• 제목/요약/키워드: Retention factors

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Drug research and development tend to hyperlipidemia (이상지질혈증과 치료제 연구개발 경향)

  • Seol, In-Chan
    • Journal of Haehwa Medicine
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    • 제18권2호
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    • pp.1-12
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    • 2009
  • Most of the cholesterol is synthesized by liver in the body while about one of third is taken via dietary. The main functions of cholesterol is to protect membranes in cell surface, avoid the arterial bleeding by hypertension, and prolong the life of erythrocytes, and so on. However, overload of cholesterol leads to arteriosclerosis associated with leading death cause. Lack of physical activity, emotional and environmental stress, and low intake of protein or vitamin E induce the unbalance between HDL- and LDL-cholesterol so become a basis of ischemic disorders in heart, brain and elsewhere in the body. So far, four major classes of medications for hyperlipidemia are HMG-CoA reductase inhibitors (statins), bile acid sequestrants, nicotinic acid, and fibric acids. The statins can lower LDL and levels triglyceride, but may induce myopathy and an elevation of liver enzyme levels. The bile acid sequestrants lower LDL levels and raise HDL levels with no effect on triglyceride levels but side effects of gastrointestinal (GI) distress, constipation, and a decrease in the absorption of other drugs. Nicotinic acid and fibric acids lower LDL and triglyceride levels with showing flushing, hyperglycemia, hyperuricemia, GI distress, and hepatotoxicity dyspepsia, gallstones, myopathy, and unexplained noncardiac death as adverse effects. Above western drugs lower cholesterol by 15 to 30% while all have notable adverse effects. In traditional medicine, hyperlipidemia is regarded as retention of phlegm and fluid disease. Etiology and pathogenesis of hyperlipidemia is basically based on Spleen-Deficiency and Phlegm-Stagnation, accumulation and stasis of -heat, and Qi & blood stagnation induced by Phlegm-damp, water-dampness, and blood stasis. Thereby, strengthening Spleen and dissolving Phlegm, clearing away heat and diuresis, and supplementing Qi and activating blood circulation are commonly used therapeutic methods for hyperlipidemia. The traditional herbal medicine, have been used for patients with CVA, hypertension or hyperlipidemia in Oriental hospital or Oriental clinic. The lock and key theory is used to develop most of western medicine, however many diseases are caused by mixed factors in body-complex system. We expect that Oriental pharmacological theory could be newborn as a novel drug showing high advantage of blood levels of lipidsand QOL of performance without side effects.

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A Study on a Design for the Korean Coast Guard Uniform (한국 해양경찰복제 디자인 연구)

  • Lee, Jae-Jung;Kim, Youn-Hee
    • Journal of the Korean Society of Costume
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    • 제61권5호
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    • pp.1-20
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    • 2011
  • As a follow-up of a study on design strategies to improve Korea's Korean coast guarduniforms, this study set out to propose Korean coast guard uniforms of a new concept that would meet the changing needs of the times and match the advanced technology and work environments. Three concepts of classical, nautical and techno chic were identified from the design strategies of the previous study. Using the results from a prototype show and preference survey, the investigator divided items into design, color, material, and detail and reflects demands for each of them. As a result, design was examined in four aspects of identity, acknowledgement, unity, and practicality and focused its improvement factors on design differentiated from other organizations' uniforms including ground police, segmentation of size system, adjustment of the length of upper garment to consider activity, and changes to the lines and silhouette to give out a modern image. As for color, the focus was placed on differentiated colors from other organizations' uniforms including ground police through dark blue and ocean color, change toward colors that reflect environmental characteristics, and unity in colors between the summer and winter uniform. As for material, the focus of improvement was put on elasticity, resistance against contamination, warmth retention, texture, wearing sensation, and functionality by taking into account convenience for field workers on coast guard vessels and branch offices who have much time in contact with ocean environments in order to make the materials high-grade. As for detail, structural details were added to give out a modern image such as changing the detail lines, efficiency of storage space, buttons, sleeve hems, ironing lines, and neck collars by taking into account environmental characteristics. The significance of the study lies in that it proposed a development model for large-scale uniform copy design by establishing copy design that secures functionality and is proper for an organization's social and cultural environment.

