• Kyungpook Mathematical Journal
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• v.60 no.1
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• pp.145-161
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• 2020

In this article, we study the solvability of the Cauchy-Dirichlet problem for a class of nonlinear parabolic equations with nonstandard growth and nonlocal terms. We prove the existence of weak solutions of the considered problem under more general conditions. In addition, we investigate the behavior of the solution when the problem is homogeneous.

• Biomolecules & Therapeutics
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• v.29 no.4
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• pp.392-398
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• 2021

In this study, we determined the effect of 24 different synthetic 4-benzylpiperidine carboxamides on the reuptake of serotonin, norepinephrine, and dopamine (DA), and characterized their structure-activity relationship. The compounds with a two-carbon linker inhibited DA reuptake with much higher potency than those with a three-carbon linker. Among the aromatic ring substituents, biphenyl and diphenyl groups played a critical role in determining the selectivity of the 4-benzylpiperidine carboxamides toward the serotonin transporter (SERT) and dopamine transporter (DAT), respectively. Compounds with a 2-naphthyl ring were found to exhibit a higher degree of inhibition on the norepinephrine transporter (NET) and SERT than those with a 1-naphthyl ring. A docking simulation using a triple reuptake inhibitor 8k and a serotonin/norepinephrine reuptake inhibitor 7j showed that the regions spanning transmembrane domain (TM)1, TM3, and TM6 form the ligand binding pocket. The compound 8k bound tightly to the binding pocket of all three monoamine reuptake transporters; however, 7j showed poor docking with DAT. Co-expression of DAT with the dopamine D₂ receptor (D₂R) significantly inhibited DA-induced endocytosis of D₂R probably by reuptaking DA into the cells. Pretreatment of the cells with 8f, which is one of the compounds with good inhibitory activity on DAT, blocked DAT-induced inhibition of D₂R endocytosis. In summary, this study identified critical structural features contributing to the selectivity of a molecule for each of the monoamine transporters, critical residues on the compounds that bound to the transporters, and the functional role of a DA reuptake inhibitor in regulating D₂R function.

• Annual Conference on Human and Language Technology
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• 2022.10a
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• pp.360-365
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• 2022

문장 표현(sentence representation)은 자연어처리 분야 내의 다양한 문제 해결 및 응용 개발에 있어 유용하게 활용될 수 있는 주요한 도구 중 하나이다. 하지만 최근 널리 도입되고 있는 사전 학습 언어 모델(pre-trained language model)로부터 도출한 문장 표현은 이방성(anisotropy)이 뚜렷한 등 그 고유의 특성으로 인해 문장 유사도(Semantic Textual Similarity; STS) 측정과 같은 태스크에서 기대 이하의 성능을 보이는 것으로 알려져 있다. 이러한 문제를 해결하기 위해 대조 학습(contrastive learning)을 사전 학습 언어 모델에 적용하는 연구가 문헌에서 활발히 진행되어 왔으며, 그중에서도 레이블이 없는 데이터를 활용하는 비지도 대조 학습 방법이 주목을 받고 있다. 하지만 대다수의 기존 연구들은 주로 영어 문장 표현 개선에 집중하였으며, 이에 대응되는 한국어 문장 표현에 관한 연구는 상대적으로 부족한 실정이다. 이에 본 논문에서는 대표적인 비지도 대조 학습 방법(ConSERT, SimCSE)을 다양한 한국어 사전 학습 언어 모델(KoBERT, KR-BERT, KLUE-BERT)에 적용하여 문장 유사도 태스크(KorSTS, KLUE-STS)에 대해 평가하였다. 그 결과, 한국어의 경우에도 일반적으로 영어의 경우와 유사한 경향성을 보이는 것을 확인하였으며, 이에 더하여 다음과 같은 새로운 사실을 관측하였다. 첫째, 사용한 비지도 대조 학습 방법 모두에서 KLUE-BERT가 KoBERT, KR-BERT보다 더 안정적이고 나은 성능을 보였다. 둘째, ConSERT에서 소개하는 여러 데이터 증강 방법 중 token shuffling 방법이 전반적으로 높은 성능을 보였다. 셋째, 두 가지 비지도 대조 학습 방법 모두 검증 데이터로 활용한 KLUE-STS 학습 데이터에 대해 성능이 과적합되는 현상을 발견하였다. 결론적으로, 본 연구에서는 한국어 문장 표현 또한 영어의 경우와 마찬가지로 비지도 대조 학습의 적용을 통해 그 성능을 개선할 수 있음을 검증하였으며, 이와 같은 결과가 향후 한국어 문장 표현 연구 발전에 초석이 되기를 기대한다.

• Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
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• 2002.10b
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• pp.325-329
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• 2002

This study targets mainly to reduce the manufacturing costs of cam spindles and manufacturing of mechanical components with longer service durations through application of surface engineering techniques on cam spindles. Within the frame of this study, we have attempted to establish the performances of cam spindles manufacture from forged steel and SGCI, through performance of wear tests in plate-disk system, metalographic investigations, SEM imaging, EDS analyses and micro hardness scans on test samples having the same sizes with original cam that once obtained from casting of Spherical Graphite Cast Iron (SGCI) are subjected partially to Boronising and partially to hardening in a salt solution and cam spindles currently manufactured from CK 45 through cauterization based reshaping.

