• Journal of the East Asian Society of Dietary Life
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• v.20 no.2
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• pp.321-327
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• 2010

Two different mixing ratios of Rosa rugosa and Rubus crataegifolius (Korean raspberry), including Rosa rugosa and one part Rosa rugosa vs five parts Rubus crataegifolius were prepared, and their fermentation characteristics were investigated during 28 days of ethanol fermentation and subsequent aging. The final $^{\circ}Brix$ and pH of Rosa rugosa wine were 12.0 and 2.9, respectively, while those of Korean raspberry-Rosa rugosa wine were $7.0^{\circ}Brix$ and pH 3.4, respectively. The final ethanol contents were 5.0% (v/v) in Rosa rugosa wine and 9.8% in Korean raspberry-rugosa wine. The level of antocyanine content, color intensity, organic acid, and free amino acid concentrations in Rosa rugosa wine were lower than those of Korean raspberry-Rosa rugosa wine. Thus, our results demonstrate that supplementation of Rosa rugosa with Korean raspberry prior to alcohol fermentation may help improve the fermentation characteristics of Rosa rugosa wine in the final product.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.5
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• pp.866-871
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• 2010

The antidiabetic effects of Rosa rugosa Radix were investigated in streptozotocine-induced diabetic rats. Research methods and procedure: In the present study, effects of oral administration of Rosa rugosa Radix extract(100, 250, and 500 mg/kg body wt.) for 28 days on the level of serum glucose, total cholosterol, triglycerides, cereatinine, aspartate amino transferase(AST) and alanine amino transferase(ALT) in normal and streotozotocine-induced diabetic rats were evaluated. Oral administrations of the Rosa rugosa Radix extract significantly decreased serum glucose, total cholesterol, triglyceride, AST, and ALT levels, while increased serum insulin and HDL-C in diabetic rats(p<0.05). The hypoglycemic effect of the Rosa rugosa Radix extract was more effective than normal group. It is concluded that the Rosa rugosa Radix must be considered as excellent candidate for future studies on diabetes mellitus.

• The Korean Journal of Food And Nutrition
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• v.28 no.2
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• pp.320-327
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• 2015

Since Korean ancient times, powder of Rosa rugosa Thunberg has been used as a folk remedy. This study was conducted to verify the effects of Rosa rugosa Thunberg powder on in vitro antioxidant properties and serum lipid levels of high-fat diet-induced mice from a nutritional viewpoint. In the case of Rosa rugosa Thunberg powders, measurement of TPC, ABTS radical scavenging activity of trolox, DPPH radical scavenging activity, and measured value of FRAP were higher in ethanol extract than water extracts. For LDL-cholesterol concentration, mice fed 10% powder of Rosa rugosa Thunberg with high-fat diets showed a high numerical value compared with other groups (p<0.05). When testing for triglyceride concentrations in blood, mice fed 10% and 20% powder of Rosa rugosa Thunberg with high-fat diets showed the lowest numerical values (p<0.05). When testing for blood insulin concentrations, the high-fat diet group showed higher levels than compared to the control group (p<0.05). When testing for blood leptin concentrations, the high-fat diet group was $5.88{\pm}3.53ng/dL$, whereas mice fed 10% powder of Rosa rugosa Thunberg with high-fat diets showed a blood leptin level of $10.36{\pm}5.96ng/dL$ (p<0.05). Therefore, results prove that powder of Rosa rugosa Thunberg reduces triglyceride concentrations in the blood, and could be used as an excellent natural antioxidant in the future.

