• Journal of the Institute of Electronics Engineers of Korea SD
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• v.46 no.10
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• pp.9-15
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• 2009

In this paper, we invented a new structure of fast ATC(Automatic Threshold Control) circuit. Using the structure we made a new burst-mode limiting amplifier with fast ATC function using commercial $0.8{\mu}m$ BiCMOS technology. It's ATC function worked so fast that even the first bit of burst-data could be detected, which confirmed that the new structure was useful for fast ATC. However, in the beginning of a burst, distortions in duty-cycle occurred and increased up to 59% of duty-cycle as amplitude of input signal increased. But we confirmed that after 10 cycles passed, duty-cycles was staying below 52% of duty-cycle for any magnitude of input signal.

• The Korean Journal of Physiology and Pharmacology
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• v.14 no.5
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• pp.299-304
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• 2010

Losartan is a selective angiotensin II (Ang II) type 1 ($AT_1$) receptor antagonist which inhibits vascular smooth muscle cells (VSMCs) contraction and proliferation. We hypothesized that losartan may prevent cell proliferation by activating AMP-activated protein kinase (AMPK) in VSMCs. VSMCs were treated with various concentrations of losartan. AMPK activation was measured by Western blot analysis and cell proliferation was measured by MTT assay and flowcytometry. Losartan dose- and time-dependently increased the phosphorylation of AMPK and its downstream target, acetyl-CoA carboxylase (ACC) in VSMCs. Losartan also significantly decreased the Ang II- or 15% FBS-induced VSMC proliferation by inhibiting the expression of cell cycle associated proteins, such as p-Rb, cyclin D, and cyclin E. Compound C, a specific inhibitor of AMPK, or AMPK siRNA blocked the losartan-induced inhibition of cell proliferation and the $G_0/G_1$ cell cycle arrest. These data suggest that losartan-induced AMPK activation might attenuate Ang II-induced VSMC proliferation through the inhibition of cell cycle progression.

• Journal of the Korean Ceramic Society
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• v.50 no.6
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• pp.390-395
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• 2013

Nanocrystalline CrN films were deposited on Si (100) substrates by means of asymmetric pulsed DC reactive magnetron sputtering. We investigated the growth behavior, corrosion resistance and mechanical properties of CrN films with a change in the duty cycle and pulse frequency. The grain size of the CrN films decreased from 25.4 nm to 11.2 nm upon a decrease in the duty cycle. The corrosion potentials for the CrN films by DC sputtering was approximately - 0.6 V, and it increased to - 0.3 V in the CrN films which underwent pulsed sputtering. The nanoindentation hardness of the CrN films also increased with a decrease in the duty cycle. This enhancement of the corrosion resistance and mechanical properties of pulsed sputtered CrN films could be attributed to the densification and surface smoothness of the microstructure of the films.

• The Korean Journal of Physiology and Pharmacology
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• v.20 no.5
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• pp.487-498
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• 2016

Leptin, an adipokine predominantly produced from adipose tissue, is well known to induce tumor growth. However, underlying molecular mechanisms are not established yet. While p53 has long been well recognized as a potent tumor suppressor gene, accumulating evidence has also indicated its potential role in growth and survival of cancer cells depending on experimental environments. In the present study, we examined if p53 signaling is implicated in leptin-induced growth of cancer cells. Herein, we demonstrated that leptin treatment significantly increased p53 protein expression in both hepatic (HepG2) and breast (MCF-7) cancer cells without significant effect on mRNA expression. Enhanced p53 expression by leptin was mediated via modulation of ubiquitination, in particular ubiquitin specific protease 2 (USP2)-dependent manner. Furthermore, gene silencing of p53 by small interfering RNA (siRNA) suppressed leptin-induced growth of hepatic and breast cancer cells, indicating the role of p53 signaling in tumor growth by leptin. In addition, we also showed that knockdown of p53 restored suppression of caspase-3 activity by leptin through modulating Bax expression and prevented leptin-induced cell cycle progression, implying the involvement of p53 signaling in the regulation of both apoptosis and cell cycle progression in cancer cells treated with leptin. Taken together, the results in the present study demonstrated the potential role of p53 signaling in leptin-induced tumor growth.

