• Journal of Korean Academy of Oral and Maxillofacial Radiology
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• v.24 no.2
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• pp.461-466
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• 1994

신경초종은 신경초에서 발생되는 성장이 느린 양성 종양으로 단발성이며 드물다. 이 종양은 말초 신경,자율 신경,뇌신경의 Schwann세포에서 발생된다. 두경부 영역의 두개외 신경성 종양은 드물며 특히 타액선에서 발생되는 예는 드물다. 저자들은 20세 여자 환자에서 아래와 같은 소견을 나타내는 신경초종을 경험하였기에 보고하는 바이다. 1.주소는 좌측 악하선 부위의 종창이었으며 촉진시 3×4㎝의 단단한 종괴가 만져졌으나 동통이나 림프절병증은 없었다. 2. 일반방사선사진에서 종괴와 관련된 골변화는 없었으나 초음파 영상에서는 불균질한 반사 양상을 보이는 종괴가 좌측 악하선 영역에서 관찰되었다. 3. 자기공명영상으로 병소의 정확한 위치를 확인할 수 있었다. 병소의 경계는 명확하였으나 신호 강도는 균일하지 않았으며 T1 강조 영상에서는 근육과 유사한 신호 강도를 보였으나 T2 강조 영상에서는 근육보다 높은 신호 강도를 나타냈다. 4. 조직 병리학적으로 Antoni type B 부위보다는 A 부위가 지배적이었으며 Verocay body도 나타났다. 종양 세포는 anti-S-100 염색에 양성으로 반응하였다.

• Korean Journal of Head & Neck Oncology
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• v.25 no.2
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• pp.143-145
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• 2009

신경초종은 전신의 말이집신경 중 어디에서나 발생할 수 있는 말초신경집 양성종양이다. 이 종양이 비강에서 발생하는 것은 흔하지 않다. 저자들은 뇌경색으로 입원하고 있던 55세 여자환자에서 다량의 비출혈을 동반한 비강 신경집종 1예를 보고하는 바이다. 부비강 컴퓨터단층촬영사진상 좌측비강과 비인두를 채우는 비균질한 저음영의 거대 종양이 관찰되었고 뼈의 재형성 역시 관찰되었다. 내시경 생검을 시행하였다. 병리검사상, 난원형의 경계가 좋은 병변이 편평상피로 화생된 비강 점막 아래에서 관찰되었고, 종양은 물결모양의 핵을 가진 방추세포로 이루어져 있었고, 방추형의 핵들이 밀집하게 모여있는 Antoni A 부분과 세포의 수가 적으며 허술하게 뭉쳐있는 Antoni B 부분으로 이루어져 있었으며 S-100 단백질 면역염색에 양성이었다. 비강의 신경초종으로 진단하였다. 따라서, 흔하지 않게 접하게 되는 비강 신경초종의 임상양상, 감별진단, 및 치료에 대해 알아보고자 한다.

• The Research Journal of the Costume Culture
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• v.13 no.4 s.57
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• pp.576-588
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• 2005

The effect of chitosan pretreatment on the dyeing of cotton fiber and silk fiber was investigated. However, it has been difficult to evaluate the effect of the chitosan precisely, since the characterization of the molecular weight and effect of the degree of deacetylation were not elucidated for the application. The treatment effect may change diversely since the chitosan solution viscosity differs a lot based on the chitosan molecular weight. In this study, three chitosan specimens, varying in molecular weight, were applied for the fabric pretreatment in order to investigate the effect of chitosan molecular weight. Also, in order to maximize the efficacy of the chitosan, highly deacetylated chitosan specimens, meeting the deacetylation degree of $100\%$, were selected far the application. The air-permeability change according to the chitosan molecular weight change, influence on the mordanting, color change, and wash fastness change were investigated.

• Journal of Fashion Business
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• v.23 no.3
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• pp.23-34
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• 2019

The aim of this study is to explore the possibility utilizing Rhododedron brachycarpum as a new natural dye resource. It was dyed in silk fabric according to different dyeing conditions such as dye concentration, dye bath temperature, dyeing time and dye bath pH. The effect of the mordanting conditions were estimated as dyeability and color changes. Additionally, the colorfastness, antibacterial property, ultraviolet protection properties of the dyed and mordanted silk fabrics were examined. The water-soluble dye of Rhododedron brachycarpum extracted with distilled water was expressed as Yellow Red color. The dye-abilities of silk generally increased depending on the increasing values of dye concentration, dye bath temperature and dyeing duration. The highest K/S values were obtained at a dye concentration of 100% (v/v), a dye bath temperature of $90^{\circ}C$, a dyeing duration 120 minutes and a dyeing of pH 2. The light fastness of dyed and Cu mordanted silk fabrics were found to be 4 grade while Al, Fe mordanted silk fabrics were found to be 2~3 grade. The dry cleaning and rubbing fastness were excellent or good. The fade of washing fastness was not good, however, the stain of washing fastness was excellent. The dyed and Al, Cu mordanted silk fabrics indicated 99.9% reduction rate. The dyed and the mordanted fabrics showed very good ultraviolet protection factors.

