• The Korean Journal of Nuclear Medicine
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• v.29 no.1
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• pp.110-117
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• 1995

Tc-99m Labeled hexamethylenepropyleneamineoxime ([$^{99m}Tc$]-HMPAO) is a famous amino-oxime compound and is widely used to construct SPECT images of cerebral blood flow. To investigate the relationship between chemical structure and radiolabeling in these kind of diamine-oxime compounds, we synthesized seven compounds by Schiff's base formation and successive reduction with sodium borohydride. They were (RR/SS )-4,8-diaza-3,6,6,9-tetramethylundecane-2,10-dione bisoxime (2), (RR/SS/meso)-4,8-diaza-3,9-dimethy-lundecane-2,10-dione bisoxime (4), (RR/SS/meso)-4,8-diaza-3,10-dimethyldodecane-2,11-dione bisoxime (5), (RR/SS/meso)-4,7-diaza-3,6,6,8-tetramethyldecane-2,9-dione bisoxime (8), (RR/SS/meso)-4,7-diaza-5,6-cyclohexyl-3,8-dimethyldecane-2,9-dione bisoxime (10), (RR/SS/meso)-3,4-bis(1-aza-2-methyl-3-oxime-1-butyl)-benzoic acid (12), and (RR/SS/ meso)-2,3-bis(1-aza-2-methyl-3-oxime-1-butyl) benzophenone (14). Chemical structures of all the synthesized compounds were identified by taking $^1H$ spectrum. Among them, 2 and 4 are propyleneamine oxime (PnAO), 6 is butyleneamine oxime (BnAO) and 8, 10, 12 and 14 are ethyleneamine oxime (EnAO). Each compound (0.5 mg) was incubated with stannous chloride (0.5 g - 8 g), carbonate-bicarbonate buffer (final concentration = 0.1 M, pH 7 - pH 10) and Tc-99m-pertechenate (1 ml). Tc-99m labeling of these compounds were checked by ITLC (acetone), ITLC (normal saline), reverse phase TLC (50 % acetonitrile) and ITLC (ethyl acetate). According to the results, EnAO's were not labeled by Tc-99m in any of above condition. About 11 % of maximum labeling efficiency was obtained with BnAO. However, 4 (PnAO) was labeled with Tc-99m to 85 % which is similar to the labeling efficiency of 2 (HMPAO). Hydrophilic impurity (9 % ) was the most significant problem with the labeling of 4, however, pertechnetate (3 % ) and colloid (3 %) were minor problem. In conclusion, we synthesized seven diamine blsoxlme compounds. Among them, four EnAO compounds were not labeled by Tc-99m. A BnAO was labeled poorly and two PnAO's were labeled well. These labeling can be explained by tertiary structure of their Tc-99m chelate.

• International Commerce and Information Review
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• v.14 no.2
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• pp.147-172
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• 2012

The aim of this research is to identify the competencies required by freight forwarding company logistics managers or supply chain managers. And this research also attempts to show their relative importance and key knowledge areas that require improvement. Using a survey questionnaire, data was collected against forty three logistics and supply chain management skills or competencies, which were then grouped into four categories and analysed. The Analysis revealed that supply chain awareness, ability to make decisions, analytical skill, communication skill, supply chain cost, people skill, and integration of internal or external information flow which belong to logistics planning group are considered the most important competencies for effective and efficient logistics functioning. On the other hand, reverse logistics and IATA regulations from environmental awareness group show little influence on logistics managers for improving their logistics performances. The results have implications for a variety of parties including prospective logisticians, students, teachers and companies considering expanding their business to Chinese market. For example, the results permit companies to employ appropriate logistics managers who are qualified with sufficient skills and competencies suggested in this research. In the case of practitioners, the results provide a benchmark for comparison with their current level of abilities and suggested competencies.

• International Commerce and Information Review
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• v.13 no.4
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• pp.251-274
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• 2011

The aim of this research is to identify the competencies required by logistics managers or supply chain managers in China. And this research also attempts to show their relative importance and key knowledge areas that require improvement. Using a survey questionnaire, data was collected against forty three logistics and supply chain management skills or competencies, which were then grouped into four categories and analysed. The Analysis revealed that supply chain awareness, ability to make decisions, analytical skill, communication skill, supply chain cost, people skill, and integration of internal or external information flow which belong to logistics planning group are considered the most important Competencies for effective and efficient logistics functioning. On the other hand, reverse logistics and IATA regulations from environmental awareness group show little influence on logistics managers for improving their logistics performances. The results have implications for a variety of parties including prospective logisticians, students, teachers and companies considering expanding their business to Chinese market. For example, the results permit companies to employ appropriate logistics managers who are qualified with sufficient skills and competencies suggested in this research. In the case of practitioners, the results provide a benchmark for comparison with their current level of abilities and suggested competencies.

