• 사상체질의학회지
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• 제32권2호
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• pp.10-21
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• 2020

Objectives Genome-wide association studies(GWAS) is a useful method to identify genetic associations for various phenotypes. The purpose of this study was to develop predictive models for Sasang constitution types using genetic factors. Methods The genotypes of the 1,999 subjects was performed using Axiom Precision Medicine Research Array (PMRA) by Life Technologies. All participants were prescribed Sasang Constitution-specific herbal remedies for the treatment, and showed improvement of original symptoms as confirmed by Korean medicine doctor. The genotypes were imputed by using the IMPUTE program. Association analysis was conducted using a logistic regression model to discover Single Nucleotide Polymorphism (SNP), adjusting for age, sex, and BMI. Results & Conclusions We developed models to predict Korean medicine constitution types using identified genectic factors and sex, age, BMI using Random Forest (RF), Support Vector Machine (SVM), and Neural Network (NN). Each maximum Area Under the Curve (AUC) of Teaeum, Soeum, Soyang is 0.894, 0.868, 0.767, respectively. Each AUC of the models increased by 6~17% more than that of models except for genetic factors. By developing the predictive models, we confirmed usefulness of genetic factors related with types. It demonstrates a mechanism for more accurate prediction through genetic factors related with type.

• 사상체질의학회지
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• 제17권3호
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• pp.172-178
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• 2005

1. Objectives pneumonia is the infection of the lungs. The typical symptoms of is cough, sputum, fever, chest pain, infiltration of chest X-ray. We have tried researching effect of herbal medicine Soeumin Doksampalmulkeunja-tang(獨蔘八物君子湯). 2. Methods This patient with serious fever, sputum which were caused by aspiration pneumonia was treated by Doksampalmulkeunja-tang(獨蔘八物君子湯), who was diagnosed as Soeumin 3. Results Doksampalmulkeunja-tang(獨蔘八物君子湯) is effective against the fever. sputum symptom of Soeumin. The chest PA test were improved. 4. Conclusions The consitutional treatment with herb-medicine may have effect on fever symptom of Soeumin. Soeumin Exterior febrile Disease must be treated by raising the stagnant yang qi. Further study on Soeumin Exterior febrile Disease is needed.

• 사상체질의학회지
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• 제28권3호
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• pp.205-214
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• 2016

Objectives This paper was aimed to review the preceding research on the origins, changes and constructive principle of Taeeumjowi-tang.Methods We reviewed Jema Lee's original works including Dongyisusebowon and relevant books to analyze Taeeumjowi-tang-related items. To compensate insufficient evidence of literature, we also refocued physiological and pathological pecularities of Taeeumin and relevant symptomatology.Results and Conclusions 1) The origins of Taeeumjowi-tang should be Mahwang-tang, Saengmaek-san, Seokchangpowonji-san, and Gondam-san. 2) Taeeumjowi-tang went through Saengmaek-san, Sanyakhwawi-jeon, Bopyesaengmaek-tang, Gilgyungsaengmaek-san, and Bopyewon-tang before it was built as the final version. 3) Taeeumjowi-tang consists of a) big blue lilyturf (麥門冬) and Omija (五味子) which are directly of help to exhale and disperse qi-fluid of Lung, b) balloon-flower (桔梗) which helps circulation of qi-fluid from Head to Lung, c) adlay (薏苡仁) and dry nut (乾栗) which are directly of help to raise up qi-fluid of Wiwan, d) ephedra (麻黃) which helps circulation of qi-fluid from Wiwan to skin, e) calamus (石菖蒲) which directly helps the psychological function of Ear, and f) radish seed (蘿葍子) which slightly eliminate the excessive function of Small intestine, treating Wiwanhan symptomatology in Taeeumin.

