Journal of Society of Preventive Korean Medicine (대한예방한의학회지)

Society of Preventive Korean Medicine (대한예방한의학회)
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Anti-allergic effects of So-Cheong-Ryong-Tang in ovalbumin-induced allergic rhinitis model

난알부민 유도 알레르기 비염 마우스에 대한 소청룡탕(小靑龍湯)의 효능 실험연구

  • Kim, Ilhwan (Department of Preventive Medicine, College of Korean Medicine, Kyunghee University) ;
  • Ku, Jinmo (Department of Preventive Medicine, College of Korean Medicine, Kyunghee University) ;
  • Hur, Hansol (Department of Preventive Medicine, College of Korean Medicine, Kyunghee University) ;
  • Na, Changhyeok (Department of Preventive Medicine, College of Korean Medicine, Kyunghee University) ;
  • Jang, Bo-Hyoung (Department of Preventive Medicine, College of Korean Medicine, Kyunghee University) ;
  • Shin, Yong-Cheol (Department of Preventive Medicine, College of Korean Medicine, Kyunghee University) ;
  • Ko, Seong-Gyu (Department of Preventive Medicine, College of Korean Medicine, Kyunghee University)
  • 김일환 (경희대학교 한의과대학 예방의학교실) ;
  • 구진모 (경희대학교 한의과대학 예방의학교실) ;
  • 허한솔 (경희대학교 한의과대학 예방의학교실) ;
  • 나창혁 (경희대학교 한의과대학 예방의학교실) ;
  • 장보형 (경희대학교 한의과대학 예방의학교실) ;
  • 신용철 (경희대학교 한의과대학 예방의학교실) ;
  • 고성규 (경희대학교 한의과대학 예방의학교실)
  • Received : 2014.11.19
  • Accepted : 2014.12.22
  • Published : 2014.12.31
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Abstract

Objective : Allergic rhinitis (AR) is an allergic inflammation of the nasal airways. Socheongryong-Tang traditionally has been used in Korea for treatment of allergy diseases. In the present study, we investigated whether SCRT suppresses the progression of AR in vivo and in vitro. Method : In this study, we investigated the effect of oral administration of SCRT on the Ovalbumin(OVA)-induced allergic rhinitis mouse models. Additionally, to find a possible explanation for the anti-inflammation effects of SCRT, we evaluated the inflammatory cytokine levels in LPS-stimulated mouse inflammation cell (RAW264.7) and mouse splenocyte. Results : The finding of this study demonstrated that SCRT reduced mast cells and inflammation cells infiltration in OVA-induced nasal cavity. Additionally, SCRT inhibited the production of inflammatory cytokines in splenocyte. However SCRT don't inhibited the production of inflammatory cytokines in RAW264.7 cells. Conclusion : Taken together, our results showed that oral administration of SCRT beneficial effects in allergic rhinitis, suggesting that SCRT might be a useful candidate for the treatment of allergic rhinitis.

Keywords

References

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