• Molecules and Cells
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• v.44 no.10
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• pp.736-745
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• 2021

Although various marine ingredients have been exploited for the development of cosmetic products, no previous study has examined the potential of seaweed extracellular vesicles (EV) in such applications. Our results revealed that EV from Codium fragile and Sargassum fusiforme effectively decreased α-MSH-mediated melanin synthesis in MNT-1 human melanoma cells, associated with downregulation of MITF (microphthalmia-associated transcription factor), tyrosinase and TRP1 (tyrosinase-related proteins 1). The most effective inhibitory concentrations of EV were 250 ㎍/ml for S. fusiforme and 25 ㎍/ml for C. fragile, without affecting the viability of MNT-1 cells. Both EV reduced melanin synthesis in the epidermal basal layer of a three-dimensional model of human epidermis. Moreover, the application of the prototype cream containing C. fragile EV (final 5 ㎍/ml) yielded 1.31% improvement in skin brightness in a clinical trial. Together, these results suggest that EV from C. fragile and S. fusiforme reduce melanin synthesis and may be potential therapeutic and/or supplementary whitening agents.

• Journal of the Korean Society of Radiology
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• v.13 no.1
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• pp.73-80
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• 2019

Neutrons are generated by the nuclear reaction, which is absorbed into the concrete wall and causes the activation during cyclotron operation. The purpose of this study is to investigate the effect of neutron activation and radiative concrete on concrete type. This experiment used Monte Carlo simulation and RESRAD model. The results of the experiment showed that the higher the content of Fe in concrete, the greater the shielding rate. The effect of $^{56}Fe(n,\;2np)^{54}Mn$ reaction on workers is also increased. However, radioactive nuclides have low activity and have very low impact on workers. Radioactive concrete should be treated as general wastes with less than its self-disposal tolerance level, and it should be recycled to the surface such as road repair rather than landfill to minimize the effect of $^{14}C$.

• Molecules and Cells
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• v.44 no.1
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• pp.50-62
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• 2021

Among all cancer types, lung cancer ranks highest worldwide in terms of both incidence and mortality. The crosstalk between lung cancer cells and their tumor microenvironment (TME) has begun to emerge as the "Achilles heel" of the disease and thus constitutes an attractive target for anticancer therapy. We previously revealed that crosstalk between lung cancer cells and endothelial cells (ECs) induces chemoresistance in multicellular tumor spheroids (MCTSs). In this study, we demonstrated that factors secreted in response to crosstalk between ECs and lung cancer cells play pivotal roles in the development of chemoresistance in lung cancer spheroids. We subsequently determined that the expression of hypoxia up-regulated protein 1 (HYOU1) in lung cancer spheroids was increased by factors secreted in response to crosstalk between ECs and lung cancer cells. Direct interaction between lung cancer cells and ECs also caused an elevation in the expression of HYOU1 in MCTSs. Inhibition of HYOU1 expression not only suppressed stemness and malignancy, but also facilitated apoptosis and chemosensitivity in lung cancer MCTSs. Inhibition of HYOU1 expression also significantly increased the expression of interferon signaling components in lung cancer cells. Moreover, the activation of the PI3K/AKT/mTOR pathway was involved in the HYOU1-induced aggression of lung cancer cells. Taken together, our results identify HYOU1, which is induced in response to crosstalk between ECs and lung cancer cells within the TME, as a potential therapeutic target for combating the aggressive behavior of cancer cells.

• Journal of the Korean Recycled Construction Resources Institute
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• v.10 no.4
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• pp.411-419
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• 2022

This study conducted acute oral toxicity test and acute dermal toxicity test to evaluate the toxicity of lightweight and high-strength cement composite containing carbon nanotube. It was compared with the toxicity of ordinary concrete that did not contain carbon nanotube. Both lightweight and high-strength cement composite and ordinary concrete were categorized in GHS category 5 as a result of acute oral toxicity test. In addition, no toxic symproms were observed during the acute dermal toxicity test in all specimens, concluding that those were judged to correspond to GHS category 5/unclassified.

