• Title/Summary/Keyword: Safety evaluation test

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Safety and Efficacy of Submucosal Midazolam When Combined with Oral Chloral Hydrate, Hydroxyzine and Nitrous Oxide Sedation by using Houpt's Scale (Midazolam을 구강 점막 하로 병용 투여한 진정법의 안정성과 Houpt Scale을 이용한 진정효과에 대한 연구)

  • Park, Mi-Koung;Kim, Yun-Hee;Jung, Sang-Hyuk;Beak, Kwang-Woo
    • Journal of The Korean Dental Society of Anesthesiology
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    • v.6 no.2 s.11
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    • pp.103-112
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    • 2006
  • Background: The purpose of this study was to compare the clinical safety and effect with and without additional submucosal midazolam to oral chloral hydrate and hydroxyzine when used for pediatric conscious sedation in a clinical dental environment. Methods: Thirty one cases of pediatric conscious sedations were performed in this study. Selection criteria included good health (ASA I), under 6 years old, 20 kg of body weight, uncooperative behavior and the need for sedation to receive dental treatment including anesthesia and restorative or surgical procedure for at least two teeth. In each visit, patients were randomly assigned into one of two groups; CH group: chloral hydrate (60 mg/kg), hydroxyzine (1 mg/kg), CH-M group: chloral hydrate (60 mg/kg). hydroxyzine (1 mg/kg) and submucoal midazolam (0.1 mg/kg). 50% nitrous oxide-oxygen was maintained during the sedation period Sedations were monitored using a pulse oximeter for estimating pulse rate (PR) and percutaneous oxygen saturation ($SpO_2$). Behavior response rated using Houpt's scale and need of restraint was assessed every 2 minutes through 30 minutes of operative procedure reviewing the videotape recording. Evaluation of overall behavior success was performed using modified overall behavior rate of Houpt's scale. Data was analyzed using t-test. Results: PR and $SpO_2$ for both groups remained within the normal values. The mean scores for sleep and movement of CH-M group were higher than those of CH group (P < 0.05). There were no significant difference in mean score for crying between two groups. The mean scores of overall behavior of CH-M group was higher than those of CH group (P < 0.01). Reinstraint of CH-M group was less required than that of CH group (P < 0.05). Conclusions: Oral chloral hydrate (60 mg/kg) and hydroxyzine (1 mg/kg) combined with submucosal injection of midazolam was safer and showed more improved sedation effect than oral chloral hydrate (60 mg/kg) and hydroxyzine (1 mg/kg) without midazolam for sedation of pediatric dental patients.

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Performance Evaluation of Long Span Bridge Columns Strengthened with High-Performance Glass Fiber (고성능 유리섬유로 보강된 해상장대교량 교각의 보강성능평가)

  • Chang, Chun-Ho;Jang, Kwang-Seok;Lee, Jae-Uk
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.16 no.1
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    • pp.125-133
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    • 2010
  • Researches and studies which have been conducted so far on external confinement of long span concrete columns have mainly concentrated on concentric loading. But, long span bridge concrete columns over the sea are mainly subjected to concentrated axial load, and at the same time lange amount of moment by eccentric load. This paper experimentally investigates the performance of externally confined high-strength concrete columns subjected to loading mechanism and evaluates the effectiveness of two confinement materials carbon fibre and high performance glass fibre. Twelve short columns with the same dimensions were cast and tested Six columns were reinforced with hoop bars, the remaining six columns were reinforced with spiral bars and wrapped with three layers of carbon failure and high performance glass FRP sheets. Test variables considered were the shape of internal reinforcement and strengthening materials according to loading location. The experimental results showed that eccentric load could obviously lower down the maximum failure load of FRP-confined concrete columns, compared with the columns under concentric load. And compared with the carbon FRP-confined reinforced concrete columns, high performance glass FRP-confined columns displayed a higher load capacity and ductility, when tested both concentrically and eccentrically.

Evaluation of Sejong Base as a Long Term Monitoring Site for Chromophoric Dissolved Organic Matter (CDOM) Variation in the Antarctic Ocean (남극해 유색 용존 유기물질의 장기 변동성 모니터링을 위한 세종 기지의 활용 가능성 평가)

