when they committed deviant acts. By calculating the average age of each experience, the following pattern was found (See Figure 1). Youths are first exposed to drugs by abuse of tonic(non - alcoholic, caffeinated beverages). At the age of 13, they amoke cigarettes, the use of antipyretic analgesics begins at 14 year old, while at the age of 15, they use tranquilizers, and at 16 hynotics. The period of drug abuse which starts from drinking caffeinated beverages and smoking cigarettes and ends in the use of hypnotics takes about three years. During this period, other delinquent behaviours begin to surface, that is, at the age of 13 when smoking cigarettes begins, the delinquent behaviour pattern starts with truancy. Next, they start taking money from others by using physical force. Prior to the age of 15, they are suspended from school, become hostile to adults, begin running away from home, and start using stimulants and alcohol. Soon they become involved even in glue-sniffing and in the use of marihuana. At the age of 15, they begin to see adult videos and carry weapons. Sexual promiscuity and usage of tranquilizers follows the viewing of adult videos. Consequently, by the time they reach the age of 16, they visit drinking establishments, and are picked up by police for committing delinquent acts. And finally, they come to use hypnotic - type drugs. From the above descriptions, drug abuse can be assumed to have a close correlation with delinquent behaviour. V. Social Factors Related to Drug Abuse As for the Korean youths, glue-sniffing is found to he related to aggressive delinquency, in such cases as run - aways, being picked up by the police, and taking money by force. Smoking cigarettes and drinking alcohol is found to be related to seeing adult videos and visiting drinking establishments. Hypnotics and marihuana were found to be representive of drugs which are related to degenerational delinquency, irrespective of social delinquency. The social factors connected with these drug abuse are as follows: 1. Individual factors Male students were more heavily involved in the usage of drug than females. Youths who do not attend church were more likely to be involved in drugs than those who attend. 2. Family factors The youths who were displeased with their mothers smoking and those who thought their parents did not love each other, or those whose parents had used drugs without prescription, were more likely to he drug users. 3. School factors Those youths who found school life boring, were unsuccessful in their studies, spend most of their time with friends, feel their teachers smoke too much, those who had a positive perception of their teachers smoking were likely to he drug users. To sum up, drug abusers depend on the influence of their parents, teachers and peers. IV. Reasons for Drug Abuse Korean students have mainly used drugs to release stress (42.8%), to stay awake (19.7%), and because of the easy accessibility of drugs( 16.6%). Other reasons are due to their ignorance of the side effects of the drugs (3.6%), natural curiosity (4.2%), and to increase strength(3.O%). From the above facts, the major reasons for drug abuse among Korean youths are to release stress and to stay awake in order to prepare exams. Furthermore, since drugs are readily available, we can conclude that drug abuse is caused by the school system(such as entrance exams) in Korea. VII. Conclusion Drug usage among Korean youths are relatively less common than those of western youths. In some cases, such as, glue-sniffing and use of stimulants, the pattern of drug abuse is found. Moreover, early drug abuse is evident, and it has a close connection with deviant behaviour, resulting in juvenile delinquency. Drug abuse cannot be attributed to any one social factor. Specifically, drug abuse depends on parents, peers, teachers and other members of the community, and also is influenced by social institutions such as the entrance exam system. Every person and organization concerned with youth must participate collectively in restraining drug abuse. Finally, it is suggested that social agencial working for youth welfare should make every effort to tackle this serious problem confronted by the Korean youths today.

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의도적 중독으로 응급실을 방문하는 환자들의 특성: 2011-2015년 응급실 손상환자 심층조사 분석 (Epidemiologic Characteristics of Intentional Poisoning: Emergency Department Based Injury in-depth Surveillance During 2011-2015)

  • 이학수;한주희;김지훈;김선표;김선휴;이지숙;조규종;한철;박준민;정성필;김민정
    • 대한임상독성학회지
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    • 제15권2호
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    • pp.131-139
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    • 2017
  • Purpose: The purpose of this study was to investigate the epidemiologic characteristics of patients who visited emergency departments (EDs) after intentional poisoning in Korea. Methods: This study retrospectively analyzed the data of of 23 hospitals during a five-year period, between 2011 and 2015. We included patients who inflicted injury to themselves - attempt of suicide - by means of poisoning. Results: A total of 18,121 patients visited an ED after intentional poisoning. Among them, 58.3% were females; however, there were more males among those aged 60 years or older. The mortality rate for males was 8.6%, which was 3.1 times higher than that for females with 2.8%. The most common poison was pesticides (35.4%) in males and sedative-hypnotics (44.0%) in females. The most common causative agent of death was pesticide in both sexes (75.2% and 65.3%, respectively). Since the production of paraquat was discontinued in 2011, the number of deaths from pesticide poisoning has decreased. The mortality rate declined in both males and females, from 12.6% and 4.5% in 2011 to 7.1% and 2.1% in 2015, respectively. Conclusion: In this study, we analyzed the epidemiologic characteristics of intentional poisoning, especially the frequency of suicide attempts by gender and age group, the cause of suicide, and the causative agent. This can be used as basic data for establishing policies to reduce and prevent suicide attempts by poisoning.

