• Journal of Life Science
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• v.17 no.6 s.86
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• pp.748-755
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• 2007

The in vitro activity of ST1571, an inhibitor of the Abl group of protein-tyrosine kinases, alone or in combination with camptothecin (CPT), a specific topoisomerase I inhibitor, was evaluated against human cancer cells with different metastatic capacity and drug resistance potency. These cell lines showed different sensitivity to ST157 on growth inhibition, and the expression of DNA-dependent protein kinase (DNA-PK), which interacts constitutively with c-Abl, was significantly decreased in drug sensitive CEM and MCF-7 cells and poorly metastatic PC3 and KMl2 cells as compared with that of multidrug resistant CEM/MDR and MCF-7/MDR cells and highly metastatic PC3-MM2 and KM/L4a cells, respectively. These results suggest differential modulation of DNA-PK by ST1571 treatment in drug resistance and metastatic degree dependent manner. We showed that CPT as well as ST1571 significantly inhibits the expression of DNA-PK. The combined treatment with ST15fl and CPT revealed synergistic effect, and the effect was accompanied by inhibition of cell proliferation due to significant reduced expression of DNA-PK components, which resulted in CPT sensitizes human cancer cells resistant to ST1571. Therefore, the results of our study suggested that the suppression of DNA-PK using combination of ST1571 and CPT could be a novel molecular target for against drugresistant and metastatic cancer cells.

• Journal of the Korean Society of Clothing and Textiles
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• v.32 no.10
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• pp.1571-1583
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• 2008

The study aimed to investigate the actual condition of working clothes in the Changwon National Industrial Complex and to analyze the industrial workers' satisfaction with and preference to the working clothes in terms of the clothing performance and work motion factors. 1 major companies in machinery, automotive, industrial engineering, shipbuilding and rolling stock industries located in the industrial complex were selected as the subject firms. Approximately 900 workers responded to the questionnaire designed for the research and the results derived from the research were as follows. (1) The subject employees were divided into 4 work groups, i.e. the $1^{st}$ work group: managerial, general affairs, sales, production planning; the $2^{nd}$ group: quality assurance, material planning and distribution, product inspection; the $3^{rd}$ group: electric, facilities, machinery, vehicles; and the $4^{th}$ group: cutting, pressing, rolling, welding and coating. (2) The significant work environmental factors considered by all work groups were air ventilation, noise and dust factors and in particular, the most dissatisfied factors evaluated by manufacture workers were insulation, noise, dust and vibration. (3) According to the employees' work motion evaluation, the work motion diversity and frequency increased in proportion to the degree of work intensity. Besides, manufacture workers more frequently wore the working clothes even during the off-duty hours comparing to the evaluation of the other work groups. (4) The most important clothing performance factors considered by manufacture work groups were perspiration absorption, stretch, air permeability, tactile sense softness, soil proof in order.

• Proceedings of the Korean Society of Surveying, Geodesy, Photogrammetry, and Cartography Conference
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• 2007.04a
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• pp.295-299
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• 2007

Today, ubiquitous technology (e.g. computers or networked devices pervade everywhere we are) has enlarged by great advancement of information and communication technologies. If ubiquitous technologies is applied to, innovation of spatial information technology is expected. traditional spatial information technologies such as survey, GIS, GPS, LBS, and RS and ubiquitous technology gradual1y have been converged. The aim of this study is to create shared visions in spatial information technologies by scenario based roadmapping. So, we surveyed the state of the art in main spatial information technologies, market status and patent map. Consequently, prospects of spatial information technologies is suggested. The aim of 1st and 2nd NGIS project focused on map supplier was to develop digital map(e.g. framework data, various thematic map). As a result, the best technology of digital mapping is achieved in the world. But, there is not enough to develop GIS and LBS solution. Current market in GIS S/W and Telematics is about 384billon won and 250billion won. a patent is applied in the order, like a USA(1571case, 47%), Japan(883case, 26%), EU(478case, 14%), Korea(446case, 13%). In the future, spatial information technology fused on ubiquitous technology will be focused on user's demand and developing convenience context. The developing target will be realtime monitoring of 3D spatial data based on high resolution coordinate system, sharing and supplying multi-sensor data considered users demand, location service by ubiquitous technologies.

• Journal of Korean Library and Information Science Society
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• v.40 no.4
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• pp.427-456
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• 2009

Jwa-lee Wonjong Gongsin-Nokgwon(佐理原從功臣錄券) is a book which recorded the titles of position and the names of retainers who made Sung-jong into Chosun dynasty's king. This study aims to research into existing only 1 books of Jua-ik Wonjong Gongsin-Nokgwon, which were to analyze the reasons of grant, structure and forms, the characteristics of meritorious retainers' official positions and social status. As the result, Jwa-lee Wonjong Gongsin-Nokgwon is the metal typologic book which was made up Eul-hae(乙亥) letter type. The structure of the Jwa-lee Wonjong Gongsin-Nokgwon was composed of the beginning(卷首) the body(本文) the end(卷末). Jwa-lee Wonjong meritorious retainers formed the total of 1,059 persons(1st grade : 64 persons, 2nd grade : 272 persons, 3rd grade : 723 persons) with 513 official titles. Also an analysis of their family name confirmed that 1,059 persons were "Lee" which constituted the largest group(21%), "Kim" were second group(15%).