• Food Science and Preservation
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• v.24 no.6
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• pp.795-801
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• 2017

Aralia elata Seemann (AE) has long been used as a folk medicine for the treatment of various diseases including diabetes mellitus, anti-arthritic, and anti-gastric ulcer agent in Korea, Japan, and China. This study was performed to establish a simple and reliable HPLC/UV analytical method for determination of most active anti-hypertensive compound, a 3-O-${\alpha}$-L-rhamnopyranosyl($1{\rightarrow}$2)-${\alpha}$-L-arabinopyranosyl hederagenin 28-O-${\beta}$-D-xylopyranosyl($1{\rightarrow}6$)-${\beta}$-D-glucopyranosylester (HE) for the standardization of the shoot extract of AE as a health functional food ingredient. The quantitative analytical method of HE was optimized by HPLC analysis using reverse-phase C18 column at $40^{\circ}C$ with $H_2O$ and acetonitrile (70:30, v/v) as an isocratic mobile phase at a flow rate of 1.0 mL/min and detection wavelength of UV 205 nm. This HPLC/UV analytical method showed good specificity and high linearity in the tested range of 0.03125-2.0mg/ml with excellent coefficient of determination ($R^2$) of 0.9999. The limit of detection and limit of quantification were $12.0{\mu}g/mL$ and $36.5{\mu}g/mL$, respectively. Relative standard deviation (RSD) values of data from intra- and inter-day precision were less than 0.2% and 0.1%, respectively. These results indicate that the established HPLC/UV analytical method is very simple, specific, precise, accurate, and reproducible and thus can be useful for the quantitative analysis of HE as a functional anti-hypertensive compound in AE extract.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.11 no.2
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• pp.204-208
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• 2018

In this paper, we proposed and evaluated the time series deep learning prediction model for learning fluctuation pattern of stock price. Recurrent neural networks, which can store previous information in the hidden layer, are suitable for the stock price prediction model, which is time series data. In order to maintain the long - term dependency by solving the gradient vanish problem in the recurrent neural network, we use LSTM with small memory inside the recurrent neural network. Furthermore, we proposed the stock price prediction model using bidirectional LSTM recurrent neural network in which the hidden layer is added in the reverse direction of the data flow for solving the limitation of the tendency of learning only based on the immediately preceding pattern of the recurrent neural network. In this experiment, we used the Tensorflow to learn the proposed stock price prediction model with stock price and trading volume input. In order to evaluate the performance of the stock price prediction, the mean square root error between the real stock price and the predicted stock price was obtained. As a result, the stock price prediction model using bidirectional LSTM recurrent neural network has improved prediction accuracy compared with unidirectional LSTM recurrent neural network.

• Journal of the Korean association of regional geographers
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• v.3 no.1
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• pp.13-34
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• 1997

The impact of a central place on daily living over wide outlying territory has been one of traditional subjects in the field of urban geography. The flow of rural population toward the central city of Chinju characterizes the population movement in Western Kyungnam, where the spillover of urban population into outlying areas, an especially prominent phenomenon in American society, does not occur. The central city of Chinju is supposed to be the most favored settlement area in Western Kyungnam. More than two thousands of teachers. who live in Chinju, cross the city boundary each morning to do their jobs in Western Kyungnam. But only ninety teachers living outside Chinju commute to the workplace in the city. The teachers willingly spend hours commuting each day to enjoy better quality of life in the central city. In fact, the central city of Chinju functions as bedroom communities for many middle-class workers in Western Kyungnam. On the basis of teachers' commuting behavior, four levels of Chinju's urban spheres are identified in Western Kyungnam. As Table-6 and Figure-2 show, the first-order level of Chinju's sphere includes most Myuns of Sanchung/Hadong Guns and some Myuns of Sachun/Gosung Guns. The second-order level comprises Sanchung/Sachun Eubs and many Myuns of Sachun /Gosung Guns. The third-order level is made up of Samchunpo, Hadong/Gosung/Eryung/Namhae/Habchun/Hamyang Eups, and many Myuns of Eryung/Namhae/Habchun Guns. And all of Guchang Gun and most Myuns of Hamyang Gun belong to the fourth-order level of Chinju's sphere. The influence sphere of Metropolitan Chinju is extended farther in the direction of less competition with other metropolises. Such a situation occurs to the west and south of Chinju. Daily commuting, defined as the journeys to and from work, is an excellent indicator for delimiting urban spheres of influence.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.6
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• pp.9-20
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• 2018

