• Korean Journal of Biological Psychiatry
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• v.9 no.1
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• pp.34-41
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• 2002

Background:Since serotonin neurotrasnmission plays an important role in the pathophysiology of depression, the drug that acts on serotonin transporter can be an effective antidepressant. The aim of this study was to investigate the relationship between serotonin transporter polymorphisms(5-HTTLPR) and the long-term effect of the antidepressant treatment. Method:The 175 depressive patients, who met DSM-IV criteria for major depressive disorder or dysthymic disorder were enrolled into three year study. The genotypes of the patients were investigated by polymerase chain reaction of genomic DNA with promoter regions of the serotonin transporter gene. The patients were assessed by the Clinical Global Impression Scale, at the 1st visit, 8th week, 16th week, 1st year, 2nd and 3rd year after the antidepressant treatment. Result:The genotypes of 138 patients were investigated and 128 of them finished this 1st year study and 107 remained in the study after 2-year treatment, and, 97 completed this 3-year study. The therapeutic response of each subset was not different at 8th, 16th week, but the subset with homozygote(l/l) of long variant showed a better antidepressant therapeutic response than heterozygote(l/s). The heterozygote(l/s) showed a better response than the subset with homozygote(s/s) of short variant at 1st, 2nd and 3rd year after the antidepressant treatment in CGI-global improvement score. Conclusion:This result shows that the serotonin transporter polymorphism may be related to the long-term effect of antidepressant treatment and there may be also ethnic difference.

• Journal of Korean Neurosurgical Society
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• v.41 no.3
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• pp.157-160
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• 2007

Objective : The purpose of this study was to evaluate the efficacy and safety of the surgical treatment for lumbar spinal stenosis in elderly patients. Methods : The authors reviewed the medical records of 49 patients older than 65 years of age with lumbar spinal stenosis who underwent surgical treatment from January 2002 to December 2004 in our institute. Results : Average age of patients was 70 years old [32 women, 17 men]. Twenty-four patients had chronic medical disorders. All patients were operated under the general anesthesia of these, 29 patients underwent decompressive laminectomy and decompressive laminectomy with instrumentation and fusion in 20 patients. The mean operation time was 193.5 minutes, mean estimated blood loss was 378cc and mean postoperative hospital stay length was 15.3 days. The mean follow-up duration was 11.9 months. The evaluation of outcome was assessed by Macnab classification. At first month after operation, the outcome showed excellent in 7 [14.3%]. good in 35 [71.4%], fair in 5 [10.2%], and poor in 2 [4.1%]. And at 6 months after operation, 17 patients were lost in follow-up, the outcome showed excellent in 4 [12.5%], good in 25 [78.1%], fair in 3 [9.4%], and no poor cases. There was no significant difference between outcome of laminectomy alone and that of laminectomy with fusion. Six patients [12.2%] experienced postoperative complications which included wound infection [3], nerve root injury [1], disc herniation [1], and reoperation due to insufficient decompression [1]. There were no deaths related to operation. Conclusion : We conclude that the surgical treatment for lumbar spinal stenosis in elderly patients can provide good results with acceptable morbidity when carefully selected. In addition, decision on lumbar spinal fusion should not be against solely on advanced age.

• Journal of Korean Neurosurgical Society
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• v.58 no.1
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• pp.36-42
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• 2015

Objective : Complete sellar floor reconstruction is critical to avoid postoperative cerebrospinal fluid (CSF) leakage during transsphenoidal surgery. Recently, the pedicled nasoseptal flap has undergone many modifications and eventually proved to be valuable and efficient. However, using these nasoseptal flaps in all patients who undergo transsphenoidal surgery, including those who had none or only minor CSF leakage, appears to be overly invasive and time-consuming. Methods : Patients undergoing endoscopic endonasal transsphenoidal tumor surgery within a 5 year-period were reviewed. Since 2009, we classified the intraoperative CSF leakage into grades from 0 to 3. Sellar floor reconstruction was tailored to each leak grade. We did not use any tissue grafts such as abdominal fat and did not include any procedures of CSF diversions such as lumbar drainage. Results : Among 200 cases in 188 patients (147 pituitary adenoma and 41 other pathologies), intraoperative CSF leakage was observed in 27.4% of 197 cases : 14.7% Grade 1, 4.6% Grade 2a, 3.0% Grade 2b, and 5.1% Grade 3. Postoperative CSF leakage was observed in none of the cases. Septal bone buttress was used for Grade 1 to 3 leakages instead of any other foreign materials. Pedicled nasoseptal flap was used for Grades 2b and 3 leakages. Unused septal bones and nasoseptal flaps were repositioned. Conclusion : Modified classification of intraoperative CSF leaks and tailored repair technique in a multilayered fashion using an en-bloc harvested septal bone and vascularized nasoseptal flaps is an effective and reliable method for the prevention of postoperative CSF leaks.

