• BMB Reports
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• v.32 no.6
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• pp.599-604
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• 1999

A highly conserved amino acid, glutamic acid (Glu), present at position 152 in the catalytic domain of the human immunodeficiency virus type 1 (HIV-1) integrase (IN) protein has been known to be critical for enzymatic function since substitution of Glu 152 with other residues results in a complete loss of enzymatic activities. In order to better understand the role of Glu 152 as a conserved residue in enzymatic action, intragenic second site mutations have been introduced around residue 152 of a mutant IN (E152A), and their biochemical properties were analyzed in terms of enzymatic activities. Disintegration activities were found to be significantly restored in several second site mutant INs, while integration activities were only recovered weakly. However, endonucleolytic activities were not discovered in all the mutant INs. These findings indicate that the second site mutations can partially restore that catalytic structure of the active site disturbed by the E152A mutation and lead to the regaining of integration and disintegration activities. In addition, it is also suggested that endonucleolytic activity requires a more accurate structure of the catalytic site than that for the integration and disintegration activities.

• Archives of Plastic Surgery
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• v.43 no.1
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• pp.66-70
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• 2016

Background In this study, we characterize the morbidity at the donor-site of partial second toe pulp free flaps in terms of wound management as well as long-term outcomes. Methods A single-institutional retrospective review was performed for patients who had undergone partial second toe pulp free flap transfer to the fingertip. Patient charts were reviewed for infection, skin necrosis, wound dehiscence, and hematoma for the donor site. Additionally, a questionnaire survey was given to patients who had a follow-up of longer than 1 year to characterize long-term postoperative pain and appearance. Results The review identified a total of 246 cases. Early wound complications were significant for wound dehiscence (n=8) and hematoma (n=5) for a wound complication rate of 5.3%. The questionnaire was distributed to 109 patients, and 54 patients completed the survey. Out of these 54 patients, 15 patients continued to have donor-site pain (28%) at a mean follow-up period of 32.4 months. However, the pain intensity was relatively low in the range between 2 to 5, on a 0-10 scale. None of these patients felt this donor-site pain interfered significantly with daily activity, nor did any patient require pain medications of any type. Donor-site appearance was satisfactory to most patients. Conclusions The partial second toe pulp flap was associated with low rates of wound complications and favorable long-term outcomes. Given the functional and aesthetic gain in the recipient finger, donor-site morbidities appear acceptable in this patient population. This study can be helpful in counseling patients regarding donor-site morbidity during the informed consent process.

• Journal of Plant Biology
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• v.29 no.3
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• pp.175-183
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• 1986

Marine algal flora and intertidal vegetation around Samchonpo power plant, south coast of Korea, were investigated at three sites, specially referred to the seasonal variation of the species from April to October, 1982. A total of 84 species were identified; 8 green, 19 brown and 57 red algae. Among three sampling sites investigated, 65 species were collected at the first site located in front of the power plant, 66 at the second site, Namildae beach, and 61 at the third, Sinsudo, respectively. The algal vegetation at the first site was dominated in cover by Sargassum thunbergii and Ulva pertusa in April, Corallina spp. Ulva pertusa in July, and Chondria crassicaulis and Ulva pertusa in October. At the second site, it was dominated in cover by Sargassum thunbergii, Gigartina tenella and Ulva pertusa in April, Sargassum thunbergii and Ulva pertusa in July, and Chondria crassicaulis and Ulva pertusa in October, whereas at the third site Sargassum thunbergii and Ulva pertusa in April, and Chondria crassicaulis in October, respectively. The biomass among three investigated sites showed 2,360 g-fresh wt/$m^2$ on an average; 283 g-dry wt/$m^2$ at the first, 277 g-dry wt/$m^2$ at the second, and 256 g-dry wt/$m^2$ at the third site, respectively.

• Journal of Environmental Impact Assessment
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• v.4 no.2
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• pp.29-37
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• 1995

The national park should be preserved in accordance with the regulation, but the development planning or facilities management planning has not been faithful to the spirits of the regulation. Recently natural environment has been radically changed, and especially damaged by large scale development of Service Facilities Zone. Thus the effective land use planning of the national park is required. Therefore, the purpose of this study is to propose the alternative site for The Second Service Facilities Zone in Mt. Kyeryong National Park using the GIS, and to compare the alternative site with the existing development site. Site selection was based on Rules of Combination which covers topographic analysis, viewshod analysis, distance analysis from hot spring well, land use analysis, and forest stand analysis.

• Journal of the Korean Institute of Landscape Architecture
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• v.13 no.1
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• pp.25-42
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• 1985

The objective of this article is to develop residential site planning techniques for the energy conservation by focusing on energy conscious site design process, influencing natural factors for energy conservation and suggestion of multi - family housing Prototypes. This article is the second part of the article titled "A Study on an Energy - Effective Site Planning for a Residential Environment"which is published in the previous issue (Vol. 12, No. 2) of this journal. The first part of the article dealt with how to make best use of energy conserving effect of natural forces such as sun, wind and water, and the selection techniques of suitable residential site for achieving energy conservation. The second part proposes the energy conscious design process of residential site development and suggests building forms of single family and multi -family housings. The three multi - family housing prototypes haute been developed which are most energy -effective ; the linear type, the cut -de -sac type and the atrium type. In the process of creating the prototypes, energy conserving design criteria have been also developed. These criteria can be used to develop some other alternative prototypes.