When a large-scale photovoltaic (PV) system is introduced into a distribution system, the customer's voltage may exceed the allowable limit ($220V{\pm}6%$) due to voltage variations and reverse power flow in the PV system. In order to solve this problem, we propose a method for adjusting the customer voltage using the existing step voltage regulator (SVR) installed in the primary feeder. However, due to the characteristics of a mechanically operating SVR, the customer voltage during the tap changing time of the SVR is likely to deviate from the allowable limit. In this paper, an energy storage system (ESS) with optimal operation strategies, and an appropriate capacity calculation algorithm are proposed, and the parallel driving scheme between the SVR and the ESS is also proposed to solve the customer voltage problem that may occur during the tap changing time of the SVR. The simulation results show that the allowable limit of the customer voltage is verified by the proposed methods during the tap changing time of the SVR when the large-scale PV system is connected to the distribution system.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.5
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• pp.22-33
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• 2021

In the case of open phase faults caused by the disconnection of distribution feeders interconnected to a PV system, many problems can occur depending on the core type and wiring method of the grid-connected transformers. Moreover, open phase faults are difficult to detect because the open phase voltage of the existing protection relay (Open Phase Relay (47)) can be maintained, even though a disconnection fault occurred, depending on the wiring method and the iron core type of the grid-connected transformer for a PV system. Therefore, this paper proposes a novel algorithm to detect open phase faults by comparing the currents and phases between the primary and secondary sides of a grid-connected transformer. In addition, this paper presents the modeling of a distribution system and protection devices for detecting open phase faults using PSCAD/EMTDC S/W, and implements a test protection device for detecting open phase faults based on the above-mentioned modeling. The simulation and test results confirmed that the proposed algorithm is useful for detecting open phase faults according to the wiring method and iron core type of grid-connected transformer for a PV system because operation slope and unbalance rate of the primary current exceed the setting value (30[%]) of the protection device.

• Journal of Korea Water Resources Association
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• v.55 no.1
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• pp.99-109
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• 2022

This study was intended to suggest the applicability of stepped boulder fishway using the concept of traditional boulder weir, focusing on the problems of existing concrete pool-and-weir fishways installed in mountain streams. To achieve this purpose, a stepped boulder fishway was designed and constructed as a pilot project in consideration of ascending capacity of the selected target fishes. Under the given discharge conditions, the hydraulic characteristics of the fishway were investigated in the field, and the characteristics and ascending capacity of the fishes were compared and analyzed. The fishway had a short length and steep slope, but the mean drops between each baffle were the range of 0.15 to 0.29 m, and this range satisfied the limit condition of about 0.40 m, which was in the limit of the drop that target fishes can ascend. The mean velocities of each baffle and pool were 0.82 to 0.87 m/sec and 0.13 to 0.24 m/sec. This result satisfied the conditions of burst speed (10 to 30 times of body length) and mean velocity of the resting pool (7 to 25% of burst speed) for target fishes. Since the bottom surface of the pool formed of boulders had a gentle reverse slope and rotational flow did not occur, the efficiency of fishway can be increased, and it will also be possible to solve the maintenance problem by flushing bed materials.

• The Journal of Internal Korean Medicine
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• v.43 no.4
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• pp.582-595
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• 2022

Objectives: To investigate the effects of acupuncture at GV20 and EX-HN1 on cerebral blood flow (CBF) velocity and cerebrovascular reactivity (CVR) in the middle cerebral arteries (MCA) and anterior cerebral arteries (ACA) and to compare the effects to acupuncture at GV20. Methods: The study was a randomized, crossover trial that included 10 healthy men aged 20 to 29 years who underwent acupuncture treatment four times with a washout period of one week. The CBF velocity and CVR were measured by transcranial Doppler sonography (TCD) on both MCAs at the first and second visits, and both ACAs at the third and fourth visits. Participants were randomly assigned to one of two groups (A and B) before the first and third visits. Group A received two phases of acupuncture intervention at a single GV20 point and a combination of GV20 and EX-HN1 acupoints. Group B received the same interventions, but in the reverse order. Results: The increase in CO₂ reactivity was significantly higher for the combination acupoints of GV20 and EX-HN1 than for the GV20 single acupoint in both MCAs (Right: 136 to 178, p=0.017; Left: 127 to 191, p=0.017) and ACAs (Right: 133 to 158, p=0.013; Left: 122 to 168, p=0.025). No significant change was noted in the corrected velocity at PETCO₂ 40 mmHg, blood pressure, or heart rate. Conclusions: The findings suggest that improvement of the CBF in the MCA and ACA after GV20 acupuncture increases when acupuncture is also performed at EX-HN1. These results clinically support the combined use of EX-HN1 and GV20 to treat disorders of MCA and ACA circulation.