• Title/Summary/Keyword: Runs

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Genome-wide scan for runs of homozygosity identifies candidate genes in Wannan Black pigs

  • Wu, Xudong;Zhou, Ren;Zhang, Wei;Cao, Bangji;Xia, Jing;Wang, Caiyun;Zhang, Xiaodong;Chu, Mingxing;Yin, Zongjun;Ding, Yueyun
    • Animal Bioscience
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    • v.34 no.12
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    • pp.1895-1902
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    • 2021
  • Objective: Runs of homozygosity (ROH) are contiguous lengths of homozygous genotypes that can reveal inbreeding levels, selection pressure, and mating schemes. In this study, ROHs were evaluated in Wannan Black pigs to assess the inbreeding levels and the genome regions with high ROH frequency. Methods: In a previous study, we obtained 501.52 GB of raw data from resequencing (10×) of the genome and identified 21,316,754 single-nucleotide variants in 20 Wannan Black pig samples. We investigated the number, length, and frequency of ROH using resequencing data to characterize the homozygosity in Wannan Black pigs and identified genomic regions with high ROH frequencies. Results: In this work, 1,813 ROHs (837 ROHs in 100 to 500 kb, 449 ROHs in 500 to 1,000 kb, 527 ROHs in >1,000 kb) were identified in all samples, and the average genomic inbreeding coefficient (FROH) in Wannan Black pigs was 0.5234. Sixty-one regions on chromosomes 2, 3, 7, 8, 13, 15, and 16 harbored ROH islands. In total, 105 genes were identified in 42 ROH islands, among which some genes were related to production traits. Conclusion: This is the first study to identify ROH across the genome of Wannan Black pigs, the Chinese native breed of the Anhui province. Overall, Wannan Black pigs have high levels of inbreeding due to the influence of ancient and recent inbreeding due to the genome. These findings are a reliable resource for future studies and contribute to save and use the germplasm resources of Wannan Black pigs.

Characterisation of runs of homozygosity and inbreeding coefficients in the red-brown Korean native chickens

  • John Kariuki Macharia;Jaewon Kim;Minjun Kim;Eunjin Cho;Jean Pierre Munyaneza;Jun Heon Lee
    • Animal Bioscience
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    • v.37 no.8
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    • pp.1355-1366
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    • 2024
  • Objective: The analysis of runs of homozygosity (ROH) has been applied to assess the level of inbreeding and identify selection signatures in various livestock species. The objectives of this study were to characterize the ROH pattern, estimate the rate of inbreeding, and identify signatures of selection in the red-brown Korean native chickens. Methods: The Illumina 60K single nucleotide polymorphism chip data of 651 chickens was used in the analysis. Runs of homozygosity were analysed using the PLINK v1.9 software. Inbreeding coefficients were estimated using the GCTA software and their correlations were examined. Genomic regions with high levels of ROH were explored to identify selection signatures. Results: A total of 32,176 ROH segments were detected in this study. The majority of the ROH segments were shorter than 4 Mb. The average ROH inbreeding coefficients (FROH) varied with the length of ROH segments. The means of inbreeding coefficients calculated from different methods were also variable. The correlations between different inbreeding coefficients were positive and highly variable (r = 0.18-1). Five ROH islands harbouring important quantitative trait loci were identified. Conclusion: This study assessed the level of inbreeding and patterns of homozygosity in Red-brown native Korean chickens. The results of this study suggest that the level of recent inbreeding is low which indicates substantial progress in the conservation of red-brown Korean native chickens. Additionally, Candidate genomic regions associated with important production traits were detected in homozygous regions.

UPPER BOUNDS FOR SUBPERMANENTS OF NONNEGATIVE MATRICES

  • Cheon, Gi-Sang
    • Communications of the Korean Mathematical Society
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    • v.10 no.1
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    • pp.27-34
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    • 1995
  • For an $n \times n$ matrix $A = [a_{ij}]$, the permanent of A, per A, is defined by $$ per(A) = \sum_{\sigma}{a_{1 \simga(1)} \cdots a_{n \sigma(n)}}, $$ where $\sigma$ runs over all permutations of ${1,\cdots,n}.

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Improvement of Active Homing Performance with Radome Slope Estimation in Spatial Engagements

  • Jin, Shin-Sang;Lyul, Song-Taek
    • 제어로봇시스템학회:학술대회논문집
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    • 2001.10a
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    • pp.64.3-64
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    • 2001
  • In this paper, an estimation scheme with the IMM algorithm to estimate radome slope and target states is used to reduce the radome induced miss distance effectively in spatial active homing engagements of an anti-air missile. The filter algorithm in conjunction with proportional navigation guidance is tested by a series of simulation runs.

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Extrusion Puffing of Pork Meat-Defatted Soy Flour-Corn Starch Blends to Produce Snack-like Products

  • Jennifer J. Jamora;Rhee, Ki-Soon;Rhee, Khee-Choon
    • Preventive Nutrition and Food Science
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    • v.6 no.3
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    • pp.163-169
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    • 2001
  • To produce expanded, minimally hard extrudates from blends of raw pork meat (20%), defatted soy flour (25%), and corn starch using a single-screw extruder, various combinations of feed moisture, process temperature, and screw speed were evaluated. First series of extrusion runs were conducted according to a central composite rotatable design/response surface methodology (RSM). Upon assessing the full model for each response, insignificant terms were eliminated to determine final response surface models. Screw speed within the range evaluated was found to have no significant effect on expansion ratio (ER) or shear force (SF) of extrudates. Since examinations of the response surfaces and their generated grids of predicted values indicated that maximum ER and minimum SF were likely to be attained with a moisture-temperature combination outside the RSM experimental range, the second series of extrusion runs were conducted with several selected combinations of moisture and temperature to determine a practical optimum extrusion condition. The combination of 22.78% feed moisture, 16$0^{\circ}C$ process temperature, and 170 rpm screw speed was chosen as such a condition, and used in the final extrusion. The final product required less force to break than did commercial pretzel sticks.

