• Journal of Microbiology and Biotechnology
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• v.17 no.6
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• pp.993-1001
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• 2007

The technique of serological analysis of antigens by recombinant cDNA expression library (SEREX) uses autologous patient sera as a screening probe to isolate tumor-associated antigens for various tumor types. Isolation of tumor-associated antigens that are specifically reactive with patient sera, but not with normal sera, is important to avoid false-positive and autoimmunogenic antigens for the cancer immunotherapy. Here, we describe a selection methodology to isolate patient sera-specific antigens from a yeast surface-expressed cDNA library constructed from 15 patient lung tissues with non-small cell lung cancer (NSCLC). Several rounds of positive selection using patient sera alone as a screening probe isolated clones exhibiting comparable reactivity with both patient and normal sera. However, the combination of negative selection with allogeneic normal sera to remove antigens reactive with normal sera and subsequent positive selection with patient sera efficiently enriched patient sera-specific antigens. Using the selection methodology described here, we isolated 3 known and 5 unknown proteins, which have not been isolated previously, but and potentially associated with NSCLC.

• The Journal of the Korea Contents Association
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• v.4 no.3
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• pp.115-123
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• 2004

This study suggests the output of the fingerprint doorlock design development through the structured methodology of concept selection in the process of design development, after characterizing the doorlock product itself. All of the early phases of product development are very important on eventual product success. Concept selection is the process of evaluating concepts with respect to customer needs and other criteria, comparing the relative strength and weaknesses of the concepts, and selecting one or more concepts for further investigation or development. To obtain the ideal concept o( new product, this work used a two-stage concept selection methodology which consist of concept screening and concept scoring. As a result, this study represents the fixed design rendering for mass production.

• Asia-Pacific Journal of Business
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• v.13 no.4
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• pp.11-24
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• 2022

Purpose - The purpose of this study was to examine how job seekers' spec influence their actual employment especially focusing on the differentiating effects of applicants' specs depending on whether general or decent job employment. Design/methodology/approach - This study conducted analyses on 54,443 samples that incorporated data from the Graduates Occupational Mobility Survey for three years (2017-2019) collected by the Korea Employment Information Service. The linear probability model and logit model were used to examine the research questions. Findings - The results analyzed with the hierarchical regression model showed that most job seekers' specs were statistically significant in predicting employment status. Interestingly, there is a difference between the factors predicting employment for a general job and a decent job. This study suggests academic and practical implications for future research in the selection/ recruitment field by clarifying the critical factors to influence applicants' employment. Research implications or Originality The results of this study follow the screening hypothesis which explains that the applicants' specs have significant impacts on actual employment. Also, the dual labor market theory, which explains that applicants' specs differently affect actual employment between general and decent jobs, was reaffirmed.

• Journal of the Society of Disaster Information
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• v.18 no.2
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• pp.252-260
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• 2022

Purpose: As the intensity and frequency of natural hazards are increasing due to climate change, external events that affecting nuclear power plants(NPPs) may increase. NPPs must be protected from external events such as natural hazards and human-induced hazards. External events that may occur in NPPs should be identified, and external events that may affect NPPs should be identified. This study introduces the methodology of identification and screening methods for external events by literature review. Method: The literature survey was conducted on the identification and screening methods of external events for probabilistic safety assessment of NPPs. In addition, the regulations on the identification and screening of external events were investigated. Result: In order to minimize the cost of external event impact analysis of nuclear power plants, research on identifying and screening external events is being conducted. In general, in the identification process, all events that can occur at the NPPs are identified. In the screening process, external events are selected based on qualitative and quantitative criteria in most studies. Conclusions: The process of identifying and screening external events affecting NPPs is becoming important. This paper, summarize on how to identify and screen external events for a probabilistic safety assessment of NPPs. It is judged that research on bounding analysis and conservative analysis methods performed in the quantitative screening process of external events is necessary.

• Proceedings of the KIEE Conference
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• 2000.07a
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• pp.69-71
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• 2000

Transient Stability of a power systems is its ability to maintain synchronous operation of machine when subjected to a large disturbance. This paper presents a new methodology for speed-up transient stability evaluation in SIME. SIME is a hybrid direct method including time simulation to enhance flexibility. It is difficult to apply the classical SIME to stable cases. To solve this problem, we propose the improved SIME, applicable to stable cases as well as unstable cases. For more fast screening, a reduced order equivalent generator is used in the first step process

• Proceedings of the KIEE Conference
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• 2000.11a
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• pp.104-106
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• 2000

Transient Stability of a power systems is its ability to maintain synchronous operation of machine when subjected to a large disturbance. This paper presents a new methodology for speed-up transient stability evaluation in SIME. SIME is a hybrid direct method including time simulation to enhance flexibility. The First features of the proposed method are that generator grouping can be performed even in very stable cases and that the stability of a contingency can be evaluated from a short period of time simulation results. The second features of the proposed method are that using power-angle trajectory and subdividing contingency classification have improved the screening capability.

• Proceedings of the KIEE Conference
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• 1992.07a
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• pp.106-109
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• 1992

This paper Introduces the concept of the generation cost of generating utilities and its calculation methods. Also, the economic evaluation method using generation cost which is called as a screening curve method will be presented along with the benefits and disadvantages of this concept. Next, the least-cost electric utility planning techniques which is used very widely in many countries will be Introduced In comparison with screening curve method. In this aspects, the optimal dynamic mix can be determined as a result. By comparing these two concepts, we will get the concrete concept why the economic evaluation method using generation cost can not be used for the future generation expansion planning.

• Proceedings of the KSME Conference
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• 2001.11a
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• pp.16-21
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• 2001

The PTS reference temperature of reactor pressure vessel for one of the Korean NPPs has been predicted to exceed the screening criteria before it reaches it's design life. To cope with this issue, a plant-specific PTS analysis had been performed in accordance with the Regulatory Guide 1.154 in 1999. As a result of that analysis, it was found that current methodology of RG. 1.154 was very conservative. The objective of this study is to examine the effects of changing various input parameters and to determine the amount of conservatism of the current PTS analysis method. To do this, based on the past PTS analysis experience, parametric study were performed for various models using modified VISA-II code. This paper discusses the analysis results and recommendations to reduce the conservatism of current analysis method.

• Journal of The Korean Society of Agricultural Engineers
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• v.58 no.2
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• pp.11-20
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• 2016

Korea has 17,500 irrigation dams and facing variety of causes that jeopardize dam safety. With limited resources available to manage large inventory, a portfolio risk analysis application method for numerous irrigation dam safety is essential. The purpose of this study is to find an optimum way to adopt the risk analysis to the large number of irrigation dams in Korea and to propose the portfolio risk analysis process for irrigation dams. In this study, the necessity of the risk analysis for reservoirs safety has been suggested and a phased process using pre-screening and screening methodology has been proposed. This proposed procedure will help to effectively introduce the risk analysis for reservoirs safety in Korea.

• IE interfaces
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• v.16 no.spc
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• pp.65-69
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• 2003

Process capability has long been viewed as a critical performance measure to indicate how well a process meet the specifications and customer requirements. Several indices, including $C_p$ and $C_{pk}$, have been proposed and widely implemented to quantify the process capability. However, these indices have been obtained without regard to inspection or screening procedures through which finished products will be truncated at the specifications. Consequently, only a fraction of outgoing products within the specifications will be passed into the customers. From the customer's point of view, it will thus be meaningful to assess the process capability with truncated samples. This article investigates how to estimate the process capability when only incomplete truncated data are available. On the basis of parameter estimation for truncated samples, the proposed methodology may be helpful to evaluate the process capability by examining a sample of items from the lots submitted.