• Title/Summary/Keyword: Rota rod

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Neuropharmacological screening of the methanolic extract of Hibiscus vitifolius flowers

  • Seethalakshmi, S;Chamundeeswari, D;Rani, S Jamuna;Parvathavardhini, S;Vasantha, J
    • Advances in Traditional Medicine
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    • v.5 no.4
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    • pp.331-335
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    • 2005
  • The methanolic extract of Hibiscus vitifolius flowers (HVE), was evaluated for neurophamacological activities by carrying out rota rod, locomotor activity and traction performance in mice and swim endurance activity in rats in different dosages (10, 30 and 100mg/kg body weight). HVE showed a significant effect on central nervous system by increasing the time taken for rota rod, traction performance and locomotor activity while swimming time was found to be decreased when compared to normal control animals. These results suggest that HVE possess significant anxiolytic and anti depressant activity which may be attributed to the presence of flavonoid in HVE.

The Effects of Galgunhaejutang + Danjuhwan and Haejujigaltang on the Experimental Behaviors of Alcohol-Intoxicated Mice (갈근해주탕(葛根解酒湯) 합(合) 단주환(斷酒丸)과 해주지갈탕(解酒枳葛湯)이 실험적(實驗的) Alcoholism 생쥐의 행동(行動)에 미치는 영향(影響))

  • Bang Hea-Yeon;Whang Wei-Wan
    • Journal of Oriental Neuropsychiatry
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    • v.5 no.1
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    • pp.93-101
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    • 1994
  • This experiment was designed to investigate the effects of Galgunhaeiutang + Danjuhwan and Haejujigaltang on the experimental behaviors of alcohol-inticxicated mice. ICR mice were used as subjects for alcohol intoxication in this experiment and sample group received Herb Medicine. The foot-step and rearing score were measured in mice. Also Rota-Rod treadmill & number of successful trials swimming time in the T-maze were done. And the following results were observed; 1. The food-step score was decreased in Galgunhaejutang + Danjuhwan group at the 8th hour, the difference was statistically significant. But Haejujigaltang group showed no significant difference. 2. The number of rearing was decreased in Galgunhaejutang + Danjuhwan group at the 3rd and 8th hour, the difference was statistical significant, while Haejujigaltang group showed no significant differnce. 3. The motor incoordination measered by the Rota-Rod treadmill was decreased in Galgunhaejutang + Danjuhwan group at the 8th hour, but Haejujigaltang group showed no significant difference. 4. The number of successful trials in T-maze showed no significant difference in both groups. 5. The passing time in T-maze was increased in Galgunhaejutang +Danjuhwan group at the 8th hour, but Haejujigaltang group showed no significant difference.

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An experimental study of Yangsymtang's effects on the activities of Central Nervous System (중추신경계(中樞神經系)에 작용(作用)하는 양심탕(養心湯)의 실험중적(實驗中的) 연구(硏究))

  • Joa Seung-Ho;Lee Jin-Yong;Kim Deok-Gon;Jeong Gyu-Man
    • The Journal of Pediatrics of Korean Medicine
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    • v.10 no.1
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    • pp.245-263
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    • 1996
  • In order to investigate the effects of Yangsymtang on the activities of central nervous system, we observed the effects on convulsions induced by pentylenetetrazole, strychnine and picrotoxin. The sedative those on spontaneous motor activity and by rota rod method, the those on sleeping time induced by barbiturate and the alleviative those on pain induced by acetic acid and hind limb pressure also were analyzed. The results were as follows: 1. The solid extracts of Yangsymtang showed no anticonvulsive effects on convulsions induced by pentylenetetrazole, strychnine and picrotoxin. 2. As to the sedative effects by rota rod method, th solid extracts of Yangsymtang were recognized as significance(P<0.01). 3. The sleeping time induced by thiopental sodium was not prolonged by the oral administration of the solid extracts of Yangsymtang. 4. The oral administration of Yangsymtang did not influenced the sleeping induced by pentobarbital sodium significantly. 5. As to the effects on spontaneous motor activity, the oral administration of Yangsymtang made spontaneous motor activity decrease significantly(P<0.05). 6. The oral administration of Yangsymtang was significant on pain induced by acetic acid(P<0.001). 7. As to alleviative effects on pain induced by hind limb pressure. The solid extracts of Yangsymtang were not significant.

