• 한방안이비인후피부과학회지
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• 제18권3호
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• pp.18-25
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• 2005

Objectives: It has a growing interest in the prevention and medical treatment of allergic rhinitis. According to many studies, it's known that Sinicheongpye-um has the inhibitory effect on the allergic rhinitis. We have studied effect of the mice on OVA-induced Production of IL-4, IL-5, $Interferone-{\gamma}$ by Murine Splenocytes and effect of OVA-induced Total IgE. Methods: Mixing Ovalbumin(OVA) $10{\mu}g$ into PBS(phoshate buffered saline) and $Al(OH)_3$, gel solution and changing into $1\;m{\ell}$, we made it into OVA solution. That was administered to normal group. After the last administration into abdominal cavity, we caused allergic rhinitis in nasal cavity of mouse of control group and sample group administering 0.1% solution dropwise 3 times a day for 7 days. Keeping separated serum at -20 degree and after refloating spleen cells, cultivating the cells and centrifuging the upper liquid and keeping it at -20 degree, we measured the amount of IL-4. IL-5, $Interferone-{\gamma}$ and OVA-induced Total IgE by ELISA. Results: 1. In Total IgE, Sinichengpae-um treated group was proved significant inhibitory effect.(p<0.05) 2. In IL-4 study, Sinichengpae-um treated group was proved significant inhibitory effect.(p<0.005) 3. In IL-4 study, Sinichengpae-um treated group was proved significant inhibitory effect.(p<0.001) 4. In $Interferone-{\gamma}$ study, Sinichengpae-um treated group showed a increasing tendency. Conclusion: Based on the above result, it is considered that Sinichengpae-um has the inhibitory effect on the allergic rhinitis of mice and suggested thai it could be used in relieving patients of the symptoms which are caused by allergic rhinitis.

• 한방안이비인후피부과학회지
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• 제21권3호
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• pp.111-123
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• 2008

Objectives : We aimed to investigate therapeutic effect of Bojungikgitang-gamibang(BI) and Mahwangshingungsan(MS) by observing changes in blood cells and the nasal mucosa of Sprague-Dawley(SD) rats with allergic rhinitis. Methods : Twenty-four SD rats were divided into three groups: normal, control, and sample group. Allergic rhinitis was induced in the control and sample group by intraperitoneal and intranasal sensitization with 0.1% and 0.4% Ovalbumin solution. Then BI was orally administered only to the sample group along with MS for 28days, while the rats in the control group was given normal saline. Results : BI and MS showed significantly decreased IgE level on the serum of the rat model, Bl and MS showed significantly decreased eosinophil level on the blood of the rat model. BI and MS inhibited the inflammatory reaction on the nasal mucosal tissue, according to nasal mucosal biopsy. Bl and MS had anti-allergic according to level, eosinophil level, nasal mucosal biopsy. BI and MS had no hepatoxicity, according to AST and ALT on the serum. Conclusion : According to the above results, it is considered that Bl and MS is helpful in treatment of allergic rhinitis.

• 한방안이비인후피부과학회지
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• 제17권1호
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• pp.45-54
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• 2004

Major symptoms of allergic rhinitis are nasal obstructions, sneezing and watery rhinorrhea. Gamigyeji-tang has been used to treat for watery rhinorrhea, which is one of the symptoms of allergic rhinitis. This experimental study was done to rescarch effects of Gamigyeji-tang. We have studied effect of mice on OVA-induced Production of IL-4, IL-5, IFN-${\gamma}$ by Murine Splenocytes, and effect of OVA-induced total IgE and OVA-Specific IgE. The results were as follows ; 1. In IL-4 study, Gamigyeji-tang treated group was proved significant inhibitory effect(p〈0.005) 2. In IL-5 study, Gamigyeji-tang treated group was proved significant inhibitory effect.(p〈0.05) 3. In IFN-${\gamma}$ study, Gamigyeji-tang treated group was proved significant inhibitory effect(p〈0.000001) 4. In Total IgE, Gamigyeji-tang treated group didn't showed significant inhibitory effect. 5. In OVA-specific IgE, Gamigyeji-tang treated group didn't showed significant inhibitory effect. According to this result, Gamigyejj-tang was concluded to be effective on anti-allergic action. More studies are required to investigate the mechanism of inhibition by herbal medicine in allergic rhinitis model.

