The Effects of Galgunhaejutang + Danjuhwan and Haejujigaltang on the Experimental Behaviors of Alcohol-Intoxicated Mice

갈근해주탕(葛根解酒湯) 합(合) 단주환(斷酒丸)과 해주지갈탕(解酒枳葛湯)이 실험적(實驗的) Alcoholism 생쥐의 행동(行動)에 미치는 영향(影響)

  • Bang Hea-Yeon (Department of Oriental Neuropsychiatry, KyungHee University) ;
  • Whang Wei-Wan (Department of Oriental Neuropsychiatry, KyungHee University)
  • 방혜연 (경희대학교 한의과대학 신경정신과교실) ;
  • 황의완 (경희대학교 한의과대학 신경정신과교실)
  • Published : 1994.12.05

Abstract

This experiment was designed to investigate the effects of Galgunhaeiutang + Danjuhwan and Haejujigaltang on the experimental behaviors of alcohol-inticxicated mice. ICR mice were used as subjects for alcohol intoxication in this experiment and sample group received Herb Medicine. The foot-step and rearing score were measured in mice. Also Rota-Rod treadmill & number of successful trials swimming time in the T-maze were done. And the following results were observed; 1. The food-step score was decreased in Galgunhaejutang + Danjuhwan group at the 8th hour, the difference was statistically significant. But Haejujigaltang group showed no significant difference. 2. The number of rearing was decreased in Galgunhaejutang + Danjuhwan group at the 3rd and 8th hour, the difference was statistical significant, while Haejujigaltang group showed no significant differnce. 3. The motor incoordination measered by the Rota-Rod treadmill was decreased in Galgunhaejutang + Danjuhwan group at the 8th hour, but Haejujigaltang group showed no significant difference. 4. The number of successful trials in T-maze showed no significant difference in both groups. 5. The passing time in T-maze was increased in Galgunhaejutang +Danjuhwan group at the 8th hour, but Haejujigaltang group showed no significant difference.

Keywords

References

  1. 韓方製制解說集 慶熙醫療院 韓方病院
  2. 褙校黃帝內經靈樞 洪元植(編纂)
  3. 神農本草經 未 詳
  4. 簡明中藥藥名辭典 桑樹榮;匡海學
  5. 本草從新 吳儀洛
  6. 本草備要 v.1;2;3 汪인庵
  7. 東垣十種醫書 李고
  8. 醫學入門 李천
  9. 최신정신의학 민성길
  10. 現代家庭醫學百科 石在鎬(外)
  11. 蒼濟證方 申卿熙
  12. DSM-Ⅲ-R 정신장애의 분류와 진단편람 이근후
  13. 內科學 이문호(外)
  14. 정신의학 이정균
  15. 肝系內科學 全國韓醫科大學 肝系內科學敎授
  16. 本草學 全國韓醫科大學 本草學敎授(共編)
  17. 藥理學 韓大燮;高啓昌;鄭址昌
  18. 家庭醫學 韓弘武
  19. 東醫寶鑑 許浚
  20. 精校黃帝內經素問 洪元植(編纂)
  21. 東醫精神醫學 黃義完;金知赫
  22. 한국정부의 술정책수립에 관한 연구 김유광;이대희
  23. 精神醫學報 v.7 알콜리즘의 진단과 치료 김진국
  24. 행동과학연구 v.7 중추성 아세칠콜린 길항제가 조건변화에 따른 학습에 미치는 영향 윤영화;김기석
  25. 신경정신의학 v.30 입원한 주정중독환자의 임상적 호전도와 자아강도와의 관계 이석환;김재환;이정국
  26. 신경정신의학 v.19 알콜장애자에 대한 임상적 연구 이영호
  27. 한국심리학회지 v.7 인삼 Glycoside가 마우스의 미로학습 및 정서행동에 미치는 영향 張鉉甲
  28. 중앙의학 v.21 중추신경 흥분제가 마우스의 미로학습에 미치는 영향 張鉉甲;洪錫英;文翊柱
  29. 행동과학연구 v.7 해마손상후 공간기억 및 준거기억을 요하는 과제에서 나타나는 행동변화 조소현;김기석
  30. 신경정신의학 v.32 주정의존의 정도와 생화학적 임상병리 검사의 이상 소견과의 관련성 최인근;문석환;석재호
  31. 경의대학교 대학원 논문집 v.4 解酒枳葛湯, 斷酒丸 및 醒酒淸肝湯이 實驗的 Alcoholism에 미치는 影響 韓敬勝;金知赫;黃義完
  32. 巢氏諸病源後論 巢元方
  33. 新編中藥大辭典 新文豊出版公司
  34. 中國秘方全書 龍和
  35. 萬病醫學顧問 內科內傷病 陸靑節
  36. 增輯驗方新編 李遜齊
  37. 本草綱目 李時珍
  38. 儒門事親 v.4;8 張子和
  39. 醫門寶鑑 周命新
  40. 中醫大辭典(本草) 編輯委員會
  41. Neuroscience v.33 no.3 Cholinergic system and memory in the rat: effects of chronic ethanol, embryonic basal forebrain brain transplants and excitotoxic lesions of cholinnergic basal forebrain projetion system Arend, T.;Allen, Y.;Marchbanks, R.M.;Schugens, M.M.
  42. Alcohol v.4 Stereotypic wall climbing in mice during ethanol withdrawal:A new measure of physical depen-dence Becker, H.C.;Anton, R.F.;Randall, C.L.
  43. J. Am. Pharmaceut . Assoc. Scientific Edit. v.XLVI no.3 A note on a simple apparatus for detecting neurological deficit in rat & mice Dunham, N.W.;Miya, T.S.
  44. Arch. Neurol. v.21 Alcohol withdrawal syndrome in mice Freund, G.
  45. J. Pharmacol. Exp. ther. v.186 Alcohol withdrawal reactiond in mice: effect of drugs that modify neuro-transmission Goldstein, D.B.
  46. Science v.172 Alcohol dependence produced in mice by inhalation of ethanol:Grading the withdrawal reaction Goldstein, D.B.;Pal, N.
  47. Psycho-pharmacol. v.102 Acute tolerance to ethanol using drug discri mination and open-field procedures in rat Hiltunen, A.J.;Jarbe, T.U.C.
  48. Federation Proc. v.40 Neurotransmitter function in the basal ganglia after acute and chronic ethanol treatment Hunt, W.A.
  49. second report: WHO Tech Rep Ser no.48 World Health Organization Expert Committee on Mental Health;Alcoholism Subcommittee