• Asian Pacific Journal of Cancer Prevention
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• 제15권22호
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• pp.9955-9960
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• 2014

Background: Promoter hypermethylation is a common event in human cancer. O6-methylguanine-DNA methyltransferase (MGMT) is a gene involved in DNA repair, which is methylated in a variety of cancers. We aimed to explore the methylation status of MGMT gene among the North Eastern population where esophageal cancer incidence and exposure to carcinogens like nitrosamines is high. Materials and Methods: A total of 100 newly diagnosed esophageal cancer cases along with equal number of age, sex and ethnicity matched controls were included in this study. Methylation specific PCR was used to determine the MGMT methylation status in serum samples. Results: Aberrant promoter methylation of the MGMT gene was detected in 70% of esophageal cancer cases. Hypermethylation of MGMT gene was found to be influenced by environmental factors like betel quid and tobacco which contain potent carcinogens like nitrosamines. Tobacco chewing and tobacco smoking habit synergistically with MGMT methylation elevated the risk for esophageal cancer development [adjusted OR=5.02, 95% CI=1.35-18.74; p=0.010 for tobacco chewing and Adjusted OR=3.00, 95% CI=1.22-7.36; p=0.014 for tobacco smoking]. Conclusions: Results suggest that the DNA hypermethylation of MGMT is an important mechanism for MGMT gene silencing resulting in esophageal cancer development and is influenced by the environmental factors. Thus MGMT hypermethylation can be used as a biomarker for esophageal cancer in high incidence region of North East India.

• 한국지역지리학회지
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• 제21권3호
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• pp.450-460
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• 2015

이명박 정부가 출범하면서 시행된 광역경제권 사업은 적어도 동남권의 경우 매우 시의적절한 것이었다. 하지만 이 사업이 얼마나 성과적이었는지에 대해서는 의문이 적지 않다. 그간의 동남권광역경제발전위원회의 사업, 실적 등을 살펴 보건대 광역적 거버넌스 체계로서 성과가 매우 미흡하다고 하지 않을 수 없을 것이다. 동남권광역경제발전위원회는 운영상 많은 문제점을 가지고 있었다. 독자적인 인력을 거의 확보하지 못하였을 뿐 아니라 가용 예산이 미미하고 권한도 제한적이었다. 그러나 보다 중요한 한계는 그것의 성격과 기능이 제대로 정립되지 않았다는 점일 것이다. 그 결과 정권이 교체되면서 전국적으로 광역위원회는 폐지되고 말았다. 향후에도 동남권은 광역경제권의 수준에 부합하는 광역적 거버넌스가 요구되고 있다. 이 경우 신설될 기관의 주요 기능으로는 동남광역경제권에 대한 조사, 연구기능과 광역적 발전전략의 제안, 권고 등을 들 수 있을 것이다. 지역경제 및 도시 문제에 대한 조사 연구센터를 설치하여 지역의 경제적 상황을 상시적, 체계적으로 진단하고 현안 과제를 도출하도록 할 필요가 있다. 이 기관의 벤치마킹 모델로는 네덜란드의 레지오 란트스타트가 주목되는데, 란트스타트는 동남권의 도시체계 및 광역경제권과 유사성이 매우 높기 때문이다. 비교적 최근에 중앙정부에 의해 설립된 레지오-란트스타트는 행정구역을 넘어선 광역적 협력과 지역발전을 위한 연구 기능을 강화해 나가고 있다.

• 대한교통학회지
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• 제32권6호
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• pp.638-650
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• 2014

