• Journal of the Korean Society for Geothermal and Hydrothermal Energy
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• v.17 no.1
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• pp.1-13
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• 2021

Before newly-built building and building remodeling, it is important to predict and analyze building energy performance through energy simulation programs. Nevertheless, simulation results widely vary depending on individual user experience and input values. Therefore, this study uses prototypical building model, a versatile tool in building energy modeling, simulation and research for researchers and policy-makers, and ASHRAE standards. Then, it analyzed the changes in design type (roof type, number of floors) for the base case. As the result, it was found that the gap of annual energy demand per between them is maximally 9.1%.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.140.2-140.2
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• 2003

Isoflavone found in Leguminosae is one of natural phytoestrogens and its effect on bone remodeling is one of key investigational interests in terms of estrogen replacement therapy (ERT). As commonly known, osteoporosis is one of hormonal deficiency diseases, especially in menopausal women. When estrogen is blocked, local factors such as 1L-1$\beta$ and IL-6 that are related in bone resorption are increased and enhance osteoclastogenesis, which is responsible for bone resorption. In the present study, we investigated the effect of isoflavones (Isocal) extracted from Sophorae Fructus on bone resorption in vitro. (omitted)

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.140.3-141
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• 2003

Isoflavones have been a central subject in natural phytoestrogens found in Leguminosae. Their effects on bone formation and remodeling are an important turning point in that they can act like estrogen by binding on estrogen receptors on target cell surface. We, therefore, believed that isoflavones may be applied in estrogen deficiency disease such as osteoporosis in terms of estrogen replacement therapy (ERT). As commonly known, osteoporosis is one of hormonal deficiency diseases, especially in menopausal women. (omitted)

• The Korean Journal of Physiology and Pharmacology
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• v.25 no.1
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• pp.1-14
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• 2021

Cardiovascular disease (CVD) accounts for approximately 30% of all deaths worldwide and its prevalence is constantly increasing despite advancements in medical treatments. Cardiac remodeling and dysfunction are independent risk factors for CVD. Recent studies have demonstrated that cardiac structure and function are genetically influenced, suggesting that understanding the genetic basis for cardiac structure and function could provide new insights into developing novel therapeutic targets for CVD. Regular exercise has long been considered a robust nontherapeutic method of treating or preventing CVD. However, recent studies also indicate that there is inter-individual variation in response to exercise. Nevertheless, the genetic basis for cardiac structure and function as well as their responses to exercise training have yet to be fully elucidated. Therefore, this review summarizes accumulated evidence supporting the genetic contribution to these traits, including findings from population-based studies and unbiased large genomic-scale studies in humans.

• BMB Reports
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• v.57 no.9
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• pp.381-387
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• 2024

The nucleus, a highly organized and dynamic organelle, plays a crucial role in regulating cellular processes. During cell differentiation, profound changes occur in gene expression, chromatin organization, and nuclear morphology. This review explores the intricate relationship between nuclear architecture and cellular function, focusing on the roles of the nuclear lamina, nuclear pore complexes (NPCs), sub-nuclear bodies, and the nuclear scaffold. These components collectively maintain nuclear integrity, organize chromatin, and interact with key regulatory factors. The dynamic remodeling of chromatin, its interactions with nuclear structures, and epigenetic modifications work in concert to modulate gene accessibility and ensure precise spatiotemporal control of gene expression. The nuclear lamina stabilizes nuclear shape and is associated with inactive chromatin regions, while NPCs facilitate selective transport. Sub-nuclear bodies contribute to genome organization and gene regulation, often by influencing RNA processing. The nuclear scaffold provides structural support, impacting 3D genome organization, which is crucial for proper gene expression during differentiation. This review underscores the significance of nuclear architecture in regulating gene expression and guiding cell differentiation. Further investigation into nuclear structure and 3D genome organization will deepen our understanding of the mechanisms governing cell fate determination.

• Molecules and Cells
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• v.37 no.1
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• pp.81-87
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• 2014

Chronic pressure-overload cardiac hypertrophy is associated with an increased risk of morbidity/mortality, largely due to maladaptive remodeling and dilatation that progresses to dilated cardiomyopathy. Alternative splicing is an important biological mechanism that generates proteomic complexity and diversity. The recent development of next-generation RNA sequencing has improved our understanding of the qualitative signatures associated with alternative splicing in various biological conditions. However, the role of alternative splicing in cardiac hypertrophy is yet unknown. The present study employed RNA-Seq and a bioinformatic approach to detect the RNA splicing regulatory elements involved in alternative splicing during pressure-overload cardiac hypertrophy. We found GC-rich exonic motifs that regulate intron retention in 5' UTRs and AT-rich exonic motifs that are involved in exclusion of the AT-rich elements that cause mRNA instability in 3' UTRs. We also identified motifs in the intronic regions involved in exon exclusion and inclusion, which predicted splicing factors that bind to these motifs. We found, through Western blotting, that the expression levels of three splicing factors, ESRP1, PTB and SF2/ASF, were significantly altered during cardiac hypertrophy. Collectively, the present results suggest that chronic pressure-overload hypertrophy is closely associated with distinct alternative splicing due to altered expression of splicing factors.

