• Toxicological Research
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• 제17권
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• pp.173-183
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• 2001

Although there are still many technical difficulties to be overcome, recent advances in the molecular and cellular biology of gene transfer have made it likely that gene therapy will soon start to play an increasing role in clinical practice. However. safety issues are raised from vector system. It is not clear whether it is safe to incorporate genes into nuclear DNA. Little is known about the antigenicity of gene product which the immune system is encountering. In this review, some safety-related topics are introduced and discussed.

• International Journal of Safety
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• 제7권1호
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• pp.26-29
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• 2008

The purpose of this study is the measurement of whole-body vibration for different road surfaces. Experimental measurements were taken on asphalt, cement, and off-road surfaces as defined by ISO 2631-1. Each experiment was conducted under the same set of conditions (measurement duration, times, speed, vehicle type). Measurement duration was 10 minutes and 3 separate measurements were taken on each road surface. Vehicle speed was 60km/h. In accordance with ISO 2631-1, an acceleration sensor is set up between the driver's seat and the human body. For evaluation, RMS(root-mean-square) values were taken as suggested by ISO 2631-1. The results suggest "health guidance caution zones", and the evaluation was based on obtaining the vector sum with "health guidance caution zones".

• Nuclear Engineering and Technology
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• 제44권6호
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• pp.663-672
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• 2012

As software based digital I&C (Instrumentation and Control) systems are used more prevalently in nuclear plants, enhancement of software dependability has become an important issue in the area of nuclear I&C systems. Critical attributes of software dependability are safety and reliability. These attributes are tightly related to software failures caused by faults. Software testing and V&V (Verification and Validation) activities are hence important for enhancing software dependability. If the risky modules of safety-critical software can be predicted, it will be possible to focus on testing and V&V activities more efficiently and effectively. It should also make it possible to better allocate resources for regulation activities. We propose a prediction technique to estimate risky software modules by adopting machine learning models based on software complexity metrics. An empirical study with various machine learning algorithms was executed for comparing the prediction performance. Experimental results show SVMs (Support Vector Machines) perform as well or better than the other methods.

• 품질경영학회지
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• 제47권4호
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• pp.783-793
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• 2019

Purpose: The purpose of this study is to apply the machine and deep learning methodology on error terms which are continuously auto-generated on the sensors with specific time period and prove the improvement effects of power generator prediction diagnosis system by comparing detection ability. Methods: The SVM(Support Vector Machine) and MLP(Multi Layer Perception) learning procedures were applied for predicting the target values and sequentially producing the error terms for confirming the detection improvement effects of suggested application. For checking the effectiveness of suggested procedures, several detection methodologies such as Cusum and EWMA were used for the comparison. Results: The statistical analysis result shows that without noticing the sequential trivial changes on current diagnosis system, suggested approach based on the error term diagnosis is sensing the changes in the very early stages. Conclusion: Using pattern of error terms as a diagnosis tool for the safety control process with SVM and MLP learning procedure, unusual symptoms could be detected earlier than current prediction system. By combining the suggested error term management methodology with current process seems to be meaningful for sustainable safety condition by early detecting the symptoms.

• Journal of Pharmaceutical Investigation
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• 제34권5호
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• pp.351-362
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• 2004

The basic concept underlying gene therapy is that human diseases may be treated by the transfer of genetics material into specific cells of a patient in order to correct or supplement defective genes responsible for disease development. There are several systems that can be used to transfer foreign genetic material into the human body. Both viral and non-viral vectors are developed and evaluated for delivering therapeutic genes. Viral vectors are biological systems derived from naturally evolved viruses capable of transferring their genetics materials into host cells. However, the limitations associated with viral vectors, in terms of their safety, particularly immunogenecity, and their limited capacity of transgenic materials, have encouraged researchers to increasingly focus on non-viral vectors as an alternative to viral vectors. Although non-viral vectors are less efficient than viral ones, they have the advantages of safety, simplicity of preparation and high gene encapsulation capability. This article reviews the most recent studies highlighting the advantages and the limitation of gene delivery systems focused on non-viral systems compared to viral systems.

