• 한국임상약학회지
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• 제26권1호
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• pp.59-69
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• 2016

Background: The subcutaneous formulation of biologic disease-modifying antirheumatic drugs (DMARDs) was preferred due to favored self-administration and would be an economical treatment option for patients with rheumatoid arthritis. This study was to compare the economic impact of biologic DMARDs administered by subcutaneous injection in patients with rheumatoid arthritis who had inadequate response to conventional DMARDs. Methods: The cost-minimization analysis was conducted to estimate the lifetime health care costs of treatment sequences with subcutaneous biologic DMARDs as first-line therapy from a health care system perspective. The Markov model was developed to represent the transitions through treatment sequences based on American College of Rheumatology response rate and discontinuation rate. The health care costs comprised the cost of medications, administration, dispensing, outpatient visits, test/diagnostic examination, palliative therapy and treatment of serious infection. All costs were expressed in 2016 Korean Won (KRW) and discounted at 5%. Results: The mean lifetime health care cost per patient was lowest in the etanercept sequence, which was estimated at KRW 63,441,679. The incremental costs of the treatment sequence started with adalimumab, golimumab, abatacept, and tocilizumab were KRW 7,985,730, KRW 4,064,669, KRW 2,869,947, and KRW 4,282,833, respectively, relative to etanercept sequence. These differences in costs mainly were attributable to medication costs. One-way and probabilistic sensitivity analyses confirmed that etanercept represented the option with the lowest cost compared with comparators. Conclusion: This study found that etanercept is likely a cost-saving treatment option among subcutaneous biologic DMARDs in patients with rheumatoid arthritis.

• 전자공학회논문지C
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• 제35C권11호
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• pp.11-20
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• 1998

검사용이성 분석에서는 회로의 모든 선에서 제어율과 관측율 값을 계산하고 이를 기반으로 결함 시험도를 평가한다. 검사용이성 분석은 응용에 따라 제어율과 관측율 값을 이용하기도 하고, 결함 시험도 값을 사용하기도 한다. 검사용이성 분석 알고리즘 ITEM은 이미 결함 시험도 측정 관점에서 평가되었다. 하지만 부분스캔과 같은 응용 분야를 위해 회로 내의 각 선들에 대한 제어율과 관측율 값도 중요한 의미를 가지므로 평가되어야 한다. 본 논문에서는 회로내의 각 선들에 대한 검출율 관점에서 STAFAN과 ITEM을 비교 평가하기 위해, 플립플롭을 스캔함에 따른 전체 회로의 검사용이성 영향을 분석하는 민감도 분석을 이용한 검사용이성 부분 스캔 기법을 통해 간접적으로 ITEM을 평가하였다. ITEM에 의해서 구해진 검사용이성은 STAFAN에 의해 구해진 것과 거의 유사한 값을 유지하였지만, 빠른 실행 시간을 보였다. ITEM은 부분 스캔과 실행 시간에 민감한 크기가 큰 회로에 있어서 효과적일 것으로 판단된다.

• BMB Reports
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• 제41권6호
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• pp.448-454
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• 2008

Two full-length cDNAs, PutPMP3-1 and PutPMP3-2, encoding PMP3 family proteins were isolated from Puccinellia tenuiflora, a monocotyledonous halophyte. Expression of both genes was induced by low temperature, salt stress, dehydration, ABA, and $NaHCO_3$. Transcripts of PutPMP3-2 were more strongly induced by these stresses relative to those of PutPMP3-1, particularly under low temperature and dehydration conditions. Expression of PutPMP3-1 and PutPMP3-2 in yeast mutants lacking the PMP3 gene can functionally complement the membrane hyper-polarization and salt sensitivity phenotypes resulting from PMP3 deletion. To compare the functions of PutPMP3-1 and PutPMP3-2, the orthologous genes in rice (OsLti6a and OsLti6b) were isolated. Both OsLti6a and OsLti6b could functionally complement the loss of PMP3 in yeast. PutPMP3-2 and OsLti6a were more effective in reversing membrane hyperpolarization than PutPMP3-1 and OsLti6b. However, the four yeast transformants each showed similar levels of salt tolerance. These results imply that these PMP3 family members don't function identically under different stress tolerance conditions.

