• The Journal of Internal Korean Medicine
• /
• v.30 no.1
• /
• pp.181-190
• /
• 2009

It is important to establish the safety of herbal medicine because of its frequent and widespread use in Korea. Several studies on the safety of herbal medicine have been performed and there have been rare serious adverse drug reactions from those reports in Korea. However, the results are not strongly supported because of not adopting appropriate enough research methodology as to make the safety issue clear. For improving the quality of the safety research on herbal medicine. including investigations of drug induced liver injury (DILl). the aim of this study was to suggest herbal medicine-induced liver injury investigation forms for performing reasonable safety research. After a systematic review of the preceding studies regarding herbal safety in Korea was performed in 2008, we assessed the quality and the limitations of the primary studies. Two investigation forms for herbal safety research were made as a following step. one a basic investigation form for herbal safety research and the other an advanced investigation form for suspected DILl cases, Those forms include the essential informations and data needed to make an appropriate assessment of whether DILl occurred during or after the use of herbal medicine. Guidelines for using those forms and other recommendations were also suggested. More rigorous studies are required for answering the safety issue of herbal medicine as well as the efficacy issue. We hope for wide use and improvement of those investigation forms in the study of herbal safety by many researchers for establishing better evidences in Korea.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.20 no.4
• /
• pp.1014-1020
• /
• 2006

This study was intended to examine the effects of electroacupuncture(EA) and therapeutic exercise on the improvement of exercise function, BNDF, and HSP70 protein expression in an ischemic stroke model induced by MCA occlusion. Experiments were conducted for 1, 3 days, 1, 8 weeks respectively. Group I was a group of EA and therapeutic exercise; Group II was a group of therapeutic exercise; Group III was a group of EA; Group IV was a sham group of EA; Group V was a control group; and Group VI was a sham group without ischemic stroke. In each group, neurologic motor behavior test, histologic observations, BDNF, and HSP70 expression were observed and analyzed. The following results were obtained. The results of behavior test suggest that 8 weeks after ischemic stroke was induced, Group I improved in degeneration and inflammation of muscle fiber and decreased in destruction of nerve cells and cerebral infarction, indicating a similar state of muscle fiber and brain to Group VI. In immunohistochemical observations, Group I showed increase in BDNF and decrease in HSP70. Based on these results, EA and therapeutic exercise may improve muscle atrophy and change in BDNF and HSP70 expression of ischemic stroke rats and contribute to the improvement of exercise function.

• Journal of Biomedical Engineering Research
• /
• v.27 no.5
• /
• pp.250-259
• /
• 2006

The information of eye movement is used in various fields such as psychology, ophthalmology, physiology, rehabilitation medicine, web design, HMI(human-machine interface), and so on. Various devices to detect the eye movement have been developed but they are too expensive. The general methods of eye movement tracking are EOG(electro-oculograph), Purkinje image tracker, scleral search coil technique, and video-oculograph(VOG). The purpose of this study is to embody the algorithm which tracks the location of the gazing point at a pupil. Two kinds of location data were compared to track the gazing point. One is the reference points(infrared LEDs) which is effected from the globe. Another is the center point of the pupil which is gained with a CCD camera. The reference point was captured with the CCD camera and infrared lights which were not recognized by human eyes. Both of images which were thrown and were not thrown an infrared light on the globe were captured and saved. The reflected reference points were detected with the brightness difference between the two saved images. In conclusion, the circumcenter theory of a triangle was used to look for the center of the pupil. The location of the gazing point was relatively indicated with the each center of the pupil and the reference point.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.15 no.5
• /
• pp.2930-2936
• /
• 2014

The purposes of this study were to investigate the characteristics of speech rate and pause in patients with flaccid dysarthria. For this purpose, 15 patients with flaccid dysarthria and 15 normal speakers matched in gender and age participated as subjects. The overall speech rate, the articulation rate, the inter-sentence and the intra-sentence pause duration and pause frequency were measured during reading the standardized passage "Autumn"(Kim, 1996). As a result, the overall speech rate and articulation rate of patients with flaccid dysarthria were significantly slower than normal speakers and intra-sentence pause duration and frequency of patients with flaccid dysarthria were significantly higher than normal speakers, but those of inter-sentence weren't. The results from this study provides the speech rate index of flaccid dysarthria and indicates that to control the speech rate of flaccid dysarthria have regard to not only the overall speech rate and the articulation rate but also the intra-sentence pause duration and the frequency.

