• The Journal of Korean Medicine
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• v.25 no.3
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• pp.1-11
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• 2004

Objectives : This study was carried out to investigate the effect of Samooltang (SMT) on the injury of gastric mucous membrane by ethanol in mice. Methods : The normal group was mice with no inflammation. The control group was mice with gastro-inflammation elicited by ethanol. The sample group was SMT-administered mice before gastro-inflammation elicitation. Results : In the immunohistochemical change, the distribution of SBA and COX-1 treated with SMT noticeably increased over the control group (p<0.05). The distribution of NF-κB P50, COX-2, and TUNEL treated with SMT noticeably decreased over the control group (p<0.05). The distribution of SMT was the same as the normal group. Conclusions : According to the above results, it is supposed that SMT would be helpful against gastritis and gastric ulcer caused by alcoholic drinks.

• The Journal of Pediatrics of Korean Medicine
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• v.31 no.2
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• pp.1-13
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• 2017

Objectives In this study, the author intended to investigate whether Gami-cheongpetang (GCP), Gagam-jeongkitang (GJG), Gami-samooltang (GSM) and Gami-ijoongtang (GIJ) significantly affect in vivo (animal model) and in vitro (cultured cells) mucin secretion and MUC5AC gene expression in airway epithelial cells. Methods For in vivo experiment, the author induced hypersecretion of airway mucin in rats by introducing SO2 for 3 weeks. Enzyme-linked immunosorbent assay (ELISA) was used to assess the effects of orally-administered GCP, GJG, GSM and GIJ in vivo mucin secretion from tracheal goblet cells of rats after 1 week. Also, the effects of the agents on TNF- or EGF-induced MUC5AC gene expression in human airway epithelial cells (NCI-H292) were investigated. Possible cytotoxicities of the agents were assessed by examining the rate of survival and proliferation of NCI-H292 cells. Results (1) GCP and GJG significantly inhibited hypersecretion of in vivo mucin, although GSM and GIJ did not affect hypersecretion of in vivo mucin; (2) GCP and GJG significantly increased in vitro mucin secretion from cultured HTSE cells. However, GSM and GIJ did not affect in vitro mucin secretion from HTSE cells; (3) GCP and GJG significantly inhibited the expression levels of EGF-induced MUC5AC gene in NCI-H292 cells. However, GSM and GIJ increased the expression levels of EGF-induced MUC 5AC gene in NCI-H292 cells; (4) GCP, GJG, GSM and GIJ did not significantly inhibit the survival and proliferation of NCI-H292 cells. Conclusions These results suggest that GCP, GJG, GSM and GIJ can not only affect the secretion of mucin but also affect the expression of mucin gene. The author suggests that the effects of GCP, GJG, GSM and GIJ with their components should be further investigated by using animal experimental models that simulate the diverse pathophysiology of pulmonary diseases.

• The Journal of Internal Korean Medicine
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• v.17 no.1
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• pp.8-33
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• 1996

The present experiment was designed to understand the effect of Boganhwan on the cardiovascular system in experimental animals. And thus the Blood pressure, isometric movement of atrium,Mg++-Ca++-ATPasc activity of sarcoplasmin reticulum. liver function, prothrombin time, and changes of blood composition were measured in the presence of Boganhwan. The results obtained here were as following: 1. The blood pressure decreased in the presence of SAMOOLTANG, and the decreasing effect was more stimulated by adding Bangpoong and Ganghwa(Boganhwan) 2. The oral administration of the drug for 7days also demonstrated the decreasing of blood pressure and the effect was stimulated by adding Bangpoong and Kanghwal. 3. The autonomic nerve blocking agents such as atropine and regitine did not demonstrate the effect on the drug action. 4. Boganhwan inhibited the cardiac isometric movement and rate by stimulating the Mg++-Ca++-ATPase activity of the heart sarcoplasmins reticulum. 5. Boganhwan increased the number of red blood cell, hematocrit percentage, hemoglobin concentration, and prothrombin time. 6. The drug stimulated the liver metabolism by stimulating the total ATPase activity. According to the results. Boganhwan demonstrated the decreased blood pressure and it also increased the hemoglobin concentration and the hematocrit percent. These effects stanches the hypertension. anemia, and cerebrovascular accident.

• Herbal Formula Science
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• v.18 no.2
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• pp.1-14
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• 2010

This report describes 57 prescriptions including Paeoniae Radix and Glycyrrhizae Radix in Dongeuibogam. Paeoniae Radix and Glycyrrhizae Radix have been used separately or concurrently in Oriental Medicine for a long time as a treatment for various disease. The following conclusions are reached through investigations on the applications of prescriptions including Paeoniae Radix and Glycyrrhizae Radix in Dongeuibogam. 1. 7 times(12.3%) prescriptions are recorded in women chapter, 6 times(10.5%) in cold chapter, 5 times(8.8%) in stool chapter and fatigue chapter each, 4 times(7.0%) in psychiatry chapter, which are arranged in order of frequency. 2. Anxiety, Yin-Yang deficiency, stroke, treating blood, cataract, fever floating due to Yin deficiency, weak and fatigue, pregnancy, abortion, women accessary disease, cold-feeling heart pain, stiffness, etc, among 51 symptoms in prescriptions including Paeoniae Radix and Glycyrrhizae Radix. 3. The dosage of Paeoniae Radix and Glycyrrhizae Radix are from 5 pun:2.5 pun to 2 nyang:1 nyang. 1 jeon:5 pun is recored 39 times(68.4%), 2 jeon:1 jeon and 1 nyang:5 jeon is 6 times(3.21%), 2 nyang:1 nyang is 2 times(1.8%) used among 57 prescriptions including Paeoniae Radix and Glycyrrhizae Radix. 4. 57 prescriptions including Paeoniae Radix and Glycyrrhizae Radix are mostly composed of Samooltang and Sagoonjatang, Gyejitang, Gamgiltang, Bowontang, Goongguitang, Jeongwoneum, Bojoongikgitang, Jigoongsan, Ijintang, Pyeongwuisan, Oryungsan, etc, according to the usage.