본 연구의 목적은 서울 도심지역의 행정동별 지역적 요소와 계획적 요소가 목적지로의 통행수단으로서 보행을 결정하는 것에 미치는 영향의 정도를 파악하고, 이에 대한 분석 결과 및 보행의 공간적 특성을 통해 지역별 특성을 파악하고자 함에 있다. 보행 결정에 영향을 미치는 요소들의 영향 정도를 파악하기 위해 본 연구에서는 전역적 차원의 회귀분석 모형인 최소자승모형을 사용하였고, 이와 더불어 다양한 공간통계 분석모형 중 지역별 보행특성을 기반으로 공간적 이질성을 고려하는 지리가중회귀모형의 적용을 통해 지역별 특성을 파악하고자 하였다. 전역적 차원의 회귀분석 결과 목적지로의 보행 선택에 영향을 주는 요소로는 지역적 요소 중 교통시설 지역 및 상업지역, 대학교 면적이, 계획적 요소 중에서는 교육.연구시설 및 계획시설 면적이 보행 선택에 정의 영향을 주었다. 마지막으로 지리가중회귀모형의 분석 결과를 통해 서울 도심지역 중 교통중심지 및 취약지, 상업 업무 중심지, 대학가 중심지, 연구시설 밀집지를 파악할 수 있었다. 본 연구의 결과를 통해 지역 및 공간적 이질성에 대한 이해 없이 진행되었던 기존의 계획 및 정책들에 지역적 특성이라는 정보를 제공함으로 이에 대한 반영의 여지를 주어 보다 지역발전 차원의 계획 수립에 기여할 수 있을 것이라는 점에 본 연구의 의의가 있을 것이라 여겨진다.

• Journal of Korea Trade
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• 제24권1호
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• pp.171-207
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• 2020

Purpose - This paper investigates the potential effect of the Regional Comprehensive Economic Partnership (RCEP) on trade liberalization among member countries in order to answer key questions in our research on whether the RCEP will be a cornerstone or just collaboration. Furthermore, it aims to measure the likely magnitude of the economic impact it has on its members. Design/methodology - Toward achieving research objectives, we developed a regional CGE model based on the GTAP 9 database. Findings - The simulation results show Korea, Australia, India, and Japan ranked the top countries with an average growth in GDP of 0.38 %, 0.36%, 0.29%, and 0.23%, respectively. Moreover, China and New Zealand followed with a percentage of 0.12% each. The lower economic performing group is the ASEAN group due to a contraction in GDP by 0.13%. Accordingly, there was a positive impact of the RCEP agreement on all member states, as empirically demonstrated. Furthermore, Korea is one of the countries that will benefit most from joining this agreement. Finally, this agreement is important; it has many economic benefits to member states, but it is not a cornerstone. Originality/value - The examination of the quantitative effects of tariff removal among the RCEP's countries is its value. We will address all member countries of the convention simultaneously using a regional CGE model GAMS language, where we employed a Mathematical Programming System for General Equilibrium (MPSGE) to establish a Regional CGE model. This study is directed to policymakers looking at evaluating RCEP agreement.

• 한국지역지리학회지
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• 제8권2호
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• pp.170-183
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• 2002

지역과 지역지리학이 재흥하고 있다. 새로운 지역지리학의 대두를 이해하기 위해서는, 자본주의 체제의 변화에 따라 새롭게 구성되는 공간적 재현 양식의 하나로서 지역의 의미도 변화한다는 점을 주목할 필요가 있다. 특정한 자본주의 체제는 자신에게 적합한 재현 양식을 요구하며 지역도 그 하나이기 때문이다. 20세기에 발전한 포드주의 자본주의 하에서, 지역 발전은 서구적 사회경제 체제의 공간적 확산과정으로 인식되었다. 국가는 조절기구로서 자본주의 체제의 확산을 촉진시키는 하부구조를 제공하고 지역적 공간 분업 구조를 조절함으로써 경계성장을 지원하였다. 지역 개발론은 이러한 국가개입에 적절한 이념과 정책 수단을 제공하는 역할을 했으며, 지역은 발전의 공간적 확산 과정을 측정하고 인식하기 위한 지리적 정보를 조직하고 분류하는 수단이었다. 지역개발론은 전통적인 지역 개념을 형식적 분류개념으로 왜소화시켰다. 포디즘에서 유전적 축적으로 자본주의 체제가 이행하면서, 지역이 다시 그 정체성과 진정성을 획득하고 있다. 지역지리학은 이러한 지역 재흥의 추세 속에서 적절한 연구 방법으로 성과를 올릴 수 있다. 유효한 방법의 하나가 문화생태학적 지역에 대한 역사적 접근이라고 믿는다. 문화생태학적 지역이 유연적 축적체제 하에서의 지방정부의 문화전략에 부합하고, 지역성을 서사적 내용과 미학적 경관으로 담아 낼 수 있기 때문이다.