• 한국한의학연구원논문집
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• 제7권1호
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• pp.1-16
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• 2001

The Objective of this article is to make a bibliographical introduction and to discuss the historical value of several literatures on the Sasang constitutional medicine established by Jema Lee$(1837{\sim}1900)$. Literatures are as follows: 1. ${\ulcorner}$HamsanSachon Donguisusebowon(咸山沙忖 東醫壽世保元 甲午舊本)${\lrcorner}$; newly found draft of ${\ulcorner}$Donguisusebowon${\lrcorner}$ that contains an old edition written in 1894. 2. ${\ulcorner}$Bojeyeonseol-Supplement of Donguisusebowon(普濟演設-東醫壽世保元補編)${\lrcorner}$; a clinical book which is regarded as to had been published before the first edition of ${\ulcorner}$Donguisusebowon${\lrcorner}$ was printed. 3. ${\ulcorner}$Gyukchigo appendix(格致藁-附錄)${\lrcorner}$, ${\ulcorner}$Sasang Medicine-A Memorandom of the first edition(四象醫學草本卷備忘錄)${\lrcorner}$; which were aquired in Yanbian(China) several years ago. 4. ${\ulcorner}$Donguisusebowon${\lrcorner}$- The first edition published in 1901; owned by Mikki Sakae(三木榮) a Japanese medical historian. 5. ${\ulcorner}$Donguisusebowon${\lrcorner}$ - Manuscript; poetry on natures of herbal drugs are appended.

• 동의생리병리학회지
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• 제33권6호
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• pp.363-369
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• 2019

This paper aims to assess the effect of herbal extract mixture, Ahn Tonic, on hair growth and examine the stability of this percutaneous hair growth ointment. The hair on the back of the mice C57b1/6N was removed, and 1% of the TXN(testosterone) was then applied for a week to prevent the hair growth. The experimental group was then treated with Ahn Tonic, 0.2 mL per day. The degree of newly grown hair was observed with a vernier caliper. We also measured the proportion of the newly growing hair section to the entire shaved section in the 4th week and 8th week by distinguishing the section turning black from the shaved area. To observe the effect of the test chemical product on hair follicles and hair roots, the biopsy was executed between week 4 and week 8. Gene expressions, which operate as a factor for growing hair in the skin tissues extracted from each experimental animals, were also observed through a real-time PCR gene amplification method. The results showed that the Ahn tonic group had statistically significant hair restoring effect compared to the control group in terms of microscopy, biopsy, and gene expressions. Ahn Tonic is considered to have an impact on the hair growth.

• 동의생리병리학회지
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• 제34권5호
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• pp.255-262
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• 2020

This study aimed to evaluate the efficacy of herbal medicine (HM) combined with chemotherapy (CT) for cervical cancer. Ten electronic databases including Pubmed, Cochrane library, Embase, Korean databases, and Chinese medical databases were systematically searched up to October 2019. All randomized controlled trials with HM combined with CT to treat cervical cancer were included. A total of 21 trials were included for analysis. Compared to the control group, HM combined with CT group significantly increased tumor response (complete and partial response) (risk ratio [RR] = 1.24, 95% CI: 1.15-1.33, p < 0.00001) and Karnofsky performance score (standardized mean difference [SMD] = 1.71, 95% CI: 1.41-2.01, p < 0.00001). Also, HM combined with CT group remarkably reduced CT toxicity. In Conclusion, our study suggests that HM might be a potential option for cervical cancer to enhance curative efficacy and reduce CT toxicity.

• 대한한의학회지
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• 제41권4호
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• pp.112-119
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• 2020

Objectives: The present study reports a case of chronic anemia patient who was significantly improved after taking Nokyongdaebo-tang (NYDBT) Methods: A 48-year-old male patient diagnosed with iron deficiency anemia (IDA) visited the Daejeon Korean medicine Hospital of Daejeon University on June 2018. The patient was treated with Korean medicine for 23 months including acupuncture, herbal medicine and Sasang constitutional medicine prescription. Improvement of anemia was assessed by changes of Hemoglobin value. Laboratory analysis was used to evaluate the safety of treatment. Results: Chronic anemia has significantly improved since taking NYDBT on 9 days (2019.12.09-2019.12.17). The Hb value has been maintained in the normal range since it first entered the normal range on January 18, 2020. The patient had become transfusion-free and this condition persisted for 6 months after stopping the transfusion. Conclusion: This case demonstrates the therapeutic potential of Sasang constitutional medicine for chronic anemia as a personalized medicine.

