• International Journal of Precision Engineering and Manufacturing
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• v.9 no.2
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• pp.84-92
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• 2008

Free-form shapes which were once considered as an aesthetic feature are now an important functional requirement. CNC industries are looking for a compact solution for reproducing free-form shapes as conventional interpolation models are inadequate, The parametric curve interpolator developed in the last decade has clearly emerged as favorite among its contemporaries in recent years, At present intense research has been done on parametric curve interpolators and interesting developments are reported. Out of the various parametric representations for curves and surfaces, NURBS has been standardized and widely used in free-form shape design. This paper presents a review of various methods of parametric interpolation for NURBS and discusses the salient features, problems and solutions. Recent approaches on variable feedrate interpolation, parameter compensation are also reviewed and research trends are addressed finally.

• The Journal of Korean Physical Therapy
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• v.12 no.2
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• pp.203-217
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• 2000

This review describes the overall knowledges of parkinson's disease. There are involved the causes. chemical characteristics, clinical features including tremor. bradykinesia, and rigidity. evaluation of movement disorders. and physical therapy of parkinson's disease. People who are diagnosed with parkinson's disease experience movement disorders that, if not managed, can lead to considerable disability. Before treated with parkinson's disease, it is important to recognise the pathogenesis of that. Then we need to develop physiotherapeutic programs based on the pathophysiology of parkinson's disease.

• Communications for Statistical Applications and Methods
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• v.22 no.2
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• pp.181-199
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• 2015

In a short history, RNA-seq data have established a revolutionary tool to directly decode various scenarios occurring on whole genome-wide expression profiles in regards with differential expression at gene, transcript, isoform, and exon specific quantification, genetic and genomic mutations, and etc. RNA-seq technique has been rapidly replacing arrays with seq-based platform experimental settings by revealing a couple of advantages such as identification of alternative splicing and allelic specific expression. The remarkable characteristics of high-throughput large-scale expression profile in RNA-seq are lied on expression levels of read counts, structure of correlated samples and genes, larger number of genes compared to sample size, different sampling rates, inevitable systematic RNA-seq biases, and etc. In this study, we will comprehensively review how robust Bayesian and non-parametric methods have a better performance than classical statistical approaches by explicitly incorporating such intrinsic RNA-seq specific features with flexible and more appropriate assumptions and distributions in practice.

• Proceedings of the Korean Nuclear Society Conference
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• 1995.05a
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• pp.602-607
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• 1995

This article presents safety review experience of microprocessor-based Interposing Logic System(ILS) of Engineering Safety Feature Actuation System(ESFAS). The ILS is the first application of computerized logic design to safety system in Korean nuclear power plants without verification of the system reliability by proven technology concept. As a result of evaluation for the ILS, Korea Institute of Nuclear Safety(KINS) concluded that the microprocessor-based ILS is not acceptable in some features detailed enough to defend against software common mode failures(CMF). Therefore, we required licensee to install hardwired interlock signal configuration and a Hardwired Backup Panel to control safety-related equipment. We believe that the microprocessor-based ILS with the hardwired backup panel and inter-connection of interlock signal by hardwired configuration will improve the plant safety.

• The Journal of Korean Medicine
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• v.31 no.3
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• pp.128-132
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• 2010

Objectives: This study aimed to review the general features of drug induced liver injury (DILI) and the important factors in consideration of herbal drugs and DILI. Methods: We reviewed general aspects of DILI such as classification, inducible factors, diagnosis methods, prevention, and the status of herbal drug-associated DILI via literature. Results: Besides the drug itself, genetic and environmental factors affect hepatic toxicity. There is a lack of definitive diagnoses of DILI by drugs, including herbal remedies. The possibility of herbal drug-associated DILI is exaggerated, and majority of herbal drug-derived hepatic injury could be easily prevented if Oriental doctors pay attention to this issue. Conclusion: This study can provide Oriental doctors an overview and be helpful in minimizing the episodes of hepatotoxicity in use of herbal drugs.