Resistance of Methyl Methacrylate-Impregnated Wood to Subterranean Termite Attack

  • Hadi, Yusuf Sudo;Massijaya, Muh. Yusram;Zaini, Lukmanul Hakim;Abdillah, Imam Busyra;Arsyad, Wa Ode Muliastuty
    • Journal of the Korean Wood Science and Technology
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    • 제46권6호
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    • pp.748-755
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    • 2018
  • Timber from fast-growing tree species is susceptible to by biodeterioration attack, particularly subterranean termites. Impregnation with methyl methacrylate (MMA) potentially increases wood resistance to subterranean termite attack. Four wood species, namely sengon (Falcataria moluccana), jabon (Anthocephalus cadamba), mangium (Acacia mangium), and pine (Pinus merkusii), were impregnated with MMA, and samples of untreated and imidacloprid-preserved wood were prepared for comparison purposes. Small stakes, sized 0.8 cm by 2 cm in cross section by 20 cm in the longitudinal direction, were inserted into the ground for 3 months, and the weight loss of each specimen was determined at the end of the test period. A factorial $4{\times}3$ completely randomized design was used for data analysis; the first factor was wood species, and the second factor was treatment. The results showed that MMA polymer loadings were 27.88%, 24.91%, 14.14%, and 17.81% for sengon, jabon, mangium, and pine, respectively, and amounts of imidacloprid retention were $7.56kg/m^3$, $5.98kg/m^3$, $5.34kg/m^3$, and $9.53kg/m^3$, respectively. According to an analysis of variance, wood species, treatment, and interaction of both factors significantly affected the weight loss of wood specimens. Mangium had the smallest weight loss, followed by pine, sengon, and jabon. MMA impregnation into the wood increased the resistance of wood samples to subterranean termite attack during in-ground testing, but the resistance level was lower than that of imidacloprid-preserved wood. Except for mangium wood, the MMA treatment did not significantly affect resistance.

Analysis of Kasugamycin in Pesticide Formulations by Reversed-Phase Ion Pair Liquid Chromatography (역상 이온쌍 액체크로마토그래피에 의한 농약 제품 중 Kasugamycin의 분석)

  • Kim, Taek-Jae;Kim, Kyong-Sun;Yoon, Chae-Hyuk;Joo, Jin-Bok;Kim, Chung-Hyo
    • Analytical Science and Technology
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    • 제10권5호
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    • pp.343-349
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    • 1997
  • Analytical method using the reversed phase ion-pair chromatography (RP-IPC) for the determination of kasugamycin(5-amino-2-methyl-6-(2,3,4,5,6-pentahydroxy cyclohexyloxy)tetrahydropyran-3-yl-amino-${\alpha}$-imino acetic acid), pesticide as fungicide bactercide has been established. The retention behavior of kasugamycin in the RP-IPC was examined with respect to the effect of concentrations of organic modifiers, pH of eluent and types and concentrations of the counter ions as ion-pair reagent. This method developed by the optimum factors, can be used for the application of the quality control in the crude product and its formulation.

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Simultaneous Determination of Polycyclic Aromatic Hydrocarbons and Their Nitro-derivatives in Airborne Particulates by Using Two-dimensional High-performance Liquid Chromatography with On-line Reduction and Fluorescence Detection

