• Bulletin of the Korean Chemical Society
• /
• v.29 no.1
• /
• pp.43-46
• /
• 2008

The aim of present study was to examine the inhibitory effects of hydroxamic acid derivatives on the melanogenesis. We found that hydroxamic acid moiety was important for anti-melanogenic activity. Compounds 1a and 1b strongly inhibited melanin synthesis via deactivation of tyrosinase. Hydroxamic acid has metal ion chelating ability which is similar to that kojic acid, however, anti-tyrosinase mechanism of compounds 1a and 1b was different from that of kojic acid. They showed noncompetitive inhibition kinetics

• Journal of Magnetics
• /
• v.6 no.1
• /
• pp.31-35
• /
• 2001

This paper describes the design method of a magnetic system to maximize the magnetic flux leakage (MFL) in a non-destructive testing (NDT) system. The defect signals in a MFL type NDT system mainly depend on the change of the magnetic leakage flux in the region of a defect. The characteristics of the B-H curves are analysed and a design method to define the operating point on B-H curves for maximum leakage is performed. The computed MFL signal by a nonlinear finite element method is verified by measurement using Hall sensors mounted on the 6 legs PIG, the traveling detector unit in gas pipe, in an 8 inch test tube with defects. The rhombic defects could be successfully identified from the defect signals.

• Kyungpook Mathematical Journal
• /
• v.55 no.3
• /
• pp.531-540
• /
• 2015

If T is an unbounded hyponormal operator on an infinite dimensional complex Hilbert space H with ${\rho}(T){\neq}{\phi}$, then it is shown that T satisfies Weyl's theorem, generalized Weyl's theorem, Browder's theorem and generalized Browder's theorem. The equivalence of generalized Weyl's theorem with generalized Browder's theorem, property (gw) with property (gb) and property (w) with property (b) have also been established. It is also shown that a-Browder's theorem holds for T as well as its adjoint $T^*$.

• 한국정보디스플레이학회:학술대회논문집
• /
• 2007.08a
• /
• pp.531-533
• /
• 2007

A new method is developed for the measurement of twist angles of LC molecules in an LC panel with angular resolution of 0.01degree, which allows measurement of LC panels with small twist angles. The method is based on the analysis of the change in polarization state of a light beam as it passes through the LC panel in test is rotated in-plane. Compared to other traditional method, including the analysis of transmittance change, our method is more sensitive and more precise. This method allows accurate determination of anchoring energy and close analysis of the rubbing process in the fabrication of IPS mode LC panels.

• The Transactions of the Korean Institute of Electrical Engineers B
• /
• v.55 no.3
• /
• pp.182-188
• /
• 2006

Contactless power system is base on power transmission by magnetic force. The transformer loss is large because it separated with the gap. Also the system has unstable factor, since the parameters in the secondary can vary with the system movement. This paper proposes light train power transmission system using contactless transformer with multiple primary winding. To increase the system efficiency and to obtain the stable power transmission to the dynamic load, a resonant inverter is adopted. The proposed system was verified by the simulation using Spice and Maxwell. The designed contactless power transmission system is implemented for 5[kW] class and experimental results are discussed.

• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.32 no.5
• /
• pp.392-399
• /
• 2008

Accurate measurement of speed and altitude of flying vehicles in air data system remains a critical technical issue. A highly reliable Pitot-static probe is required to obtain air data such as total pressure and static pressure. In this study, an analysis of the characteristics of flowfield around the Pitot-static probe was performed by using a Navier-Stokes CFD code. In addition, for the purpose of finding an optimal configuration, a technique based on the response surface method is applied to the problem with design parameters including shape of the nose section and cone angle. It is shown that the optimal configuration fulfills the MIL specification in wider range of high angles of attack.

• Bulletin of the Korean Chemical Society
• /
• v.25 no.9
• /
• pp.1403-1407
• /
• 2004

Dielectric relaxation measurements on 3-nitrotoluene (3-NT) mixture of dimethylacetamide (DMA), dimethylformamide (DMF) and dimethysulphoxide (DMSO) have been carried out across the entire concentration range using Time domain reflectometry technique at 15, 25, 35 and $45^{\circ}C$ over the frequency range from 10 MHz to 20 GHz. For all the mixtures, only one dielectric loss peak was observed in this frequency range and the relaxation in these mixtures can be well described by a single relaxation time using Debye model. Bilinear calibration method is used to obtain complex permittivity ${\varepsilon}^{*}({\omega})$ from complex reflection coefficient ${\rho}^{*}({\omega})$ over frequency range 10 MHz to 20 GHz. The excess permittivity, excess inverse relaxation time, Kirkwood correlation factor, molar energy of activation are also calculated for these mixtures to study the solute-solvent interaction.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• v.33 no.6
• /
• pp.636-642
• /
• 2007

