• 대한치과교정학회지
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• 제20권2호
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• pp.381-390
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• 1990

The purpose of this study was to evaluate the effects of heat treatment on mechanical properties in $0.016^{{\prime}{\prime}}{\times}0.022^{{\prime}{\prime}}$ blue Elgiloy wires and to measure the amounts of nickel and chromium released from the wires in artificial saliva. Ultimate tensile strength, yield strength and elongation were measured with universal testing machine (Instron). and the amounts of nickel and chromium released from the sample were measured with atomic absorption spectrophotometer after one week immersion in the artificial saliva. Ultimate tensile strength and yield strength were progressively increased below $1000^{\circ}F$, but elongation was decreased. And the results were reversed above $1100^{\circ}F$. After heat treatment of the sample for 9 minutes at $1000^{\circ}F$, the maximum tensile strength and yield strength were $213.6kg/mm^2$, $140.1kg/mm^2$, respectively. Both tensile strength and yield strength were decreased progressively above $1100^{\circ}F$. Elongation was appeared the minimum value (8.6%) after heat treatment for 9 minutes and 12 minutes at $1000^{\circ}F$. There was a pronounced increase in nickel and chromium liberation with increasing time and temperature. The maximum amounts of nickel and chromium released form the sample were $4.947{\mu}m/cm^2$, $3.088{\mu}g/cm^2$, respectively after heat treatment for 12 minutes at $1300^{\circ}F$. Heat treatment is applied to orthodontic wires, especially cobalt-chromium alloys, for the purpose of stress-relievning and hardening. When the heat-treatment of orthodontic wires, the heating procedure should be well controlled in order to have no effect on corrosion resistance and mechanical properties.

• Journal of Korean Neurosurgical Society
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• 제30권9호
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• pp.1059-1064
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• 2001

Objective : 6R-Tetrahydrobiopterin(BH4) is a cofactor for the aromatic amino acid hydroxylases which is essential for the biosynthesis of catecholamines and serotonin. It also acts as a cofactor for nitric oxide synthase, and stimulates the release of some neurotransmitters such as dopamine, serotonin, acetylcholine and glutamate. Recently, it has been reported that BH4 could induce cellular proliferation and enhance neuronal survival. This study was performed to investigate the antioxidative effect of BH4 on the various oxidative insults in mouse cerebral cortical cell cultures. Methods : Iron ion(FeCl2), zinc ion(ZnCl2), sodium nitroprusside(SNP) and buthionine sulfoximine(BSO, a glutathione depletor) were used as oxidants. Cell death was assessed by measurement of lactate dehydrogenase efflux to bathing media at the end of exposure. Result : All 4 oxidants induced neuronal cell death associated with cell body swelling, which was markedly inhibited by trolox($100{\mu}M$), a vitamin E analog. BH4($10-100{\mu}M$) markedly inhibited the neuronal cell death induced by all 4 oxidants($20{\mu}M\;Cu^{2+}$, $20{\mu}M\;Zn^{2+}$, $1{\mu}M$ SNP or 1mM BSO). However, BH4 failed to inhibit the neuronal cell death induced by 24hr exposure to $20{\mu}M$ NMDA. Conculsion : These results suggest that BH4 has antioxidative action independently of any actions of enzyme cofactor.

• BMB Reports
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• 제44권11호
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• pp.747-752
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• 2011

To investigate the effects of disulphide bond position on the salt resistance and lipopolysaccharide (LPS)-neutralizing activity of ${\alpha}$-helical homo-dimeric antimicrobial peptides (AMPs), we synthesized an ${\alpha}$-helical model peptide ($K_6L_4W_1$) and its homo-dimeric peptides (di-$K_6L_4W_1$-N, di-$K_6L_4W_1$-M, and di-$K_6L_4W_1$-C) with a disulphide bond at the N-terminus, the central position, and the C-terminus of the molecules, respectively. Unlike $K_6L_4W_1$ and di-$K_6L_4W_1$-M, the antimicrobial activity of di-$K_6L_4W_1$-N and di-$K_6L_4W_1$-C was unaffected by 150 mM NaCl. Both di-$K_6L_4W_1$-N and di-$K_6L_4W_1$-C caused much greater inhibitory effects on nitric oxide (NO) release in LPS-induced mouse macrophage RAW 264.7 cells, compared to di-$K_6L_4W_1$-M. Taken together, our results indicate that the presence of a disulphide bond at the N- or C-terminus of the molecule, rather than at the central position, is more effective when designing salt-resistant ${\alpha}$-helical homo-dimeric AMPs with potent antimicrobial and LPS-neutralizing activities.