• Natural Product Sciences
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• v.9 no.2
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• pp.49-51
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• 2003

The underground part of Rosa rugosa Thunb. has been used in Korean folk medicine for treating diabetes. The $^{1}H-NMR$ signal of procyanidin B3 isolated from Rosa rugosa was fully assigned by utilizing $^{1}H-^{1}H$ COSY. Procyandin B3 showed a moderate inhibitory activity against HIV-1 protease.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.4
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• pp.928-933
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• 2005

This study was carried out to understand the effects of Bambusae Caulis in Liquamen manufactured by different production process and Rosa rugosa on blood sugar in the db/db mice. Bambusae Caulis in Liquamen(L-BCL, H-BCL) manufactured by low or high temperature production process and Rosa rugosa were used. The effects of L-BCL, L-BCL+Rosa rugosa, H-BCL and H-BCL+Rosa rugosa were observed in terms of blood sugar, creatinine, BUN, ALT in db/db mice. The results were as follows : The amount of glucose was significantly decreased (P<0.01) in the experimental groups compared with the control. The amount of Creatinine ovserved decrease in the case of L-BCL group. The amount of blood urea nitrogen observed significant decrease in the case of H-BCL and H-BCL+Rosa rugosa groups. The amount of ALT did not show any differences among five groups.

• Korean Journal of Pharmacognosy
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• v.17 no.1
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• pp.35-38
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• 1986

From the Roots of Rosa rugosa Thunb., which were used for diabetes as folkloric remedy, quercetin was isolated and identified by chemical spectral analysis and direct comparison with authentic sample.

• Archives of Pharmacal Research
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• v.10 no.4
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• pp.219-222
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• 1987

From the underground parts of Rosa rugosa(Rosaceae), 28-0-glucosides of euscaphic acid, tormentic acid and arjunic acid were isolated and characterized by spectral data.

• YAKHAK HOEJI
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• v.37 no.4
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• pp.365-369
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• 1993

Five phenolic compounds have been isolated from the stems and leaves of Rosa rugosa Thunb. (Rosaceae) in Korea. They were methyl gallate and catechin from the stems, and quercetin, methyl gallate and hyperin from the leaves respectively. The structures were established by spectroscopic and chemical methods.

• The Journal of Korean Medicine
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• v.22 no.4
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• pp.79-89
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• 2001

Objectives : This study has been carried out to investigate the effects of the Saengjinyanghyutang-gamibang and Rosa rugosa extracts on pancreas of the hyperglycemia mice induced with streptozotocin. Methods : We examined immunohistochemistry for insulin and COX-2, ultrastructural changes of acini by electron microscope, and changes of the blood glucose and BUN levels. Results : The ${\beta}-cells$ on Langerhnan's islet were destructed by administration of streptozotocin, so that few insulin-positive cells were observed in the control group. However, a lot of insulin-positive cells were observed in the experimental groups. These cells had recovered from the damage. As a result of COX-2 immunostain, COX-2 expression were highest in the control group other than the Saengjinyanghyutang-gamibang and Rosa rugosa extracts administered groups. As the electron microscopical observation, the centroacinar cells and acini of pancreas were destructed or damaged by administration of streptozotocin in the control group, but these recovered !Tom the damage in the other experimental groups. The levels of serum glucose were decreased remarkably on the Rosa rugosa and Saengjinyanghyutang-gamibang extracts administered groups compared with control group. Conclusions : These results suggest that administration of the Rosa rugosa and Saengjinyanghyultang-gamibang extracts to the mice reduced the damage induced by streptozotocin.

• Korean Journal of Pharmacognosy
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• v.36 no.1 s.140
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• pp.38-43
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• 2005

This study was undertaken to evaluate the gastrotherapeutic effects of the extract of Rosa rugosa. It can be regarded that the antigastric and anti-ulcerative effect of Rosa rugosa is originated from the reduction of total acid output identified by gastric secretion test. To clarify the protective mechanism of the Rosa rugosa extract, the gastropathy was induced in rats with alcohol-salicylate and the activities of the free radical scavenging enzymes were examined. The acitivity of superoxide dismutase and glutathione peroxide were significantly increased and the total content of glutathione was recovered. We concluded that the protective effect of the extract of Rosa rugosa on gastropathy in rats is its ability increased the activities of the free radical scavenging enzymes.