Background: CpG DNA plays an important role in immune cell function. This study examined whether the temporal control of toll-like receptor (TLR)9 by CpG DNA can regulate the expression of matrix metalloproteinase-9(MMP-9). Methods and materials: Macrophages were cultured in the presence of 10% FBS. For the various MMP genes analysis, RT-PCR and real-time PCR were performed. In addition, zymography assay performed for the MMP activity. The phosphorylation assay did for the ERK1/2 and NF${\kappa}B$ activation, and luciferase promoter assay was for the NF${\kappa}B$ activity. Results: CpG DNA induced the mRNA expression of MMP-2, MMP-9, and MMP-13, but not of MMP-7, MMP-8, and MMP-12, in a time-dependent manner. Especially, the mRNA expression of MMP-9 was strongly induced by CpG DNA using real-time RT-PCR. The TLR9 inhibitor, chloroquine, suppressed CpG DNA-induced MMP-9 expression and its activity. Moreover, CpG DNA induced the phosphorylation of ERK and the inhibition of ERK by U0126 suppressed CpG DNA-induced MMP-9 expression and its activity. CpG DNA stimulated $I{\kappa}B-{\alpha}$ degradation and luciferase activity. In addition, pretreatment of SN-50, the inhibitor of NF${\kappa}B$, strongly blocked the CpG DNA-induced MMP-9 expression and activity. Conclusion: These observations suggest that CpG DNA may play important roles in the activation of macrophages by regulating the production of MMP-9 via the sequential TLR9-ERK-NF${\kappa}B$ signaling pathway.

• The Korean Journal of Food And Nutrition
• /
• v.27 no.2
• /
• pp.213-218
• /
• 2014

The enterotoxin production and antimicrobial susceptibility on hemolytic strains from stools of diarrheal pigs was investigated in this study. Through morphological observation, gyrB nucleotide sequence, and API kit analysis, the selected potential pathogenic strain BY06 was identified as Bacillus cereus. Because the characteristic of enterotoxin symptoms were widely caused by Bacillus cereus strains, a PCR test was carried out in order to check the enterotoxin genes (hblA) in this strain. According to the results, this strain was an enterotoxin positive strain containing the hblA gene. The minimum inhibitory concentrations of 10 different antimicrobial agents were screened by the agar dilution test, indicating that this strain was resistant to penicillin G and intermediate to erythromycin; however, it susceptible to cephalothin, vancomycin, clindamycin, fusidic acid, gentamicin, ciprofloxacin, tetracycline and rifampin. These results suggest that the B. cereus BY06 isolated from pig feces has a potential risk of producing enterotoxin and is resistant to penicillin G, but susceptible to various antimicrobial agents.

• The Pure and Applied Mathematics
• /
• v.16 no.4
• /
• pp.327-344
• /
• 2009

In this paper, we deal with the following system of nonlinear singular boundary value problems(BVPs) on time scale $\mathbb{T}$ $$\{{{{{{x^{\bigtriangleup\bigtriangleup}(t)+f(t,\;y(t))=0,\;t{\in}(a,\;b)_{\mathbb{T}},}\atop{y^{\bigtriangleup\bigtriangleup}(t)+g(t,\;x(t))=0,\;t{\in}(a,\;b)_{\mathbb{T}},}}\atop{\alpha_1x(a)-\beta_1x^{\bigtriangleup}(a)=\gamma_1x(\sigma(b))+\delta_1x^{\bigtriangleup}(\sigma(b))=0,}}\atop{\alpha_2y(a)-\beta_2y^{\bigtriangleup}(a)=\gamma_2y(\sigma(b))+\delta_2y^{\bigtriangleup}(\sigma(b))=0,}}$$ where $\alpha_i$, $\beta_i$, $\gamma_i\;{\geq}\;0$ and $\rho_i=\alpha_i\gamma_i(\sigma(b)-a)+\alpha_i\delta_i+\gamma_i\beta_i$ > 0(i = 1, 2), f(t, y) may be singular at t = a, y = 0, and g(t, x) may be singular at t = a. The arguments are based upon a fixed-point theorem for mappings that are decreasing with respect to a cone. We also obtain the analogous existence results for the related nonlinear systems $x^{\bigtriangledown\bigtriangledown}(t)$ + f(t, y(t)) = 0, $y^{\bigtriangledown\bigtriangledown}(t)$ + g(t, x(t)) = 0, $x^{\bigtriangleup\bigtriangledown}(t)$ + f(t, y(t)) = 0, $y^{\bigtriangleup\bigtriangledown}(t)$ + g(t, x(t)) = 0, and $x^{\bigtriangledown\bigtriangleup}(t)$ + f(t, y(t)) = 0, $y^{\bigtriangledown\bigtriangleup}(t)$ + g(t, x(t)) = 0 satisfying similar boundary conditions.