• Current Optics and Photonics
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• 제6권1호
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• pp.92-103
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• 2022

The development of midinfrared (mid-IR) quantum cascade lasers (QCLs) has enabled rapid high-contrast measurement of the mid-IR spectra of biological tissues. Several studies have compared the differences between the mid-IR spectra of colon cancer and noncancerous colon tissues. Most mid-IR spectrum classification studies have been proposed as machine-learning-based algorithms, but this results in deviations depending on the initial data and threshold values. We aim to develop a process for classifying colon cancer and noncancerous colon tissues through a deep-learning-based convolutional-neural-network (CNN) model. First, we image the midinfrared spectrum for the CNN model, an image-based deep-learning (DL) algorithm. Then, it is trained with the CNN algorithm and the classification ratio is evaluated using the test data. When the tissue microarray (TMA) and routine pathological slide are tested, the ML-based support-vector-machine (SVM) model produces biased results, whereas we confirm that the CNN model classifies colon cancer and noncancerous colon tissues. These results demonstrate that the CNN model using midinfrared-spectrum images is effective at classifying colon cancer tissue and noncancerous colon tissue, and not only submillimeter-sized TMA but also routine colon cancer tissue samples a few tens of millimeters in size.

• 대한치매학회지
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• 제23권1호
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• pp.11-21
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• 2024

Background and Purpose: Although dementia with Lewy bodies (DLB) is the second most common cause of neurodegenerative dementia, its clinical prevalence is low. We developed a short and easy-to-complete DLB screening questionnaire (DLBSQ) to raise diagnostic sensitivity in routine clinical settings. Methods: A total of 501 participants were retrospectively enrolled, including 71 controls, 184 patients without DLB, and 246 patients with probable DLB. All patients underwent clinical evaluation, including core features of DLB, the DLBSQ, brain magnetic resonance imaging, and detailed neuropsychological assessments. The diagnostic performance of the DLBSQ for probable DLB was investigated using a receiver operating characteristic curve analysis. Results: Total DLBSQ score was associated with visuospatial and frontal/executive dysfunction and the diagnosis of probable DLB. The area under the receiver operating characteristic curve for total DLBSQ score was 0.727. Youden's method revealed an optimal cutoff value of 3. The sensitivity and specificity of the DLBSQ were 68.7% and 62.4%, respectively. Its discriminating performance improved when cognitive test profiles were additionally considered (area under the curve: 0.822, sensitivity: 80.6%, and specificity: 70.4%). Conclusions: The DLBSQ might be a useful screening tool for DLB in routine clinical practice with good sensitivity and specificity.

• Journal of Preventive Medicine and Public Health
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• 제26권3호
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• pp.457-468
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• 1993

본 연구는 1차 의료기관과 3차 진료기관의 검사 내용 및 이들 간의 중복검사율을 파악할 목적으로 대구직할시내 1개 3차 진료기관에 1992년 3월 16일부터 4월 11일까지 진료의뢰서를 갖고 내과, 일반외과, 정형외과, 신경외과 외래를 방문한 초진환자 498명을 대상으로 설문지 및 의무기록을 통해 조사하였는데 그 결과를 요약하면 다음과 같다. 대상자는 3차 진료기관이 속한 중진료권에 거주하는 환자가 48.8%였고 나머지가 대진료권에 속한 환자였으며, 1차 의료기관의 방문목적이 진단과 치료를 위해서 방문한 경우가 74.1%였고 진료의뢰서를 발급받기 위해서가 25.9%였다. 진료의뢰서를 본인이 원해 발급받은 경우가 전체의 52.6%였는데 순수하게 의사의 판단에 의해 발급받은 환자가 47.4%로서 아직도 환자 의뢰체계가 제대로 완비되었다고 말하기 어렵다. 진료의뢰서의 발급기관은 의원급이 67.5%, 병원급이 16.3%, 보건기관이 14.2%였다. 1차 의료기관에서 검사를 하고 3차 진료기관을 방문한 환자는 49.4%였는데, 이 중에서 진료한 1차 의료기관에서 다른 진료기관으로 검사를 의뢰해서 검사를 실시한 경우가 7.8%였다. 1차 의료기관에서는 대상자의 20.9%가 X-ray 검사를 받았고, 10.6%가 소변검사, 9.0%가 심전도검사를 받았으며, 의료보험 비급여 대상종목인 컴퓨터단층촬영과 초음파검사는 각각 3.4%, 6.4%였다. 3차 진료기관에서도 방문환자의 45.2%가 X-ray 검사를 받았고, 간기능검사 24.7%, 소변검사 19.1%, 심전도검사 15.7%의 순으로 나타났다. 1차 의료기관에서 검사를 받은 사람 중 검사결과지를 지참한 환자의 비율은 컴퓨터단층촬영이 76.5%로 가장 많았고, 다음이 초음파검사로 31.3%여서 고가 의료장비 이용시 검사결과지 지참율이 높았다. 1차 의료기관과 3차 진료기관에서의 중복검사율은 각 진료과에 따라 특성이 있으나 전체적으로 보면 갑상선 기능검사가 71.4%로 가장 높았고, 다음이 혈액검사(Routine CBC)가 67.9%, X-ray검사가 64.4%였다. 그리고 초음파검사 62.5%, 컴퓨터단층촬영 11.8%, 심전도검사 35.6%, 위내시경검사 45.2%였다. 1차 의료기관에서의 검사결과지를 지참한 경우만을 기준으로 하면 혈액 검사가 75.0%, 간기능검사가 72.7%로 높았으나 X-ray 52.2%, 초음파검사 60.0%였는데, 고가장비인 컴퓨터 단층촬영은 15.4%였다. 이상의 결과에서 3차 진료기관에서는 1차 의료기관에서 실시한 검사를 중복검사한 경우가 많고 1차 의료기관에서의 검사결과지를 지참하는 환자의 중복검사율도 특수한 경우를 제외하고는 큰 차이가 없었음을 감안할 때 진료의뢰시 보다 상세한 진료결과지를 지참하도록 하는 등 환자의뢰체계를 합리적으로 개선하여야 확인검사로 인한 중복검사를 경감시킬 수 있을 것으로 생각된다. 아울러 불필요한 검사를 줄이기 위해서는 의료분쟁을 줄일 수 있는 방안이 마련되어야 하고, 의료보험수가의 조정도 필요할 것이다.

