The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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Effects of Saengjinyanghyutang-gamibang and Rosa rugosa on the Pancreas in the Streptozotocin Treated Mice for Induction of Diabetes

생진양혈탕가미방과 매괴화가 Streptozotocin으로 유발된 고혈당 생쥐의 췌장에 미치는 영향

  • 홍광표 (동신대학교 한의과대학 한의학과) ;
  • 나창수 (동신대학교 한의과대학 한의학과) ;
  • 장경선 (동신대학교 한의과대학 한의학과) ;
  • 김희철 (동신대학교 한의과대학 한의학과) ;
  • 박민희 (동신대학교 한의과대학 한의학과) ;
  • 김정상 (동신대학교 한의과대학 한의학과)
  • Published : 2001.12.01
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Abstract

Objectives : This study has been carried out to investigate the effects of the Saengjinyanghyutang-gamibang and Rosa rugosa extracts on pancreas of the hyperglycemia mice induced with streptozotocin. Methods : We examined immunohistochemistry for insulin and COX-2, ultrastructural changes of acini by electron microscope, and changes of the blood glucose and BUN levels. Results : The ${\beta}-cells$ on Langerhnan's islet were destructed by administration of streptozotocin, so that few insulin-positive cells were observed in the control group. However, a lot of insulin-positive cells were observed in the experimental groups. These cells had recovered from the damage. As a result of COX-2 immunostain, COX-2 expression were highest in the control group other than the Saengjinyanghyutang-gamibang and Rosa rugosa extracts administered groups. As the electron microscopical observation, the centroacinar cells and acini of pancreas were destructed or damaged by administration of streptozotocin in the control group, but these recovered !Tom the damage in the other experimental groups. The levels of serum glucose were decreased remarkably on the Rosa rugosa and Saengjinyanghyutang-gamibang extracts administered groups compared with control group. Conclusions : These results suggest that administration of the Rosa rugosa and Saengjinyanghyultang-gamibang extracts to the mice reduced the damage induced by streptozotocin.

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References

  1. 黃帝內經素問靈樞合編 馬蒔;志聰
  2. 大韓韓醫學會誌 v.16 no.2 生津養血湯이 고혈당 쥐의 혈중지질성분에 미치는 영향 김신석;최종원;이경희;이철완
  3. 新編中醫大辭典 江蘇新醫學院
  4. 方藥指鍼 孟華燮
  5. 임상내분비학 민헌기
  6. 내분비학 서울대학교의과대학
  7. 당뇨병학 김응진(외)
  8. 내과학 서울대학교 의과대학 내과학교실
  9. 景岳全書 張仲景
  10. 備急千金要方 孫思邈
  11. 醫學入門 李천
  12. 실용중의내과학 황문동
  13. 方藥合編解說 申載鏞
  14. 沈氏尊生書 沈金鰲
  15. 古今醫方集成 吳克潛
  16. 東醫寶鑑 許浚
  17. 大韓韓醫學會誌 v.16 no.2 고혈당 쥐의 췌장 효소활성에 미치는 生津養血湯의 영향 김신석;최종원;이철완
  18. 韓藥臨床應用 李尙仁(外)
  19. 약초의 성분과 이용 문관심
  20. 新編中醫大辭典 江蘇新醫學院
  21. 부산대학교 박사학위 논문 해당화 지하부의 성분에 관한 연구 박종철
  22. 중앙대학교 석사학위 논문 해당화근의 Buthanol fraction이 Streptozotocin 유발 고혈당 Rat의 간과 췌장에서의 과산화지질생성에 미치는 영향 천세영
  23. 동의생리학회지 v.6 no.1 해당화근이 Streptozotocin 당뇨 흰쥐의 간 Glycogen 함량에 미치는 영향 손낙원;유진화
  24. 本草學 李尙仁
  25. 한글판 중서의 결합 v.9 Ligustrazine(三芎진)이 CyclosproinA(CsA)로 일으킨 흰쥐 Langerhans'islets$\beta$ 세포독성에 미치는 방어보호작용의 실험 연구 顧明君;劉志民
  26. 한글판 중서의 결합 v.5 실험성 당뇨병흰쥐 신장비대 및 고여과 작용에 대한 대황의 영향 楊俊偉;黎磊石
  27. Ana Rec. v.251 no.2 Immunohistochemical and morphometric of the fetal pancreas in diabetic pregnants. Effects of insulin administration Calbo, R.M.;Forcen, R.;Obregon, M.J.;Escobar, del Rey F.;Moreale, de Escobar, G.;Regadera, J.
  28. Am J Physiol Endocrinol Metab v.278 no.4 Islet amyloid polypeptide(amylin)-deficient mice develop a more severe form of alloxan-induced diabetes Mulder, H.;Gebre-Medhin, S.;Betsholtz, C.;Sundler, F.;Ahren, B.
  29. Histochem J. v.31 no.5 An immunohistochemical study of macrophage influx and the co-localization of inducible nitric oxide synthase in the pancreas of non-obese deabetic(NOS) mice during disease acceleration with cyclophosphamide Reddy, S.;Yip, S.;Karanam, M.;Poole, C.A.;Ross, J.M.
  30. Am J Physiol v.270 no.6 Tyrosine kinase inhibitors prevent cytokine-induced expression of iNOS and COX-2 by human islets Corbett, J.A;Kwon, G.;Marino, M.H.;Rodi, C.P.;Sullivan, P.M.;Turk, J.;McDaniel, M.L.
  31. J Clin Invest v.104 no.4 Aberrant prostaglandin synthase 2 expression defines an antigen-presenting cell defect for insulin-dependent deabetes mellitus Litherland, S.A.;Xie, X.T.;Huston, A.D.;Wasserfall, C.;Whittaker, D.S.;She, J.X.;Hofig, A.;Dennis, M.A.;Fuller, K.;Cook, R.;Schatz, D.;Moldawer, L.L.;Clare-Salzler, M.J.
  32. Diabetes v.47 no.9 Dominance of cyclooxygenase-2 in the regulation of pancreatic islet prostaglandin synthesis Robertson, R.P.
  33. Proc Soc Exp Bio Med v.211 no.1 Cytokines and nitric oxide in islet inflamation and diabetes ML, Kwon, G.;Hill, J.R.;Marshall, C.A.;Corbett, J.A.
  34. Biochem Biophys Res Commun v.19;265 no.2 Cyclooxygenase-2 transcription is stimulated and amylase secretion is inhibited in pancreatic acinar cells after induction of acute pancreatitis Zabel-Langhenning, A.;Holler, B.;Engeland, K.;Mossner, J.
  35. Carciongenesis v.21 no.2 Cyclooxygenase-2 expression in human pancreatic adenocacinomas Yip-Schneider, M.T.;Barnard, D.S.;Billings, S.D.;Cheng, L.;Heilman, D.K,;Lin, A.;Marshall, S.J.;Crowell, P.L.;Marshall, M.S.;Sweeney, C.J.
  36. Clin Cancer Res v.5 no.8 Overexpression of cyclooxygenase-2 in carcinoma of the pancreas Okami, J.;Yamamoto, H.;Fujiwara, Y.;Tsujie, M.;Kondo, M.;Noura, S.;Oshima, S.;Nagano, H.;Dono, K.;Umeshita, K.;Ishikawa, O.;Sakon, M.;Matsuura, N.;Nakamori, S.;Monden, M.