• Proceedings of the Korean Institute of Building Construction Conference
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• 2018.11a
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• pp.89-90
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• 2018

In recent years, harmful substances and fine dust in the air are caused by respiratory and cardiovascular diseases through various mechanisms when they are introduced into the human body through respiration, thereby exacerbating human health and causing cancer by prolonged exposure do. In order to prevent such fine dust from being introduced into the room and to improve indoor air quality, improvement of air quality has attracted attention. Among indoor air pollutants, fine dust and CO₂ are pollutants that are directly affected by indoor number and activity. The purpose of this study is to evaluate the basic performance of cement matrix using photosynthetic bacteria as a basic study of fine dust and CO₂ adsorption type matrix to suppress indoor air pollution and improve air quality.

• Journal of Microbiology and Biotechnology
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• v.15 no.6
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• pp.1337-1345
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• 2005

Vibrio vulnificus is the causative agent of foodborne diseases such as gastroenteritis and life-threatening septicemia. Microbial pathogenicity is a complex phenomenon in which expression of numerous virulence factors is frequently controlled by a common regulatory system. In the present study, a mutant exhibiting decreased cytotoxic activity toward intestinal epithelial cells was screened from a library of V. vulnificus mutants constructed by a random transposon mutagenesis. By a transposon-tagging method, an open reading frame, fexA, a homologue of Escherichia coli areA, was identified and cloned. The nucleotide and deduced amino acid sequences of the fexA were analyzed, and the amino acid sequence of FexA from V. vulnificus was $84\%\;to\;97\%$ similar to those of AreA, an aerobic respiration control global regulator, from other Enterobacteriaceae. Functions of the FexA were assessed by the construction of an isogenic mutant, whose fexA gene was inactivated by allelic exchanges, and by evaluating its phenotype changes in vitro and in mice. The disruption of fexA resulted in a significant alteration in growth rate under aerobic as well as anaerobic conditions. When compared to the wild-type, the fexA mutant exhibited a substantial decrease in motility and cytotoxicity toward intestinal epithelial cell lines in vitro. Furthermore, the intraperitoneal $LD_{50}$ of the fexA mutant was approximately $10^{1}-10^{2}$ times higher than that of parental wild-type. Therefore, it appears that FexA is a novel global regulator controlling numerous genes and contributing to the pathogenesis as well as growth of V. vulnificus.

• Korean Journal of Health Education and Promotion
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• v.2 no.1
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• pp.81-92
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• 1984

To find out the amount of knowledge and the attitude which a group of students attending local universities have toward family health, I distributed 690 questionaires to three local universities which I chose. I arrived at the following conculsion after 628 questionnairs were returned. 1) 431 male students(89.8%) and 126 femals students (86.2%) felt that family health science is important enough to be part of the cirriculum. 2) 374 male students (74.5) and 132 female students (90.4%) answered that they get a basic knowledge of health and disease through massmedia. 3) Should an information bureau for health and diseare be retup, 369 students(63.2%) answered that they would join information bureau. 4) In regard to a basic knowledge of health, the report says that 419 ma1e students(83.4%) and 117 female students(80%) don't know about Blood pressure, and 422 male students(84%) and 124 female students (84.9%) don't know about normal pulse and 467 male students(93%) and 128 femal stdents(87.6%) don't know about normal respiration. 5) In regard to communicable disese, 186 male students(37.1%) and 61 female students(41.7%) have a basic knowledge of these disease. In regard to diseases which commonly afflict the eldrly, 157 male students (31.2%) and 62 female students (42.4%) have a basic knowledge of these diseases. In regard to other diseases, the finding of this report are that on the average male students(74.6%) and female students of(73.4%) don't have a basic knowledge of family health. 6) 182 male students (36.2%) and 50 female students (34.2%) anwered that the way to promote health and prevent disease is to have a medical examination regularly and also 142 male students (28.2%) and 33 female students(22.6%) answered that it is necessary to have knowledge about how to keep health. 7) 254 male students (50.4%) and 90 female students (61.6%) said that when they are sick they depend on help from the pharmacist.

• Tuberculosis and Respiratory Diseases
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• v.81 no.4
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• pp.261-273
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• 2018

Chronic obstructive pulmonary disease (COPD) results in high morbidity and mortality among patients nationally and globally. The Korean clinical practice guideline for COPD was revised in 2018. The guideline was drafted by the members of the Korean Academy of Tuberculosis and Respiratory Diseases as well as the participating members of the Health Insurance Review and Assessment Service, Korean Physicians' Association, and Korea Respiration Trouble Association. The revised guideline encompasses a wide range of topics, including the epidemiology, diagnosis, assessment, monitoring, management, exacerbation, and comorbidities of COPD in Korea. We performed systematic reviews assisted by an expert in meta-analysis to draft a guideline on COPD management. We expect this guideline to facilitate the treatment of patients with respiratory conditions by physicians as well other health care professionals and government personnel in South Korea.