• Radiation Oncology Journal
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• v.17 no.1
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• pp.1-8
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• 1999

Purpose : Experimental studies have implicated the wild type p53 In cellular response to radiation. Whether altered p53 function can lead to changes in clinical radiocurability remains an area of ongoing study. This study was performed to investigate whether any correlation between change of p53 and outcome of curative radiation therapy in patients with head and neck cancels. Methods : Immunohistochemical analysis with a mouse monoclonal antibody (DO-7) specific for human p53 was used to detect to overexpression of protein in formalin fixed, paraffin-embedded tumor sample from 55 head and neck cancer patients treated with curative radiation therapy (median dose of 7020 cGy) from February 1988 to March 1996 at 51. Mary's Hospital. Overexpression of p53 was correlated with locoregional control and survival using Kaplan-Meier method. A Cox regression multi-variate analysis was peformed that included all clinical variables and status of p53 expression. Results : Thirty-seven (67.2$\%$) patients showed overexpression of p53 by immunohistochemical staining in their tumor. One hundred percent of oral cavity, 70$\%$ of laryngeal, 66.7$\%$ of oropharyngeal, 66.7$\%$ of hypopharyngeal cancer showed p53 overexpression (P=0.05). The status of p53 had significant relationship with stage of disease (P=0.03) and history of smoking (P=0.001). The overexpression of p53 was not predictive of response rate to radiation therapy. The locoregional control was not significantly affected by p53 status. Overexpression of p53 didn't have any prognostic implication for disease free survival and overall survival. Primary site and stage of disease were significant prognostic factors for survival. Conclusions : The p53 overexpression as detected by immunohistochemical staining had significant correlation with stage, primary site of disease and smoking habit of patients. The p53 overexpression didn't have any predictive value for outcome of curative radiation therapy in a group of head and neck cancers.

• Restorative Dentistry and Endodontics
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• v.34 no.5
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• pp.415-423
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• 2009

The purpose of this study is to investigate the response of human pulp cell on Portland cement mixed with $\beta$-glycerophosphate. To investigate the effect of $\beta$-glycerophosphate and/or dexamethasone on human pulp cell, ALP activity on various concentration of $\beta$-glycerophosphate and dexamethasone was measured and mineral nodule of human pulp cell was stained with Alizarin red S. MTS assay and ALP activity of human pulp cell on Portland cement mixed with various concentration of $\beta$-glycerophosphate (10 mM, 100mM, 1M) was measured and the specimens were examined under SEM. Addition of $\beta$-glycerophosphate or dexamethasone alone had no effect however, the addition of 5 mM $\beta$-glycerophosphate and 100 nM dexamethasone had the largest increasement in ALP activity. There was no toxicity in all samples and the data showed that Portland cement mixed with 10 mM $\beta$-glycerophosphate had more increase in ALP activity compared with control. In conclusion, Portland cement mixed with $\beta$-glycerophosphate has no toxicity and promotes differentiation and mineralization of pulp cell compared with additive-free Portland cement. This implicated that application of Portland cement mixed with $\beta$-glycerophosphate might form more reparative dentin and in turn it would bring direct pulp capping to success.

• Journal of Yeungnam Medical Science
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• v.10 no.1
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• pp.212-217
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• 1993

Since discovery of X-rays, radiotherapy has evolved into one of the most scientific branches of medicine and has established its role as the primary line or the secondary line of attack, after surgery, in the treatment of malignant cancers. Nowadays its importance is illustrated by the fact that as many as 70 per cent of all pastients with cancer will receive radiation therapy at sometime during their disease process. Biologic effects of X-rays began to be apparant soon after the discovery by Roentgen in 1895. In clinical radiotherapy, the biologic endpoint of most importance is loss of cellular reproductive ability or clonogenicity. One of the commonest ways to assess cell survival is to use an in vitro plating assay. We analyzed radiation effect on colony formation of HaLa.S3(SC) cell line and obtained results are as follows: The plating efficiency is 0.464. The shape of cell survival curve is similar to multi-target plus single hit component model. Estimated values of Do, Dq, and extrapolation number are 150 cGy, 80 cGy and 1.7 respectively. We reported these experimental data with review of literature.