• Journal of Nutrition and Health
• /
• v.15 no.2
• /
• pp.98-106
• /
• 1982

This study was carried out to investigate the nutritional status of physically handicapped children with cerebral palsy in order to contribute to their welfare by studying their healthy status, nutrient intake, daily energy expenditure, and living environment. The survey was conducted at two rehabilitation institutions from May 25 to June 30, 1981. A special questionnaire was designed to investigate the living environment. The 24 hr. recall method was used in evaluation the nutrient intake of 67 children. Anthropometric measurement was made of height, weight, chestgirth, upper-arm circumference, and triceps skinfold thickness. The biochemical status of the children with cerebral palsy was assessed with measurement of hemoglobin and hematocrit. The results may be summarized as follows : 1. The children with cerebral palsy, the intakes of all nutrients except vitamin A, thiamin, and ascorbic acid were lower than Korean recommend dietary allowances (1980). They had significantly higher intakes of vitamin A and calcium than the normal children, but the calcium intake was low as 62% of the Korea RDA. 2. All the children with cerebral palsy were very short and low weight in comparison with the accepted standards, but chestgirth was above the accepted standards for Korean school children. 3. The average hemoglobin value was 12.2gm%, hematocrit 39.3%, and mean corpuscular hemoglobin concentration (MCHC) 31.1%. 4. The possible etiological factors of cerebral palsy were, prenatal factors 16%, natal 44.9%, postnatal 27.5%, and unknown 11.6%. Eighty four percent of the children showed their first symptoms within the first year after birth. 5. Thirty percent of the parents said that the handicapped children lead to marital problems, and 84.1% of the parents mentioned that medical expenses for the children influenced their family finances.

• The Journal of Korean society of community based occupational therapy
• /
• v.4 no.2
• /
• pp.75-83
• /
• 2014

Objective : The purpose of this study is to find out the effects of a Home-based cognitive occupational therapy program conducted for the dementia patients in the initial stages living in Taebaek region in Gangwon-do. Methods : This study carried out Home-based cognitive occupational therapy intervention by 30 Occupational Therapy Dept. students and volunteers targeting 30 dementia patients in the initiative stages for eight sessions, once a week. To identify the change of cognitive function of the participants before and after the program, MMSE-K was used for measuring. Results : As a result of applying Home-based cognitive occupational therapy to the dementia patients in the initial stages, overall cognitive function improvement was demonstrated. Especially, statistically significant improvement was exhibited in orientation, memory retrieval, the concentration of attention, and language ability. Conclusion : The program for cognitive function improvement is considered to be usefully applied to intervention in the dementia patients. The development of various Home-based occupational therapy intervention programs is required in order to adopt the Home-based occupational therapy service in the future.

• Osong Public Health and Research Perspectives
• /
• v.9 no.6
• /
• pp.354-361
• /
• 2018

Objectives: The purpose of this study was to explore the effects of injection laryngoplasty (IL) with hyaluronic acid in patients with vocal fold paralysis (VFP). Methods: A total of 50 patients with VFP participated in this study. Pre- and post-IL assessments were performed, which included analyzing the sustained vowel /a/ phonation, and the patient reading 1 Korean sentence from the "Walk" passage that comprised 25 syllables in 10 words. To investigate the effect of IL on vocal fold function, acoustic analysis (acoustic voice quality index, cepstral peak prominence, maximum phonation time, speaking fundamental frequency) was conducted and auditory-perceptual (grade and overall severity), visual judgment (gap), and self-questionnaire (voice handicap index-10) assessments were performed. Results: The patients with VFP showed statistically significant differences between pre-and post-IL assessments for acoustic and auditory-perception, visual judgment, and self-questionnaire assessments. Conclusion: The patients with VFP showed positive change in vocal fold function between pre- and post-IL measurements. The findings showed that IL with hyaluronic acid is an effective method to improve vocal fold function in patients with VFP.