• Journal of the Economic Geographical Society of Korea
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• v.26 no.1
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• pp.40-54
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• 2023

The purpose of this study is to present implications using local government data, focusing on the occurrence of empty houses, one of the serious social problems emerging due to population extinction and aging. The subjects of the study were Mokpo-si, which has the highest percentage of empty houses in the country, and the spatial distribution status was identified by schematizing the status of empty houses by grade on a map through data from the local government's survey on empty houses. As a result of the survey on vacant houses, it was confirmed that 90% of empty houses in Mokpo City were included in the project district of the urban regeneration strategy plan underway in Mokpo City. Currently, the empty house maintenance project is difficult to proceed smoothly due to difficulties in purchasing empty houses and lack of budget for local governments, so in order for the project to proceed quickly, it is necessary to come up with a plan to promote the project in connection with the urban regeneration strategy plan in Mokpo.

• Proceedings of the Korea Water Resources Association Conference
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• 2023.05a
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• pp.9-9
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• 2023

하천의 관리 및 활용을 위해서는 하천의 유량, 수심, 유속과 같은 수리량을 측정하고 모니터링하는 것은 매우 중요하다. 이러한 수리량은 측정하는 방법은 직접 측정하는 방법과 구조물을 이용하여 측정하는 방법이 있으며, 직접 측정하는 방법도 지점 유속을 측정하여 도섭법으로 측정하는 방법, 초음파 방식 도플러 유속계를 이용한 횡단 측정방법 및 특정 수심에서 측정한 유속을 이용하여 지표유속법으로 유량을 산정하는 방법 등이 있다. 또한 '수자원의 조사·계획 및 관리에 관한 법률' 제11조제1항에 따르면 수문조사의 방법·기준 및 수문조사 자료의 처리·활용 방법 등은 표준화해야 한다고 명시되어 있다. 정부에서는 WTO의 TBT협정 등 국제규범에 대응하기 위하여 국제표준인 ISO, IEC 등에 부합하는 국가표준운영체계를 유지하기 위하여 여러 분야의 국제 표준에 대한 대응을 수행하고, 국가표준을 관리하고 있다. 그 중 유량측정과 관련된 국가 및 국제 표준은 2018년부터 환경부 국립환경과학원에서 총괄하고, 한국건설기술연구원과 한국수자원공사에서 표준관리를 위한 표준개발협력기관과 국제표준 대응협력을 위한 ISO 국내 간사기관으로 운영되고 있다. 국가표준의 유량분야(TC 113)는 4개의 세부분과위원회(SC)로 구성되어 있고, 하천에서 수행되는 유량, 수심, 유속 측정 및 측정장비의 검정, 강수량 측정기기 등에 대한 39종이 제정되고 관리하고 있다. 한국건설기술연구원에서는 유량분야의 일반사항, 하천에서의 유량측정방법 및 유량측정기기에 관한 표준을 담당하고 있으며, 유량분야의 국제표준의 개발에 관한 과업을 수행하고 있다. 본 발표에서는 한국건설기술연구원에서 관리하는 유량분야 국가표준 및 국제표준의 종류 및 현업에서 수행중인 하천의 유량 측정과 국가표준의 관계에 대하여 설명하고자 한다.

• Journal of the Korean Society for Precision Engineering
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• v.13 no.10
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• pp.154-160
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• 1996

The control of diamond turning is usually achieved through a laser-interferometer feedback of slide position. The limitation of this control scheme is that the feedback signal does not account for additional dynamics of the tool post and the material removal process. If the tool post is rigid and the material removal process is relatively static, then such a non-collocated position feedback control scheme may surfice. However, as the accuracy requirement gets tighter and desired surface cnotours become more complex, the need for a direct tool-tip sensing becomes inevitable. The physical constraints of the machining process prohibit any reasonable implementation of a tool-tip motion measurement. It is proposed that the measured force normal to the face of the workpiece can be filtered through an appropriate admittance transfer function to result in the estimated dapth of cut. This can be compared to the desired depth of cut to generate the adjustment control action in additn to position feedback control. In this work, the design methodology on the admittance model-based control with a conventional controller is presented. The recursive least-squares algorithm with forgetting factor is proposed to identify the parameters and update the cutting process in real time. The normal cutting forces are measured to identify the cutting dynamics in the real diamond turning process using the precision dynamoneter. Based on the parameter estimation of cutting dynamics and the admitance model-based nanodynamic control scheme, simulation results are shown.