• 한국수자원학회논문집
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• 제42권9호
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• pp.703-713
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• 2009

유역에서의 댐은 이수와 치수 측면에서 매우 큰 역할을 담당하고 있으며, 특히 집중호우 기간 동안의 댐 방류는 강우에 의해서 발생되는 유출과 더불어 댐 하류의 홍수조절에 직접적인 영향을 미치고 있다. 본 연구에서는 댐 방류와 강우에 의한 유출의 영향을 동시에 받는 댐 하류 지점에 대한 유출모의를 위해서 HyGIS (Hydro Geographic Information System) 환경에서 운영되는 분포형 강우-유출 모형인 GRM (Grid based Rainfall-runoff Model)을 적용하고 이에 대한 적용성을 평가하고자 한다. 대상 유역은 한강 수계의 여주 수위관측소 상류로 선정하였으며, 충주 조정지댐과 횡성댐의 방류량 및 강우의 영향을 반영하여 유출모의를 수행하고, 이를 여주 수위관측소에 대해서 검증 하였다. 모형의 적용결과 모의된 유출 수문곡선은 관측 수문곡선을 잘 재현하였으며, 이를 통해서 GRM 모형은 댐방류와 강우가 유역유출에 미치는 영향을 적절히 모의할 수 있는 것으로 나타났다.

• 대한한의정보학회지
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• 제14권2호
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• pp.79-93
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• 2008

Objectives : Taichi for arthritis was developed in 1997 by Paul Lam, M.D. of family medicine in Australia. It is an exercise treatment program and a good approaching method of the oriental medicine for arthritis. However, clinical and academical researches were rare. The purpose of this study is to investigate the effectiveness of the Taichi for arthritis. Methods : We used the medical literature search system, MEDLIS and the database of academic journal, DBpia to search medical studies published in korea. Keywords were "Taichi", "Tai Chi Chuan" and "Arthritis". We classified literatures with two criteria, year of publishment and study design. Then we classified as placebo design and summarized whole material. We determined its effectiveness by positive-negative results of Taichi for arthritis. Results : Taichi for arthritis could release pain of the rheumatoid or degenerative arthritis. Also it is thought to increase muscular power and enhance physical flexibility, balance. Conclusions : There were limits to ensure effectiveness because of small number of studies comparing Taichi with other exercise program for arthritis. However the Taichi for arthritis could have positive effect to treat the rheumatoid and degenerative arthritis. We hope further studies to be followed in oriental medical field.

• 사물인터넷융복합논문지
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• 제5권1호
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• pp.29-34
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• 2019

백필터 집진기는 여러개 또는 수십개의 여과포를 구성하여 미세먼지를 정화시켜 깨끗한 공기를 대기에 방출시키는 일종의 공기청정기이다. 백필터 길이가 5m 이하인 경우 다이아프램 밸브에서 발생되는 압축공기를 벤추리를 통과시키는 것만으로도 백필터에 부착된 분진 및 흄을 효율적으로 탈진 할 수 있었다. 7m 이상의 롱백 탈진에 만족스러운 결과를 얻기 위해서는 더욱 효율이 높고 경제성 있는 인젝터 개발이 시급한 실정이다. 기존 국내외 인젝터의 경우 유지 보수시 다수의 블루튜브 해체작업과 인젝터와 블루튜브가 결합되어 중량증가로 인한 작업의 불편성 등 많은 문제를 내포하고 있는 실정이다. 본 연구에서는 코안다 효과를 이용한 최적의 인젝터 개발을 위한 유동해석과 4차 산업의 지능형 자동화 탈진 기술이 접목되어, 기존 설비 대비 에너지 비용저감 및 필터 수명향상 등을 획기적으로 개선시키고자 하는 상용화 연구를 수행하였다.

• The Korean Journal of Physiology
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• 제26권1호
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• pp.45-54
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• 1992

Effects of pH, $PCO_2$, and adenosine on the vascular contractility were investigated in the pig coronary arteries. The helical strips of isolated coronary arteries were immersed in the HEPES or $HCO_3^-/CO_2$-buffered Tyrode's solution equilibrated with 100% $O_2\;or\;95%\;O_2-5%\;CO_2\;at\;35^{\circ}C$. The contraction was recorded isometrically using a force transducer. The amplitudes of contraction induced by ACh, high $K^+$, and electrical Held stimulation (EFS) were decreased by elevating extracellular pH (pHo) and were increased by lowering pHo. A shift from $0%\;CO_2\;to\;5%\;CO_2$ at constant pHo (pH 7.4) reduced the contractions induced by ACh, high $K^+$, EFS. However the contraction induced by 100mM $K^+$ was less influenced by the change of pHo or $CO_2$. The contraction induced by ACh in $Ca^{2+}$free Tyrode's solution as well as the contraction developed by the addition of extracellular of $Ca^{2+}$ were decreased by lowering pHo and were increased by elevating pHo. High $K^+$ (25mM) induced contraction at pH 6.8 was not returned to the level of the contraction at pH 7.4 by the elevation of extracellular. calcium $[Ca^{2+}]_o$. Adenosine-induced relaxation was more significant with 5% $CO_2$ than 0% $CO_2$ in the high $K^+$-induced contraction and was more significant with low pHo than high pHo in the contraction induced by EFS. From the above results, it is suggested that $H^+$ and $CO_2$ inhibit $Ca^{2+}$ influx as well as $Ca^{2+}$ release from intracellular $Ca^{2+}$ storage sites and enhance the relaxing effect of adenosine in the pig coronary artery.