• Journal of the Korean Society of Propulsion Engineers
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• v.26 no.6
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• pp.10-20
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• 2022

The present study developed a design code for preburner of staged combustion cycle engines, which calculates preburnt gas at high-pressure oxidizer-rich conditions and predicts conjugate heat transfer and hydraulics of cryogenic fluid flow through cooling passages. It has been written based on the open-source library Cantera, into which this study has incorporated new source codes to predict correctly non-ideal thermodynamics and transport anomalies of the cryogenic fluid. For a preburner of 100 tonf-class booster engine currently under preliminary design, the present code demonstrated predictive capability and usability as a design code by comparing with CFD simulation.

• Proceedings of the KSME Conference
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• 2007.05b
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• pp.3236-3240
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• 2007

This paper describes the results of steam turbine performance tests. The objectives of performance test is to exactly evaluate the degradation(decrease in performance) of the coal-fired steam turbine generator in order to provide plant information to help performance engineers identify problems, improve performance, and make economic decisions about scheduling maintenance and optimizing operation. To achieve these goals, the periodic thermal performance tests have been carried out since the initial operation period, 1997. We made the calculation program and guidelines for the tests and developed the performance index of the turbine cycle on the basis of the ASME PTC. By comparing the performance changes throughout the whole operation period, we confirmed the performance reliabilities of the turbine and its conditions.

• Transactions of the Korean Society of Automotive Engineers
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• v.6 no.5
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• pp.37-44
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• 1998

Lean burn combustion is an important concept for improving the fuel consumption and exhaust emissions. However, the lean burning is associated with increased cycle-to-cycle combustion variations due to the ignition instabilities and redu- ced flame propagation rates. Engine stability under lean mixture conditions could be improved by increasing flame speed through enhanced flow characteristics and by securing ignitability with improvement of ignition systems. The effects of flow motion and ignition characteristics on the combustion performances were investigated in a 4-valve SI engine. Flow motions of tumble-swirl were varied with a swirl control valve attached at the inlet ports, while ignition energy and its distribution were controlled in a high -frequency ignition system by changing spark duration and spark frequency. The improvement of lean burn performance by the optimum flow motion and ignition characteristics is discussed.

• Transactions of the Korean Society of Automotive Engineers
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• v.8 no.6
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• pp.1-8
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• 2000

A new method of knock detection in SI engines, using a change of ion concentration in the combustion chamber, was developed. In order to measure in-cylinder ionization current, ionization probes were installed at spark plug and cylinder head of production engine. It was found that the electric current generated by ionized gas in core burned gas region of knocking cycle is between 2 and 10 times larger than that of normal cycle, because the burned gas temperature which is the dominant parameter of a change of ion concentration increases. However, a change of ionization current in boundary region of burned gas is relatively weak. Hence a change of ion concentration in core burned gas region can be used for knock detection.

• Journal of the korean Society of Automotive Engineers
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• v.5 no.1
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• pp.79-88
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• 1983

A prediction of emission concentrations was made by calculating chemical equilibrium on the basis of an indicated pressure diagram in spark ignition engine using methanol as a fuel. A prediction according to Otto cycle was also made and for carbon dioxide, carbon monoxide and nitric oxide, emission test was performed using a conventional SI engine that was modified a little considering fuel characteristics. An investigation was made for those three cases-results from an indicated pressure diagram, Otto cycle and emission test. A good agreement between the measured values and the predicted ones existed for carbon dioxide and carbon monoxide, but not for nitric oxide. And good results existed for the other emission concentrations.

• Proceedings of the Korea Concrete Institute Conference
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• 2006.05b
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• pp.281-284
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• 2006

The marine Transmission tower infrastructure erected in the SI-HWA lake is deteriorated and damaged by the various environment effect, and then, there is a possibility of going bad in the safety. The appropriate maintenance to ensure the security of the structure during life cycle is necessary. Specially the Jacket or the steel file foundation in the sea is apt to be corroded quickly. In this research, to establish life management system of 345kV Yonghung marine transmission tower structure, the actual durability research facility which can obtain the actual proof data is constructed. the maintenance guideline and procedure of the structure are established. Hereafter, there is a plan which will advance the research against the composition of the life prediction model, which is based on the data acquired from the actual durability research facility.