• 대한수의학회지
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• 제36권3호
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• pp.607-614
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• 1996

Several methods for rapid and accurate detection of VTe-producing E coli were established. These methods contain beta-glucuronidase-secretion test, beta-haemolysis-production test in blood agar, verocytotoxicity test, and PCR. All of the VTe-producing strains made beta-haemolysis on 5% sheep blood agar. VTe-producing strains secreted beta-glucuronidase whereas 0157:H7 strains producing VTI or VTII did not secrete that enzyme. Verocytotoxicity test was established for rapid diagnosis. VTe detection was rapider in Vero cell suspension than Vero cell monolayer. In PCR, there was a positive result only in VTe-producing E coli, not in VTI or VTII-producing E coli. In this experiment, 165 strains of E coli were islated from feces or intestinal contents of post-weaning piglets showing nervous sign or diarrhea. And 20 strains of E coli that produced VTe were selected by verocytotoxicity test and PCR. According to these experiments, there was a direct correlation between verocytotoxicity test and PCR. And verocytotoxicity test is recommended as a routine diagnostic method and PCR does as a accurate diagnostic method to detect VTe-producing E coli.

• 영어어문교육
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• 제7권1호
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• pp.89-112
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• 2001

The purpose of this study is to verify the effect of the method of English teaching and learning through the student-centered environmental instruction. I've been skeptical about the traditional instruction, which is composed of the teachers-centered instruction, because of the lack of creativity. Until now, I've always wished to have an alternative method that can be substituted for routine's style. To achieve it, I selected 90 students from 2 classes, in the 3rd year at a girls' high school in Chungnam as the subject of study. I divided them into two groups, the student-centered environmental instruction and the teacher-centered traditional instruction. The tools used in this study are a preliminary English achievement test, a self-directed learning attitudes test and two teaching plans. For this test, a high school text book was assigned. I have treated 20 times of the test each for two groups using two types of teaching-learning plans which I made for this purpose. To verify the hypotheses after administrating the test, I selected t-verification for post test result. Based on this test result, I could conclude that there was a significant improvement of English proficiency and a change in the self-directed learning attitudes; also the student-centered environmental instruction is more effective than teachers-centered instruction.

• 한국군사과학기술학회지
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• 제10권1호
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• pp.44-54
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• 2007

In the military field, according to the MIL-STD-188-220, which is an Ad-Hoc communication protocol used for sending out or receiving data and voice smoothly among nodes in the situation that wireless communication nodes move arbitrarily, data communication is cut off because nodes can not know topology changes perpetually in the link disconnection state due to node movement in the case that transmitters do not confirm whether data is delivered to receivers or not, and transmit only the data having routine precedence continuously. In order to solve this problem, we have proposed the technique that makes efficient data communication possible by achieving a rapid topology change detection and link information update using TEST frame. We have analyzed TEST frame application effects in the two aspects of the topology update delay time and the data transmission success ratio.

