• 식품과학과 산업
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• 제55권3호
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• pp.264-275
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• 2022

The regulation of macrophages is a major target for dietary immune modulation for their involvement in both innate and adoptive immune responses. Studies revealed that macrophages are unique in their plasticity to polarize into either inflammatory M1 subset or anti-inflammatory M2 cells. Recently, cellular energy metabolism including both glycolysis and oxidative phosphorylation is demonstrated to control macrophage dichotomy. In this review, the differential utilization of glucose, lipids, amino acids, and irons by M1 and M2 cells are discussed in detail. In addition, several dietary approaches for the alteration of inflammatory M1 cells to M2 phenotypes are reviewed for development of functional foods for immune regulation.

• 운동영양학회지
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• 제15권4호
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• pp.153-161
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• 2011

The maintenance of skeletal muscle mass is very important for the prevention of life style-related diseases and the improvement of quality of life. It is well-known that resistance exercise and nutrition (especially amino acids) are the most effective interventions for maintaining skeletal muscle mass. It has been reported that many molecules are involved in the regulation of protein synthesis in response to resistance exercise and nutrition. Understanding the molecular mechanisms regulating muscle protein synthesis is crucial for the development of appropriate interventions. The role of intracellular signaling pathways through the mammalian target of rapamycin (mTOR), a serine/threonine protein kinase in the regulation of muscle protein synthesis, has been extensively investigated for these years. Control of protein synthesis by mTOR is mediated through phosphorylation of downstream targets that modulate translation initiation and elongation step. In contrast, upstream mediators regulating mTOR and protein synthesis in response to resistance exercise and amino acid still needed to be determined. In this brief review, we discuss the current progress of intracellular mechanisms for exercise- and amino acid-induced activation of mTOR pathways and protein synthesis in skeletal muscle.

• Anatomy and Cell Biology
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• 제56권1호
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• pp.16-24
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• 2023

Endothelial cells (EC) are the anatomical boundaries between the intravascular and extravascular space. Damage to ECs is catastrophic and induces endothelial cell dysfunction. The pathogenesis is multifactorial and involves dysregulation in the signaling pathways, membrane lipids ratio disturbance, cell-cell adhesion disturbance, unfolded protein response, lysosomal and mitochondrial stress, autophagy dysregulation, and oxidative stress. Autophagy is a lysosomal-dependent turnover of intracellular components. Autophagy was recognized early in the pathogenesis of endothelial dysfunction. Autophagy is a remarkable patho (physiological) process in the cell homeostasis regulation including EC. Regulation of autophagy rate is disease-dependent and impaired with aging. Up-regulation of autophagy induces endothelial cell regeneration/differentiation and improves the function of impaired ones. The paper scrutinizes the molecular mechanisms and triggers of EC dysregulation and current perspectives for future therapeutic strategies by autophagy targeting.

• 한국수소및신에너지학회논문집
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• 제25권5호
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• pp.500-508
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• 2014

In the ongoing debates over the need to identify new sources of energy and to reduce the emissions of greenhouse gases. Hydrogen has emerged as one of the most promising alternatives due to its emissions from the vehicle being virtually zero. The governments have identified the development of regulations and standards as one of the key requirements for commercialization of HFCV. Regulations and standards will help overcome technological barriers to commercialization. The development of Global Technical Regulation (GTR) for HFCV occurred under the World Forum for Harmonization of Vehicle Regulations. Development of a technique for safety assessment of HFCV include four tasks, research for regulation system and policy, hydrogen safety, vehicle operation safety and protection against high-voltage. The objective is to establish a technique for safety assessment and amend safety standards for HFCV and consequently reflect research results to vehicle management policy. We devised safety standards and evaluation techniques with regard to high-pressure gas and high voltage of hydrogen fuel cell vehicle. KMVSS for HFCV was amended to June 10, 2014. including the results of the safety assessment technology for high-voltage and hydrogen characteristics.

• 대한감각통합치료학회지
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• 제1권1호
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• pp.61-72
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• 2003

The suck/swallow/breathe(SSB) synchrony, serving as the earlist primary motor mechanism, is the rhythmical, coordinated pattern of sucking, swallowing and breathing. The development of an intact SSB is an important precursor for further sensorimotor and cognitive development including speech and language development, state regulation, postural control, feeding, eye/hand coordination and social/emotional development. Arousal means a neurological mechanism for preparing one's body to orienting stimulus. Its levels are regulated with an interaction of the reticular formation, the limbic system, the hypothalamus and the autonomic nervous system. General strategies such as blowing, sucking, chewing, munching and licking to effectively modulate arousal state are related to SSB. The SSB synchrony is an important treatment principle for children with sensory integration disorder and problems with the modulation of arousal. The purpose of this article is to review concepts of SSB synchrony and the underlying relation between the modulation of arousal and SSB synchrony.

