• Journal of Pharmaceutical Investigation
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• v.37 no.5
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• pp.305-309
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• 2007

Arsenic compounds have been used to treat various diseases including cancer in oriental medicine. Arsenic trioxide ($As_2O_3,\;Trisenox^{(R)}$) has been used for the treatment of leukemia and its anti-solid tumor activity has also been reported recently. Tetra-arsenic oxide ($As_4O_6,\;TetraAs^{(R)}$) is a newly developed arsenic compound which has shown an anticancer activity in some human cancer cell lines. The purpose of this study was to evaluate the anti-gastric cancer potential of TetraAs and to search for an agent with synergistic interaction with TetraAs against human gastric cancers. We analysed anti-proliferative effect of TetraAs when given alone and in combination with other chemotherapeutic agents such as 5-FU, paclitaxel, and cisplatin in SNU-216, a human gastric cancer cell line. The $IC_{50}$ of these 4 anti-cancer drugs ranged from 5.8 nM to $7.5\;{\mu}M$ with a potency rank of order paclitaxel>TetraAs>cisplatin>5-FU. TetraAs showed 10-fold greater potency than 5-FU and cisplatin at the same effect level of $IC_{50}$. TetraAs+5-FU and TetraAs+paclitaxel showed synergistic and additive interaction, respectively. On the other hand, TetraAs with cisplatin group appeared to be strongly antagonistic. Apoptotic population was measured and compared between single and combination treatment. The apoptotic cells for the combination of TetraAs+5-FU showed significant increase compared to single TetraAs treatment. On the contrary, TetraAs+cisplatin showed less apoptotic cells compared to TetraAs or cisplatin alone treatment. Overall, our results indicate that TetraAs can be effectively combined with 5-FU or paclitaxel, but not with cisplatin for synergistic anti-cancer effect, which warrants further evaluation using in vivo models.

• Journal of Digital Contents Society
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• v.11 no.1
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• pp.47-55
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• 2010

Cultural Content Industry, a core industry based on knowledge, is becoming an economic model making new benefits by adding human creativity, imagination, sensitivity and style in to information technology. Cultural Contents Industry representing cultures of each countries is facing major changes towards a new competitive industry of each nation. Cultural content of a country is upbringing new contents power developing into a new industry by flattening the barriers within nations. But cooperations face difficulties in launching the industry because of limited information about the current market and lack of understanding in cultural differences. In order to solve this problem, this paper aims to create global network leading to increase of export and creation of new market with cultural contents and train local specialists. In order to search for the ways to maintain Korean contents in other nations and expand exportation. cooperations invite leading cultural contents groups to South Korea, let the groups experience Korea's contents. Cooperations initiated invite training, dispatch training by Korean companies and international students training. The purpose of this paper is to support education system, ETS-CS(Educational Training System for Contents Specialist) and analyse practices applied in the field to develop a better cultural contents industry.

• The Journal of Korean Medicine
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• v.38 no.3
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• pp.124-142
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• 2017

Objectives: This study aimed to learn what should be considered in [Guideline of Clinical Trial with Herbal Medicinal Product for Gastric Cancer)] by analyzing the existing guidelines and clinical trials. Methods: The development committee searched guidelines for herbal medicinal product or gastric cancer developed already. Then, clinical trials for gastric cancer using herbal medicine were searched. The searched trials were analyzed in terms of inclusion and exclusion of participants, intervention, comparator, outcomes and trial design. Then, we compared the results of analysis with the regulations and guidelines of Ministry of Food and Drug Safety to suggest the issue that we will have to consider when making the [Guideline of Clinical Trial with Herbal Medicinal Product for Gastric Cancer]. Results: As a result, few guidelines for anti-tumor agent and clinical trial with herbal medicinal product were searched in the national institution homepage. In addition, 10 articles were searched by using the combination following search term; 'stomach neoplasm', 'herbal medicine', 'Medicine, Korean traditional', 'Medicine, Chinese Traditional', 'TCM', 'TKM', 'trial'. Most trials included gastric cancer participants with medical history of operation. The type of intervention was various such as decoction, granules, and fluid of intravenous injection. Comparators were diverse such as placebo, conventional treatment including chemotherapy and nutritional supplement. The most frequently used outcome for efficacy was quality of life. Besides, the symptom score, tumor response, and survival rate were used. Safety was investigated by recording adverse events. Conclusion: We found out some issue by reviewing the existing guidelines and comparing it with clinical trials for gastric cancer and herbal medicinal products. These results will be utilized for developing [Guideline of Clinical Trial with Herbal Medicinal Product for Gastric Cancer].

• The Journal of Korean Association of Computer Education
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• v.3 no.1
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• pp.127-134
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• 2000

Distance education, which emerged under the influence of both the rapid development of hi-tech information technology and the constructivism theory of learning, enables learners to acquire knowledge and skills needed by monitoring their learning process for themselves. Emphasis on web-based distance education and contructivism as a basis of learner-centered education does not mean that those education systems are performed without teachers or in noninterference. This study proposes a model of distance education system in which learners are taught in various levels of learning with the help of teacher agents. In the model teacher agents produce the learners' respective learning model considering the information on individual learners and also control the progress to the next step of learning with the result of the evaluation of learning accomplishment. The model of distance education system suggested in this study is able to help solve the problem that the learning resources web-based distance education provides were used only as objects of web search and to supply a basis of realizing learner-centered education.

