• Toxicological Research
• /
• 제18권3호
• /
• pp.267-273
• /
• 2002

Fructose 1,6-diphosphate(FDP), a glycolytic metabolite, is reported to ameliorate inflammation and inhibit the nitric oxide production in murine macrophages stimulated with endotoxin. It is also reported that FDP has cytoprotective effects against hypoxia or ischemia/reperfusion injury in brain and heart, and may play a protective role in ultraviolet B (UVB, 280~320 nm)-injured keratinocyte by attenuating prostaglandin (PG)-E$_2$production and cyclooxygenase (COX)-2 expression, which are possibly through blocking the intracellular reactive oxygen species (ROS) accumulation. Therefore FDP is considered to act as a potent antioxidant especially in the skin. We conducted the several safety tests (single-dose toxicity, primary skin irritation test, eye irritation test, skin sensitization test, phototoxicity test, photosenitization test and human patch test) to see if FDP is safe in case used for the skin application. Our data obtained hitherto suggest that FDP is very safe if applied to the skin.

• 대한전기학회:학술대회논문집
• /
• 대한전기학회 2004년도 춘계학술대회 논문집 전기기기 및 에너지변환시스템부문
• /
• pp.272-274
• /
• 2004

Test evaluation field of railroad system that safety and reliability are important is to verify basic performances of unit products and system that were producted according to the specifications. Also, it is important works that verify finally in respect to commercialize verifying reliability and safety. As one part of system technology, this field is to construct database based on know-how of accumulated technology till now than high technical idea and, is to construct test evaluation system of railroad system that can utilize the constructed database. According to the necessity, our researchers investigated good measuring system of foreign country and performed research on performance test and evaluation technology of high-speed tilting vehicle that suits to domestic state.

• 한국안전학회지
• /
• 제21권2호
• /
• pp.98-106
• /
• 2006

The substructure of temporary bridges used during the construction period of main bridges needs to be simple and strong at the same time so that it doesn't block running water. When the water flow is hindered by sub-structure of the bridges, as it happens when H beams with bracing are used, either the water floods or the bridge gets damaged. Therefore, using round beams for the substructure and connect them together is a preventive choice considering the intensive raining in the summer. The bridges using round beams for the substructure have also benefited by fast construction because of fewer bracing and in-situ welding. Because the round-pile-connecting method is relatively new, the safety evaluation of the constructed bridge is an essential procedure before being used in the field. The field evaluation of a bridge including the vehicle loading test and moving load analysis has been conducted and the results showed the safety requirement is satisfied.

• 한국항행학회논문지
• /
• 제28권1호
• /
• pp.95-101
• /
• 2024

본 논문에서는 다양한 eVTOL (electric vertical take-off and landing) 항공기의 안전성 평가 수행을 위한 가변형 시뮬레이션 환경을 구축하고자 한다. eVTOL 항공기마다 적용되는 Inceptor, 항공기 동역학 모델, 제어기가 상이하므로, 이를 가변형으로 구성하여 eVTOL 항공기마다 안전성 시험 평가 시뮬레이션을 수행할 수 있도록 구성하였다. eVTOL 항공기의 안전성 평가 수행을 위한 시험 항목 및 성능 지표를 설정하였으며, 시험 항목별 시험절차에 따라 안전성 시험 평가 시 필요한 지상보조설비를 구상하여 시뮬레이션 환경에 구현하였다. 또한, 시뮬레이션 내 eVTOL 항공기의 데이터를 활용한 안전성 성능 분석을 위해 MATLAB/Simulink 기반의 시뮬레이션 비행데이터 수집 환경을 구축하고, 안전성 성능 분석을 위한 툴을 구현하였다. 최종적으로 본 논문에서 구현한 가변형 시뮬레이션 환경에서의 안전성 시험 비행 수행 및 성능 분석을 수행하였으며, 정상적으로 수행되는 것을 확인함으로써 시뮬레이션 환경을 검증하였다.

• 대한안전경영과학회지
• /
• 제17권2호
• /
• pp.89-96
• /
• 2015

The weapon systems development has some distinct characteristics in that a big size of government budget (derived from national tax) has been expended frequently and the completion of the development projects seems to take long. Thus, the impact of the potential changes in the required operational capability on the development activities can induce some type of project risks. As such, proper management of project risk has been one of crucial subjects in the weapon systems development. Although a variety of methods can be considered, an approach based on the test and evaluation (T&E) process has been selected in this paper in order to appropriately handle those potential risks. In the study of the underlying T&E process, the safety consideration (for instance, explosiveness) of weapon systems is also included. To achieve the objective of the paper, a step-by-step procedure is first presented in the analysis of the T&E process. Then, to pursue some enhancement on the process, a set of necessary and useful activities are added in terms of risk and safety management. The resultant process is further analyzed and tailored based on a design structure matrix method. The case study of a tank development is also discussed.