• BMB Reports
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• 제53권11호
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• pp.551-564
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• 2020

Proper development of the nervous system is critical for its function, and deficits in neural development have been implicated in many brain disorders. A precise and predictable developmental schedule requires highly coordinated gene expression programs that orchestrate the dynamics of the developing brain. Especially, recent discoveries have been showing that various mRNA chemical modifications can affect RNA metabolism including decay, transport, splicing, and translation in cell type- and tissue-specific manner, leading to the emergence of the field of epitranscriptomics. Moreover, accumulating evidences showed that certain types of RNA modifications are predominantly found in the developing brain and their dysregulation disrupts not only the developmental processes, but also neuronal activities, suggesting that epitranscriptomic mechanisms play critical post-transcriptional regulatory roles in development of the brain and etiology of brain disorders. Here, we review recent advances in our understanding of molecular regulation on transcriptome plasticity by RNA modifications in neurodevelopment and how alterations in these RNA regulatory programs lead to human brain disorders.

• BMB Reports
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• 제44권3호
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• pp.187-192
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• 2011

TGF-$\beta$ activated kinase-1 (TAK1) plays a pivotal role in developmental processes in many species. Previous research has mainly focused on the function of TAK1 in model organisms, and little is known about the function of TAK1 in hymenoptera insects. Here, we isolated and characterized the TAK1 gene from Apis cerana cerana. Promoter analysis of AccTAK1 revealed the presence of transcription factor binding sites related to early development. Real-time quantitative PCR and immunohistochemistry experiments revealed that AccTAK1 was expressed at high levels in fourth instar larvae, primarily in the abdomen, in the intestinal wall cells of the midgut and in the secretory cells of the salivary glands. In addition, AccTAK1 expression in fourth instar larvae could be dramatically induced by treatment with pesticides and organic solvents. These observations suggest that AccTAK1 may be involved in the regulation of early development in the larval salivary gland and midgut.

• 한국어병학회지
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• 제16권2호
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• pp.111-118
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• 2003

Androgen plays an important role in the regulation of gonadotropin production in vertebrates . We have investigated the transcriptional pattern of androgen receptor (AR) in a variety of tissues in maturing male and female goldfish by RT-PCR. Specific primer for AR was designed based on goldfish AR gene from the GenBank (accession number AY090897). AR was shown 10 be maturity- and tissue-dependent gene expression pattern in goldfish. In immature male goldfish, significantly higher transcript level of AR was observed in the pituitary und testis , compared [0 brain and liver. Mature male goldfish showed a similar expression pattern to immature male goldfish. Interestingly. when compare to male goldfish, female goldfish showed AR mRNA expression that was found 10 be weak in pituitary, and very low expression in brain. They could not be found 10 have expression in any other tissues. Taken together. the- transcriptional analysis of AR depending on the tissue, sex. and maturity of a goldfish provides the opportunity for the study of goldfish reproductive physiology ,The results provided for the first time a comparison of the tissue distribution of AR mRNA in sexually maturating male and female goldfish.

• 한국물환경학회지
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• 제22권5호
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• pp.807-814
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• 2006

Sapkyo Lake Watershed occupies about 19.3% of total area of Chungnam Province, and it is necessary to make a plan of counter-measure for the maintenance of public waterbody sound as well as to ensure water resources due to urbanization and industrialization in this area so densely populated and excessively developed. Conventionally water quality management has been enforced by concentration-based system which is not considered the carrying capacity of receptors, hence there are no proper measures for the prevention of an excessive pollutant load over a waterbody. So even though emission sources abide by the conventional permission regulation, then the quantity of wastewater is increased continuously and encountered water shortage to use finally. Therefore this research focused on the review of introduction of total water quality management system in Sapkyo Lake watershed to maintain public waterbody sound and to ensure water resources. By doing this research in introduction of the system in advance, it can contribute to establish the methodology on systematic water quality management. Also the application of this system in Sapkyo Lake watershed can promote the sustainable development of the area by harmonizing the environment and regional economy ultimately.

• 한국자동차공학회논문집
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• 제23권2호
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• pp.178-184
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• 2015

According to the regulation on the environment and fuel efficiency is becoming strict, many experiments are conducted to improve efficiency and emission in internal combustion engines. LTC (Low temperature combustion) technology is a promised solution for low emissions but there are a few barriers for the commercial engine. This paper includes optimization that applies LTC method to heavy duty diesel engine. Adequate LTC was applied to low and middle load as adaptability in heavy duty diesel engine, and optimization focused on reduction of fuel consumption was proceeded at high load. Through this research, strategy for practical use of LTC was selected, and fuel consumption has improved on the condition that satisfies the emission regulation at systematic viewpoint.