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강제진동 풍동시험을 통한 비행선의 동안정성 분석

  • Chang, Byeong-Hee;Ok, Ho-Nam;Lee, Yung-Gyo
    • Aerospace Engineering and Technology
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    • v.2 no.2
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    • pp.1-10
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    • 2003
  • An airship is statically unstable, because it has no wing, comparatively small tail and large hull. Hence, an accurate prediction of dynamic stability is critical. In this study, dynamic stability data of the Mid-Size Airship is acquired through forced oscillation wind tests. The test was done in BAR LAMP which is Birhle Applied Research Inc's facility located in Germany. The test was composed with 16 static runs and 26 dynamic runs. As a result, dynamic characteristics of the airship depends on sideslip angle, angular rate and its direction as well as angle of attack. Generally, it is obtained that 3 directional moments have damping, but normal force, side force, and cross-derivatives are unstable. The dynamic derivatives are not sensitive to control surfaces, but have nonlinear dependency on sideslip angle.

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Watershed Scale Drought Assessment using Soil Moisture Index (토양수분지수를 이용한 유역단위 가뭄 평가)

  • Kim, Ok-Kyoung;Choi, Jin-Yong;Jang, Min-Won;Yoo, Seung-Hwan;Nam, Won-Ho;Lee, Joo-Heon;Noh, Jae-Kyoung
    • Journal of The Korean Society of Agricultural Engineers
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    • v.48 no.6
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    • pp.3-13
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    • 2006
  • Although the drought impacts are comparably not catastrophic, the results from the drought are fatal in various social and economical aspects. Different from other natural hazards including floods, drought advances slowly and spreads widely, so that the preparedness is quite important and effective to mitigate the impacts from drought. Soil moisture depletion directly resulted from rainfall shortage is highly related with drought, especially for crops and vegetations, therefore a drought can be evaluated using soil moisture conditions. In this study, SMI (Soil Moisture Index) was developed to measure a drought condition using soil moisture model and frequency analysis for return periods. Runs theory was applied to quantify the soil moisture depletions for the drought condition in terms of severity, magnitude and duration. In 1994, 1995, 2000, and 2001, Korea had experienced several severe droughts, so the SMI developed was applied to evaluate applicability in the mid-range hydrologic unit watershed scale. From the results, SMI demonstrated the drought conditions with a quite sensitive manner and can be used as an indicator to measure a drought condition.

A Physics-Based Modelling of Multipbase Fluid Phenomena (물리적 모델에 기반한 다상 유체 현상 애니메이션)

  • Song, Oh-Young;Shin, Hyun-Cheol;Ko, Hyeong-Seok
    • Journal of the Korea Computer Graphics Society
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    • v.10 no.3
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    • pp.52-60
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    • 2004
  • This paper presents a physically based technique for simulating complex multiphase fluids. This work is motivated by the "stable fluids" method developed by Stam to handle gaseous fluids. We extend this technique to water, which calls for the development of methods for modeling multiphase fluids and suppressing dissipation. We construct a multiphase fluid formulation by combining the Navier-Stokes equations with the level set method. By adopting constrained interpolation profile (CIP)-based advection, we reduce the numerical dissipation and diffusion significantly. We further reduce the dissipation by converting potentially dissipative cells into droplets or bubbles that undergo Lagrangian motion. Due to the multiphase formulation, the proposed method properly simulates the interaction of water with surrounding air, instead of simulating water in a void space. Moreover. the introduction of the non-dissipative technique means that, in contrast 10 previous methods, the simulated water does not unnecessarily lose mass and its motion is not damped to an unphysical extent. Experiments showed that the proposed method is stable and runs fast. It is demonstrated that two-dimensional simulation runs in real-time.

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A Study of the PDCA and CAPD Economic Designs of the $\bar{x}$ Control Chart

  • Sun, Jing;Tsubaki, Michiko;Matsui, Masayuki
    • Industrial Engineering and Management Systems
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    • v.6 no.1
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    • pp.11-21
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    • 2007
  • The PDCA (Plan, Do, Check and Act) cycle is often used in the field of quality management. Recently, business environments have become more competitive, and the due time of products has shortened. In a short production run process, to increase efficiency of management, the necessity for distinguishing the PDCA design that starts with PLAN and the CAPD design that starts with CHECK has been clarified. Starting from Duncan (1956), there have been a number of papers dealing with the economic design of control charts from the viewpoint of production run. Some authors (Gibra, 1971; Ladany and Bedi, 1976; etc.) have studied the economic design for finite-length runs; other authors (Crowder, 1992; Del Castillo and Montgomery, 1996; etc.) have studied the economic design for short runs. However, neither the PDCA nor the CAPD design of control charts has been considered. In this paper, both the PDCA and CAPD designs of the $\bar{\x}$ chart are defined based on Del Castillo and Montgomery's design (1996), and their mathematical formulations are shown. Then from an economic viewpoint, the optimal values of the sample size per each sampling, control limits width, and the sampling interval of the two designs are studied. Finally, by numerically analyzing the relations between the key parameters and the total expected cost per unit time, the comparisons between the two designs are considered in detail.