• 한국안전학회지
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• 제32권5호
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• pp.179-185
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• 2017

Accident analysis is an essential process to make basic data for accident prevention. Most researches depend on survey data and accident statistics to analyze accidents, but these kinds of data are not sufficient for systematic and detailed analysis. We, in this paper, propose an accident classification model that extracts task type, original cause materials, accident type, and the number of deaths from accident reports. The classification model is a support vector machine (SVM) with word occurrence features, and these features are selected based on mutual information. Experiment shows that the proposed model can extract task type, original cause materials, accident type, and the number of deaths with almost 100% accuracy. We also develop an accident ontology to express the information extracted by the classification model. Finally, we illustrate how the proposed classification model and ontology effectively works for the accident analysis. The classification model and ontology are expected to effectively analyze various accidents.

• 대한안전경영과학회지
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• 제17권4호
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• pp.335-342
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• 2015

The increasing interests on patents have led many individuals and companies to apply for many patents in various areas. Applied patents are stored in the forms of electronic documents. The search and categorization for these documents are issues of major fields in data mining. Especially, the keyword extraction by which we retrieve the representative keywords is important. Most of techniques for it is based on vector space model. But this model is simply based on frequency of terms in documents, gives them weights based on their frequency and selects the keywords according to the order of weights. However, this model has the limit that it cannot reflect the relations between keywords. This paper proposes the advanced way to extract the more representative keywords by overcoming this limit. In this way, the proposed model firstly prepares the candidate set using the vector model, then makes the graph which represents the relation in the pair of candidate keywords in the set and selects the keywords based on this relationship graph.

• 한국안전학회지
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• 제17권4호
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• pp.87-93
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• 2002

This paper is presented new fuzzy controller for high performance of induction motor drive. New fuzzy controller took out appropriate amounts of accumulated control input according to fuzzy described situations in addition to the incremental control input calculated by conventional direct fuzzy controller. The structures of the proposed controller was motivated by the problems of direct fuzzy controller. The direct controller was given generally inevitable overshoot when one tries to reduce rise time of response. The undesirable characteristics of the direct fuzzy controller are caused by integrating operation of the controller, even though the integrator itself is introduced to overcome steady state error in provide a thorough comparative insight into the behavior of induction motor drive with direct and new fuzzy speed controller. The validity of the comparative results is confirmed by the simulation results for induction motor drive system.

• 한국멀티미디어학회논문지
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• 제14권5호
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• pp.595-606
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• 2011

This paper proposes a robust watermarking scheme for GIS digital map by using the geometric properties of polyline and polygon, which are the fundamental components in vector data structure. In the proposed scheme, we calculate the lengths and the perimeters of all polylines and polygons in a map and cluster them to a number of groups. Then we embed the binary watermark by changing the mean of lengths and perimeters in an embedding group. For improving the safety and robustness, we permute the binary watermark through PRNS(pseudo-random number sequence) processing and embed it repeatedly in a model. Experimental results verified that our scheme has a good invisibility, safety and robustness to various geometric attacks and also our scheme needs not the original map in the extracting process of watermark.

• Journal of Positioning, Navigation, and Timing
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• 제11권4호
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• pp.287-295
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• 2022

The GNSS coordinate time series is used as important data for geophysical analysis such as terrestrial reference frame establishment, crustal deformation, Earth orientation parameter estimation, etc. However, various factors may cause discontinuity in the coordinate time series, which may lead to errors in the interpretation. In this paper, we describe the discontinuity in the coordinate time series due to the equipment replacement for domestic GNSS stations and discuss the change in movement magnitude and velocity vector difference in each direction before and after discontinuity correction. To do this, we used three years (2017-2019) of data from 40 GNSS stations. The average magnitude of the velocity vector in the north-south, east-west, and vertical directions before correction is -12.9±1.5, 28.0±1.9, and 4.2±7.6 mm/yr, respectively. After correction, the average moving speed in each direction was -13.0±1.0, 28.2±0.8, and 0.7±2.1 mm/yr, respectively. The average magnitudes of the horizontal GNSS velocity vectors before and after discontinuous correction was similar, but the deviation in movement size of stations decreased after correction. After equipment replacement, the change in the vertical movement occurred more than the horizontal movement variation. Moreover, the change in the magnitude of movement in each direction may also cause a change in the velocity vector, which may lead to errors in geophysical analysis.