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Differential gene expression pattern in brains of acrylamide-administered mice

  • Han, Chang-Hoon
    • Korean Journal of Veterinary Research
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    • v.52 no.2
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    • pp.99-104
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    • 2012
  • The present study was performed to evaluate the relationship between the neurotoxicity of acrylamide and the differential gene expression pattern in mice. Both locomotor test and rota-rod test showed that the group treated with higher than 30 mg/kg/day of acrylamide caused impaired motor activity in mice. Based on cDNA microarray analysis of mouse brain, myelin basic protein gene, kinesin family member 5B gene, and fibroblast growth factor (FGF) 1 and its receptor genes were down-regulated by acrylamide. The genes are known to be essential for neurofilament synthesis, axonal transport, and neuroprotection, respectively. Interestingly, both FGF 1 and its receptor genes were down-regulated. Genes involved in nucleic acid binding such as AU RNA binding protein/enoyl-coA hydratase, translation initiation factor (TIF) 2 alpha kinase 4, activating transcription factor 2, and U2AF 1 related sequence 1 genes were down-regulated. More interesting finding was that genes of both catalytic and regulatory subunit of protein phosphatases which are important for signal transduction pathways were down-regulated. Here, we propose that acrylamide induces neurotoxicity by regulation of genes associated with neurofilament synthesis, axonal transport, neuro-protection, and signal transduction pathways.

Effects of Electroacupuncture on Activity of GOT, GPT, LDH and Functional Recovery in the Motor Injury Rats by the 6-hydroxydopamine (6-hydroxydopamine에 의한 운동손상 흰 쥐에서 전침이 GOT, GPT, LDH 활성도 및 기능회복에 미치는 영향)

  • Ha, Mi-Sook;Rho, Min-Hee
    • Journal of the Korean Society of Physical Medicine
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    • v.5 no.2
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    • pp.265-272
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    • 2010
  • Purpose : This study was investigated the effect of electroacupuncture stimulation on the change of blood biochemical components in the rat spinal cord injury(SCI) damaged by the 6-hydroxydopamine. Methods : SCI model rats were damaged in L1-L2 injected with 6-hydroxydopamine. The thirty Sprague-Dawley adult male rats were randomly divided into normal group, control group and electroacupuncture group. Experimental groups were applied as electroacupuncture(Es-160, ITO, Japan) for 15minutes during the low frequency(2 Hz) stimulation to zusanli. The enzyme concentration levels analysis of the hematological changes were measured of Glutamate Oxaloacetate Transaminase(GOT), Glutamate Pyruvate Transaminase(GPT), Lactate dehydrogenase(LDH) and motor function recovery change was evaluated by the rota-rod test. Results : This study were as follow : The concentration of GOT, LDH in experimental group was lower than control group(p<.05). The experimental group showed increase of motor function recovery more in compared to control group(p<.05). Conclusion : The results of this study showed that electroacupuncture to zusanli point have an effect on functional recovery after the 6-hydroxydopamine induced SCI in rats.

The Ameliorating Effect of Hoveniae Semen Seu Fructus Extract against Ethanol-induced Psychomotor Alterations in Rats (흰쥐에서 지구자 추출물의 에탄올 유도 숙취 행동 개선 효능)

  • dela Pena, Irene Joy I.;de la Pena, June Bryan;Cheong, Jae Hoon
    • YAKHAK HOEJI
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    • v.58 no.5
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    • pp.300-306
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    • 2014
  • Ethanol consumption causes psychomotor alterations. Hovenia Semen seu Fructus (HS), widely distributed in Korea, China, and Japan, has been reported to have beneficial effects on acute alcohol-induced liver injury. The present study sought to assess the effects of HS extract on ethanol-induced psychomotor alterations in rats. Sprague-Dawley rats were orally (p.o.) given ethanol (4 g/kg) (ethanol group) to induce psychomotor alterations. A separate group (HS-treated groups), were treated with different dosages of HS (50, 100, and 200 mg/kg, p.o.), 30 minutes before ethanol treatment. The control group received only the vehicle (saline). Ethanol-induced psychomotor alterations were evaluated in the open-field, rota-rod, hanging wire, and cold swimming test. In addition, blood ethanol and acetaldehyde concentrations were also measured. Behavioral evaluations and blood analysis were carried out 0.5, 1, 2, 4, and 8 hours after ethanol administration. Pre-treatment of HS ameliorated ethanol-induced alterations in the open-field, rota-rod, and cold swimming test, significantly evident in 2 and 4 hours after ethanol treatment. These improvements coincided with decrease in blood ethanol and acetaldehyde concentration. Based on these results, the present study suggests that HS may have ameliorating effects against ethanol-induced psychomotor alterations.