  • Jeon, Mi-Hae;Park, Mi-Ok;Kang, Sung-Ho;Jeon, Misa
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.25 no.7
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    • pp.898-905
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    • 2019
  • As the positive feedback between the absorption of chromophoric dissolved organic matter (CDOM) and acceleration of ice melt can impact the aquatic biota and dynamic heat budget, long-term monitoring of the CDOM variation in the polar ocean is necessary. However, the monitoring of CDOM is not easy because of harsh weather and difficult access, especially in the Antarctic Ocean. Therefore, the purpose of this study was to find a suitable long-term monitoring site for CDOM variation; we selected Maxwell Bay and Marian Cove at Sejong Base and horizontal and vertical distributions of CDOM were measured. After a 72 hr time-series measurement test of the CDOM variation at Sejong Dock and Sejong Cape in Maxwell Bay, Sejong Dock was selected, as it does not haveland discharge effects. The seasonal variation of CDOM was evident and the average CDOM concentration of Maxwell Bay was comparable with the adjacent sea. The CDOM at Sejong Dock from February to November 2010 was the highest in the fall and winter and the lowest during spring and summer. Thus, based on our one-year CDOM data, we suggest that Sejong Dock in Maxwell Bay is suitable for long-term monitoring of CDOM as an indicator of photochemical and biological environmental change and an important factor in determining the heating budget in the Antarctic Ocean.

Evaluation of Fire Investigation as the Separation Distances for Several Types of Insulation Panels (단열패널 종류별 이격거리에 따른 화재감식 평가)

  • Kim, Jeong-Hun;Kim, Da-Seul
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.22 no.4
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    • pp.403-412
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    • 2021
  • Despite strengthening requirements for fire retardancy and applied buildings of insulation panels, the number of fires and influence of damage have increased. In this study, the thermal effects were evaluated as the separation distances, and three types of EPS panel, glass wool panel, and gypsum board panel were then selected. Temperature sensors on the panels were installed vertically from the ground. The fire source on the lamination layer of lumber was ignited by changes in the separation distances (0 cm, 25 cm, 50 cm) from the panels. The test results suggested that the maximum temperature was 349 ℃ in the EPS panel. The inside/outside shape changes were limited by the height of the low and middle positions until the critical point of a 25 cm separation distance. Furthermore, the combustion marks appeared after 500 s on average, and then the EPS panel with a high fire strength showed a broad "U type" pattern, glass wool panel, and gypsum board panel showed medium or narrow "V type" pattern. Therefore, the acquired data can provide valuable information for evaluating the fire risks and verifying fire investigation from buildings composed of these insulation panels.

Study on Development of LED Camping Light Design Based on IOT and Emotional Lighting Contents (IOT 및 감성조명 콘텐츠 기반의 LED 캠핑등 디자인 개발에 관한 연구)

  • Kim, Hee-Jun
    • The Journal of the Korea Contents Association
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    • v.18 no.12
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    • pp.332-342
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    • 2018
  • This study is aimed at suggesting information about technical choices for designing LED camping lights based on emotional lighting contents of integrated IOT and design areas which take a central role in creation and knowledge based industries and the procedure for materializing them. 'i-Light,' a portable LED camping light, is 'connected lighting' connecting men, space and emotion and a smart camping light based on IOT and emotional lighting contents. 'i-Light' has two functions. One is about lighting for adjusting color and color temperature naturally and the other is about safety for detecting harmful gases. 'i-Light' also has various emotional functions for experiencing interaction and taste of light. For the purpose, portable LED camping lights were designed, first of all, and then a highly color rendering/full-color lighting module, a smart sensor module and an IOT device platform were developed. In addition, efforts were made to establish detailed data about emotional lighting contents and to develop a Web application based on them. Finally, prototypes of portable LED camping lights were made to get a test bench and usability evaluation from related organizations. According to the results, all of 12 developed emotional lighting contents and three IOT safety sensors were suitable and prototypes were satisfactory. This paper will suggest a direction about actual technical choices for development of contents and products integrating artificial intelligence and big data and about the procedure for materializing them.

A Study on Placement, Management, and Utilization Improvement of the Automatic External Defibrillator in Ships (선박 내 자동심장충격기 설치 및 관리와 활용개선에 관한 연구)

  • Hwang, Jeong-Hee
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.26 no.7
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    • pp.820-829
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    • 2020
  • Because ships have limited support from land, it is necessary to equip them with automatic external defibrillators (AEDs) in preparation for the incidences of cardiac arrest patients and to properly place and manage AEDs. The seafarer must have the ability to use the AEDs. This is a study to identify the placement and management of AEDs in order to increase the utilization of AEDs in ships, analyze the ability of seafarers to use AEDs and their intention to use it, and suggest improvement plans. The study was conducted from September 9, 2019, to February 20, 2020, and a total of 244 ships and 244 seafarers were surveyed. The data were analyzed by the frequency, percentage, and chi-square test using SPSS WIN 23.0 program. As a result, most of the ships with one AED number were identified, and some ships with insufficient AED placement and management were also identified. A total of 142 seafarers (58.2 %) had experience in participating in AED education; 136 seafarers (55.7 %) had intention to use AEDs; and the most barrier factor was "I don't know how to use" (63.0 %). The intention to use AEDs was high among seafarers in the position of the captain, navigator, and deck department personnel, and when they had an experience in AED training and the training period was less than six months, they were active in using AEDs. In addition, efforts to raise an awareness and education of AEDs are required for occupational groups other than navigators who are not willing to use AEDs in ships, and it is necessary to review appropriate retraining cycles through an evaluation of the seafarer's ability to use AEDs.