• 대한암한의학회지
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• 제27권1호
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• pp.57-66
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• 2022

Objective: To report the improvements with Korean medicine-based integrative cancer therapies on adverse effects of adjuvant chemotherapy in non-small cell lung cancer patients. Method: There were two patients complained cough, rhinorrhea, numbness, general weakness, nausea and dyspepsia after chemotherapy. They got treated centered on Korean medicine including herbal medicine, acupuncture, electro-acupuncture, pharmacopuncture, moxibustion, hand and foot bath. They were also treated Western immunotherapies like Thymosin at regular intervals. The symptoms were measured by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 15 for Palliative Care(EORTC QLQ C-15 PAL) and their subjective assessments. Results: Their chief complaints were relieved and their quality of life scores was improved even though they have been receiving chemotherapy continuously. Conclusion: These cases revealed a possibility that Korean medicine-based integrative cancer therapies could improve some symptoms after chemotherapy in non-small cell lung cancer.

• 사상체질의학회지
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• 제16권3호
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• pp.70-75
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• 2004

1. Objectives The Purpose of this study was to evaluate whether use of Sasang -Bang with western medication may injury the liver and the kidney function. We clinically studied the change Liver function test and BUN/Cr in patients who were hospitalized in Hana oriental Medical center for more than 1 month. 2. Methods The subjects were 33 patients admitted in Hana Oriental Medical center. All patients had been checked Liver Function Test and BUN/Cr three times every 2 weeks. 3. Results Aspartate Aminotransferase(AST), Alanine Aminotransferase(ALT), Gamma-Glutamyl transferase(GGT), Total billirubin, BUN, Creatine didn't change, compared with previous 2 weeks and 4 weeks. 4. Conclusions This study suggests that even though there are few toxic Sasang-Bang, in general, herbal medications with western medications which are prescribed by oriental medicine doctors should be carefully administered not to hurt liver and kidney function.

• 사상체질의학회지
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• 제23권1호
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• pp.53-62
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• 2011

1. Background: This is the first documented study on the four medications for the Mangeum symptomatology (亡陰證) in the Soyangin disease category. The four medications, Hyeongbangsabaek-san (荊防瀉白散), Jeoryeongchajeonja-tang (猪苓車前子湯), Hyeongbangjihwang-tang (荊防地黃湯), and Hwalseokgosam-tang (滑石苦蔘湯), were comparatively analyzed on their compositive principles and respective symptomatologies. 2. Methods: Previous literature, including classical works on earlier Sasang Constitutional Medicine (different editions of Donguisusebowon and Dongmuyugo), were reviewed for relevant material on the Mangeum medications. 3. Results and Conclusions: 1) Hyeongbangsabaek-san (荊防瀉白散) is used in pathologies of early stages of invasion of the internal heat in the lower-most burn-center (locus related to the Kidney system). 2) Jeoryeongchajeonja-tang (猪苓車前子湯) is used when pathogenic dampness-heat invades the lower-most burn-center (locus related to the Kidney system). 3) Hyeongbangjihwang-tang (荊防地黃湯) is used to treat deficient heat involving injury of the lower-most burn-center (locus related to the Kidney system). 4) Hwalseokgosam-tang (滑石苦蔘湯) is used when the lower-most burn-center (locus related to the Kidney system) is in the early stages of exhaustion, expecially accompanied by concomitant dampness-heat. 5) The Mangeum symptomatology (亡陰證) was fully understood only after the completion of the 1901 Sinchuk edition (辛丑本) of Donguisusebowon (東醫壽世保元).