• Journal of Korean Elementary Science Education
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• v.24 no.3
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• pp.203-213
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• 2005

In this study, the biological units of elementary school science were classified to the lower categories of Dimensions of Learning out of the 1 st to the 7th National Curriculum using the Dimensions of Learning Project developed by ASCD in USA. Also they were investigated which lower categories of Dimensions of Learning were used to the Curriculum. The results were as follows; First, the average percentages of using the lower categories of Dimensions of learning increased gradually from lower to higher grade regardless of any versions of Curriculum. For example, the percentages of using the lower categories according to grade 3 to 6 were increased by $56.1\%,\;61.4\%.\;67.1\%,\;86.8\%$ in the 7th Curriculum (r = .942). Second, as a result of investigating the percentages of using lower categories of Dimensions of Learning according to the change of curriculum, the average percentages appeared to be $37.9\%,\;42.9\%,\;41.1\%,\;47.6\%,\;47.6\%,\;50.5\%,\;67.9\%$ from the 1st to the 7th National Curriculum, respectively. In addition, the average percentages were increased gradually from the 1st to the 7th National Curriculum (r = .878). Third, the average percentages of using the lower categories of Dimensions of Learning decreased approximately from 1 st to 5th Dimension. The results are considered to be a desirable organization considering the physiological, cognitive development of elementary students.

• Clinics in Shoulder and Elbow
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• v.5 no.1
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• pp.37-41
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• 2002

Purpose : To evaluate the effect of radial head resection on longevity in nonconstrained total elbow arthroplasty, Materials and Methods : The results of 20 cases of radial head replaced Pritchard ERS and 18 cases of radial head excised Kudo elbow was followed for 6 to 16 years, 10.6 years in average. The rate of loosening, osteolysis, radial head subluxation, joint dislocation and valgus deformity were compared between the two groups. Results'There was no exaggerated cubitus valgus in Pritchard ERS group. However there developed one case of delayed subluxation of radial head occurred in 6 years postoperatively, one case of loosening, and one case of sponta- neous fracture of humeral shaft due to osteolysis. In Kudo elbow group,5 cases (27.8%) showed exaggerated valgus deformity with instability. There were one case of loosening and one case of delayed dislocation occurred in a year postoperatively. Conclusion : The most clear feature of Kudo elbow was exaggerated cubitus valgus. However, the ostolysis was developed in both groups and there was no difference in rate of the other complications between the two groups.

• Journal of Korean Society of Water and Wastewater
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• v.8 no.2
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• pp.1-11
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• 1994

This study was conducted to develop a new RBC process available for the effective removal of organic matters and nitrogen in sewage. The RBC process for the oxidation organic compounds and nitrification was designed to occur at the 1st-stage and next-stage RBC respectively. Then nitrified water was recycled to the denitrifying RBC located at the lower part of the 1st-stage RBC. Some results were summarized as follows. 1. The loading limitation was represented as $60g{\cdot}COD/gm^2/day$ in experiment of simultaneous removal of organic matter and nitrogen. The maxmum COD % removal was 85% at the load $35g{\cdot}COD/m^2/day$. 2. The $NO_3-N$ % removal was approximately 80% at the load $60g{\cdot}COD/m^2/day$ and the maximum $NO_3-N$ remaval rate was $3.9g{\cdot}COD/m^2/day$ and the overall C/N ratio of 11.0 as required to achive 80% of $NO_3-N$% removal. 3.$NO_3-N$ removal rate was rapidly decreased above the load $7g{\cdot}NH_4{^+}-N/m^2/day$ and the maximum $NO_3-N$ removal rate was $3.7g{\cdot}NO_3-N/m^2/day$. 4. Irrespective of the recycle ratio, the COD % removal at the system of 2-stage RBC unit was nearly constant as 89% while the maximum one in the 1st-stage unit was 77% in the case of 50% recycle. 5. The maximum COD % removal in the 3-stage RBC system was 93% while 1st-stage one being 80%, under the $NH_4{^+}-N$ load of $7.4g/m^2{\cdot}d$. Also maximum percentage of nitrification and denitrification was 69% and 41% respectively, under the same $NH_4{^+}-N$ load.

• Journal of Preventive Medicine and Public Health
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• v.34 no.1
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• pp.41-46
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• 2001

Objectives : To investigate the effects of particulate matter (PM), a marker of environmental pollution derived from combustion sources, on lung epithelial cells (A549) and macrophage (RAW 264.7). Methods : The production of reactive radicals from lung cells, the lipid peroxidation of cell membrane, and the cytotoxicity of PM were measured using an in vitro model. The results were compared with a control group. Results : The presence of PM significantly increased the production of reactive oxygen species and reactive nitrogen species with time and in a dose dependent pattern and also increased the malondialdehyde concentration in lung epithelial cells. The cytotoxicity of PM was increased with increasing concentration of PM. Conclusions : It has been suggested that urban particulate matter causes an inflammatory reaction in lung tissue through the production of hydroxyl radicals, nitric oxides and numerous cytokines. The causal chemical determinant responsible for these biologic effects are not well understood, but the bioavailable metal in PM seems to determine the tonicity of inhaled PM.