• The Journal of Korean Obstetrics and Gynecology
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• v.18 no.4
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• pp.195-202
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• 2005

Purpose　：　The purpose of this study is to report clinical management of acute　dermatitis patient during the period of pregnancy by oriental medicine.　Methods : Generally acute dermatitis is treated by corticosteroids, antibiotics,　antihistamines ec. But the use of these drugs may affect pregnancy women　adversely. So we think that oriental medical therapy is useful to treat a pregnancy　women who has acute dermatitis. We experienced a case of acute dermatitis patient　during the period of pregnancy. In the beginning of treatment, she has severe　itching, burning sensation, bulla, papule. We treated her with herbal medicine and normal saline wet dressing. Results : After treatment during 10days(admission treatment-herb medication, normal saline wet dressing), her symptoms was improved fairly After that she took herb medicine for a month, and all of her symptoms was disappeared. So she was satisfied with the result. Conclusion : Dermatosis gravidarum is a pregnancy-associated disease, which include itching, papule, eczema ec. It is generally due to blood deficiency(血虛)　under pregnancy condition. So samooltang is effective on dermatitis under blood deficiency.

• Journal of Society of Preventive Korean Medicine
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• v.18 no.1
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• pp.53-65
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• 2014

The concentration of 5 metals such as As, Cd, Co, Cr and Pb in 5 frequent using herbal medicinal prescriptions in Korea were analyzed according to the consuming area. The ready prepared 5 prescription samples were obtained from Korean regional hospitals nationwide. All the sample were well powdered and pre-treated to being a solution, and then analyzed by ICP/MS. As was detected the highest concentration of 0.55 mg/kg in Ojeoksan of Gyunggi-do, the lowest was 0.01 mg/kg of Sipjeondaebotang of Seoul C. The highest concentration of Co was found to be in Bojoongikgitang of Seoul B and the lowest was also detected in Bojoongikgitang of Seoul A. Cd concentration, Ojeoksan of Chungcheong-do, Bojoongikgitang of Seoul B and yookmijihwangtang of Chungcheong-do showed the low level of 0.1 mg/kg. In turn, the highest level of Cr was 5.59 mg/kg in Ojeoksan of Gyunggi-do B. The lowest concentration of Cr was 0.04 mg/kg in Sipjeondaebotang of Seoul C and the highest was 0.94 mg/kg in Samooltang of Gangwon-do. Finally, the lowest concentration of Pb was 0.00 mg/kg in Sipjeondaebotang of Chungcheong-do and the highest was 0.134 mg/kg in Ojeoksan of Jeju-do. As a result it seems that the same prescription can not guaranteed the safety from toxic metals since those metal concentrations are dramatically varied according to the area where the each prescribed medicine available.

• Herbal Formula Science
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• v.18 no.2
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• pp.25-51
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• 2010

This report describes 214 prescriptions including Angelicae Gigantis Radix and Cnidii Rhizoma in Dongeuibogam. Angelicae Gigantis Radix and Cnidii Rhizoma have been used separately or concurrently in Oriental Medicine for a long time as a treatment for various diseases. The following conclusions are reached through investigations on the applications of prescriptions including Angelicae Gigantis Radix and Cnidii Rhizoma in Dongeuibogam. 1. 34 times(15.9%) prescriptions are recorded in women chapter, 24 times(11.2%) in wind chapter, 13 times(6.1%) in children chapter and 12 times(5.6%) in intumescence chapter, which are arranged in order of frequency. 2. Treating blood, stroke and fetal movement are ranked top, regulating blood, headache, cataract, carbunculosis, pregnancy, abortion, underdevelopment, etc, among 137 symptoms in prescriptions including Angelicae Gigantis Radix and Cnidii Rhizoma. 3. The dosages of Angelicae Gigantis Radix and Cnidii Rhizoma are ranged from 2.5 pun~6 nyang. 1 jeon is recorded 54 times(25.2%), 7 pun is 29 times(13.6%), 5 pun is 24 times(11.2%), 1 nyang is 21 times(9.8%), same amount is 11 times(5.1%), 5 pun is 10 times(4.7%), 8 pun is 9 times(4.2%) used among 187 prescriptions including Angelicae Gigantis Radix and Cnidii Rhizoma. 4. The dosages of Angelicae Gigantis Radix and Cnidii Rhizoma are ranged from 2.5 pun~6 nyang. 2.5 pun~1.5 jeon, 2 jeon~6 nyang, same amount which are recorded by percent(decoction groups: the other groups) are 69.0%(98.0:2.0%), 25.5%(18.5:81.5%), 5.1%(18.2:81.8%) respectively. The less using dosage of Angelicae Gigantis Radix and Cnidii Rhizoma has a more percentage of decoctions groups, The more using dosage of Angelicae Gigantis Radix and Cnidii Rhizoma has a more percentage of the other groups except decoctions. The less using prescriptions have an effects of controling menstrual pain, enhancing blood and chi, etc, as a whole. The more using prescriptions as a form of compound powder have an effects in epilepsy, chronic diseases, etc. 5. The 214 prescriptions including Angelicae Gigantis Radix and Cnidii Rhizoma in Dongeuibogam are mainly composed of Goongguitang, Samooltang, Sagoonjatang and Gobangpoongtang, etc.