• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2002년도 생물공학의 동향 (X)
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• pp.53-56
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• 2002

Mammalian cell based biosensor kits are expected to be in assessment of samples toxicity more sensitive and accurate. A recombinant fluorescent Chinese Hamster Ovary (CHO) cell line was known to be responsive to the various toxicants Specially. KFC- AlO cell line. which contain the c-fos SRE::GFP plasmid (pKFG). was found to be able to detect toxicants sensitively. A biosensor kit was developed by using an immobilized KFC-A10 cell line. Immobilized recombinant fluorescent cells within agarose, known as a representative hydrogel matrix, have been maintained in the matrix viably and have shown constant fluorescent levels for long time. Immobilized cells have shown the ability to detect the chemical toxicity in the keep of fluorescent level as the metabolism is inhibited under toxic conditions.

• International Journal of Reliability and Applications
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• 제10권1호
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• pp.17-32
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• 2009

The aim of this work is to generalize reliability equivalence technique to apply it to a system consists of n independent and non-identical components connected in series system, that have mixing constant failure rates. We shall improve the system by using some reliability techniques: (i) reducing some failure rates; (ii) add hot reduncy components; (iii) add cold reduncy components; (iv) add cold reduncy components with imperfect switches. We start by establishing two different types of reliability equivalence factors, the survival equivalence (SRE), and mean reliability equivalence (MRE) factors. Also, we introduced some numerical results.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 1997년도 봄 학술발표회 논문집
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• pp.442-448
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• 1997

An analytical method based on the nonlinear layered finite element method is developed to simulate the load-dsflection behavior of strengthened beams. Beams considered in this study are the ones strengthened either with external steel plate or Carbon Fiber Sheets(CFS) bonded to the overlay soffit. The theoretically obtained load-deflections and strains of the strengthened beams are compared to the corresponding experimental values. Parametric studies are, then. performed using the developed model to investigate the effects of design variables on the flexural behavior of the strengthened beams. Simply supported beams under monotonically increasing loads sre considered exclusively.

• 말소리와 음성과학
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• 제9권2호
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• pp.85-94
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• 2017

Conventional speaker verification systems using time delay neural network, identity vector and probabilistic linear discriminant analysis (TDNN-Ivector-PLDA) are known to be very effective for verifying long-duration speech utterances. However, when test utterances are of short duration, duration mismatch between enrollment and test utterances significantly degrades the performance of TDNN-Ivector-PLDA systems. To compensate for the I-vector mismatch between long and short utterances, this paper proposes to use probabilistic linear discriminant analysis (PLDA) model adaptation with augmented data. A PLDA model is trained on vast amount of speech data, most of which have long duration. Then, the PLDA model is adapted with the I-vectors obtained from short-utterance data which are augmented by using vocal tract length perturbation (VTLP). In computer experiments using the NIST SRE 2008 database, the proposed method is shown to achieve significantly better performance than the conventional TDNN-Ivector-PLDA systems when there exists duration mismatch between enrollment and test utterances.

• 한국생물물리학회:학술대회논문집
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• 한국생물물리학회 1999년도 학술발표회 진행표 및 논문초록
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• pp.69-69
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• 1999

The human genetic disorder ataxia-telangiectasia (A-T) is a multisystem disease characterized by extreme radiosensitivity. The recent identification of the gene mutated in A-T, ATM, and the demonstration that it encodes a homologous of phosphatidylinositol 3-kinase (PI3-K), the catalytic subunit of an enzyme involved in transmitting signals from the cell surface to the nucleus, provides support for a role for this gene in signal transduction.(omitted)

• ETRI Journal
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• 제45권4호
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• pp.678-689
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• 2023

This paper describes a novel end-to-end deep generative model-based speaker recognition system using prosodic features. The usefulness of variational autoencoders (VAE) in learning the speaker-specific prosody representations for the speaker recognition task is examined herein for the first time. The speech signal is first automatically segmented into syllable-like units using vowel onset points (VOP) and energy valleys. Prosodic features, such as the dynamics of duration, energy, and fundamental frequency (F₀), are then extracted at the syllable level and used to train/adapt a speaker-dependent VAE from a universal VAE. The initial comparative studies on VAEs and traditional autoencoders (AE) suggest that the former can efficiently learn speaker representations. Investigations on the impact of gender information in speaker recognition also point out that gender-dependent impostor banks lead to higher accuracies. Finally, the evaluation on the NIST SRE 2010 dataset demonstrates the usefulness of the proposed approach for speaker recognition.