  • Boongla, Yaowatat;Orakij, Walaiporn;Nagaoka, Yuuki;Tang, Ning;Hayakawa, Kazuichi;Toriba, Akira
    • Asian Journal of Atmospheric Environment
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    • 제11권4호
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    • pp.283-299
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    • 2017
  • An analytical method using high-performance liquid chromatography (HPLC) with fluorescence (FL) detection was developed for simultaneously analyzing 10 polycyclic aromatic hydrocarbons (PAHs) and 18 nitro-derivatives of PAHs (NPAHs). The two-dimensional HPLC system consists of an on-line clean-up and reduction for NPAHs in the 1st dimension, and separation of the PAHs and the reduced NPAHs and their FL detection in the 2nd dimension after column-switching. To identify an ideal clean-up column for removing sample matrix that may interfere with detection of the analytes, the characteristics of 8 reversed-phase columns were evaluated. The nitrophenylethyl (NPE)-bonded silica column was selected because of its shorter elution band and larger retention factors of the analytes due to strong dipole-dipole interactions. The amino-substituted PAHs (reduced NPAHs), PAHs and deuterated internal standards were separated on polymeric octadecyl-bonded silica (ODS) columns and by dual-channel detection within 120 min including clean-up and reduction steps. The limits of detection were 0.1-9.2 pg per injection for PAHs and 0.1-140 pg per injection for NPAHs. For validation, the method was applied to analyze crude extracts of fine particulate matter ($PM_{2.5}$) samples and achieved good analytical precision and accuracy. Moreover, the standard reference material (SRM1649b, urban dust) was analyzed by this method and the observed concentrations of PAHs and NPAHs were similar to those in previous reports. Thus, the method developed here-in has the potential to become a standard HPLC-based method, especially for NPAHs.

The Effects of M-CRM Characteristics, Market Orientation on Customer Loyalty and the Moderating Role of Relationship Length in Insurance Companies (보험기업의 M-CRM 특성과 시장지향성이 고객충성도에 미치는 영향: 관계기간의 조절효과)

  • Jung, Chul-Ho;Jung, Duk-Hwa
    • The Journal of the Korea Contents Association
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    • 제16권6호
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    • pp.726-738
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    • 2016
  • This paper aims to examine structural relationship between the influence factors of customer loyalty, hypothesizing that m-CRM characteristics, market orientations, relationship quality and relationship length plays a crucial role in achieving customer loyalty in insurance companies. Total of 255 valid sample data were used to test study hypotheses. By using Structure Equation Modeling(SEM) method, the results show that m-CRM characteristics and customer orientation significantly influence to relationship quality except competitor orientation and all relationship quality are very significantly influence to customer loyalty being consisted of customer retention and word of mouth effect. In addition, the modulation effect of relationship length is confirmed about relationship between relationship quality and customer loyalty. A real situation we conducted our research may enable academics and practitioners to understand the antecedents and outcomes of m-CRM implementation in terms of market orientation.

Categorical Financial Analyses on the Level of Corporate Cash Reserves for the Korean Chaebol Firms in the Post-Era of the Global Financial Crisis (국제금융위기 이후 한국 재벌기업들의 현금유보 수준에 대한 계층별 재무적 특성요인 분석)

  • Kim, Hanjoon
    • The Journal of the Korea Contents Association
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    • 제16권2호
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    • pp.729-739
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    • 2016
  • The primary objective of implementing the study was to further investigate any pronounced financial components affecting the level of cash retention for the Korean chaebol firms. The research was framed to test for two hypotheses on the cash savings with utilizing the chaebol firms during the post-era of the global financial turmoil (from 2009 to 2013). In the first hypothesis test, any significant explanatory variables relative to the cash holdings, were identified in each corresponding category of the conditional quantile regression (CQR) model, while multilogistic regression analysis was performed to discriminate relevant financial factors in each pair of classes consisting of the chaebol firms. Concerning the results, liquidity, agency costs, and cash conversion cycle were found to be statistically significant in the majority of classified categories in the former test and liquidy, firm size, and dividend yield, also showed discriminating powers in each pair of categorical for the firms in the latter test.