• 한방안이비인후피부과학회지
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• 제17권1호
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• pp.75-81
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• 2004

Objective: The study is performed to assure the effect of Sochungyong-tang against the wide-spread syndrome allergic rhinitis. For this purpose, the Sochungyong-tang is administered to the rat, which was induced the allergic rhinitis, then the histological change is observed. And the change of the number of neutrophil and eosinophil is also observed. Methods: The Sprague-Dawley male rats, about 200g of body weight, by Saemtako BIO Korea were divided into normal, control, and experimental group. The rats were adapted under the constant temperature and humidity for a week. The solid feed and the water were provided ad lid during the whole experiment By the Levine & Vaz method, the allergic reaction induced with ovalbumin as antigen by intraperitoneal route. As the Sochungyong-tang is administered, the histological changes of neutrophil, eodinophil, and mucosal findings were observed. Results: 1. Number of neutrophil was significantly decreased in the experimental group as compared with the control group. 2. Number of eosinophil was significantly decreased in the experimental group as compared with the control group. 3. The mucosa and submucosa of the nose in experimental group were appeared as normal histological findings. Conclusion: According to the above results, it is supposed that the Sochungyong -tang has considerable effect on allergic rhinitis.

• 대한예방한의학회지
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• 제18권3호
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• pp.69-80
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• 2014

Objective : Allergic rhinitis (AR) is an allergic inflammation of the nasal airways. Socheongryong-Tang traditionally has been used in Korea for treatment of allergy diseases. In the present study, we investigated whether SCRT suppresses the progression of AR in vivo and in vitro. Method : In this study, we investigated the effect of oral administration of SCRT on the Ovalbumin(OVA)-induced allergic rhinitis mouse models. Additionally, to find a possible explanation for the anti-inflammation effects of SCRT, we evaluated the inflammatory cytokine levels in LPS-stimulated mouse inflammation cell (RAW264.7) and mouse splenocyte. Results : The finding of this study demonstrated that SCRT reduced mast cells and inflammation cells infiltration in OVA-induced nasal cavity. Additionally, SCRT inhibited the production of inflammatory cytokines in splenocyte. However SCRT don't inhibited the production of inflammatory cytokines in RAW264.7 cells. Conclusion : Taken together, our results showed that oral administration of SCRT beneficial effects in allergic rhinitis, suggesting that SCRT might be a useful candidate for the treatment of allergic rhinitis.

• 한방안이비인후피부과학회지
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• 제23권3호
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• pp.216-224
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• 2010

Objective : The purpose of this study was investigated the effect of auricular Acupuncture treatment in Allergic rhinitis patients. Methods : This study was carried out on the 16 allergic rhinitis patients who had been treated at Cheongdogun public health center for The Good-Breath program. The Good-Breath program included auricular acupuncture was performed 2 times a week during 4 weeks. Auricular acupuncture points used were M101(肺), M13(副腎), M16(內鼻), M22(內分泌), M33(額), M55(神門). Patients nasal symptoms and QOL were assessed before and after 4 weeks treatment by the Severity Scoring Systems of Rhinitis(SSSR) and Quality of Life Questionnaire for Korean Rhinitisian(QLQKR). Results : 1. Total Severity Scoring Systems of Rhinitis(SSSR) Scores were significantly improved. but Each items was no significant difference. 2. Among items of QLQKR, Itching worry about western medicine worry about change of environment Role limitation-physical were significantly improved. and Total Quality of Life Questionnaire for Korean Rhinitisian(QLQKR) Scores were significantly improved.

• 한방안이비인후피부과학회지
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• 제18권2호
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• pp.36-50
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• 2005

Background and Objectives: Allergic rhinitis is an allergic reaction characterized by sneezingm itchy nose, mouth and throat, congestion and/or nasal discharge. The offending allergenes are usually pollens, molds, dust mites and animal allergen. Recently, the incidence of infectious nasal diseases tend to decrease. However, allergic rhinitis has increased and treatment in most cases has only deat with the symptom. Tongkyu-tang was composed of sixteen crude drugs. The Oriental Medical References mention therapeutic effects of Tongkyu-tang on nasal obstruction, watery nasal discharg. And Tongkyu-tang has clinically been used for the treatment of common cold, headache, sternutation, rhinitis etc. Speacially Tongkyu-tang is one of the most frequently used medical treatment for the allergic rhinitis. Experimental studies were conducted to investigate for the effect of Tongkyu-tang on the changes of neutrophil segment, lymphocyte, total IgE and nassal tissue in allergic rhinitis of ovalbumin-inhalation rat. Meterial and Methods: Fifteen Sprague-Dawley rats were divided into three group: normal group, control group, experimental group. To induce the allergic rhinitis in control group and experimental group, rats were sentitized intraperitoneally with 0.1 % ovalbumin solution 3 times at intervals of I week. Then intranasal sensitization was performed by diffusing 0.1 % ovalbumin solution 3 times at intervals of 2 days. After that time, rat in the experimental group were oral administration treated by Tongkyu-tang for 28 days. We observed changes in nasal tissue; changes in the number of white blood cell, red blood cell and total Ig E; also changes in the segment of neutrophil and lymphocyte in blood. And we observed the changes of AST, ALT of three group. We used anova test statistically. Result: The number of leucocyte remained unchanged between three group. The number of erythrocyte was increased in experimental group and control group when compared with the normal group. The segment of neutrophil, in blood was decreased in experimental group when compared with the control group but, that was not significant statistically(p<0.05). The promotion of lymphocyte in blood was significantly decreased in experimental group when compared with the Control group(p<0.05). Total IgE was decreased in experimental group when compared with the control group but, that was not significant statistically(p<0.05). The cilium be well preserved in experimental group: the nasal tissue in experimental group was similar to in the normal group. Congestion and expantion of grandular cell in nasal submucosa, hypertropy of epithelium in nasal mucosa, acid mucus in epithelium and neutral mucus in subepithelium were decreased in experimental group when compared with the control group. Effect of Tongkyu-tang on the liver function were also studies in rats. Treatment of Tongkyu-lang did not affected on AST and ALT. Conclusion: Considering the above experimental results, it is suggested that oral administration treatment using Tongkyu-lang, without worry about liver function injury, decreased response on an Animal model with Allergic Rhinitis.