• 농촌계획
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• 제19권4호
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• pp.33-46
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• 2013

The present study aims to provide an analytical framework for achieving aid and development effectiveness of agricultural cooperation with a demand-oriented perspective. This paper pays particular attention to categorize the stages of agricultural development of African recipients to identify demands for agricultural aid of the categorized groups. To do so, first of all, it establishes theoretical background to apply the demand-oriented concept and utilize the phase of agricultural development as an alternative for aid and development effectiveness. On the basis of the theoretical robustness, it conducts a series of analyses to categorize the African recipients by the development stages, incorporating factor analysis, cluster analysis and comparison between the present-future agricultural development levels. The findings propose analysis indicators for phase of agricultural development and clustered results including 18 countries of KAFACI members and priority countries in Africa. In addition to the practical application of the results, the methodological flow can be used as steps for sketching a future roadmap to construct the demand-oriented ODA(Official Development Assistance) plan. This paper also offers implications regarding ODA strategy of Korea in response to the phase of agricultural development and the aid demands.

• 산경연구논집
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• 제9권8호
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• pp.7-16
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• 2018

Purpose - The effect of regional culture has been acknowledged for decades. However, very little research takes it as an important issue in the medical tourism service decision process. This study focuses on regional culture to identify customers' preference for medical tourism in the international environment. It is proposed that regional culture may work as an critical moderator in the international medical tourism destination choice process. Especially, the destination attributes may vary according to regional culture. Research design, data, and methodology - By the questionnaire survey, the sample is collected from 2,041 potential Chinese residents in different regions of China. Regression analysis is constructed to test the effect of regional culture on Chinese customers' destination preference. Results - Results imply that regional culture plays a critical moderating role in the destination choice process. Results also indicate that destination attributes including medicine and travel characteristics are the important predictors of destination preference. Conclusions - This study provides the fundamental base to use regional culture as a descriptive variable for segmentation when establishing an effective marketing strategy. Furthermore, this research suggests that different strategies relied on destination attributes should be made to attract more Chinese customers for the development of medical tourism industry.

• International Journal of Computer Science & Network Security
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• 제22권5호
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• pp.61-66
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• 2022

The main purpose of the article is to analyze the key aspects of didactic games and exercises in the sensory development of preschoolers. The relevance of the chosen subject determines the fact that there are a number of problems in the specifics of the development of preschoolers and their characteristics, which manifest themselves individually. The importance of using didactic games and exercises in the development of preschoolers has been proved. The methodology includes a number of theoretical and practical methods, which together form the research methodology. Based on the results of the study, key aspects of the importance of the influence of dadactic games and exercises in the sensory development of preschoolers were identified. Further research requires the question of analyzing modern technologies for the formation of modern methods of sensory development for preschoolers.

• 지역연구
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• 제11권2호
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• pp.63-86
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• 1995

One of the innovative and most promising approaches to new high-tech business formation from university is technology business incubators, which attempts to enhance small high-tech start-up firms' chances of survival. To date, there is few comprehensive effort to do a comparative study of technology business incubatiors between European Countries and U.S. to evaluate the impacts of them on regional development. With these consideration in mind this research anlayzed key findings of 6 case studies of university related Technology Business Incubators in the U.K., Germany, and U.S. to explore relationship of university to regional development. These included Cambridge Science Park(CSP) '||'&'||' West of Scotland Science Park in the U.K., Dortmund Technologiezentrum '||'&'||' Berlin Technologiezentrum, and Rensselaer Technology Development Center of the Georgia Institute of Technology in the U.S. The primary objective of this study was to advance our understanding of the impact and utility of technology business incubators and to get some policy implications for the future development in this area in Korea. Among the major question examined hear was "how do they contribute the overall economy of the communities in which they are located\ulcorner". The results of the case study about this question were very positive. The technology business incubators contributed to foster new high-tech small business formation from university, to facilitate the cooperation between university and industry and Incubator tenants created jobs and income, pay taxes, and in doing so, had a multiplier effects on the local economy. The same was true of incubator graduates. With this consideration in mind the university related business regioned development policy in korean local communities.

• 국제학술발표논문집
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• The 1th International Conference on Construction Engineering and Project Management
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• pp.947-951
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• 2005

This paper studies the economic development situation of eastern, central, and western regions in China, and the functions of Chinese universities, which include education, research and contribution to the society. A new Chinese innovation system has been emerging in forms of university-run enterprise. The commitment of Chinese government to further introduction of a market economy has been elaborated with a focus on the relations between university and industry. A new regional development scheme by using of the functions of university is considered as the effective strategy to promote economic development of China in this stage.