알코올의존 환자에서의 수면장애에 대한 아침 광치료의 임상시도 (Open Clinical Trial of Morning Light Therapy in Sleep Disturbance of Alcohol Dependent Patients)

  • 고영훈;조숙행;전승규;김병규;권성민
    • 정신신체의학
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    • 제11권2호
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    • pp.196-204
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    • 2003
  • 연구목적: 알코올의존 환자의 수면 장애에 대한 치료에 있어서 기존의 진정수면제 등의 약물은 교차 내성을 일으키고, 수면의 질을 악화시키기도 한다. 광치료는 일주기리듬장애, jet-lag, 순환제교대근무에서 나타나는 수면장애와 노화와 관련된 수면 장애의 치료에 효과적인 비약물적 치료중재이다. 따라서 저자들은 이미 여러 질환의 수면장애에 시도되고 있던 광치료의 회복기 알코올의존환자의 수면장애에 대한 치료적 효과를 알아보고자 하였다. 연구방법: 알코올 금단 증상을 보이지 않는 13명의 알코올의존 환자들을 대상으로 하여 2500Lux의 광상자로 하루에 오전 1시간 씩 3일에 걸쳐 광치료를 시행하였다. 총수면시간, 실제수면시간, 수면잠복기, 수면효율, 각성빈도 등을 수면기록지를 통해 평가하였으며, visual-analogue scale을 통해 주관적인 수면의 만족도를 평가하였다. 오전 8시, 오후 2시, 오후 8시 3차례에 걸쳐 연구대상자의 졸림 정도를 스탠포드졸림척도를 통해 평가하였으며, visual-analogue scale을 통해 불안, 우울 기분 및 피로감을 평가하였다. 수면상태를 반영하는 수행 능력의 평가를 위하여 기초단계와 연구 4일째에 기호잇기검사(trail making test)A, B 및 기호바꿔쓰기검사(digit symbol substitution test)를 시행하였다. 각 측정값은 반복측정분산분석법을 이용하여 비교하였으며 수행능력의 평가는 사전사후차이검증을 이용하였다. 결 과: 수면기록지로 평가된 수면잠복기, 수면효율은 광치료의 효과를 확인할 수 있었으며 기초 단계에 비해 연구 1일째부터 유의한 차이를 보였다. 수면에 대한 만족도도 광치료에 따라 유의하게 증가하였으며 연구 1일째부터 유의한 차이를 나타내었다. 오후 2시에 평가된 졸림은 광치료의 효과를 확인할 수 없었지만 오전 8시에는 광치료에 따라 졸림이 유의하게 감소하였고 오후 8시에는 유의하게 증가하였다. 기호잇기검사와 기호바꿔쓰기검사에서 환자들은 광치료 전후 수행 시간이 유의하게 감소하였다. Visual analogue scale에 의한 피로감의 평가에서 오후 2시와 오후 8시에 광치료에 따라 유의하게 피로감의 감소가 나타났으며 우울기분과 불안은 광치료의 효과를 확인할 수 없었다. 결 론: 본 연구에서는 금단 증상에서 회복된 후에도 지속적으로 수면장애를 호소하는 알코올의존 환자들에 있어 비록 제한적이지만 광치료의 효과를 확인할 수 있었고, 임상 실제에서 알코올중독 환자들의 수면장애에 단기간의 광치료가 효과적인 치료도구가 될 수 있음을 제시하고 있다. 추후 보다 객관적인 수면 평가 도구를 이용한 장기간의 대조군 연구가 필요할 것으로 생각된다.

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영남대학교 의과대학 부속병원 외래환자에 대한 약물처방 동향의 분석 (Drugs Most Frequently Used in OPD of Yeungnam University Hospital: March to August, 1985)

  • 이광윤;김원준;김승훈
    • Journal of Yeungnam Medical Science
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    • 제2권1호
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    • pp.95-102
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    • 1985
  • 대구 및 그 인접지역의 질병 발생 경향을 추정하고, 영남대학교 의과대학 부속병원의 약제수급 계획을 위한 참고자료를 얻기 위하여, 1985년 3월부터 동년 8월까지 당 병원 외래에 내원한 환자들을 위하여 내려진 약물 처방을 전산 집계하여 다음과 같은 결과를 얻었다. 가장 빈번히 처방된 약물로 부터 100종의 약물을 처방빈도 순으로 나열하였던 바, diazepam, aluminum compound, acetaminophen, isoniazid, metoclopramide, $polaranine^{(R)}$, carboxymethylcystein, ephedrine, codeine, caroverine (이하생략) 등의 순으로 나타났으며, 이와 같이 선정된 100종의 약물을 임상용도별로 분류하여 총 처방회수 521,855회에 대한 백분율을 조사한 결과는 다음과 같다. 중추신경계약물 (20.57%)이 가장 많았고, 다음은 위장관 및 평활근에 작용하는 약물 (18.64%), 호흡기계약물 (16.11%), 항균제 (15.12%), 심혈관 계약물 (5.64%)의 순으로 많았으며, 그 다음은 소염제 (4.33%), 단독비타민제 (3.76%), 호르몬 및 항호르몬제 (3.29%), 감기치료제 (3.12%), 이뇨제 (2.81%), 간기능이상치료제 (2.02%), 자율신경계약물 (1.89%), 항히스타민제 (1.02%) 및 소독약 (0.74%) 등의 순으로 나타났다.

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