• BMB Reports
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• v.52 no.7
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• pp.445-450
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• 2019

TTYH2 is a calcium-activated, inwardly rectifying anion channel that has been shown to be related to renal cancer and colon cancer. Based on the topological prediction, TTYH2 protein has five transmembrane domains with the extracellular N-terminus and the cytoplasmic C-terminus. In the present study, we identified a vesicle transport protein, ${\beta}$-COP, as a novel specific binding partner of TTYH2 by yeast two-hybrid screening using a human brain cDNA library with the C-terminal region of TTYH2 (TTYH2-C) as a bait. Using in vitro and in vivo binding assays, we confirmed the protein-protein interactions between TTYH2 and ${\beta}$-COP. We also found that the surface expression and activity of TTYH2 were decreased by co-expression with ${\beta}$-COP in the heterologous expression system. In addition, ${\beta}$-COP associated with TTYH2 in a native condition at a human colon cancer cell line, LoVo cells. The over-expression of ${\beta}$-COP in the LoVo cells led to a dramatic decrease in the surface expression and activity of endogenous TTYH2. Collectively, these data suggested that ${\beta}$-COP plays a critical role in the trafficking of the TTYH2 channel to the plasma membrane.

• Archives of Plastic Surgery
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• v.48 no.3
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• pp.310-322
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• 2021

The incidence of extremity amputation is estimated at about 200,000 cases annually. Over 25% of patients suffer from terminal neuroma or phantom limb pain (TNPLP), resulting in pain, inability to wear a prosthetic device, and lost work. Once TNPLP develops, there is no definitive cure. Therefore, there has been an emerging focus on TNPLP prevention. We examined the current literature on TNPLP prevention in patients undergoing extremity amputation. A literature review was performed using Ovid Medline, Cochrane Collaboration Library, and Google Scholar to identify all original studies that addressed surgical prophylaxis against TNPLP. The search was conducted using both Medical Subject Headings and free-text using the terms "phantom limb pain," "amputation neuroma," and "surgical prevention of amputation neuroma." Fifteen studies met the inclusion criteria, including six prospective trials, two comprehensive literature reviews, four retrospective chart reviews, and three case series/technique reviews. Five techniques were identified, and each was incorporated into a targetbased classification system. A small but growing body of literature exists regarding the surgical prevention of TNPLP. Targeted muscle reinnervation (TMR), a form of physiologic target reassignment, has the greatest momentum in the academic surgical community, with multiple recent prospective studies demonstrating superior prevention of TNPLP. Neurorrhaphy and transposition with implantation are supported by less robust evidence, but merit future study as alternatives to TMR.

• Journal of dental hygiene science
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• v.21 no.4
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• pp.199-212
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• 2021

Background: Various oral health management programs in Korea affect the oral health improvement in the elderly Several studies have been conducted to date; however, those studies have not shown uniform results due to the differences in research methods or designs. Hence, this study aimed to review the overall research trends of the reported oral health care programs for the elderly in Korea, verify their effects, and clarify them based on the systematic literature review. Methods: The literature search selected intervention studies that applied the oral health care program for the elderly in Korea from 2001 to 2020. Following the COre, Standard, and Ideal (COSI) models presented by the US National Library of Medicine, we selected databases including Korean studies Information Service System (KISS), ScienceOn, Research Information Sharing Service (RISS), DBpia, PubMed, and Google Scholar. Of the 1,335 studies searched using keywords, titles, and abstracts, 21 were finally selected based on primary and secondary exclusion criteria. Results: The most frequent intervention period was 4 weeks, and the number of interventions varied between 2 and 90 times. As for the type of intervention, 14 studies that conducted both theory and practice were the most frequent. Significant differences in the clinical indicators, such as calculus, halitosis, salivation rate, swallowing function, and dry mouth, were found in most oral health care programs. Conclusion: Based on the results of this study, the intervention program needs further verification using multiple indicators in future studies. In addition, a study extending the intervention period and the number of samples is considered necessary for verifying continuous effectiveness of the intervention program.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.38 no.2
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• pp.27-32
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• 2001

In this paper, the three dimension scanner system employing the parallel camera model is discussed. The camera calibration process and the three dimension scanning algorithm are developed. The laser strip line is utilized for assisting stereo matching. An object being scanned rotates on the plate which is activated by a stepping motor, The world coordinate which is. the measured distance from the camera to the object is converted into the model coordinate. The facets created from the point. cloud of the model coordinate is used for rendering the scanned model by using the graphic library such as OpenGL. The unmatched points having no validate matching points are interpolated from the validate matching points of the vicinity epipolar lines.