Pharmacological Studies on the Behavioral Effects of Cinnarizine Coadministered with Propranolol or Metoprolol (Cinnarizine을 Propranolol이나 Metoprolol과 병용할 때의 행동약리학적 연구)

  • 허인회;안형수
    • YAKHAK HOEJI
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    • v.29 no.1
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    • pp.11-17
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    • 1985
  • The behavioral effects of propranolol (60mg/kg) and metoprolol (100mg/kg) each alone and coadministered orally with cinnarizine (100mg/kg) were investigated and compared with each of betablockers alone treated group in rodents. Propranolol showed depressive effects through locomotor activity, conditioned avoidance response, rota-rod test, traction test, and analgesic effect in mice. When combined with cinnarizine and propranolol, the behavioral depressive effect of propranolol was reduced comparing with propranolol alone treated group. However, metoprolol alone or combined with cinnarizine didn't showed any behavioral depressive effect so much as propranolol.

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애엽 추출분획(DA-9601)의 일반 약리작용

  • 고석태;유강준;신동숙;강선영
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1996.04a
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    • pp.196-196
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    • 1996
  • Artemisia extract powder (DA-9601)의 일반약리 작용을 mice, rat 및 rabbit에서 검토하였다. DA-9601은 rota-rod test에 의한 운동 협조능, 초산 writhing 반응, tail-flick test 및 randall-sellito test를 이용한 진통작용, thiopental sodium의 수면작용, 장관 수송능, carrageenan의 염증, 현수에 의한 근이완작용, 정상체온, strychnine의 경련작용, 수정관, 자궁각 및 Evans blue의 피부혈관 투과성에 별다른 영향을 미치지 않았다. DA-9601은 토끼의 적출회장 운동을 억제하였고 혈압 강하작용과 이뇨작용을 나타내었다

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Effects of Aquatic Exercise on Vestibulo-motor and Expression of GAP-43 in Diffuse brain Injury Rats (수중운동이 미만성 뇌손상 백서의 전정-운동 및 GAP-43 발현에 미치는 영향)

  • Yang, Seung-Hoon
    • The Journal of the Korea Contents Association
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    • v.9 no.12
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    • pp.656-664
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    • 2009
  • The purposes of this study were to examine whether aquatic exercise has influence on the neuroplasticity and vestibulo-motor function in diffuse brain injury rats. 80 Sprague-Dawley rats were assigned to four groups; Group I: control group (n=20), Group II: aquatic exercise (n=20), Group III: treadmill exercise with change of velocity and inclination (n=20), Group IV: simple treadmill exercise (n=20). And we applied exercise each groups for 3 weeks except Group I. Before the rats were sacrificed to identify immunohistochemistry study at each time of measurement day, Rota-Rod test was given to assess changes in vestibulomotor function. then, the immunohistochemistry study of GAP-43 in discrete regions of the rat brain was performed to measure changes in neuroplasticity. The results demonstrate that aquatic exercise group is more effective than other groups. expression of GAP-43 and vestibulo-motor function were increased most in aquatic exercise group. Therefore, this study suggest that aquatic exercise may effective therapeutic approach to increase neuroplasticity and vestibulo-motor function in traumatic brain injury.

A study on the anti-convulsive, sedative and analgesic effects of Sanpoongdan in mouse (산풍단(散風丹)이 생쥐의 항경련(抗痙攣), 진정(鎭靜) 및 진통작용(鎭通作用)에 미치는 영향(影響))

  • Lee Hee-Sung;Kim Deok-Gon
    • The Journal of Pediatrics of Korean Medicine
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    • v.11 no.1
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    • pp.205-226
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    • 1997
  • Sanpoongdan(SPD) has been known effective on infantile convulsive disorders in clinical field of oriental medicine. The purpose of this study was to investigate the anti-convulsive, sedation and analgesic effects of SPD in mouse. The anticonvulsive effect was evaluated In mice treated with pentylenetetrazol, stychnine, and picrotoxin. For the sedative effect, observations were made on the sleeping time induced by thiopental sodium and pentobarbital sodium following oral administration of SPD. Furthermore, reduction of spontaneous movements and ataxia using rota rod method were evaluated. Analgesic effects on the writhing syndrome induced by acetic acid and on hindlimb pain induced by pressure were also observed. The findings were as follows : 1. The solid extracts of SPD revealed no effect on convulsions induced by pentylenetetrazol, strychnine, and picrotoxin. 2. Thiopental sodium-induced sleeping time was prolonged by the administration of the solid extracts of SPD, but this result was devoid of statistical significance. 3. The oral administration of SPD enhanced the sleeping induced by pentobarbital sodium. 4. Spontaneous movements were significantly depressed following the oral administration of the solid extracts of SPD. 5. Ataxia was not shown in rota rod method following the oral administration of the solid extracts of SPD. 6. The solid extracts of SPD showed positive analgesic effects on the acetic acid-induced writhing syndrome. 7. The solid extracts of SPD raised the threshold of the hindlimb pressure pain, but the result was not statistically significant. From the results, it can be concluded that SPD has sedative and analgesic effects.

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