• 대한기계학회논문집A
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• 제36권2호
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• pp.231-236
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• 2012

본 논문에서는 홀 효과(Hall effect) 기반 회전형 위치 센서의 출력 전압에 대한 선형성 및 민감도를 최적화하기 위해 DFSS(Design for Six Sigma) 방법을 적용하였다. 이를 위해 영구 자석의 치수 및 홀센서에 대한 상대 위치 등을 설계 인자로 하여 완전 요인 배치법을 사용하였다. 설계 인자의 수준별 센서 출력 전압값은 자속 밀도에 대한 Biot-Savart 해석해 및 홀 센서 고유의 자속 밀도-출력 전압에 대한 관계식을 이용하여 구하였다. 최적화된 설계 인자들을 반영하여 제작된 회전형 위치 센서의 개선된 출력 전압 측정 결과를 통해 제안된 방법은 간편하면서 실용적으로도 매우 유용한 방법임을 확인하였다.

• 한국해안해양공학회지
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• 제19권5호
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• pp.457-466
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• 2007

북서태평양의 $115{\sim}150^{\circ}E,\;20{\sim}52^{\circ}N$ 사이의 해역을 $1/12^{\circ}$ 격자망으로 구성한 광역 조석 모델을 수립, 연안역 수심 조정이 전체 조석 모델 결과에 미치는 영향을 검토하였다. 최소 수심을 10 m에서 35 m까지 5 m 간격으로 증가시키며 계산된 모델의 정확도를 비교한 결과, $M_2,\;S_2,\;K_1$ 진폭의 정확도가 최소 수심이 25m일 경우최소 수심 10 m인 경우와 비교하여 각각 약 42%, 32%, 26% 정도 개선되는 것으로 나타났다. 제주도 주변 해역의 $M_2$ 조석 진폭은 연안역 수심 조정에 따라 약 20cm이상 차이를 나타냈으며 발해만 내에 존재하는 무조점의 위치도 크게 변화하였다. 해저마찰계수 및 최소수심에 따른 평균상대오차(ARE)를 계산해 본 결과 해저마찰계수 0.0015와 최소수심 25 m의 조합이 오차를 최소화 할 수 있는 최적 값으로 확인되었다.

• 센서학회지
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• 제24권1호
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• pp.41-46
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• 2015

In this work, pure hierarchical ZnO structure was prepared using a simple hydrothermal method, and Ag nanoparticles doped hierarchical ZnO structure was synthesized uniformly through photochemical route. The reduced graphene oxide (rGO) has been synthesized by typical Hummer's method and reduced by hydrazine. Prepared Ag/ZnO nanostructures are uniformly dispersed on the surface of rGO sheets using ultrasonication process. The synthesized samples were characterized by SEM, TEM, EDS, XRD and PL spectra. The average size of prepared ZnO microspheres was around $2{\sim}3{\mu}m$ and showed highly uniform. The average size of doped-Ag nanoparticles was 50 nm and decorated into ZnO/rGO network. The $C_2H_2$ gas sensing properties of as-prepared products were investigated using resistivity-type gas sensor. Ag/ZnO-rGO based sensors exhibited good performances for $C_2H_2$ gas in comparison with the Ag/ZnO. The $C_2H_2$ sensor based on Ag/ZnO-rGO had linear response property from 3~1000 ppm of $C_2H_2$ concentration at working temperature of $200^{\circ}C$. The response values with 100 ppm $C_2H_2$ at $200^{\circ}C$ were 22% and 78% for Ag/ZnO and Ag/ZnO-rGO, respectively. In additions, the sensor still shows high sensitivity and quick response/recovery to $C_2H_2$ under high relative humidity conditions. Moreover, the device shows excellent selectivity towards to $C_2H_2$ gas at optimal working temperature of $200^{\circ}C$.

• 대한원격탐사학회지
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• 제36권1호
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• pp.67-81
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• 2020

The rapid climatic changes being caused by global warming are resulting in abnormal weather conditions worldwide, which in some regions have increased the frequency of landslides. This study was aimed to analyze and compare the landslide susceptibility using the Frequency Ratio (FR), Statistical Index, Weight of Evidence, Certainty Factor, and Index of Entropy (IoE) at Woomyeon Mountain in South Korea. Through the construction of a landslide inventory map, 164 landslide locations in total were found, of which 50 (30%) were reserved to validate the model after 114 (70%) had been chosen at random for model training. The sixteen landslide conditioning factors related to topography, hydrology, pedology, and forestry factors were considered. The results were evaluated and compared using relative operating characteristic curve and the statistical indexes. From the analysis, it was shown that the FR and IoE models were better than the other models. The FR model, with a prediction rate of 0.805, performed slightly better than the IoE model with a prediction rate of 0.798. These models had the same sensitivity values of 0.940. The IoE model gave a specific value of 0.329 and an accuracy value of 0.710, which outperforms the FR model which gave 0.276 and 0.680, respectively, to predict the spatial landslide in the study area. The generated landslide susceptibility maps can be useful for disaster and land use planning.

