• Bulletin of the Korean Chemical Society
• /
• v.29 no.3
• /
• pp.551-554
• /
• 2008

An improved HPLC method for the separation of madecassoside isomers (madecassoside and asiaticoside-B) has been developed. The isomers can be separated with high resolution from extracts of Centella asiatica by HPLC using $\beta$-cyclodextrin as a mobile phase added on a $C_{18}$ column. The result shows that the isomers can be separated with a mobile phase consisting of methanol:water (50:50, v/v) with 4 mmol/L $\beta$-CD. To elucidate the mechanism of the separation of madecassoside and asiaticoside-B, this paper studied the separation of their aglycon parts (madecassic acid and terminolic acid), another pair of isomers. The isomers can also be separated with high resolution with a mobile phase consisting of methanol:water (65:35, v/v) with 4 mmol/L $\beta$-CD and the pH of the mobile phase was adjusted to 4. The paper also studied the separation of the two isomers by HPLC using $\alpha$-CD and Glucosyl-$\beta$-CD as a mobile phase additive in order to elucidate the mechanism of the separation process.

• KSBB Journal
• /
• v.15 no.6
• /
• pp.630-634
• /
• 2000

Chiral epoxides are useful chiral synthons in organic synthesis, and various biological methods have been investigated for their production. In this work, the enantioselective resolution of racemic styrene oxide was investigated using Aspergillus niger sp. for the production of optically pure (S)-styrene oxide. The enantioselectivity and initial hydrolysis rates of the racemic substrate were highly dependent of the pH, temperature, and the volume ratio of cosolvent. Experimental sets of pH, temperature, and the volume ratio of cosolvent were investigated using a central composite experimental design, and reaction conditions were optimized by response surface analysis. The optimal conditions of pH, temperature, and the volume ratio of cosolvent were determined to be 7.78, $28.32^{\circ}C$, and 2.4%(v/v), respectively, and optically pure (S)-styrene oxide (>99% ee) was obtained at 35% yield using this microbial enantioselective hydrolysis reaction.

• Publications of The Korean Astronomical Society
• /
• v.30 no.2
• /
• pp.269-270
• /
• 2015

We carried out near-IR photometric and optical spectroscopic observations of V582 Aur, which is a FU Orionis type object, to investigate any periodic and/or aperiodic variations. We obtained light curves on the scale of a night and a year, in J, H and Ks bands with KASINICS (KASI Near Infrared Camera System) attached to the BOAO (Bohyun-san Optical Astronomy Observatory) 1.8-m reflector in Youngcheon, South Korea and examined photometric variations on the two time scales. So far we have not found any periodic brightness variations on the scale of a night. On the other hand, we have found that there seems to be a periodic brightness variation with a period of approximately 45 days. In addition, high-resolution optical spectroscopic observations of V582 Aur were performed from February 2013 to May 2014 with the high-resolution echelle spectrograph BOES attached to the BOAO 1.8-m reflector. We analyzed several spectral lines to understand the physical state of V582 Aur. The P Cyg profiles are clearly shown in the $H{\alpha}$ line and Na I D line.

• The Korean Journal of Applied Statistics
• /
• v.28 no.5
• /
• pp.951-963
• /
• 2015

The conjoint analyst in marketing are anxious to know whether there exist synergy or antagonistic effects between two attributes. That is to say, they are interested in estimating the main effects as well as the two factor interaction effects.We research the design of survey questionnaire so that all the main effects and two factor interaction effects are estimable by employing the resolution V balanced Incomplete Block Fractional Factorial Design. We screen vital few effects, find the proper model and obtain information for efficient concepts optimization by analyzing all respondents survey data.

• Nuclear Engineering and Technology
• /
• v.4 no.2
• /
• pp.116-131
• /
• 1972

A fast neutron time-of-flight spectrometer has been constructed with suitable choice of target thickness and proton bombarding energy in Li$^{7}$ (p, n) Be$^{7}$ nuclear reaction for a continuous keV spectrum of neutrons at 0 degree in 1-nsec pulse from a Van do Graaff and a time-pick-up fast neutron detector assembled with a 5 mm-thick 92% enriched B$^{10}$ slab and four heavily shielded 4＂$\times$3＂ NaI scintillation detectors. Energy resolution of this spectrometer is better than 0.3% at 50 keV and the signal-to-background ratio is also improved. Total cross section measurements of several separated single isotopes have been carried out with this spectrometer and analyzed by Rmaxtrix multi-level computer code. The spin values and resonance parameters of each individual resonances are given.