Application of Damage Index for Limit State Evaluation of a Steel Pipe Tee (강재 배관 Tee의 한계상태 평가를 위한 손상지수의 적용)

  • Kim, Sung-Wan;Yun, Da-Woon;Jeon, Bub-Gyu;Kim, Seong-Do
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.26 no.4
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    • pp.30-39
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    • 2022
  • Maintaining structural integrity of major apparatuses in a nuclear power plant, including piping system, is recognized as a critical safety issue. The integrity of piping system is also a critical matter related to the safety of a nuclear power plant. The actual failure mode of a piping system due to a seismic load is the leakage due to a fatigue crack, and the structural damage mechanism is the low-cycle fatigue due to large relative displacement that may cause plastic deformation. In this study, in-plane cyclic loading tests were conducted under various constant amplitudes using specimens composed of steel straight pipes and a steel pipe tee in the piping system of a nuclear power plant. The loading amplitude was increased to consider the relative displacement generated in the piping system under seismic loads, and the test was conducted until leakage, which is the limit state of the steel pipe tee, occurred due to fatigue cracks. The limit state of the steel pipe tee was expressed using a damage model based on the damage index that used the force-displacement relationship. As a result, it was confirmed that the limit state of the steel pipe tee can be quantitatively expressed using the damage index.

Multiple damage detection of maglev rail joints using time-frequency spectrogram and convolutional neural network

  • Wang, Su-Mei;Jiang, Gao-Feng;Ni, Yi-Qing;Lu, Yang;Lin, Guo-Bin;Pan, Hong-Liang;Xu, Jun-Qi;Hao, Shuo
    • Smart Structures and Systems
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    • v.29 no.4
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    • pp.625-640
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    • 2022
  • Maglev rail joints are vital components serving as connections between the adjacent F-type rail sections in maglev guideway. Damage to maglev rail joints such as bolt looseness may result in rough suspension gap fluctuation, failure of suspension control, and even sudden clash between the electromagnets and F-type rail. The condition monitoring of maglev rail joints is therefore highly desirable to maintain safe operation of maglev. In this connection, an online damage detection approach based on three-dimensional (3D) convolutional neural network (CNN) and time-frequency characterization is developed for simultaneous detection of multiple damage of maglev rail joints in this paper. The training and testing data used for condition evaluation of maglev rail joints consist of two months of acceleration recordings, which were acquired in-situ from different rail joints by an integrated online monitoring system during a maglev train running on a test line. Short-time Fourier transform (STFT) method is applied to transform the raw monitoring data into time-frequency spectrograms (TFS). Three CNN architectures, i.e., small-sized CNN (S-CNN), middle-sized CNN (M-CNN), and large-sized CNN (L-CNN), are configured for trial calculation and the M-CNN model with excellent prediction accuracy and high computational efficiency is finally optioned for multiple damage detection of maglev rail joints. Results show that the rail joints in three different conditions (bolt-looseness-caused rail step, misalignment-caused lateral dislocation, and normal condition) are successfully identified by the proposed approach, even when using data collected from rail joints from which no data were used in the CNN training. The capability of the proposed method is further examined by using the data collected after the loosed bolts have been replaced. In addition, by comparison with the results of CNN using frequency spectrum and traditional neural network using TFS, the proposed TFS-CNN framework is proven more accurate and robust for multiple damage detection of maglev rail joints.

Efficacy and Safety Evaluation of an Air Sterilizer Equipped With an Electrolytic Salt Catalyst for the Removal of Indoor Microbial Pollutants (염촉매 전기분해 공기살균기의 효능 평가)

