• The Journal of Korea CHUNA Manual Medicine
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• v.3 no.1
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• pp.85-96
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• 2002

Objectives : The purpose of this study is to get knowledge about osteopathy and to applicate the osteopathy to oriental medicine. Methods: We investigated several books and literatures on osteopathy related sites explored by internet to know the general theories and present conditions of osteopathy in Korea and other countries. Results & Conclusion : 1. The principles of osteopathy are as follows. First, the human being is a dynamic unit of function. Second, the body possesses self regulating mechanisms which are self healing in nature. Third, structure and function are reciprocally interrelated. Fourth, the body rational therapy is based upon knowledge and use of the above three principles. 2. Doctors of osteopathy evaluate the musculoskeletal system to identify structural problems and to support the body's natural tendency toward health and self healing. 3. We can applicate the osteopathy to oriental clinical medicine based on interpreting the principles of osteopathy.

• BMB Reports
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• v.41 no.3
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• pp.177-183
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• 2008

Ubiquitin is an essential, highly-conserved small regulatory protein in eukaryotic cells. It covalently modifies a wide variety of targeted proteins in the forms of monomer and polymers, altering the conformation and binding properties of the proteins and thus regulating proteasomal delivery, protein activities and localization. Mass spectrometry has emerged as an indispensable tool for in-depth characterization of protein ubiquitination. Ubiquitinated proteins in cell lysates are usually enriched by affinity chromatography and subsequently analyzed by mass spectrometry for identification and quantification. Ubiquitin-conjugated amino acid residues can be determined by unique mass shift caused by the modification. Moreover, the complex structure of polyubiquitin chains on substrates can be dissected by bottom-up and middle-down mass spectrometric approaches, revealing potential novel functions of polyubiquitin linkages. Here I review the advances and caveats of these strategies, emphasizing caution in the validation of ubiquitinated proteins and in the interpretation of raw data.

• Proceedings of the Korea Concrete Institute Conference
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• 2004.05a
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• pp.340-343
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• 2004

The cement-based composites have been used for construction industry because of their economy, suitability for architecture and structure function, fire resistance, low fee of repair, easiness for acquisition. but the limited strain capacity of these makes them tension-weak, brittle, and considerable notch-sensitive. As one of solution, FRC(fiber reinforced concrete) have been investigated for regulating weakness of the cement-based composites. In these day different fiber types are proposed for better performance such as HFRC(hybrid fiber reinforced concrete). This study shows experimental results to search the ultimate strength, the ultimate mean strain, and the tension toughness of HFRC. The tension toughness is proportional to the amount of steel fiber and carbon fiber. In this experimental program we kept the total of steel fiber and carbon fiber as $1.0\%,\;1.5\%$, respectively.

• Journal of the Korean Magnetic Resonance Society
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• v.14 no.2
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• pp.127-133
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• 2010

Redox-dependent conformational change of human 8-kDa Dynein light chain (LC8) plays important role in regulating NF-${\kappa}B$ signaling pathway. In this study we characterized the structural states of the oxidized and reduced forms of LC8 by using NMR spectroscopy. The $^1H-^{15}N$ 2D HSQC spectra of oxidized LC8 indicated that no significant change in tertiary structure of LC8 occurred upon oxidation. The chemical shift perturbations of LC8 upon oxidation suggest a redox-dependent quaternary structural change.

• 제어로봇시스템학회:학술대회논문집
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• 1996.10b
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• pp.840-843
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• 1996

This paper presents an adaptive cutting force controller for milling process, which can be attached to most commercial CNC machining centers in a practical way. The cutting forces of X,Y and Z axes measured indirectly from the use of currents drawn by AC feed-drive servo motors. A typical model for the feed-drive control system of a horizontal machining center is developed to analyze cutting force measurement from the drive motor. The pulsating milling forces can be measured indirectly within the bandwidth of the current feedback control loop of the feed-drive system. It is shown that indirectly measured cutting force signals can be used in the adaptive controller for cutting force regulation. The robust controller structure is adopted in the whole adaptive control scheme. The conditions under which the whole scheme is globally convergent and stable are presented. The suggested control scheme has been implemented into a commercial machining center, and a series of cutting experiments on end milling and face milling processes are performed. The adaptive controller reveals reliable cutting force regulating capability under various cutting conditions.