• Proceedings of the KSAR Conference
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• 2001.03a
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• pp.53-53
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• 2001

Two trials were conducted in a commercial dairy farm on heifer synchronization with PGF$_2$ $\alpha$. Animals showing estrus following the first injection were bred and animals not showing estrus were given the second injection 10 days later. In the first trial, the injection sites were rump and rump. In the second trial, the injection sites were rump and shoulder. Estrous detection was peformed 24 h after injection. Animals were bred by the same technician. In the first trial, the response rate for the first injection was 51.4% and the subsequent pregnancy rate of these animals was 60.0%. The response rate in the second injection was 57.1% and the pregnancy rate was 50.0%. In the second trial, the response rate in the first injection on the rump was 48.7% and the subsequent pregnancy rate was 70.6%. The second injection was given on the shoulder and the response rate was 60.0% and the subsequent pregnancy rate was 25.0%. The data suggests that the site of PGF2 $\alpha$ administration was critical to achieve success in estrous synchronization and pregnancy rates.

• Journal of Advanced Navigation Technology
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• v.16 no.6
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• pp.935-943
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• 2012

In this paper a three step procedure was derived to select the GNSS network receiving site candidates for GNSS based infrastructure technology development and according to the proposed procedure the 4 site candidates was selected for final network configuration. In the first step, the site requirement was produced for GNSS based infrastructure technology development referring regulation of the international organizations related to permanent GNSS data receiving and the first candidates were selected using the proposed requirement. In the second step, the second candidates were selected among the first candidates by analyzing the visual measurement, environment test and so on. In the third step the final candidates were selected among the second candidates by analyzing sky clearance, radio frequency interference. Through above the three step procedure 16,7,4 candidates of site were selected sequentially and receiving station site could be effectively selected.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.10 no.3
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• pp.38-51
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• 2007

The purpose of this study is to analyze of biotope types and to develop assessment for forest ecosystem evaluation method. Vegetation types divided into 27 types. Considering the vegetation types, vegetation structures, DBH, potentials, and disturbance, it was decided to apply 58 biotope types and survey site's biotopes were divided into 24 biotope types. Assessment indicators were naturaliness, diversity, rarity, stability, potential, and disturbance. The areas given the first grade in ecological value included 9.2% of the site's total land. Areas with the second grade accounted for 43.0% of the total land. Areas with the third grade made up 47.8% of the site and mostly they were areas with dominance of fired area and artificial forest. To plan to build naturally-development for Site, there should be plans to conserve areas with the first grades. For the areas with the second, and third grades, plans for ecological land use based on conservation and restoration in terms of securing biodiversity are needed.

• Journal of Korean Society of Rural Planning
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• v.20 no.1
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• pp.161-173
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• 2014

This study aimed to adaptive reuse plan a take advantage of Suncheon Bay Garden Expo 2013. Detailed objectives included: to identify and foster cultural and ecological resources in Suncheon Bay and Garden Expo Site; and to search and propose characterized program in the site for efficient utilization; and to revitalize a site for the vitalizations of the region where garden culture and garden industries for strengthening local competitiveness. The study was multi-phased. The first stage included basic surveys such as site status and environmental context analysis, and questionnaires and similar case studies, and the second stage was to review the direction of preliminary planning, develop associated industries and strategies for regional revitalization and review and incorporate project details. And the third stage aimed to develop a comprehensive plan from spatial plans and program plans and suggest plans to vitalize the operation of the site. The results of the study are as follows: First, the characterization strategy is 'healing experience tourism', 'healing garden', 'healing herbal care' are suitable for the site and regional revitalization. Second, the dimension of 2013 Suncheon Bay Garden Expo which was distinguished into four areas, in consideration of the characteristics and contents of the garden expo site for efficient operation and maintenance. Four area are as follows: the park oriented area, the experiential tourism oriented area, the existing conservation oriented area, and the area for associated industries. Third, the practice of private and public partnerships is needed in order to efficiently manage and operations. The significance of this study is that it is seeking to take advantage of the Garden Expo site and set the plan by existing resources and in consideration of local characteristics, in conjunction with area to envision and proposed management plan. Some problems are remained which have not been able to deal with details program and organization and financial planning programs for the operation of the site. This is for further study.

• Journal of Periodontal and Implant Science
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• v.42 no.3
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• pp.105-109
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• 2012

Purpose: Soft tissue recessions frequently cause esthetic disharmony and dissatisfaction. Compared with soft tissue coverage around a tooth, the coverage of an implant site is obviously unpredictable. Particularly in the cases of thin mucosa, a significant greater amount of recession takes place compared to thick mucosa. To overcome this problem, this case report demonstrates a two-step mucosal dehiscence coverage technique for an endosseous implant. Methods: A 33-year-old female visited us with the chief complaint of dissatisfaction with the esthetics of an exposed implant in the maxillary left cental incisor region. A partial-thickness pouch was constructed around the dehiscence. A subepithelial connective tissue graft was positioned in the apical site of the implant and covered by a mucosal flap with normal tension. At 12 months after surgery, the recipient site was partially covered by keratinized mucosa. However, the buccal interdental papilla between implant on maxillary left central incisor region and adjacent lateral incisor was concave in shape. To resolve the mucosal recession after the first graft, a second graft was performed with the same technique. Results: An esthetically satisfactory result was achieved and the marginal soft tissue level was stable 9 months after the second graft. Conclusions: The second graft was able to resolve the mucosal recession after first graft. This two-step approach has the potential to improve the certainty of esthetic results.