• Journal of Environmental Science International
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• v.23 no.2
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• pp.181-192
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• 2014

In Korea, the chemical oxygen demand($COD_{sed}$) in freshwater sediments has been measured by the potassium permanganate method used for marine sediment because of the absence of authorized analytical method. However, this method has not been fully verified for the freshwater sediment. Therefore, the use or modification of the potassium permanganate method or the development of the new $COD_{sed}$ analytical method may be necessary. In this study, two modified $COD_{sed}$ analytical methods such as the modified potassium permanganate method for $COD_{Mn}$ and the modified closed reflux method using potassium dichromate for $COD_{Cr}$ were compared. In the preliminary experiment to estimate the capability of the two oxidants for glucose oxidation, $COD_{Mn}$ and $COD_{Cr}$ were about 70% and 100% of theoretical oxygen demand(ThOD), respectively, indicating that $COD_{Cr}$ was very close to the ThOD. The effective titration ranges in $COD_{Mn}$ and $COD_{Cr}$ were 3.2 to 7.5 mL and 1.0 to 5.0 mL for glucose, 4.3 to 7.5 mL and 1.4 to 4.3 mL for lake sediment, and 2.5 to 5.8 mL and 3.6 to 4.5 mL for river sediment, respectively, within 10% errors. For estimating $COD_{sed}$ recovery(%) in glucose-spiked sediment after aging for 1 day, the mass balances of the $COD_{Mn}$ and $COD_{Cr}$ among glucose, sediments and glucose-spiked sediments were compared. The recoveries of $COD_{Mn}$ and $COD_{Cr}$ were 78% and 78% in glucose-spiked river sediments, 91% and 86% in glucose-spiked lake sediments, 97% and 104% in glucose-spiked sand, and 134% and 107% in glucose-spiked clay, respectively. In conclusion, both methods have high confidence levels in terms of analytical methodology but show significant different $COD_{sed}$ concentrations due to difference in the oxidation powers of the oxidants.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.42 no.4
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• pp.393-401
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• 2016

Ultraviolet (UV) irradiation from the sun is the primary environmental factor that causes skin damages including skin cancer and premature skin aging. Because, even the most powerful sunscreen can't always afford enough protection, it is necessary to enhance the defensive power of skin against UV. Recently, constitutive photomorphogenic protein-1 (COP1) has shown to contribute to the regulation of UVB response of keratinocytes. In this study, we represent that COP1 and its associated protein, de-etiolated 1 (DET1), might participate in photoaging process in human skin as Arabidopsis COP1 does sun-protective function in plants. After UVB irradiation, the decrease of COP1 and DET1 mRNA expression was followed by the increase of c-Jun total protein. Moreover, transfection with DNA vectors expressing COP1 and DET1 down-regulated the c-Jun total protein. We found that Zanthoxylum piperitum extract (ZE) up-regulated the expression of COP1 and DET1 on human keratinocytes, and inhibited the expression of MMP1 which is one of the genes regulated by c-Jun signal. In addition, ZE has been reported to stimulate PPAR-${\alpha}$ and strengthen the skin barrier. We found that ZE decreased the UVB-induced IL-6 and IL-8 in NHEK cells. In human study, ZE protected skin against UV-B induced erythema and erythema-induced pigmentation. These results indicate that ZE could be useful for the protection against the adverse effects of UV irradiation through various mechanisms.

• KIPS Transactions on Computer and Communication Systems
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• v.2 no.9
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• pp.381-392
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• 2013

During the last decade, the multitude of advances attained in terminal computers, along with the introduction of mobile hand-held devices, and the deployment of high speed networks have led to a recent surge of interest in Quality of Service (QoS) for video applications. The main difficulty is that mobile devices experience disparate channel conditions, which results in different rates and patterns of packet loss. One way of making more efficient use of network resources in video services over wireless channels with heterogeneous characteristics to heterogeneous types of mobile device is to use a scalable video coding (SVC). An SVC divides a video stream into a base layer and a single or multiple enhancement layers. We have to ensure that the base layer of the video stream is successfully received and decoded by the subscribers, because it provides the basis for the subsequent decoding of the enhancement layer(s). At the same time, a system should be designed so that the enhancement layer(s) can be successfully decoded by as many users as possible, so that the average QoS is as high as possible. To accommodate these characteristics, we propose an efficient transmission scheme which incorporates SVC-aware dual-channel repetition to improve the perceived quality of services. We repeat the base-layer data over two channels, with different characteristics, to exploit transmission diversity. On the other hand, those channels are utilized to increase the data rate of enhancement layer data. This arrangement reduces service disruption under poor channel conditions by protecting the data that is more important to video decoding. Simulations show that our scheme safeguards the important packets and improves perceived video quality at a mobile device.