• Journal of the Korean Society for Precision Engineering
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• v.15 no.4
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• pp.68-75
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• 1998

A one-stage direction and flow control valve was studied theoretically and experimentally. A direction and flow control valve maintains a constant flow rate by changing the spool-orifice area under the variation of valve pressure drop, since the spool-orifice area is varied by the action of flowforces on the spool. A direction and flow control valve has the advantage of simple and low-cost structure compared to a conventional flow control valve utilizing a pressure regulating spool which regulates the pressure drop caused by flow through the metering orifice. The static and dynamic characteristics of a one-stage direction and flow control valve was analyzed. Experimental results on the flow control characteristics of the manufactured valve show satisfactory agreement with simulation results.

• Molecules and Cells
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• v.28 no.6
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• pp.501-507
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• 2009

Fragile X syndrome (FXS) is caused by a lack of the fragile X mental retardation protein (FMRP) due to silencing of the Fmr1 gene. As an RNA binding protein, FMRP is thought to contribute to synaptic plasticity by regulating plasticity-related protein synthesis and other signaling pathways. Previous studies have mostly focused on the roles of FMRP within the hippocampus - a key structure for spatial memory. However, recent studies indicate that FMRP may have a more general contribution to brain functions, including synaptic plasticity and modulation within the prefrontal cortex. In this brief review, we will focus on recent studies reported in the prefrontal cortex, including the anterior cingulate cortex (ACC). We hypothesize that alterations in ACC-related plasticity and synaptic modulation may contribute to various forms of cognitive deficits associated with FXS.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.56 no.12
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• pp.2233-2239
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• 2007

The pantograph-catenary system is one of important components for high-speed rail system that are powered electrically. Electrical power is delivered from a catenary structure to the train via a pantograph and thus it is very important to regulate the contact force between catenary and pantograph. Although a lot of research results for active pantograph have been reported, most of them have made an unrealistic assumption that the catenary displacement is constant with respect to the time. In this paper, we present a new pantograph model that regards the catenary displacement as an unknown disturbance input. Moreover, a disturbance observer based controller is proposed to remove the effect of disturbance, i.e., the catenary displacement variation. The computer simulation result shows that the substantial improvement in regulating the contact force can be achieved by the proposed controller.

• BMB Reports
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• v.41 no.6
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• pp.435-443
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• 2008

Post-translational modifiers can alter the function of proteins in many different ways. The conjugation of ubiquitin (Ub) and ubiqutin-like modifiers (Ubls) to proteins has been shown to be especially crucial in regulating a variety of cellular processes including the cell cycle, growth control, quality control, localization and many more. It is a highly dynamic process and involves a number of enzymes called E1, E2 and E3. Ub and Ubls are removed from the target proteins by deubiquitinating enzymes (DUBs) or Ubl-specific proteases (ULPs), thereby deconjugation can act as an additional level of control over the ubiquitin-conjugation system. In addition, DUBs and ULPs are responsible for activating Ub and Ubls from their inactive corresponding precursor forms. Here we review recent progress in molecular details of these deconjugating enzymes of Ubls.

• Journal of international Conference on Electrical Machines and Systems
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• v.1 no.3
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• pp.360-365
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• 2012

Cascaded H-Bridge rectifier (CHBR) is a more attractive solution in traction application for its transformerless structure. Because of the currents of different cells are exactly the same one, it is a challenge job to regulate the voltages of cells with only one current controller. In this paper, a PI-based control scheme is presented to deal with the voltages balance issue in CHBR. To satisfy the demand of rectifier such as unity power factor and regulated output DC voltages, the proposed control scheme consists of two parts. One is for shaping the grid current waveform and regulating the sum of DC-link voltages of all the cells; the other one is for balancing DC-link voltages. The latter is more concerned in this paper and is discussed in detail especially. Simulations and experiments are carried on. The results verified the feasibility and effectiveness of the proposed scheme.