• Journal of Digital Convergence
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• v.11 no.9
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• pp.189-194
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• 2013

Semantic Web is what supports a search, data integration, and automated web service by developing technology of giving help so that a computer can understand information a little more on the web. As amount of information gets growing and diverse, there is a problem of offering by efficiently extracting and processing only information proper for users' demand. Semantic Web isn't what is distinguished completely from the existing web. It gives a meaning, which was well defined, to information of being inserted on web by expanding the current web. Through this, a computer and a person come to perform work cooperatively. To implement Semantic Web, the limit of HTML needs to be overcome. The existing access authorization has not taken information and semantics into account due to the limitations of HTML. It is difficult to expand or integrate many relevant documents by using HTML. Program or software agent, not a person, cannot extract a meaning of document automatically. This study suggests a method of Access Authorization Policy Management that is in the Semantic Web configuration. Accordingly, the policy, which was designed in this study, improved the authorization process more than the existing method.

• YAKHAK HOEJI
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• v.49 no.2
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• pp.140-146
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• 2005

Candida albicans, a polymorphic fungus, causes systemic and local infections. Recent reports show that the fungus is a main etiological agent for the arthritis. For trea tment, antifungal drugs and/or rheumatoid drugs are used, but resistance and side effects limit application of the drugs. In search of new sources for treatment of the fungal arthritis, we choose Egb 761 (extract of Ginkgo leaves 761), one of the most popular over-the-counter herbal medicines. The Egb 761 contains two major ingredients such as terpene and flavonoid. In the present study, we examined if the terpene portion of Egb 761 had anti-inflammatory activity against C.albicans-caused arthritis. The terpene was extracted with combination of methanol and water from the Egb 761, followed by gel-permeation chromatography. Presence of terpene was determined by the Salkowski colorimetric method and HPLC analysis. For an animal model of inflammation induction, mice were given an emulsion form of C.albicans cell wall mixed with Complete Freund's Adjuvant (CFA) by footpad-injection. Results showed that intraperitoneal administration of the water-soluble portion that contained terpene and flavonoid reduced the inflammation. Whereas the terpene had anti-inflammatory activity, flavonoid portion had no such activity, For determination of possible mechanism of the activity, the terpene seemed to be suppression of nitric oxide (NO) production from LPS-treated macrophages. Taken together the Ginkgo terpene may have anti-inflammatory effect against C.albicans-caused arthritis, possibly by blocking NO production.

• Genomics & Informatics
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• v.14 no.2
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• pp.53-61
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• 2016

Toxoplasma gondii is an intracellular Apicomplexan parasite and a causative agent of toxoplasmosis in human. It causes encephalitis, uveitis, chorioretinitis, and congenital infection. T. gondii invades the host cell by forming a moving junction (MJ) complex. This complex formation is initiated by intermolecular interactions between the two secretory parasitic proteins-namely, apical membrane antigen 1 (AMA1) and rhoptry neck protein 2 (RON2) and is critically essential for the host invasion process. By this study, we propose two potential leads, NSC95522 and NSC179676 that can efficiently target the AMA1 hydrophobic cleft, which is a hotspot for targeting MJ complex formation. The proposed leads are the result of an exhaustive conformational search-based virtual screen with multilevel precision scoring of the docking affinities. These two compounds surpassed all the precision levels of docking and also the stringent post docking and cumulative molecular dynamics evaluations. Moreover, the backbone flexibility of hotspot residues in the hydrophobic cleft, which has been previously reported to be essential for accommodative binding of RON2 to AMA1, was also highly perturbed by these compounds. Furthermore, binding free energy calculations of these two compounds also revealed a significant affinity to AMA1. Machine learning approaches also predicted these two compounds to possess more relevant activities. Hence, these two leads, NSC95522 and NSC179676, may prove to be potential inhibitors targeting AMA1-RON2 complex formation towards combating toxoplasmosis.

• Journal of the Institute of Convergence Signal Processing
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• v.3 no.4
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• pp.35-41
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• 2002

To solve the large scale optimization problem approximately, various approaches have been introduced. They are mainly based on recent research advancement of simulations for evolutions, flocking, annealing, and interactions among organisms on artificial environments. The typical ones are simulated annealing(SA), artificial neural network(ANN), genetic algorithms(GA), tabu search(TS), etc. Recently the particle swarm optimization(PSO) has been introduced. The PSO simulates the process of birds flocking or fish schooling for food, as with the information of each agent Is share by other agents. The PSO technique has been applied to various optimization problems of which variables are continuous. However, there are seldom trials for visualization of searching process. This paper proposes a new visualization tool for searching process particle swarm optimization(PSO) algorithm. The proposed tool is effective for understanding the searching process of PSO method and educational for students.

• Journal of KIISE:Computing Practices and Letters
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• v.11 no.2
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• pp.180-191
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• 2005

The rapid growth of mobile communication technology has provided the expansion of mobile internet services, particularly mobile commerce takes much weight among them. Even though current mobile commerce service has serious problems which check its development, such as limited contents, expensive charge system and hardware restriction of mobile device, it is strongly expected as one of the next generation Internet services. In this paper, we summarize the problems like above and provide some total solution to meet them as follows: a function for automatic gathering of product information on online Internet and automatic translation it to data for mobile commerce, a middlelet application which provides functions for product search and order on the mobile device through off-line processing, and a function of user adaptive recommendation. We have actually designed and implemented the proposed system and verified the functions and effectiveness of the system.

• The KIPS Transactions:PartD
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• v.9D no.3
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• pp.457-466
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• 2002

In this paper, we designed and implemented a web-based dictionary of computing which keeps the data up-to-date. This dictionary shows the English information based on the FOLDOC (Free On-Line Dictionary Of Computing) dictionary file at the beginning of searching, and then one or more users can translate the information into Korean. This function is the new one only this dictionary has. Also, we can easily find any words we want to took up, even if we don't know the spelling completely, because the dictionary has various searching interfaces (searching for the words starting with inputted characters, searching for the words including inputted characters in the description, etc.) using a SQL Server DBMS and SQL. The performance test for CPU load factor shows that the server can support at least 1780 users at the same time.