• Tuberculosis and Respiratory Diseases
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• v.51 no.1
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• pp.44-52
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• 2001

Background : Oxygen concentrators are convenient to operate and economical for patients with chronic obstructive pulmonary disease (COPD). However, oxygen concentrators are not manufactured domestically and the COPD patients are currently treated with imported oxygen concentrators. To evaluate the efficacy and safety of domestically developed prototype oxygen concentrator before clinical application, the efficacy and safety of the domestic oxygen concentrator were evaluate by comparing with the imported one. Material and Methods : The clinical tests were performed on 36 hyperhydrosis patients from April 1999 to August 1999. Domestic and imported oxygen concentrators were in turn applied to the same patient, who inspired oxygen for 60 minutes at a rate of 3 liters per minute through nasal prong. The oxygen concentrator, which was applied first, was randomly allocated. The arterial partial oxygen pressure ($PaO_2$) was estimated to compare the efficacy; and the carboxy hemoglobin(COHb), pH, arterial $CO_2$ partial pressure, pulse rate, blood pressure, and respiration rate to compare the safety before and after applying each oxygen concentrator. A student t-test was used to analyze the results. Result : In respect to efficacy, the difference in the change of $PaO_2$ before and after the application between two concentrators was not statistically significant. In respect to safety, the differences in the changes of COHb, pH, partial pressure of arterial $CO_2$, pulse rate, blood pressure, respiration rate between two concentrators were also not statistically significant. Conclusion : The domestically developed oxygen concentrator, showed satisfactory efficacy and safety when compared with the imported one.

• Journal of Acupuncture Research
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• v.28 no.5
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• pp.65-76
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• 2011

Objectives : Study about needle retaining time. Methods : We reviewed the ancient and the present text of China with using the China academic journal(CAJ) of China national knowledge infrastructure(CNKI) Results & Conclusions : 1. Needle retaining time is important in acupuncture, because the therapy effect is influenced by it. 2. The time of needle retaining is up to those conditions like different disease, viscera and bowels(臟腑), meridian and collateral(經絡), obtaining Qi(得氣), seasons, constitution of the patients and acupuncture tools. In ${\ll}$Hwangdineijing(黃帝內經) ${\gg}$, needle retaining time is called by 'Zhiruzhichu(直入直出)', 'Jichu(疾出)', 'Liu(留)', 'Buliu(不留)', 'Jiuliu(久留)' and 'Liu ${\bigcirc}$ hu(留${\bigcirc}$呼)', and the time was shorter than nowadays. 3. The respiration number was counted to check needle retaining time but we can't find out any evidence. Recently in China, 'obtaining Qi(得氣)' and 'Qi arrival(氣至)' is used to check it. 4. Looking into clinical researches, different diseases need different needle retaining time. For example, 20~30min is appropriate time for musculoskeletal system. 60min is for circulatory system, 10~20min is for peripheral facial nerve paralysis. Insomnia and some stubborn diseases need longer time. Cold and heat(寒熱), deficiency and excess(虛實) are always influences the needle retaining as well. 5. It is important to figure out the most effective needle retaining time for different disease with the base of connection between needle retaining time and effect.

• Research in Plant Disease
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• v.24 no.1
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• pp.59-65
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• 2018

Pyraclostrobin is a broad-spectrum fungicide that inhibits mitochondrial respiration. However, it may also induce systemic resistance effective against bacterial and viral diseases. In this study, we evaluated whether pyraclostrobin enhanced resistance against the bacterial spot pathogen, Xanthomonas euvesicatora on pepper (Capsicum annuum). Although pyraclostrobin alone did not suppressed the in vitro growth of X. euvesicatoria, disease severity in pepper was significantly lower by 69% after treatments with pyraclostrobin alone. A combination of pyraclostrobin with streptomycin reduced disease by over 90% that of the control plants. The preventive control of the pyraclostrobin against bacterial spot was required application 1-3 days before pathogen inoculation. Our findings suggest that the fungicide pyraclostrobin can be used with a chemical pesticide to control bacterial leaf spot diseases in pepper.