• Journal of Food Hygiene and Safety
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• v.16 no.2
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• pp.117-124
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• 2001

The main constituent of green tea, catechins have been reported to have numberous biological anti-vites including antimutagenic, antibacterial, hypocholesterolemic, antioxidant and antitumor properties. In the present study, we examined the protective effect of catechin on UVB-induced skin damage. Catechin (3 mg/mouse) was topically treated to dorsal area of SHK-1 hairless mouse daily for 2 weeks. UVB (100 mJ/$\textrm{cm}^2$) was also treated soon after application of catechin alone or with catechin for 2 weeks. Catechin reduced UVB-induced infiltration of inflammatory cells, fibrosis of cells and collagen-fiber formation. In addition, catechin also prevented UVB-induced DNA fragmentation and apoptosis cell number, but not changed p53 level. Furthermore catechin inhibited UVB-induced cell proliferation. There results showed that catechin have preventive effect aganinst UVB-induced skin damages. and these effects could contribute to the antitumor promoters activity.

• Journal of the Korean Society for Marine Environment & Energy
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• v.9 no.3
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• pp.160-167
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• 2006

Harpacticoid copepod Tigriopus japonicus is widely distributed in coastal waters of Korea and plays important role in marine trophic structure as a first consumer. In this study, a series of experiment were conducted to test the potential of the species as a standard test species for marine bioassay. Tolerance on salinity and pH, sensitivity on the reference materials(copper sulfate and cadmium chloride) and response on the ocean dumping materials(waste sludge) we re tested to identify if the species satisfy the basic criteria as standard species for marine bioassay. The nauplius of the species($100{\sim}200{\mu}m$) showed wide tolerance on salinity with >90.0% survival rates exposed to $5.0{\sim}35.0psu$ for 48 h. Wide adaptability on pH's were also observed from 6.3 to 8.2 with >90.0% survival rates during the test. $LC_{50}$ values for copper sulfate and cadmium chloride were $3.6{\pm}0.7ppm,\;1.7{\pm}0.8ppm$, respectively. The variations in mortality between replicates were less than 10.0%. Comparison of $LC_{50}$ values indicated that T. japonicus nauplius was lower sensitive to copper sulfate than the most marine crustaceans included copepods, however, the sensitivity of test animal to cadmium chloride higher than the adults of copepod T. japonicus, Paracalanus parvus, and marine rotifer Brachinonus plicatilis. There were significant concentration-response relationship in the mortality of T. japonicus nauplius using the elutriates of three ocean dumping materials(industrial waste sludge). 48 h $LC_{50}$ values we re $31.1{\pm}1.1%$ for the elutriate of sludge from leather processing company and $54.4{\pm}15.1%$ for that of dye production company. Based on the above experimental results, bioassay using benthic harpacticoid T. japonicus nauplius must be a good estimation tool for marine ecotoxicological assessment of waste or chemicals. Wide tolerance on the salinity and pH, and significant linear relationship between concentration and response(mortality) supported the high potential of the species as a standard test species.

• Journal of Life Science
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• v.33 no.10
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• pp.797-807
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• 2023

To improve the functionality of mulberry, samples were fermented with Lactobacillus plantarum JCM 1149 (LP) or Pichia kudriavzevii Atz-EN-01 (PK), and their antioxidant and anti-obesity activities were compared to those of unfermented mulberry. After fermenting for 60 hr, the total polyphenol and flavonoid content of the PK-fermented mulberry (PKFM) and LP-fermented mulberry (LPFM) was 1.5-fold and 2-fold higher, respectively, while the total anthocyanin content was 1.3-fold and 1.5-fold higher in the PKFM and LPFM, respectively. DPPH radical scavenging activity was found to be 16.3% higher (86% vs. 100%) after PK fermentation and 8.1% higher (86% vs. 93%) after LP fermentation. The lipase inhibitory activity of the LPFM and PKFM was 62.9% and 52.5%, respectively. 3T3-L1 preadipocytes were treated with unfermented mulberry, LPFM, or PKFM at 200, 400, or 800 ㎍/ml and stained with oil-red-O. A slight difference in the staining was observed in samples treated with 400 ㎍/ml. However, treatment with 800 ㎍/ml significantly reduced staining compared to the control, and the LPFM exhibited relatively higher adipogenesis inhibitory activity than the PKFM. Blood triglyceride content increased by 9.5% in the high-fat diet group, but decreased by 17.1% in the control group, 37.1% in the LPFM group, and 41.6% in the PKFM group. The blood triglyceride content of the LPFM group decreased by 43.1% and 21.4% compared to the high-fat diet group and the control group, respectively, and that of the PKFM group decreased by 48.6% and 28.9% compared to the same groups. In conclusion, the results indicate that fermented mulberry has increased antioxidant activity, lipase inhibitory activity, and adipogenesis inhibition activity, and decreased blood triglyceride content compared to unfermented mulberry.