  • Sun Nyoung Yu;Ho-Yeon Jeon;Bu Kyung Kim;Ae-Li Kim;Kyung Il Jung;Gye Rok Jeon;Soon Cheol Ahn
    • Journal of Life Science
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    • v.34 no.7
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    • pp.500-508
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    • 2024
  • Recently, there has been increasing interest in enhancing the indoor air quality, particularly in response to the growing utilization of public facilities. The focus of this study was on assessing the efficacy and safety of an air sterilizer equipped with electrolytic salt catalysts. To that end, we evaluated the antimicrobial activity of the vapor spraying from the air sterilizer and its cytotoxicity in condensed form on human cell lines (HaCaT, BEAS-2B, and THP-1). Against the test organisms, which comprised five bacterial strains (Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhimurium) and one fungal strain (Candida albicans), the air sterilizer exhibited relatively high antimicrobial activities ranging from 10.89 to 73.98% following 1 and 3 hr of vapor spraying, which were notably time-dependent. Importantly, cytotoxicity assessments on human cells indicated no significant harmful effect even at a 1.0% concentration. Comprehensive safety evaluations included morphological observations, gene expression (Bcl-2, Bax) tests, and FACS analysis of intracellular ROS levels. Consistent with previous cytotoxicity findings, these estimates demonstrated no significant changes, highlighting the air sterilizer's safety and antimicrobial activities. In a simulated 20-hr operation within an indoor environment, the air sterilizer not only showed an 89.4% removal of total bacteria but also a 100.0% removal of Escherichia sp. and fungi. This research outlines the potential of the developed electrolytic salt catalyst air sterilizer to effectively remove indoor microbial pollutants without compromising human safety, underscoring the solution that it offers for improving indoor air quality.

The Study of Effect and Safety related to Dong-gi Acupuncture(DGA) and Complex therapy on Lumbago due to blood stasis and sprain (좌섬(挫閃)·어혈(瘀血) 요통(腰痛)에 동기침법(動氣鍼法) 및 복합치료(複合治療)의 유효성(有效性) 및 안정성(安定性) 연구(硏究))

  • Kim, Kee-Hyun;Lim, Hyung-Ho;Hwang, Hyeon-Seo;Song, Ho-Sueb;Song, Young-Sang;Kwon, Soon-Jung;Kim, Kyung-Nam;Ahn, Koang-Hyun;Lee, Seong-No;Kang, Mi-Suk;Gyun, Im-Jung
    • Journal of Acupuncture Research
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    • v.19 no.3
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    • pp.107-114
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    • 2002
  • Objective : This study was designed to find the most effective and safest way to overcome Lumbago due to blood stasis and sprain involved in a few Meridian Tendino-musculatures by evaluating the effect of two kinds of Dong-gi(Dong-qi) Acupuncture(DGA) and by reporting their side effects. Material : 97 patients of out and admission patients were selected, who were diagnosed with lumbar sprain caused by repetitive bending, heavy weight lifting, unsuitable posture, concussion and falling down and whose Lumbago due to blood stasis and sprain in the concept of oriental medicine. Methods : 97 patients were divided into three groups. One is exclusive DGA group to which DGA and the method retaining needles on the acupoints for about 20 minutes were applied, the other is DGA combined active exercise group in which patients stretched their Meridian Tendino-muscuIatures with their hips moving up and downward repeatedly during DGA, the third is DGA combined passive exercise group in which patients were made to flex or extend their bodies on the auto flexion-distraction table in a prone position, from 10 to 20 degree, during DGA. In each group, bed rest, physical therapy and herbal medicine were used according to symptoms, in addition to DGA. In DGA method, "Su(Shu)" points of the meridian related to the involved Meridian Tendino-musculature were mainly chosen, that is, Sokkol(Shugu, B65), Hugye(Houxi, SI3), ChungJo(Zhongzhu, TE3) were used, for most LBP belonged to Bladder and Gallbladder Meridian Tendino-musculature disorders. Pyong-Bo-Pyong-Sa(Ping-Bu-Ping-Xie) such as Dong-Gi and Yeom-Jeon(Nian-Zhuan) was applied as Bo-Sa method. For evaluation of effectiveness, new score system was devised by severity of pain and range of movement. the score was given twice at patients' first and last visit and the difference between first and last score was regarded as a evaluation scale, the effectiveness was classified into four grade by evaluation scale.(scale : 12-15; excellent, 8-11; good, 4-7; fair, 0-3; bad) Results : 1. Exclusive DGA, DGA combined active exercise and DGA combined passive exercise group showed 97, 87 and 89% in effectiveness. 2. Exclusive DGA, DGA combined active exercise and DGA combined passive exercise group showed no aggravation of pain, range of movement. 3. In blood test of 34 patients, only one patient showed abnormal rise of sGOT, sGPT and $\gamma$-GTP at his first visit and the others didn't show any detrimental change. DGA had no bad influence upon BUN and creatinine of patients. Conclusion : For complex theraphy combining DGA, exercise, physical therapy and Herbal medicine proved to be highly effective on treating lumbago due to blood stasis and sprain, this is expected to be available for clinical use.

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