• Molecules and Cells
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• v.39 no.5
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• pp.395-402
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• 2016

Identifying Hoxc8 target genes is at the crux of understanding the Hoxc8-mediated regulatory networks underlying its roles during development. However, identification of these genes remains difficult due to intrinsic factors of Hoxc8, such as low DNA binding specificity, context-dependent regulation, and unknown cofactors. Therefore, as an alternative, the present study attempted to test whether the roles of Hoxc8 could be inferred by simply analyzing genes frequently coexpressed with Hoxc8, and whether these genes include putative target genes. Using archived gene expression datasets in which Hoxc8 was differentially expressed, we identified a total of 567 genes that were positively coexpressed with Hoxc8 in at least four out of eight datasets. Among these, 23 genes were coexpressed in six datasets. Gene sets associated with extracellular matrix and cell adhesion were most significantly enriched, followed by gene sets for skeletal system development, morphogenesis, cell motility, and transcriptional regulation. In particular, transcriptional regulators, including paralogs of Hoxc8, known Hox co-factors, and transcriptional remodeling factors were enriched. We randomly selected Adam19, Ptpn13, Prkd1, Tgfbi, and Aldh1a3, and validated their coexpression in mouse embryonic tissues and cell lines following $TGF-{\beta}2$ treatment or ectopic Hoxc8 expression. Except for Aldh1a3, all genes showed concordant expression with that of Hoxc8, suggesting that the coexpressed genes might include direct or indirect target genes. Collectively, we suggest that the coexpressed genes provide a resource for constructing Hoxc8-mediated regulatory networks.

• Journal of Korean Society for Atmospheric Environment
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• v.28 no.4
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• pp.435-445
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• 2012

The aim of this study is to understand the characteristics of volatile oranic compounds (VOCs) and provide information about the present Indoor Air Quality (IAQ) at residential apartments. All samples were collected in 60-min interval using the tenax absorption trap between May, 2011 and February, 2012. And the effects of environmental factors such as temperature, humidity and construction characteristics were analyzed in relation to the measured concentrations. The results of this study showed that the mean concentration of VOCs was lower than the Ministry of the Environment's standards for maintenance of indoor air quality. The correlation analysis showed that ethylbenzene and xylene (r=0.916, p<0.01), toluene and ehtylbenzene (r=0.810, p<0.01), toluene and xylene (r=0.803, p<0.01) and toluene and styrene (r=0.588, p<0.01) were significant. The result of regression analysis was found that the influenece factors associated with the concentration of VOCs were the age and location of the apartment, remodeling, the temperature and the season.

• Journal of The Korea Institute of Healthcare Architecture
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• v.25 no.4
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• pp.27-35
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• 2019

Purpose: As the improvement in quality of medical environment and the spatial consideration for the prevention of infection in the hospital have become increasingly important in the recent years, specific and practical planning for air conditioning room's area has become a major issue accordingly. However, the air conditioning room tends to be discussed focusing on technical factors such as air conditioning systems that are irrelevant to building plans, while discussions of most departments related to the medical functions have actively taken placed. Therefore, this study aims to investigate the factors influencing the planning for the air conditioning room area, and through subsequent analysis of the area of the air conditioning room, to propose a way to improve effective planning for the air conditioning room area. Methods: This study examines the case hospitals that fall into two types: each floor supply system and concentrated supply system, and compares and analyzes the air conditioning room area-related factors and the characteristics of changes in the interior of air conditioning room before and after remodeling through air conditioning floor plan of those case hospitals. Results: The air conditioning room can be classified into the net area of the functional space such as duct passages, and the public area such as aisle space, and of those the public area is an important factor in calculating the area of the air conditioning room. The public area of the air-conditioning room should not be planned considering only the spaces for mobile passage or maintenance activities, but should be planned taking into account internal changes such as expansion and replacement of equipment in the future from the beginning. Implications: When planning a medical facility, it is used as basic data for the planning of the air conditioning room area, which is a significant fixed factor in the initial setting.

• Proceedings of the Korean Institute of Interior Design Conference
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• 2006.05a
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• pp.268-271
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• 2006

The purpose of this study was to identify the influence of living factors on TVOC(Total Volatile Organic Compounds) concentrations for newly-built apartments. The field measurements of TVOC concentrations were made totally 30 times(5 times per one subject house) in six apartment units in which residents recently moved. Those apartments authorized its business approval before May 2004, the Act of Indoor Air auality Management for multi-use facilities. The findings were as follows: The TVOC concentrations of the measured subject apartments ranged from about 1/10 of the recommended standard for multi-use facilities($400{\mu}g/m^3$) to up to 90 times as high as the standard. Since then, the Recommended Standard of Indoor Air Quality Management for newly-built apartment house was announced in December 2005. In accordance with this standard($2390{\mu}g/m^3$) it ranged from about 1/100 to up to 15 times as high as the standard. The subject house whose TVOC concentrations reduced below the recommendation standard in the shortest period had the largest amount of ventilation (all the windows were open for ventilation in the past three months) among ail measured houses. The reason of another house whose TVOC concentrations were much higher than the rest was fronted with new furniture in the room. It's recommended that they should open all the windows for at least three months for ventilation in newly-built houses, and it would be better to avoid remodeling than needs be.