• 한국동물위생학회지
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• 제30권3호
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• pp.385-391
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• 2007

A novel enzyme linked immunosorbent assay (ELISA) is described and compared with other established serologic tests for bovine brucellosis, namely the rose bengal test (RBT), the complement fixation test (CFT), and the tube agglutination test (TAT) approved and used in Korea. A total of 109 bovine serum samples were tested using all the 4 assays and analyzed as to specificity, sensitivity, reproducibility and predictive value. The ELISA showed 100% agreement with the CFT. The least agreement between ELISA was observed with the TAT. The agreement between the ELISA and RBT was not significantly different from that observed between the CFT and the ELISA. It is concluded that the new assay would be a good candidate for routine serologic survey for brucellosis in Korea. A protocol combining the ELISA and the CFT would increase the power for detection of serologically positive individuals and herds.

• 전력전자학회:학술대회논문집
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• 전력전자학회 2016년도 추계학술대회 논문집
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• pp.190-191
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• 2016

국제 핵융합실험로인 ITER 장치의 초전도자석 전원장치용 CCU/L(Correction Coil Upper/Lower), CCS(Correction Coil Side) 그리고 VS1($1^{st}$ Vertical Stabilization) 형식 등 각 변압기 초도품의 제작을 완료하고 공장시험(FAT, Factory Acceptance Test)을 실시하였다. 이 변압기들은 각 형식별로 2대에서 6대를 제작하지만 각 형식별 초도품 1대에 대해서는 Type Test를 실시하고 나머지 후속물량에 대해서는 Routine Test로 공장시험을 실시하도록 계획되어 있다. 따라서 이 초도품 변압기들에 대해서는 Type Test로 공장시험으로 실시하였고, 그 대표적인 시험항목으로는 단락시험, %임피던스 시험, 뇌임펄스 시험, 정격전류 온도상승시험, 상용주파수 내전압시험 등이 있다. 이들 중 CCU/L, CCS 각 형식의 초도품에 대해서는 2015년도 공장시험을 실시하여 요건에 부합됨을 확인하였고, 본 논문에서는 VS1 컨버터 변압기 초도품에 대하여 Type Test로 실시한 공장시험 내용과 그 결과를 보여준다.

• Journal of Audiology & Otology
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• 제25권2호
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• pp.72-79
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• 2021

Background and Objectives: The speech-in-noise test is typically performed using an audiometer. The results of the digit-in-noise recognition (DIN) test may be influenced by the flat frequency response of free-field audiometry and frequency of the hearing aid fit based on fitting rationale. This study aims to investigate the DIN test in unaided and aided conditions. Subjects and Methods: Thirty four adults with moderate and severe sensorineural hearing loss (SNHL) participated in the study. The signal-to-noise ratio (SNR) for 50% of the DIN test was obtained in the following two conditions: 1) the unaided condition, performed using an audiometer in a free field; and 2) aided condition, performed using a hearing aid with an unvented individual earmold that was fitted based on NAL-NL2. Results: There was a statistically significant elevation in the mean SNR for the severe SNHL group in both test conditions when compared with that of the moderate SNHL group. In both groups, the SNR for the aided condition was significantly lower than that of the unaided condition. Conclusions: Speech recognition in hearing-impaired patients can be realized by fitting hearing aids based on evidence-based fitting rationale rather than by measuring it using free-field audiometry measurement that is utilized in a routine clinic setup.

• 지역사회간호학회지
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• 제15권3호
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• pp.376-384
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• 2004

Purpose: The CHP program has been evaluated as one of the most successful program in the public health area in Korea. The objects of this study were as follows: 1) to evaluate the job activities of the CHP program, using service contents analysis. 2) to figure out personal factors and the outcome of CHP's activities. Method: Data were collected by sending questionnaires to 130 subjects through the mail from May to December 2003. The response rate was 48.0%. The Data were analyzed by the SPSS WIN program with t test and Pearson correlation coefficient. In using these methods. independent variables are CHP's personal factors (age, experience, certification of specialty) and regional factors (geographical classification, aged population, village workers, cooperation of community leaders, work-conditions), and a dependent variable is the outcome of CHP's job activities. Result: The results of t test analysis show that regional differences between factors are influential in the welfare service, the routine job, and the consultation. As a whole, this is shown that CHPs represent experience, the number of village workers and CHPs living condition of work and most of the categories of jobs that influenced over statistical meaning of differences (t=2.417, p=1.043, t=6.123, p=.004, t=4.309, p=.000). There is a significant positive relation between the routine job and the consultation(r=.455, p=.000), the consultation and the education(r=.461, p=.000). Conclusion: Finally, according to the results of this study, the CHP program should be developed and continue to meet the basic health care needs of the residents in accordance with the philosophy of their own primary health care.