• 대한공간정보학회지
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• 제22권4호
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• pp.47-52
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• 2014

종분포모형은 생물다양성 평가, 보호지역 지정, 서식지 관리 및 복원, 기후변화 예측 등의 다양한 분야에 활용되고 있으나 공공이나 정책분야에서는 모형의 불확실성으로 인하여 활용이 제한적이었다. 최근에는 이러한 모형의 불확실성을 저감하기 위하여 앙상블이나 합의모형 등의 다중모형을 적용하는 연구가 증가하고 있다. 이에 본 연구에서는 히어리를 대상으로 단일모형과 앙상블(다중) 모형을 적용하고 이를 비교하는 연구를 수행하였다. 모형은 AUC와 kappa, TSS를 이용하여 적합도를 평가하였으며, 이 중 모형 간의 비교가 용이하고 이항형 지도로 바로 변환할 수 있는 TSS가 효과적이었다. 단일모형과 앙상블 모형 모두 높은 모형적합도를 나타내었으며, 다중 모형 중에서는 RF, Maxent, GBM이 높게, GAM, SRE는 비교적 낮게 평가되었다. 예측지도에서는 단일모형에 비해 다중모형의 예측범위가 과대 추정되는 경향이 있었다. 이는 여러 모형이 중첩된 결과로 현장전문가와 모형전문가들 간의 협력연구를 통하여 적절한 모형 선택과 가중치 부여 등을 통하여 문제를 해결할 수 있다. 앙상블모형을 공간의사결정이나 보호지역계획에 활용하기 위해서는 불확실성의 정도와 원인을 파악하고, 이를 저감하려는 개선작업과 함께 결과의 불확실성이나 위험성을 인지하고 의사결정을 해야 한다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권5호
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• pp.3357-3362
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• 2013

The human skeleton is the most common organ to be affected by metastatic cancer and bone metastases are a major cause of cancer morbidity. The five most frequent cancers in Malaysia among males includes prostate whereas breast cancer is among those in females, both being associated with skeletal lesions. Bone metastases weaken bone structure, causing a range of symptoms and complications thus developing skeletal-related events (SRE). Patients with SRE may require palliative radiotherapy or surgery to bone for pain, having hypercalcaemia, pathologic fractures, and spinal cord compression. These complications contribute to a decline in patient healthrelated quality of life. The multidimensional assessment of health-related quality of life for those patients is important other than considering a beneficial treatment impact on patient survival, since the side effects of treatment and disease symptoms can significantly impact health-related quality of life. Cancer treatment could contribute to significant financial implications for the healthcare system. Therefore, it is essential to assess the health-related quality of life and treatment cost, among prostate and breast cancer patients in countries like Malaysia to rationalized cost-effective way for budget allocation or utilization of health care resources, hence helping in providing more personalized treatment for cancer patients.

• BMB Reports
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• 제43권3호
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• pp.193-198
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• 2010

In this study, we report the identification and characterization of a novel C2H2 zinc finger protein, ZNF552, from a human embryonic heart cDNA library. ZNF552 is composed of three exons and two introns and maps to chromosome 19q13.43. The cDNA of ZNF552 is 2.3 kb, encoding 407 amino acids with an amino-terminal KRAB domain and seven carboxyl-terminal C2H2 zinc finger motifs in the nucleus and cytoplasm. Northern blotting analysis indicated that a 2.3 kb transcript specific for ZNF552 was expressed in liver, lung, spleen, testis and kidney, especially with a higher level in the lung and testis in human adult tissues. Reporter gene assays showed that ZNF552 was a transcriptional repressor, and overexpression of ZNF552 in the COS-7 cells inhibited the transcriptional activities of AP-1 and SRE, which could be relieved through RNAi analysis. Deletion studies showed that the KRAB domain of ZNF552 may be involved in this inhibition.

• 동의신경정신과학회지
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• 제23권4호
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• pp.133-152
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• 2012

Objectives : The purpose of this study is to investigate the effect of Sihogayonggolmoryeo-tang on the anxiety of Hwa-byung. Methods : In this randomized, double blinded, placebo-controlled study, we planned to give Sihogayonggolmoryeo-tang or controlled medication for anxiety of Hwa-byung. Hamilton Anxiety Scale (HAM-A) was measured as the 1st evaluative instrument, and Korean State-Trait Anxiety Inventory (STAI-K), Likert scale for major symptom of Hwa-byung, Hwa-Byung Scale Score, Korean Beck's Depression Inventory (BDI-K), Korean State-Trait Anger Expression Inventory (STAXI-K), Insomnia severity Index (ISI), Instrument of Oriental Medical Evaluation for Hwa-Byung, WHO Quality of Life Avvreviated (WHOQOL-BREF), genral self-Efficacy Scale (GSES), Rosenberg Self-Esteem Inventory (SRE) and Heart Rate Variability (HRV) were also measured as the 2nd evaluative instrument before treatment. Results : Clinical characteristics-vital signs and demographic characteristics showed no significant difference between both groups. The characteristics of disease-chief complaint, pattern Identification, period, etiological factor, and etc, also showed similarity of distribution in both groups. The results of Chest PA, EKG and clinicopathologic examination showed no significant difference between both groups. There were no significant difference between both groups in all valuation scales; HAM-A was measured as the first evaluative instrument, and STAI-K, Likert scale for major symptom of Hwa-byung, Hwa-Byung Scale Score, BDI-K, STAXI-K, ISI, Instrument of Oriental Medical Evaluation for Hwa-Byung, WHOQOL-BREF, GSES, SRE and HRV. Conclusions : We considered that establishment of the experimental group and controlled group was objective and worth conducting this research. In addition, this methodology is expected to be applied to the subsequent research. Further, we hope to make up for this study through various study and discussion.