• Bulletin of the Korean Chemical Society
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• v.33 no.8
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• pp.2597-2602
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• 2012

Novel 1,4-substituted piperazine derivatives 5, Series A and B were designed by fragment analysis and molecular modification of 4 selected piperazine-containing compounds which possess antidepressant activity. We synthesized new 39 analogues of Series A and 10 compounds of Series B, respectively. The antidepressant screening against DA, NE, and serotonin neurotransmitter uptake inhibition was carried out using the Neurotransmitter Transporter Uptake Assay Kit. The compounds in Series B showed relatively higher reuptake inhibitory activity for SERT, NET, and DAT than those in Series A. The length of spacer between the central piperazine core and the terminal phenyl ring substituted at the piperazine ring in Series B seems to exert an important role in the activity.

• Journal of the Korean Mathematical Society
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• v.55 no.6
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• pp.1337-1358
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• 2018

In this paper, we study the solvability of the nonlinear Dirichlet problem with sum of the operators of independent non standard growths $$-div\({\mid}{\nabla}u{\mid}^{p_1(x)-2}{\nabla}u\)-\sum\limits^n_{i=1}D_i\({\mid}u{\mid}^{p_0(x)-2}D_iu\)+c(x,u)=h(x),\;{\in}{\Omega}$$ in a bounded domain ${\Omega}{\subset}{\mathbb{R}}^n$. Here, one of the operators in the sum is monotone and the other is weakly compact. We obtain sufficient conditions and show the existence of weak solutions of the considered problem by using monotonicity and compactness methods together.

• Safety and Health at Work
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• v.14 no.1
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• pp.78-84
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• 2023

Background: Since the advent of the COVID-19 pandemic, physicians have been the unsung heroes of the pandemic. However, many are about to give up the battlefield. This study investigated the effect of occupational moral injury on physicians' career abandonment intention, taking into account the possible mediating role of emotional exhaustion. Methods: Cross-sectional data collected from 201 physicians were analyzed using the partial least squares structural equation modeling (PLS-SEM) with SmartPLS to determine the relationship among physicians' moral injuries, emotional exhaustion, and career abandonment intention. Results: The results indicated that occupational moral injury was positively related to emotional exhaustion and career abandonment intention. In addition, emotional exhaustion was found to play a mediating role in the relationship. Conclusion: To reduce physicians' intention to leave their career, physicians should be prepared for moral injury and psychological issues by offering psychological support and meeting their needs early at both the individual and organizational levels during and after the pandemic.

• Journal of the Korean Mathematical Society
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• v.60 no.3
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• pp.565-586
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• 2023

We study the Dirichlet problem for the degenerate nonlocal parabolic equation u_t - a(||∇u||²_L²(Ω))∆u = C_b ||u||^β_L²(Ω) |u|^q(x,t)-2 u log |u| + f in Q_T, where Q_T := Ω × (0, T), T > 0, Ω ⊂ ℝ^N, N ≥ 2, is a bounded domain with a sufficiently smooth boundary, q(x, t) is a measurable function in Q_T with values in an interval [q^-, q⁺] ⊂ (1, ∞) and the diffusion coefficient a(·) is a continuous function defined on ℝ₊. It is assumed that a(s) → 0 or a(s) → ∞ as s → 0⁺, therefore the equation degenerates or becomes singular as ||∇u(t)||2 → 0. For both cases, we show that under appropriate conditions on a, β, q, f the problem has a global in time strong solution which possesses the following global regularity property: ∆u ∈ L²(Q_T) and a(||∇u||²_L²(Ω))∆u ∈ L²(Q_T ).

• Steel and Composite Structures
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• v.44 no.6
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• pp.769-788
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• 2022

In this paper a mathematical model for the prediction of the fire resistance of slim-floor steel beams based on an Artificial Neural Network modeling procedure is presented. The artificial neural network models are trained and tested using an analytical database compiled for this purpose from analytical results based on FEM. The proposed model was selected as the optimum from a plethora of alternatives, employing different activation functions in the context of Artificial Neural Network technique. The performance of the developed model was compared against analytical results, employing several performance indices. It was found that the proposed model achieves remarkably improved predictions of the fire resistance of slim-floor steel beams. Moreover, based on the optimum developed AN model a closed-form equation for the estimation of fire resistance is derived, which can prove a useful tool for researchers and engineers, while at the same time can effectively support the teaching of this subject at an academic level.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.3
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• pp.1307-1312
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• 2014

Background: The objective of this study was to examine the effect of self-concept levels and perceived academic achievements of sixth, seventh and eighth grade primary school students upon their perceptions about smoking. Method: The data were collected with the Socio-Demographic Data Collection Form, Pier-Herris Self-Concept scale and Children's Decision Balance Scale. The study sample consisted of 374 students receiving education in the sixth, seventh and eighth grades of three primary schools, which were selected among primary schools of Izmir Provincial Directorate for National Education representing three socio-economic groups with a simple random sampling method. The data were collected in December 2012-January 2013. Percentages and the t test were used in the evaluation of the data. Results: While students with a positive self-concept had score averages of $7.12{\pm}2.18$ regarding the lower dimension of smoking pros and $29.0{\pm}2.47$ regarding the lower dimension of smoking cons, their counterparts with a negative self-concept had score averages of $8.61{\pm}3.76$ (p=0.000) and $28.1{\pm}3.49$ (p=0.004), respectively. According to self-perception, there was statistical difference between perceptions of students regarding smoking (p<0.01). While students perceiving themselves successful had score averages of $7.81{\pm}3.13$ and $28.5{\pm}3.19$ regarding the lower dimension of smoking benefit and harm, students perceiving themselves unsuccessful had score averages of $8.27{\pm}3.39$ (p=0.333) and $29.01{\pm}2.05$ (p=0.235), with no difference determined. Conclusion: Students with a positive self-perception had a low perception of smoking pros and a high perception of smoking cons. Perception of academic achievement did not affect the pros and cons perceptions of children regarding smoking.