• Journal of Korean Physical Therapy Science
• /
• v.26 no.2
• /
• pp.51-60
• /
• 2019

Background: The purpose of this study was to investigate the effects of HBOT (hyperbaric oxygen therapy) on the pain, ROM (range of motion) and muscle fatigue recovery of DOMS (delayed onset muscle soreness). Design: Randomized Controlled Trial. Methods: Twenty-six subjects who are student in their 20s at a university participated in this study, these subjects were assigned into two groups, a control group (n=12) and an experiment group (n=14). The subjects in experimental group were intervened by HBOT (40 minutes, 1.3 ATA), while ones on control group weren't by any intervention after induced DOMS. Results: First, in the comparison of VAS (visual analog scale), there were significant variations with the period (p<0.001), interaction of period (p<0.05) and group (p<0.05). In the comparison of PPT (pressure pain threshold), there were significant variations with the period (p<0.001) and interaction of period (p<0.05). Second, in the comparison of ROM, there were significant variations with the period (p<0.001), interaction of period (p<0.001) and group (p<0.01). Third, in the comparison of CK (creatine kinase) and LDH (lactate dehydrogenase), there no signigicant variations with all measure variables. Conclusion: The above results indicated that HBOT were effective to decrease the pain and improve the ROM in DOMS. Also the statistical significant variations of blood factors of muscle fatigue were not found in this.

• The Journal of Internal Korean Medicine
• /
• v.40 no.5
• /
• pp.822-831
• /
• 2019

Objective: This study reports the effect of Hyungbangjihwang-tang-gami as a treatment for Soyang-in patients with chronic diarrhea. Methods: We treated three male patients with chronic diarrhea who did not improve after taking herbal medicine, as determined by zang-fu (organ) pattern diagnosis. After changing our approach to a Sasang constitution, we prescribed Hyungbangjihwang-tang-gami and assessed the effect by the frequency or form of defecation. Results: The patients' complaints worsened when they were administered a herbal medicine unsuited to their Soyang constitutions, which caused an exuberance of Yang. Changing the herbal medicine to Hyungbangjihwang-tang-gami improved their symptoms. Conclusions: This study suggested that Soyang-in patients may have side effects when administered unsuitable herbs, even if they were diagnosed using zang-fu (organ) pattern diagnosis. When we treat patients, we have to consider their Sasang constitution, as well as the zang-fu (organ) pattern diagnosis.

• Physical Therapy Korea
• /
• v.26 no.4
• /
• pp.10-19
• /
• 2019

Background: In patients with lumbar spinal stenosis (LSS), lumbar flexion exercise (LFE) is considered a standard therapeutic exercise that widens the space between the spinal canal and intervertebral foramen. However, some researchers have reported that lumbar extension exercise (LEE) may improve lumbar pain and functional ability in patients with LSS. Although exercise intervention methods for patients with LSS have been widely applied in clinical settings, few studies have conducted comparative analysis of these exercise methods. Objects: This study aimed to compare the effects of LFE, LEE, and lumbar flexion combined with lumbar flexion-extension exercise (LFEE) on pain, range of motion (ROM), pelvic tilt angle, and functional gait ability in patients with LSS. Methods: A total of 30 patients with LSS, LFE (n1=10), LEE (n2=10), and LFEE (n3=10) were assigned to each of the three exercise groups. The numerical pain rating scale (NPRS), modified-modified schober test (MMST)-flexion, MMST-extension, pelvic tilt inclinometer, and 6-minute walking test (6MWT) were measured. Results: After the intervention, statistically significant differences were observed in the NPRS (p=.043), MMST-flexion (p<.001), MMST-extension (p<.001), and 6MWT (p=.005) between groups. According to the post hoc test, the NPRS was statistically significant difference between the LFEE and LEE groups (p=.034). The MMST-flexion was statistically significantly different between the LFE and LEE (p=.000), LFE and LFEE (p=.001), and LEE and LFEE (p=.001) groups. The MMST-extension was statistically significantly different between the LFE and LEE (p<.001), LFE and LFEE (p=.002), and LEE and LFEE (p=.008) groups. The 6MWT was statistically significantly different between the LFE and LFEE (p=.042) and the LEE and LFEE (p=.004) groups. Conclusion: This study suggested that LFEE was the most effective exercise for pain and functional gait ability in patients with LSS, LFE was the most effective exercise for lumbar flexion ROM, and LEE was the most effective exercise for lumbar extension ROM.