• Journal of Pharmaceutical Investigation
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• v.29 no.4
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• pp.343-348
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• 1999

The purpose of this study is to prepare the controlled release adhesive patch containing naproxen. Pressuresensitive adhesive (PSA)-type patch was fabricated by casting of polyisobutylene (PIE.) and mineral oil in toluene. Membrane-controlled release (MCR)-type patch was prepared by the attachment of the controlled release membrane on the PSAtype patch. The membrane was mainly composed of Eudragit, polyethylene glycol(PEG) and glycerin. The drug release profile and skin permeation test with various patches were evaluated in vitro. The release of naproxen from PIE-based PSAtype patch with various loading doses fitted Higuchi's diffusion equation. However, the permeation of naproxen through hairless mouse skin from PSA-type patch followed zero-order kinetics. In MCR-type patch, thickness of controlled release membrane affected on the drug release rate highly. In the composition of membrane, the release rate was decreased as the ratio of Eudragit increased. The drug release from the MCR-type patch followed zero order kinetics. The permeation of naproxen through hairless mouse skin from MCR-type patch showed lag time for the intial release period and didn't fit the zero-order kinetics

• Transactions of the Korean Society of Mechanical Engineers B
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• v.34 no.5
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• pp.449-456
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• 2010

The HCCI engine is a prospective internal combustion engine with which high diesel-like efficiencies and very low NOx and particulate emissions can be achieved. However, several technical issues must be resolved before HCCI engines can be used for different applications. One of the issues concerning the HCCI engine is that the operating range of this engine is limited by the rapid pressure rise caused by the release of excessive heat. This heat release is because of the self-accelerated combustion reaction occurring in the engine and the resulting engine knock in the high-load region. The purpose of this study is to evaluate the role of thermal stratification and fuel stratification in reducing the pressure rise rate in an HCCI engine. The concentrations of NOx and CO in the exhaust gas are also evaluated to confirm combustion completeness and NOx emission. The computation is carried out with the help of a multizone code, by using the information on the detailed chemical kinetics and the effect of thermal and fuel stratification on the onset of ignition and rate of combustion. The engine is fueled with dimethyl ether (DME), which allows heat release to occur in two stages, as opposed to methane, which allows for heat release in a single stage.

• Journal of Biomedical Engineering Research
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• v.28 no.4
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• pp.449-454
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• 2007

An electrohydraulic (EH) pump-driven closed-loop blood pressure regulatory system was developed based on flow-mediated vascular occlusion using the vascular occlusive cuff technique. It is very useful for investigating blood pressure-dependant physiological variability, in particular, that could identify the principal mediators of renal autoregulation, such as tubuloglomerular feedback (TGF) and myogenic (MYO), during blood pressure regulation. To address this issue, renal perfusion pressure (RPP) should be well regulated under various experimental conditions. In this paper, we designed a new EH pump-driven RPP regulatory system capable of implementing precise and rapid RPP regulation. A closed-loop servo-controlwas developed with an optimal proportional plus integral (PI) compensation using the dynamic feedback RPP signal from animals. An in vivo performance was evaluated in terms of flow-mediated RPP occlusion, maintenance, and release responses. Step change to 80 mmHg reference from normal RPP revealed steady state error of ${\pm}3%$ during the RPP regulatory period after PI action. We obtained rapid RPP release time of approximately 300 ms. It is concluded that the proposed EH RPP regulatory system could be utilized in in vivo performance to study various pressure-flow relationships in diverse fields of physiology, and in particular, in renal autoregulation mechanisms.

• Transactions of the Korean Society of Automotive Engineers
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• v.16 no.5
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• pp.164-170
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• 2008

A typical clutch system for automotive manual transmissions transfers hydraulic pressure generated by driver's pedal manipulation to the clutch diaphragm spring. The foot effort history during the period of push is different than the period of the clutch pedal's return. The effort or load difference is called clutch foot effort hysteresis. It is known that the hysteresis is caused by friction. The frictional force and moment are produced between various component contact points such as between the rubber seal and the inner wall inside the hydraulic cylinder and between the diaphragm spring and the pressure plate, etc. Understanding the clutch pedal foot effort hysteresis is essential for a clutch release system design and analysis. The dynamic model for a clutch release system is developed for the foot effort hysteresis prediction and a simulation analysis is performed to propose a tool for analysing a clutch system.

• Journal of Pharmaceutical Investigation
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• v.23 no.4
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• pp.207-211
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• 1993

Reservoir type devices were designed for long-term implantable drug delivery system. The reservoir type device was prepared with the polymethacrylic acid gel coated with polyurethane membrane. Release controlling agent (RCA) were employed to control drug release from devices via generation of micropores in the membranes. The polyurethane membrane functioned as a rate controlling barrier. The drug release pattern of hydrogel demonstrated zero order kinetics. The release rate of drugs could be regulated by varying hydrophobicity/hydrophilicity and content of the RCA, as well as the thickness of the polyurethane membrane. The release of drugs from this system was governed by pore mechanism via simple diffusion and osmotic pressure.