• Clinical and Experimental Pediatrics
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• v.63 no.8
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• pp.329-334
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• 2020

Background: Birth asphyxia is a leading cause of neonatal mortality. Ischemia-modified albumin (IMA) levels may have a predictive role in the identification and prevention of hypoxic disorders, as they increase in cases of ischemia of the liver, heart, brain, bowel, and kidney. Purpose: This study aimed to assess the value of IMA levels as a diagnostic marker for neonatal hypoxic-ischemic encephalopathy (HIE). Methods: Sixty newborns who fulfilled 3 or more of the clinical and biochemical criteria and developed HIE as defined by Levene staging were included in our study as the asphyxia group. Neonates with congenital malformation, systemic infection, intrauterine growth retardation, low-birth weight, cardiac or hemolytic disease, family history of neurological diseases, congenital or perinatal infections, preeclampsia, diabetes, and renal diseases were excluded from the study. Sixty healthy neonates matched for gestational age and with no maternal history of illness, established respiration at birth, and an Apgar score ≥7 at 1 and 5 minutes were included as the control group. IMA was determined by double-antibody enzyme-linked immunosorbent assay of a cord blood sample collected within 30 minutes after birth. Results: Cord blood IMA levels were higher in asphyxiated newborns than in controls (250.83±36.07 pmol/mL vs. 120.24±38.9 pmol/mL). Comparison of IMA levels by HIE stage revealed a highly significant difference among them (207.3±26.65, 259.28±11.68, 294.99±4.41 pmol/mL for mild, moderate, and severe, respectively). At a cutoff of 197.6 pmol/mL, the sensitivity was 84.5%, specificity was 86%, positive predictive value was 82.8%, negative predictive value was 88.3%, and area under the curve was 0.963 (P<0.001). Conclusion: IMA levels can be a reliable marker for the early diagnosis of neonatal HIE and can be a predictor of injury severity.

• Journal of Acupuncture Research
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• v.31 no.1
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• pp.1-6
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• 2014

Objectives : This study was aimed to investigate the view of disease and the view of body in Zubi Shiyi Mai Jiujing. Methods : With Zubi Shiyi Mai Juijing which was excavated from Mawangdui Han Dynasty tomb, we compared this document to other three documents excavated from Mawangdui. Results : 1. Zubi Shiyi Mai Jiujing is the oldest document about meridian pulse system excavated. 2. Zubi Shiyi Mai Jiujing sorted disease to Yang bing and san Yin bing. Yang bing is Zu san yang mai's disease and San yin bing is Zu san yin mai's disease. Zu san yang mai's diseases are mostly pain and swelling. 3. Zu san yin mai's diseases are zu shao yin mai which is realated to pulsation and respiration, Zu tai yin mai which is realated to stomach and digestion, Zu jue yin mai which is related to excretion. 4. The most important symptom in Zubi Shiyi Maizu san yin mai is Fan xin. It is realated to Zubi Shiyi Mai thinking Zu shao yin mai important about concept of body. Because in Zubi Shiyi MaiZu tai yin mai and Zu jue yin mai does'nt come up to abdominal cavity so Zu shao yin mai is the only meridian which comes into body cavity. Conclusions : Zu san yin mai is related to heart and fan xin by Zu shao yin mai. In this perspective Zu shao yin mai is important in view of body of Zubi Shiyi Mai Jiujing.

• Tuberculosis and Respiratory Diseases
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• v.78 no.2
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• pp.85-91
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• 2015

Background: In sepsis patients, target mean arterial pressures (MAPs) greater than 65 mm Hg are recommended. However, there is no such recommendation for patients receiving mechanical ventilation. We aimed to evaluate the influence of MAP over the first 24 hours after intensive care unit (ICU) admission on the mortality rate at 60 days post-admission in patients showing acute hypoxemic respiratory failure under mechanical ventilation. Methods: This prospective, multicenter study included 22 ICUs and compared the mortality and clinical outcomes in patients showing acute hypoxemic respiratory failure with high (75-90 mm Hg) and low (65-74.9 mm Hg) MAPs over the first 24 hours of admission to the ICU. Results: Of the 844 patients with acute hypoxemic respiratory failure, 338 had a sustained MAP of 65-90 mm Hg over the first 24 hours of admission to the ICU. At 60 days, the mortality rates in the low (26.2%) and high (24.5%) MAP groups were not significantly different. The ICU days, hospital days, and 60-day mortality rate did not differ between the groups. Conclusion: In the first 24 hours of ICU admission, MAP range between 65 and 90 mm Hg in patients with acute hypoxemic respiratory failure under mechanical ventilation may not cause significantly differences in 60-day mortality.