• Journal of the Korean Institute of Telematics and Electronics
• /
• v.23 no.6
• /
• pp.807-813
• /
• 1986

Measurements of interface states in a MOS capacitor by DLTS system using wideband monophase lock-in amplifier are discussed. A new signal analysis method that takes into account the bias pulse width and the gate off width is presented to remove the errors in the measured parameters of interface states resulting from the traditional method which neglects the effect of those widths. Theoretical calculations are made for the parameters related to the rate window, signal to noise ratio, and the energy resolution. On the grounds of this discussion, interface states of the MOS capacitor on p-type substrate of (110) orentation are measured with the optimal gate-off width with respect to the S/N ratio and the energy resolution. The results are interface state density of the order of 10**10 (cm-\ulcornereV**-1) to 10**11 (cm-\ulcornereV**-1) in the energy range of Ev+0.15(dV) to Ev+0.5(eV), and constant capture cross section of the order of 10**-16 (cm\ulcorner.

• Journal of the Institute of Electronics Engineers of Korea SD
• /
• v.48 no.2
• /
• pp.20-27
• /
• 2011

A CMOS Image Sensor(CIS) mounted on mobile appliances always needs a low power consumption because of the battery life cycle. In this paper, we propose novel power reduction techniques such as a data flip-flop circuit with leakage current elimination, a low power single slope A/D converter with a novel comparator, and etc. Based on 0.13um CMOS process, the chip satisfies QVGA resolution($320{\times}240$ pixels) whose pitch is 2.25um and whose structure is 4-Tr active pixel sensor. From the experimental results, the ADC in the middle of CIS has a 10-b resolution, the operating speed of CIS is 16 frame/s, and the power dissipation is 25mW at 3.3V(Analog)/1.8V(Digital) power supply. When we compare the proposed CIS with conventional ones, the power consumption is reduced approximately by 22% in sleep mode, 20% in operating mode.

• Progress in Medical Physics
• /
• v.13 no.1
• /
• pp.44-50
• /
• 2002

CsI(T1) single crystal was grown in a Bridgman growing apparatus, which has the diameter of 11 mm and the mole ratio of 0.001 mol%. Radiation sensors were made with CsITl)crystal and two photodiodes, and measured spectroscopic characteristics and linearity for gamma-ray and X-ray. The energy resolution of CsI(T1) radiation sensor has been measured with $^{22}$ Na, $^{137}$ Cs and $^{60}$ Co gamma standard sources. Also output linearity of CsITl) sensor was measured for diagnostic radiation region. The energy resolutions of CsI(T1) radiation sensor for 0.511MeV gamma-ray from Na-22 source, 0.662MeV from Cs-137 source, and 1.17MeV and 1.332MeV from Co-60 source were 13.2%, 8.3%, 6.7%, and 5.1% respectively. Also the output linearity up to 80mAs current for 60kVp, 80kvp, 100kVp, 120kVp tube voltages has been studied.

• Journal of IKEEE
• /
• v.24 no.4
• /
• pp.1074-1080
• /
• 2020

This paper proposes a digitally controlled buck converter insensitive to process, voltage and temperature and capable of three modes of operation depending on the state of the output voltage. Conventional digital-controlled buck converters utilized A/D converters, counters and delay line circuits for accurate output voltage control, resulting in increasing the number of counter and delay line bits. This problem can be resolved by employing the 8-bit and 16-bit bidirectional shift registers, and this design technique leads a buck converter to be able to control duty ratio up to 128-bit resolution. The proposed buck converter was designed and fabricated with a CMOS 180 nano-meter 1-poly 6-metal process, generating an output voltage of 0.9 to 1.8V with the input voltage range of 2.7V to 3.6V, a ripple voltage of 30mV, and a power efficiency of up to 92.3%. The transient response speed of the proposed circuit was measured to be 4us.

• ETRI Journal
• /
• v.33 no.3
• /
• pp.366-373
• /
• 2011

In this paper, we propose a low-power all-digital phase-locked loop (ADPLL) with a wide input range and a high resolution time-to-digital converter (TDC). The resolution of the proposed TDC is improved by using a phase-interpolator and the time amplifier. The phase noise of the proposed ADPLL is improved by using a fine resolution digitally controlled oscillator (DCO) with an active inductor. In order to control the frequency of the DCO, the transconductance of the active inductor is tuned digitally. The die area of the ADPLL is 0.8 $mm^2$ using 0.13 ${\mu}m$ CMOS technology. The frequency resolution of the TDC is 1 ps. The DCO tuning range is 58% at 2.4 GHz and the effective DCO frequency resolution is 0.14 kHz. The phase noise of the ADPLL output at 2.4 GHz is -120.5 dBc/Hz with a 1 MHz offset. The total power consumption of the ADPLL is 12 mW from a 1.2 V supply voltage.