• Ocean and Polar Research
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• v.43 no.3
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• pp.99-111
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• 2021

Occurrence of epiphytic dinoflagellates (EPDs) in coastal waters off Jeju was first reported in 2011 based on 45 substrate samples from 24 macroalgal species. When re-analyzing, the extreme heterogeneous distribution of whole and genus-specific EPDs was reconfirmed across the sampling stations and substrate macroalgal species, as well as even across substrate samples of the same species. Abundance maximum of an EPD genus (cells g-wwt^-1) at a fixed surface-to-volume ratio (SA/V ratio) of the macroalgal species increased as the SA/V ratio increased up to 500 (cm² cm^-3). However, the abundance maximum of Ostreopsis further increased even in the MG2 (morphological group 2) macroalgae with the SA/V ratios over 500. The number of substrate macroalgal species on the plane of the MG and sampling station was more or less evenly scattered than the average EPD abundance, which was primarily driven by Gambierdiscus and Ostreopsis. Of the total EPD abundance of the five stations, 90.6% were represented by the two most common and abundant genera, Gambierdiscus and Ostreopsis, each accounting for 41.6% and 49.0%. Spatially, 95.9% of the total EPD abundance was found in St. 4 and St. 5, of which St. 4 with higher water temperature had more Ostreopsis spp. (31.8%), and St. 5 with higher salinity had more Gambierdiscus spp. (27.3%). Thus, the environmental transition to favorable T-S condition to MG2, the thin filamentous macroalgal group with very high SA/V ratios, is thus likely to support further success in EPD genera led by Ostreopsis in the coastal waters of Jeju.

• Clinics in Shoulder and Elbow
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• v.22 no.3
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• pp.135-138
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• 2019

Background: The aims of this study were (1) to examine the footprint of the subscapularis tendon using the traditional posterior portal and $30^{\circ}$ arthroscope by simple internal rotation of the arm during surgery, and (2) to classify the pattern of a subscapularis partial-thickness tear. Methods: This study analyzed a total of 231 patients with a partial-thickness subscapularis tear from 550 consecutive patients undergoing an arthroscopic operation who had a visualization of the subscapularis tendon footprint by internal rotation of the arm. First, the patients were classified into four categories according to the tear pattern: (1) stable lamination, (2) unstable lamination, (3) avulsion, and (4) laminated avulsion. Randomized arthroscopic videos were reviewed blindly by two independent orthopedic surgeons. The pattern of the tear of the subscapularis at the neutral position and after internal rotating the arm were assessed and compared with the treatment decision (level IV case series). Results: Stable lamination, unstable lamination, avulsion, and laminated avulsion were observed in 9.1% (n=21), 20.8% (n=48), 41.1% (n=95), and 29.0% (n=67) of cases, respectively. In 145 out of 231 cases (62.8%), the decision was changed after inspecting the footprint after internal rotation of the arm, and the treatment method was changed in 116 (50.2%) cases. Conclusions: In a subscapularis tendon partial-thickness tear, inspecting the footprint of the subscapularis tendon is essential to diagnosing and deciding on the appropriate treatment. In addition, simply internal rotating the arm during surgery when using the traditional posterior portal and $30^{\circ}$ arthroscope can be a valuable method.

• Journal of Hospice and Palliative Care
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• v.24 no.2
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• pp.116-129
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• 2021

Purpose: The purpose of this study was to examine the knowledge, caregiving performance, stress levels, and mental health of family caregivers of terminal cancer patients with delirium, insofar as these characteristics are relevant for delirium. Methods: Between May 1, 2019, and June 1, 2020, 96 family caregivers of terminal cancer patients with delirium completed a structured survey, the results of which were analyzed. Results: The average correct answer rate for delirium-related knowledge was 53.2% across all subcategories, which included knowledge of causes (41.5%), symptoms (65.4%), and caregiving (51.7%). The average score for family caregivers' performance of caregiving for delirium was 2.60±0.5, with subcategories including caregiving for patients without delirium (2.16±0.95), caregiving for patients with delirium (2.84±1.01), and stress related to caregiving for delirium (39.88±16.55), as well as categories such as patient-related caregiving (44.32±28.98), duty-related caregiving (44.21±30.15), and interpersonal relationship-related caregiving (22.35±25.03). For mental health, the average score among family caregivers was 1.96±0.70, with the highest score being for the category of additional items (2.28±0.84). Family caregivers of patients with hyperactive delirium as the delirium subtype had higher scores for caregiving performance than caregivers of patients with mixed delirium. Conclusion: Scores for the delirium-related knowledge and caregiving performance of family caregivers were low, while their caregiving stress levels were high due to their lack of knowledge and experience. This indicates the importance of delirium-related education for family members of patients with delirium and the necessity of developing nursing intervention programs to help manage stress and promote mental health among family caregivers.