• 대한임상검사과학회지
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• 제51권2호
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• pp.134-144
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• 2019

대사증후군과 알레르기 비염은 중요한 만성질환이다. 본 연구에서는 대사증후군의 각 항목에 따른 알레르기 비염 유병률의 관계를 분석하였다. 제4, 5, 6기 및 제7기 1차년도 국민건강 영양조사 자료를 이용한 것으로(KNHANES IV, V, VI, VII-1) (2007~2016년) 이 자료를 통합하여. 51,854명의 연구대상자를 선정하였다. 연령대는 청장년(19~39세), 중년(40~64세), 노년(65세 이상)으로 분류하였다. 또 대사증후군에 영향을 미치는 일반적인 특성인 근력운동, 걷기운동, 흡연, 음주가 미치는 영향이 있다는 사실에 근거하여 조사하였다. 따라서 본 연구는 연령대 및 근력운동, 걷기운동, 흡연, 음주에 따라서 대사증후군 및 알레르기 비염의 유병률에 미치는 영향을 조사했다. 연구 결과 전 연령대에서 대사증후군이 없는 대상자가 대사증후군이 있는 대상자보다 알레르기 유병률이 높았고, 이는 연령대가 낮을 수록 알레르기 유병률이 높은 것으로 나타났다. 종합해 보면, 이 연구의 결과는 연령별, 일반적 특성별(근력운동, 걷기운동, 흡연, 음주), 대사증후군 또는 대사증후군 각각의 항목별로 알레르기 비염 유병률에 유의한 영향을 미친다는 것을 확인하였다. 본 연구에서 발견된 근거를 바탕으로 대사증후군과 알레르기 비염 유병률의 상관관계를 더 잘 이해하는데 도움이 될 것이다.

• 대한한방내과학회지
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• 제26권2호
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• pp.467-474
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• 2005

The main symptoms of allergic rhinitis are sternulation, rhinorrhea and rhinanchon. It is also characterized by frontal headache, ohotophobia and epiphora. Alleric rhinitis occurs when inhaled alleren is in contact with nasal mucosa which causes immune response. Bojungiki-Tang is one of the most frequently used medical treatment for the allergic rhinitis. Two chronic perennial allergic rhinitis sutterers, whose alleraies are thought to be due to house dust and ticks, were investigated through the eosinoohil numerical index and the subject symptom numerical index for three months. After treatment, both patients showed a lower index for both tests. The symptom index scores diminished from 17 to 3, and from 16 to 5. The eosinophil numerical index taken through blood tests, diminised from 4 to 2, and from 4 to 3. The above results suggest that Bojungiki-Tang has the inhibitory effects on allergic rhinitis.

• 대한한방내과학회지
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• 제43권5호
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• pp.901-908
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• 2022

Objective: The purpose of this study is to report the efficacy of using Korean medical treatment for suspected allergic rhinitis. Methods: We used Korean medical treatments (herbal medicines and acupuncture) to treat a hospitalized patient with suspected allergic rhinitis. To evaluate the treatment, we used Total Nasal Symptom Scores to measure sneezing, rhinorrhea, itching, and obstruction. The degree of rhinitis was also evaluated using the Visual Analogue Scale, and the patient's generic health status was measured using the European Quality of Life 5 Dimensions Scale. Results: Visual Analogue Scale and European Quality of Life 5 Dimensions Scale scores improved after treatment. The change in Total Nasal Symptom Scores showed that the patient's suspected allergic rhinitis symptoms were relieved. Conclusions: The results of this study suggest that Korean medicine therapies may be effective for treating suspected allergic rhinitis.