• Journal of International Academy of Physical Therapy Research
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• v.11 no.2
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• pp.2042-2051
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• 2020

Background: Many trials have been conducted the methods and types of intervention of form rollers, but no research has been done yet that mixes the methods and types of intervention. Objectives: To analyze the effects of myofascial release on the improvement of range of motion (ROM), flexibility, pain pressure threshold, and balance. Design: Randomized controlled trial. Methods: All subjects measured ROM, flexibility, pressure pain threshold, and dynamic balance by pre-test. After pre-test, subjects were randomized that static-vibration foam rolling group (n=12), dynamic-vibration foam rolling group (n=12), general foam rolling group (n=12). For the intervention, 3 sets of 90 seconds were applied to each group, and rest time was set to 60 seconds between sets. In the post-test and follow-up test after 10 minutes, all three groups were measured the ROM, flexibility, pressure pain threshold, and dynamic balance. Results: The results of comparing ROM, flexibility, pressure pain thresholds, dynamic balance ability appeared higher significant difference in the pre-post-10 minutes follow up test in comparison between time in the intragroup (P<.001). As a result of comparing the change of pre-post-10 minutes follow up, static vibration foam rolling showed higher significant difference compared to control groups (P<.001). Conclusion: Through this study, when foam rolling is applied within the same intervention time, static foam rolling can be expected to have a better effect than the existing dynamic foam rolling as well as vibration foam roller can expect better effect than general foam rolling.

• Transactions of the Korean Society of Automotive Engineers
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• v.17 no.4
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• pp.126-132
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• 2009

Automotive heat exchangers use louver fins for their high efficiency. However, the efficiency can significantly drop for constructional vehicles or heavy equipments due to dust deposited on the louver fins with narrow slits. Thus it is necessary to develop new fins that lead to less fouling, so that a better performance can be achieved after exposure to a dusty environment over long period of time. New wavy fins were considered in the study and numerically analysed to compare with louver fins in the areas of air-side pressure drop, heat release rate, and particulate deposition. In addition, an experiment was done on the pressure drop and the particulate deposition. The results showed that the wavy fins would be a better choice for long-term use due to the excellent dust-proof performance in comparison to louver fins, in spite of the initial inferior performance of heat release.

• Proceedings of the KSME Conference
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• 2001.11b
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• pp.853-858
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• 2001

The knowledge of flame structure is essential for control of combustion instability phenomena. Some results of an experimental study on mechanism of naturally occurring combustion oscillations with a single dominant frequency are presented. Tests were conducted in a laboratory-scale dump combustor at atmospheric pressure. Sound level meter was used to track the pressure wave inside the combustor. The observed instability was a longitudinal mode with a frequency of $\sim341.8Hz$. Instability map was obtained at the condition of inlet temperature of $360^{\circ}C$, mean velocities of $8.5\sim10.8m/s$ and well premixed mixture. It showed that combustion instability was susceptible to occur in the lean conditions. In this study, unstable flame was observed from stoichiometric to 0.7 in overall equivalence ratio. At selected unstable conditions, phase-resolved OH chemiluminescence images were captured to investigate flame structure with various mean velocities. As mean velocity is increased, the flame grows and global heat release was changed. Due to these effects, combustion instability can be maintained at more lean air-fuel ratio. Also, these results give an insight to the controlling mechanism for an increasing heat release at maximum pressure.

• Journal of ILASS-Korea
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• v.20 no.4
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• pp.254-260
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• 2015

The objective of this study is to investigate the effect of multi-hole nozzle on the performance of small CRDI engine. Combustion and exhaust emission characteristics of engine were studied by using CFD simulation with ECFM-3Z combustion model. The conditions of simulation were varied with nozzle geometry, injection timing and injection quantity. In addition, the results were compared in terms of combustion pressure, rate of heat release, $NO_x$ and soot emissions. It was found that combustion pressure was increased when injection timing was advanced. The rate of heat release of 6 hole nozzle was higher than that of 12 hole nozzle since the quantity of fuel impinged at the bottom of piston rim was different under different injection timing conditions. In the case of $NO_x$ emission, 6 hole nozzle generated more $NO_x$ emission than 12 hole nozzle. On the other hand, in the case of soot emission, 12 hole nozzle showed higher value than 6 hole nozzle because injected fuel droplets from multi-hole nozzle were coalesced.

• Nuclear Engineering and Technology
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• v.36 no.1
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• pp.36-46
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• 2004

The ISAAC fission product release calculation is based on detailed FPRAT models developed by Jaycor. For volatile fission product release calculations, either the Cubicciotti steam oxidation correlation or the NUREG-0772 correlation is used. In this study, evaluation is carried out for these volatile fission product release models. As a result, in the case of early release, the IDCOR model with an in-vessel Te release option shows the most conservative results and for the late release case, the NUREG-0772 model shows the most conservative results. Considering both early and late release, the IDCOR model with an in-vessel Te bound option is evaluated to show mitigated conservative results. In addition, a sensitivity study on detailed core nodalization is performed. In the study, 380 horizontal fuel channels in the Wolsong plant are nodalized into 12 (6 channels per loop, $3{\times}3$ Core Pass) representative channels and detailed by 16/20/24 channels. For reference accidents, LOAH and large LOCA are selected as representing high and low pressure sequences, respectively. According to the results, the original 12 channel approach with $3{\times}3$ core passes is evaluated to be sufficient as an optimal scheme.