• 한국화재소방학회논문지
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• 제19권1호
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• pp.20-28
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• 2005

미국, 유럽 등의 대형 화학회사들은 효율적인 위험관리를 위해 단계적 위험성평가 전략을 채택하고 있다. HAZOP이나 정량적위험성평가와 같은 상세한 평가를 수행하기 위한 사전단계로서 위험선별(risk screening)기법을 도입하였다. 본 연구에서는 Khan과 Abbasi가 제안한 위험선별방법인 화재폭발손실지수 법(Fire & Explosion Damage Index, FEDI)을 국내의 BTX플랜트에 적용시켜 보았다. 적용결과를 정량적위험성평가의 결과와 비교해 본 결과, 화재폭발손실지수법이 위험잠재성을 파악하는데 효과적으로 사용될 수 있음을 알 수 있었다. 또한 화재폭발손실지수 법에 대한 민감도분석을 수행함으로써 화재 및 폭발에 영향을 미치는 가장 큰 인자는 설비내 물질의 특성과 양(quantity)임을 알 수 있었다. 본 연구의 결과를 바탕으로 하여 HAZOP의 사전단계로서 화재폭발손실지수 법을 적용한다면 보다 효율적인 위험성 평가가 가능할 것이다.

• 한국농공학회논문집
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• 제59권5호
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• pp.93-99
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• 2017

A model was developed using Artificial Neural Networks (ANNs) based on Principal Component Analysis (PCA), to accurately predict the air humidity inside an experimental greenhouse located in Daegu (latitude $35.53^{\circ}N$, longitude $128.36^{\circ}E$, and altitude 48 m), South Korea. The weather parameters, air temperature, relative humidity, solar radiation, and carbon dioxide inside and outside the greenhouse were monitored and measured by mounted sensors. Through the PCA of the data samples, three main components were used as the input data, and the measured inside humidity was used as the output data for the ALYUDA forecaster software of the ANN model. The Nash-Sutcliff Model Efficiency Coefficient (NSE) was used to analyze the difference between the experimental and the simulated results, in order to determine the predictive power of the ANN software. The results obtained revealed the variables that affect the inside air humidity through a sensitivity analysis graph. The measured humidity agreed well with the predicted humidity, which signifies that the model has a very high accuracy and can be used for predictions based on the computed $R^2$ and NSE values for the training and validation samples.

• 대한수의학회지
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• 제32권4호
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• pp.543-553
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• 1992

Properties of unitary ATP-sensitive $K^+$ channels were studied using planar lipid bilayer technique. Vesicles were prepared from bullfrog (Rana catesbeiana) skeletal muscle. ATP-sensitive $K^+$ (K (ATP)) channels were identified by their unitary conductance and sensitivity to ATP. In the symmetrical solution containing 200mM KCI, 10mM Hepes, 1mM EGTA and pH 7.2, single K (ATP) channels showed a linear current-voltage relations with slight inward rectification. Slope conductance at reversal potential was $60.1{\pm}0.43$ pS(n=3)). Micromolar ATP reversibly inhibited the channel activity when applied to the cytoplasmic side. In the range of -50~＋50 mV, the channel activity was not voltage-dependent, but the channel gating within a burst was more frequent at negative voltage range. Varying the concentrations of external/internal KCl(mM) to 40/200, 200/200, 200/100 and 200/40 shifted reversal potentials to $-30.8{\pm}2.9$(n=3), $-1.1{\pm}2.7$(n=3), 10.5 and 30.6(mV), respecrivety. These reversal potentials were close to the expected values by the Nernst equation, indicating nearly ideal selectivity for $K^+$ over $Cl^-$. Under bi-ionic conditions of 200mM external test ions and 200mM internal $K^+$, the reversal potentials for each test ion/K pair were measured. The measured reversal potentials were used for the calculation of the releative permeability of alkali cations to $K^+$ ions using the Goldman-Hodgkin-Katz equation. The permeability sequence of 5 cations relative to $K^+$ was $K^+$(1), $Rb^+$(0.49), $Cs^+$(0.27), $Na^+$(0.027) and $Li^+$(0.021). This sequence was recognized as Eisenman's selectivity sequence IV. In addition, modelling the permeation of $K^+$ ion through ATP-sensitive $K^+$ channel revealed that a 3-barrier 2-site multiple occupancy model can reasonably predict the observed current-voltage relations.