• BMB Reports
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• v.33 no.1
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• pp.59-62
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• 2000

Hepatitis C virus (HCV) nonstructural 5B (NS5B) protein is an RNA-dependent RNA polymerase (RdRp). To determine whether it can contribute to viral replication by interaction with cellular proteins, the yeast two-hybrid screening system was employed to screen a human liver cDNA library. Using the HCV NS5B as a bait, we have isolated positive clones encoding a cellular protein. The NS5B interacting protein, 5BIP, is a novel cellular protein of 170 amino acids. Interaction of the HCV NS5B protein with 5BIP was confirmed by a protein-protein blotting assay. Recently, we have demonstrated that NS5B possesses an RdRp activity and thus it is possible that 5BIP, in association with NS5B, plays a role in HCV replication.

• Journal of Information Science Theory and Practice
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• v.1 no.3
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• pp.12-32
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• 2013

The paper introduces the research area of interactive information retrieval (IIR) from a historical point of view. Further, the focus here is on evaluation, because much research in IR deals with IR evaluation methodology due to the core research interest in IR performance, system interaction and satisfaction with retrieved information. In order to position IIR evaluation, the Cranfield model and the series of tests that led to the Cranfield model are outlined. Three iconic user-oriented studies and projects that all have contributed to how IIR is perceived and understood today are presented: The MEDLARS test, the Book House fiction retrieval system, and the OKAPI project. On this basis the call for alternative IIR evaluation approaches motivated by the three revolutions (the cognitive, the relevance, and the interactive revolutions) put forward by Robertson & Hancock-Beaulieu (1992) is presented. As a response to this call the 'IIR evaluation model' by Borlund (e.g., 2003a) is introduced. The objective of the IIR evaluation model is to facilitate IIR evaluation as close as possible to actual information searching and IR processes, though still in a relatively controlled evaluation environment, in which the test instrument of a simulated work task situation plays a central part.

• The korean journal of orthodontics
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• v.49 no.3
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• pp.140-149
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• 2019

We are currently living in an era where the use of computer-aided design/computer-aided manufacturing has allowed individualized orthodontic treatments, but has also incorporated enhanced digitalized technology that does not permit improvisation. The purpose of this systematic review was to analyze publications that assessed the accuracy and efficiency of the $Invisalign^{(R)}$ system. A systematic review was performed using a search strategy to identify articles that referenced $Invisalign^{(R)}$, which were published between August 2007 and August 2017, and listed in the following databases: MEDLINE, Embase, Cochrane Library, Web of Knowledge, Google Scholar, and LILACS. Additionally, a manual search of clinical trials was performed in scientific journals and other databases. To rate the methodological quality of the articles, a grading system described by the Swedish Council on Technology Assessment in Health Care was used, in combination with the Cochrane tool for risk of bias assessment. We selected 20 articles that met the inclusion criteria and excluded 5 due to excess biases. The level of evidence was high. Although it is possible to treat malocclusions with plastic systems, the results are not as accurate as those achieved by treatment with fixed appliances.

• Journal of the Korean Society for Library and Information Science
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• v.39 no.4
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• pp.45-69
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• 2005

The purpose of this article lies in investigating the problems and limitations of the current LIS education in Korea with an emphasis on the viewpoints of librarians. Also identified are the librarians suggestions for a better LIS educational system, in particular, for the renovation of the current LIS curriculum to upgrade the competencies of future librarians. To this end, 347 librarians from public, academic, special, and school libraries were e-mail surveyed. And the collected data were analyzed and interpreted to find out the specific problems and suggestions based on the types of libraries as well as the overall problems and suggestions.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.11 no.2
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• pp.1234-1249
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• 2017

One of the difficulties developers encounter in maintaining tasks of a large-scale software system is the updating of suitable libraries on time. Developers tend to miss or make mistakes when searching for and choosing libraries during the development process, or there may not be a stable library for the developers to use. We present a novel approach for helping developers modify software easily and on time and avoid software failures. Using a tool previously built by us called GPES, we collected information of projects, such as abstract syntax trees, tokens, software metrics, relations, and evolutions, for our experiments. We analyzed the contexts of source codes in existing projects to predict changes automatically and to recommend suitable libraries for the projects. The collected data show that researchers can reduce the overall cost of data analysis by transforming the extracted data into the required input formats with a simple query-based implementation. Also, we manually evaluated how the extracted contexts are similar to the description and we found that a sufficient number of the words in the contexts is similar and it might help developers grasp the domain of the source codes easily.

• The Transactions of the Korea Information Processing Society
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• v.6 no.7
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• pp.1724-1737
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• 1999

Multimedia data service applications have to store and manipulate LOBs(unstructured large objects) composing multimedia data. As such, the tertiary storage devices such as an optical disk jukebox and a tape library that consist of a number of platters (the disks in case of an optical disk jukebox and the cartridge tapes in case of a tape library) have been considered essential for the storage system of a DBMS in order to efficiently support storage and management of vary large volume of data. Since the latency with tertiary storage is too long, the schemes for efficient retrieval of LOBs out of tertiary storage need to be investigated. In this paper, we investigated the tertiary I/O Considering the performance characteristics of the LOBs, we proposed various I/O scheduling heuristic algorithms that reduce latency in query processing with LOB retrieval from tertiary storage, and evaluated their performance through a detailed simulation.