• Imaging Science in Dentistry
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• v.48 no.2
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• pp.139-145
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• 2018

Aspergilloma of the maxillary sinus is considered rare in immunocompetent patients, but a considerable increase has recently been seen in the incidence of reported cases. Dental procedures involving the antral region are thought to predispose individuals to this form of aspergillosis. Because aspergilloma shares similar clinical features with other sinus pathologies, its diagnosis may be delayed. Thus, an early diagnosis confirmed by a histopathological examination plays a crucial role in the adequate management of aspergilloma. This article provides a concise review of the reported cases of aspergilloma associated with dental procedures and reports 2 new cases of aspergilloma in middle-aged female patients, with a presentation of their cone-beam computed tomographic findings.

• Genomics & Informatics
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• v.12 no.4
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• pp.136-144
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• 2014

Besides single-nucleotide variants in the human genome, large-scale genomic variants, such as copy number variations (CNVs), are being increasingly discovered as a genetic source of human diversity and the pathogenic factors of diseases. Recent experimental findings have shed light on the links between different genome architectures and CNV mutagenesis. In this review, we summarize various genomic features and discuss their contributions to CNV formation. Genomic repeats, including both low-copy and high-copy repeats, play important roles in CNV instability, which was initially known as DNA recombination events. Furthermore, it has been found that human genomic repeats can also induce DNA replication errors and consequently result in CNV mutations. Some recent studies showed that DNA replication timing, which reflects the high-order information of genomic organization, is involved in human CNV mutations. Our review highlights that genome architecture, from DNA sequence to high-order genomic organization, is an important molecular factor in CNV mutagenesis and human genomic instability.

• Molecules and Cells
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• v.41 no.6
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• pp.506-514
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• 2018

The transcriptional regulation of genes determines the fate of animal cell differentiation and subsequent organ development. With the recent progress in genome-wide technologies, the genomic landscapes of enhancers have been broadly explored in mammalian genomes, which led to the discovery of novel specific subsets of enhancers, termed super-enhancers. Super-enhancers are large clusters of enhancers covering the long region of regulatory DNA and are densely occupied by transcription factors, active histone marks, and co-activators. Accumulating evidence points to the critical role that super-enhancers play in cell type-specific development and differentiation, as well as in the development of various diseases. Here, I provide a comprehensive description of the optimal approach for identifying functional units of super-enhancers and their unique chromatin features in normal development and in diseases, including cancers. I also review the recent updated knowledge on novel approaches of targeting super-enhancers for the treatment of specific diseases, such as small-molecule inhibitors and potential gene therapy. This review will provide perspectives on using super-enhancers as biomarkers to develop novel disease diagnostic tools and establish new directions in clinical therapeutic strategies.

• Structural Engineering and Mechanics
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• v.45 no.2
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• pp.159-168
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• 2013

The effect of structural uncertainties or measurement errors on damage detection results makes the robustness become one of the most important features during identification. Due to the wide use of vibration signatures on damage detection, the development of vibration-based techniques has attracted a great interest. In this work, a review on vibration-based robust detection techniques is presented, in which the robustness is considerably improved through modeling error compensation, environmental variation reduction, denoising, or proper sensing system design. It is hoped that this study can give help on structural health monitoring or damage mitigation control.

• International Journal of High-Rise Buildings
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• v.8 no.4
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• pp.265-273
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• 2019

The purpose of this review paper is to briefly describe main the features of novel procedures developed by the National of Standards and Technology (NIST) for the design of tall buildings. Topics considered in the paper include: the division of tasks between wind and structural engineers; the determination of wind effects with specified mean recurrence intervals by accounting for wind directionality; the risk-consistent design of structures subjected to multiple wind hazards; iterative dynamic analyses and member sizing, including the use of modern optimization approaches; and commonalities of and differences between Database-assisted Design (DAD) and Equivalent Static Wind Loads procedures. An example of the application of the DAD procedure is presented for a reinforced concrete structure. Also included in the paper is an introduction to ongoing research on the estimation of wind load factors or of augmented design mean recurrence intervals commensurate with the uncertainties in the factors that determine the wind effects.