• The Korean Journal of Physiology
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• 제16권2호
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• pp.209-213
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• 1982

This study was conducted to investigate the effect of ingestion of sesame (Sesamum indicum) gruel as a nourishing meal upon the plasma gastrin concentration in normal Korean. Sixteen normal persons with no history of gastrointestinal diseases, including male and female were studied. After an overnight(about 15 hrs) fast, eight persons(mean age: 26.6, range: $20{\sim}40$ years) of them ingested a 350 ml sesame gruel corresponding to 12 g protein, 13 g fat and 99 g carbohydrate, and the remaining 8 subjects(mean age: 21.3, range: $20{\sim}24$ years) ingested a 350 ml glutinous rice gruel(control meal) corresponding to 8 g protein, 1 g fat and 115 g carbohydrate. The venous blood samples were drawn before and after the ingestion of the test meal for the measurement of gastrin by means of radioimmunoassay. 1) Plasma gastrin concentration in response to the ingestion of sesame gruel or glutinous rice gruel increased significantly compared with the concentration in fasting state. 2) Mean increment or percent increment in postprandial plasma gastrin concentration after the ingestion of sesame gruel was not significantly different from that after the control meal, i.e. the glutinous rice gruel. It is inferred from the above results that the ingestion of sesame contained in sesame gruel may have no significant influence on gastrin release in normal human subjects.

• 유통과학연구
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• 제14권10호
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• pp.147-152
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• 2016

Purpose - High quality films are affected by both the production stage and various variables such as the size of the movie investment and marketing that changes consumers' perceptions. Consumer preferences should be recognized first to ensure that the movie is successful. If a film is produced without pre-investigation and analysis of consumer demand and taste, the probability of success will be low. This study investigates the balance of production costs, marketing costs, and profits using game theory, suggesting an optimization strategy using the simplex method of linear programming. Research design, data, and methodology - Before the release of the movie, initial demand is assumed to be driven largely by marketing costs. In the next phase, demand is assumed to be driven purely by a movie's production cost and quality, which might also further determine consumer demand. Thus, it is essential to determine how to distribute pure production costs and other costs (marketing) in a limited movie production budget. Moreover, it should be taken into account how to optimally distribute under the assumption that the audience and production company's input resources are limited. This research simplifies the assumptions for large-scale and relatively small-scale movie investments and examines how movie distribution participant profits differ when each cost is invested differently. Results - When first movers or market leaders have to choose both quality and marketing, it has been proven that pursuing a strategy choosing only one is more likely than choosing both. In this situation, market leaders should maximize marketing costs under the premise that market leaders will not lag their quality behind the quality of second movers. Additionally, focusing on movie marketing that produces a quick effect while ceding creative activity to increase movie quality is a natural outcome in the movie distribution environment since a cooperative strategy between market competitors is not feasible. Conclusions - Government film development policy should ignore quality competition between movie production companies and focus on preventing marketing competition. If movie production companies focus on movie production quality improvement then a creative competition would ensue.

• 한국수산과학회지
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• 제45권6호
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• pp.553-560
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• 2012

Hizikia fusiformis, a brown alga that is widely consumed in Korea, Japan, and China, possesses a number of potentially beneficial compounds, including antioxidants and anticoagulants. However, the molecular mechanisms of H. fusiformis in hepatoma cells have not been elucidated. This study investigated the antiproliferative effect and mechanism of action of a glycoprotein from H. fusiformis (HFGP) in HepG2 human hepatoma cells. In an MTS assay, 25 ${\mu}g/mL$ HFGP inhibited the proliferation of HepG2 cells by $52.36{\pm}2.37%$. HFGP caused the dose-dependent growth inhibition of HepG2 cells by inducing apoptosis and a sub-G1 phase arrest. The antiproliferative activity of HFGP was confirmed based on the expression of several apoptosis-related proteins, which was assessed by Western blot analysis. The expressions of Fas, Fas-associated death domain protein, Bax, and Bad was significantly up-regulated in HFGP-treated cells, and HFGP induced the translocation of Bax to mitochondria and the release of cytochrome c into the cytosol. Therefore, HFGP might be useful in the treatment of liver cancer.