• 한국자동차공학회논문집
• /
• 제21권5호
• /
• pp.162-168
• /
• 2013

Recently, there have been efforts in many countries to reduce social expenses and casualties resulting due to car accidents. As such, ASS (active safety systems) are being researched and developed to prevent accidents and target mitigation. Among many useful active safety systems, it has been reported that commercial AEBS (Advanced Emergency Braking System) effectively prevents accidents and reduces casualties simultaneously. Accordingly, it is necessary to set Korean AEBS standards, and this research analyzes international AEBS standards for this necessity. In addition to the evaluation methodology of AEBS ECE Regulation, this study suggests traffic scenarios that occur frequently in domestic road environments, and provides an evaluation system for AEBS of the scenarios. Finally, the performance and safety of AEBS are evaluated through field test.

• 한국신뢰성학회지:신뢰성응용연구
• /
• 제16권2호
• /
• pp.125-133
• /
• 2016

Purpose: The purpose of this study is to evaluate durability of platform safety step system in railway. Method: We performed finite element analysis & durability analysis of platform safety step system with VPD (Virtual Product Development) techniques and examined the durability standard & qualification life through the rig test during no failure test time in reliability qualification test. We continued to test 1 million cycles in KRS (Korea Railway Standard) for system's robust design performance. Result: FEM analysis results are 14.9MPa & 14.7MPa of pin-joint, pivot and durability analysis result is above 1 million cycles. we calculated theoretically no failure test time 855,000 cycles and through the 1 million cycles durability rig test in KRS standard we confirmed product quality. Conclusion: This platform safety step system was designed very safe in terms of a mechanical strength & durability.

• Environmental Analysis Health and Toxicology
• /
• 제30권sup호
• /
• pp.4.1-4.7
• /
• 2015

Objectives Approximately 2000 phase-in substances are subject to registration according to the Act on the Registration and Evaluation, etc. of Chemical Substances (K-REACH), and the expected testing cost is 2.06 trillion Korean won assuming all the test data required for registration are acquired. The extent to which these enormous test costs can be reduced depends on the availability of existing data that can be used to meet the requirements of the K-REACH we examined the current availability of test data that can be used for chemical substance registration. Methods We analyzed the possibility of utilizing the existing test data obtained from 16 reference databases for 369 of 518 kinds of phase-in substances subject to registration that were reported in last October 2014. Results The physical and chemical properties were available for 57.1% of substances, whereas data regarding human hazards and environmental hazards were available at considerably lower rates, 8.5% and 11.8%, respectively. Conclusions Physical and chemical properties were available for a fairly high proportion, whereas human hazards and environmental hazards were reported for considerably fewer substances.

• 한국의류산업학회지
• /
• 제13권4호
• /
• pp.624-634
• /
• 2011

The purpose of this study is to develop the pattern of safety clothes used at flat or mountainous areas and to identify the pattern of safety clothes by conducting experimental evaluation of virtual wear. Three subjects were selected, based on fire fighters' physical constitution. A prototype design for safety clothing was determined after in-depth interviewing of professionals and surveying of Forest service staff and related agency. Wearing test should be carried out in the order of pattern making, virtual and real wearing evaluation. For data analysis, technical statistical values should be obtained by using body measurements of subject, frequency analysis and T-test. The jacket is designed to have a front extension and the entire length of clothing enough for wearer to put on it over ordinary shirts or sweater. The collar of jacket is of round type. Cyber reality enables to identify the movement and activity of virtual fitting model and to find out errors or problems in safety clothing prior to on-the-spot wear test, thus raising the precision level of pattern. There was significant difference between real and virtual fit preference. The results show that the virtual try-on system need the development of a specific style.

• 자동차안전학회지
• /
• 제9권2호
• /
• pp.20-25
• /
• 2017

KNCAP is a program to evaluate the automobile safety, providing consumer vehicle safety assessment results. The safety evaluation tests are Frontal Impact, Offset Frontal Crash, Side Crash, Side Pole Crash, Rear Impact. This is the study of the offset frontal impact safety evaluation. Currently, IIHS is performing a small overlap test. NHTSA plans to implement the oblique moving deformable barrier test. Euro-NCAP plans to implement a mobile frontal impact test. Simulation is used to compare occupant behavior and injury. We have investigated whether the introduction of the test at KNCAP is necessary. The dummy model used in the simulation was the 50th percentile male Hybrid III dummy.