• Korean Journal of Biological Psychiatry
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• v.5 no.1
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• pp.46-55
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• 1998

Any compound which disrupts the integrity of psychological aspects of performance, in particular, cognitive ability and psychomotor function analogous to the psychological behaviors of routine life, is known to be behaviorally toxic. A significant level of behavioral toxicity will interfere with patient safety and quality of life, and also may be counter-therapeutic by exacerbating the condition that the drug was prescribed for. Now, behavioral toxicity of psychotropic drugs has become one of the main growth areas of psychopharmacological research. Evaluation of the potential of drug-induced behavioral toxicity is important not only to the experimental researcher involved in human psychopharmacology, but also to the clinical practitioner treating psychiatric patients. This article attempts to describe behavioral toxicity of the three classes of psychotropic drugs - benzodiazepines, antidepressants and neuroleptics. After a brief discussion of some methodological issues arising in the investigation of behavioral toxicity, each of these drug classes is reviewed in the context of practical importance rather than purely scientific concern. The last session summarizes some suggestions for future studies on drug-induced behavioral toxicity.

• Steel and Composite Structures
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• v.7 no.6
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• pp.421-440
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• 2007

An optimal design method in cooperated with nonlinear inelastic analysis is presented. The proposed nonlinear inelastic method overcomes the difficulties due to incompatibility between the elastic global analysis and the limit state member design in the conventional LRFD method. The genetic algorithm used is a procedure based on Darwinian notions of survival of the fittest, where selection, crossover, and mutation operators are used to look for high performance ones among sections in the database. They are satisfied with the constraint functions and give the lightest weight to the structure. The objective function taken is the total weight of the steel structure and the constraint functions are load-carrying capacity, serviceability, and ductility requirement. Case studies of a planar portal frame, a space two-story frame, and a three-dimensional steel arch bridge are presented.

• International Journal of Aeronautical and Space Sciences
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• v.16 no.4
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• pp.602-613
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• 2015

As one of the mission payloads to be verified through the cube satellite mission of Cube Laboratory for Space Technology Experimental Project (STEP Cube Lab), we developed a hinge driving separation nut-type holding and releasing mechanism. The mechanism offers advantages, such as a large holding capacity and negligible induced shock, although its activation principle is based on a nylon cable cutting mechanism triggered by a nichrome burn wire generally used for cube satellite applications for the purpose of holding and releasing onboard appendages owing to its simplicity and low cost. The basic characteristics of the mechanism have been measured through a release function test, static load test under qualification temperature limits, and shock measurement test. In addition, the structural safety and operational functionality of the mechanism module under launch and on-orbit environments have been successfully demonstrated through a vibration test and thermal vacuum test.

• Journal of Biomedical Engineering Research
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• v.35 no.3
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• pp.62-67
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• 2014

The purpose of the study was to identify the effect of laser parameters on photocoagulation to maximize safety and efficacy during varicose vein treatment. CW and pulsed modes at 1470 nm were initially compared as a function of power on bovine liver tissue. In the pulsed mode, various parameters including repetition rate, duty cycle, and irradiation time were compared to evaluate tissue response during thermal treatment. The results demonstrated that CW and pulsed modes yielded almost similar coagulation development possibly due to shorter irradiation time of 5 sec. Regardless of laser mode, both repetition rate and duty cycle presented constant coagulation rate whereas longer irradiation time facilitated coagulation process.

• Proceedings of the KSR Conference
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• 2003.10c
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• pp.59-64
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• 2003

This paper describes the result of structure analysis and load test of body structure. The purpose of the analysis and test is to evaluate an safety which body structure shall be considered fully sufficient rigidity so as to satisfy proper system function under maximum load and operating condition. Material of body structure applied an aluminum alloy. This strength test is based on 'Performance Test Standard for Electrical Multiple Unit, noticed by Ministry of Construction & Transportation, in 2000' and reference code is JIS E 7105

• Journal of the Computational Structural Engineering Institute of Korea
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• v.23 no.6
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• pp.667-673
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• 2010

Recently, structures are becoming longer and higher because of the developments of new materials and construction techniques. However, such modern structures are more susceptible to excessive structural vibrations which cause deterioration in serviceability and structural safety. A modified probabilistic neural network(MPNN) approach is proposed to reduce the structural vibration. In this study, the global probability density function(PDF) of MPNN is reflected by summing the heterogeneous local PDFs automatically determined in the individual standard deviation of each variable. The proposed algorithm is applied for the vibration control of a three-story shear building model under Northridge earthquake. When the control results of the MPNN are compared with those of conventional PNN to verify the control performance, the MPNN controller proves to be more effective than PNN methods in decreasing the structural responses.

• Journal of the Korean Solar Energy Society
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• v.37 no.3
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• pp.13-22
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• 2017

Anti-islanding scheme of grid-connected inverter is a key function of standards compliance, since unintentional islanding results in safety hazards, reliability, and many other issues. Therefore, many anti-islanding schemes have been researched, however, most of them have problems, which deteriorate performance of islanding detection under parallel-operation. Therefore, this paper proves the reason of problems and proposes a new anti-islanding scheme that has precise islanding detection under parallel-operation in single-phase and three-phase system. Finally, both simulation and experimental result validate the proposed scheme.

• International Journal of Automotive Technology
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• v.4 no.3
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• pp.135-140
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• 2003

In the deterministic optimization of a structural system, objective function, design constraints and design variables, are treated in a nonstatistical fashion. However, such deterministic engineering optimization tends to promote the structural system with lest reliability redundancy than obtained with conventional design procedures using the factor of safety. Consequently, deterministic optimized structures will usually have higher failure probabilities than unoptimized structures. Therefore, a balance must be developed between the satisfactions of the design requirements and the objectives of reducing manufacturing cost. This paper proposes the reliability-based design optimization (RBDO) technique, which enables the optimum design that considers confidence level for the vibration characteristics of structural system. Response surface method (RSM) is utilized to approximate the performance functions describing the system characteristics in the RBDO procedure. The proposed optimization technique is applied to the pillar section design considering natural frequencies of a vehicle structure.

• Proceedings of the KIEE Conference
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• 2005.07b
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• pp.1653-1656
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• 2005

Korea Railroad Research Institute(KRRI) has developed the rubber-tired AGT system from 1999 to 2005. The rubber-tired AGT system is now on test for its performance and function at the test line in Gyeong-San. This paper is concerned with the recent development of the AGT system and its reliability evaluation technology which are now being applied in test line. Also, we made the reliable program to assure required the RAMS((reliability, availability, maintainability & safety) of the AGT system.

• Proceedings of the KIEE Conference
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• 1998.11a
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• pp.344-346
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• 1998

The OBCS(On-Board Computer System) achieves train system diagnosis and control. For commercial train operation, it must guarantee the reliability for safe and have low cost operational algorithm. To guarantee the diagnosis function and the control ability of OBCS, sufficient actual railway running test under severe conditions is required. But, running test has some limitations for making severe conditions because of safety and it demands quite long time and a lot of costs. So simulator is required and is utilized in many countries. We designed a simulator to test various functions and performance of controllers for high speed train's power car under various conditions and it is represented briefly.