Runoff Reduction Effect of Rainwater Retentive Green roof (저류형 옥상녹화의 우수유출저감에 대한 연구)

  • Baek, So-Young;Kim, Hyun-Woo;Kim, Mi-Kyeong;Han, Moo-Young
    • KIEAE Journal
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    • 제16권1호
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    • pp.67-71
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    • 2016
  • Purpose: There is a growing interest in rainwater runoff reduction effect of green roof, as flooding caused by increasing impervious surface is becoming more and more frequent in urban areas. This study was conducted to prove runoff reduction and runoff delay effect of the retentive green roof and to investigate its influencing factors to the rainfall events that occurred in the summer of 2013. Method: The experiment intended to monitor the runoff quantity of the retentive green roof($140m^2$) and normal roof($100m^2$) in #35 building in Seoul National University, Seoul, Korea for 75 days in 2013. Result: On analysis of 9 rainfall events, it showed that the retentive green roof has 24.8~100% of runoff reduction ratio, 21.2~100% of peak flow reduction ratio, 0.5~3.75 hours of peak delay, and $1.8{\sim}7.2m^3$ of retaining capacity in an area of $140m^2$. It shows different results depending on rainfall and antecedent dry days. The results show that runoff reduction effect is effective when the rainfall is less than 50 mm and antecedent dry day is longer than five days on average. By installing retentive green roofs on buildings, it can help mitigate urban floods and rehabilitate urban water cycle.

The Relationship among Career Plateau, Self-efficacy, Job Embeddedness and Turnover Intention of Nurses in Small and Medium Sized Hospitals (중소병원 간호사의 경력정체, 자기효능감, 직무배태성과 이직의도와의 관계)

  • Kim, Yu-Mi;Kang, Young-Sil
    • Journal of the Korea Academia-Industrial cooperation Society
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    • 제14권10호
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    • pp.5078-5090
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    • 2013
  • This study was to identify the relationship among small-medium sized hospitals nurse's career plateau, self-efficacy, job embeddedness and turnover intention. The study was conducted through a survey on 217 nurses in five small-medium sized hospitals in J city. The data were collected from August 5, 2013 to August 20, 2013. The data were analyzed by SPSS/WIN 18.0 program. The mean score of turnover intention was 3.07. The positive correlations between career plateau and turnover intention were found, but the negative correlation between self-efficacy, job embeddedness and turnover intention were found. The significant factors influencing turnover intention were job embeddedness, present clinical career, career plateau and work unit. To decrease turnover intention, therefore, nursing managers need to develop the nurse retention program for increasing job embeddedness and apply to nursing field.

A Study on the Synthesis of Titanium Carbonitride by SHS(Self-propagating High-temperature Synthesis) Method (자체반응열 고온합성법을 이용한 Titanium Carbonitride의 합성에 관한 연구)

  • Ha, Ho;Hwang, Gyu-Min;Lee, Hee-Cheol
    • Journal of the Korean Ceramic Society
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    • 제31권6호
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    • pp.637-642
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    • 1994
  • Using SHS(Self-propagating High-temperature Synthesis) method, the optimum synthetic condition of titanium carbonitride was established by controlling the parameters such as relative density of mixture (Ti+C), nitrogen pressure, additive amounts of titanium hydride(TiH1.924) and protecting heat loss. Under 1 atm nitrogen pressure, nitridation ratio with changing relative density of the sample compacts has a maximum (87.2%) at about 55%, and in the case of enveloping the pellet with a quartz tube, the highest nitridation ratio of 90% was obtained at about 68%. At relative density of 55%, nitridation ratio with the nitrogen pressure has a miximum (87.3%) at 7 atm. As the amounts of additive titanium hydride increased, nitridation ratio decreased at below 7 atm nitrogen pressure and, increased at above this pressure until percent of addition percent reached 15 wt% and decreased abruptly upon futher increases in titanium hydride. In the synthesis of TiCxNy by combustion reaction, heat transfer from combustion zone to preheating zone and nitrogen gas penetration into the compact were found to be important factors affecting the TiCxNy formation. It was difficult to obtain high nitridation ratio when the conbustion temperature was either too high or too low, and it seems that the retention of high temperature after a combustion wave sweeped through the reactant mixture pellet is critical to obtain a satisfactory nitridation ratio.

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